4-Acetamidoantipyrin (BioDeep_00000270941)

   

Chemicals and Drugs Volatile Flavor Compounds


代谢物信息卡片


N-Acetylaminoantipyrine

化学式: C13H15N3O2 (245.116421)
中文名称: 4-乙酰氨基安替比林
谱图信息: 最多检出来源 Viridiplantae(plant) 98.41%

分子结构信息

SMILES: CC(=O)Nc1c(C)n(C)n(-c2ccccc2)c1=O
InChI: InChI=1S/C13H15N3O2/c1-9-12(14-10(2)17)13(18)16(15(9)3)11-7-5-4-6-8-11/h4-8H,1-3H3,(H,14,17)

描述信息

A member of the class of pyrazoles that is antipyrine substituted by an acetylamino group at position 4. It is a drug metabolite of metamizole.
CONFIDENCE standard compound; INTERNAL_ID 2001
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 1010
CONFIDENCE standard compound; INTERNAL_ID 4082
CONFIDENCE standard compound; EAWAG_UCHEM_ID 236

同义名列表

4 个代谢物同义名

4-Acetamidoantipyrine; 4-Acetamidoantipyrin; N-Acetylaminoantipyrine; 4-Acetamidoantipyrine



数据库引用编号

33 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Adriana Miriam Domínguez-Ramírez, Patricia Carrillo Calzadilla, Alma Rosa Cortés-Arroyo, Marcela Hurtado Y de la Peña, José Raúl Medina López, Martín Gómez-Hernández, Francisco Javier López-Muñoz. High-performance liquid chromatographic assay for metamizol metabolites in rat plasma: application to pharmacokinetic studies. Journal of pharmaceutical and biomedical analysis. 2012 Dec; 71(?):173-8. doi: 10.1016/j.jpba.2012.07.029. [PMID: 22917546]
  • Maren Kahle, Ignaz J Buerge, Markus D Müller, Thomas Poiger. Hydrophilic anthropogenic markers for quantification of wastewater contamination in ground- and surface waters. Environmental toxicology and chemistry. 2009 Dec; 28(12):2528-36. doi: 10.1897/08-606.1. [PMID: 19681643]
  • Dirk F Feldmann, Sebastian Zuehlke, Thomas Heberer. Occurrence, fate and assessment of polar metamizole (dipyrone) residues in hospital and municipal wastewater. Chemosphere. 2008 Apr; 71(9):1754-64. doi: 10.1016/j.chemosphere.2007.11.032. [PMID: 18164746]
  • A Mary Vilay, Mariann D Churchwell, Bruce A Mueller. Clinical review: Drug metabolism and nonrenal clearance in acute kidney injury. Critical care (London, England). 2008; 12(6):235. doi: 10.1186/cc7093. [PMID: 19040780]
  • Sebastian Zuehlke, Uwe Duennbier, Thomas Heberer. Investigation of the behavior and metabolism of pharmaceutical residues during purification of contaminated ground water used for drinking water supply. Chemosphere. 2007 Nov; 69(11):1673-80. doi: 10.1016/j.chemosphere.2007.06.020. [PMID: 17662339]
  • S C Pierre, R Schmidt, C Brenneis, M Michaelis, G Geisslinger, K Scholich. Inhibition of cyclooxygenases by dipyrone. British journal of pharmacology. 2007 Jun; 151(4):494-503. doi: 10.1038/sj.bjp.0707239. [PMID: 17435797]
  • S Wiegel, A Aulinger, R Brockmeyer, H Harms, J Löffler, H Reincke, R Schmidt, B Stachel, W von Tümpling, A Wanke. Pharmaceuticals in the river Elbe and its tributaries. Chemosphere. 2004 Oct; 57(2):107-26. doi: 10.1016/j.chemosphere.2004.05.017. [PMID: 15294435]
  • M Levy, R Safadi, E Zylber-Katz, L Granit, Y Caraco. Impairment of the metabolism of dipyrone in asymptomatic carriers of the hepatitis-B virus does not occur in rapid acetylators. European journal of clinical pharmacology. 2001 Sep; 57(6-7):461-5. doi: 10.1007/s002280100341. [PMID: 11699610]
  • O Cohen, E Zylber-Katz, Y Caraco, L Granit, M Levy. Cerebrospinal fluid and plasma concentrations of dipyrone metabolites after a single oral dose of dipyrone. European journal of clinical pharmacology. 1998 Sep; 54(7):549-53. doi: 10.1007/s002280050511. [PMID: 9832297]
  • G Heinemeyer, H J Gramm, I Roots, R Dennhardt, W Simgen. The kinetics of metamizol and its metabolites in critical-care patients with acute renal dysfunction. European journal of clinical pharmacology. 1993; 45(5):445-50. doi: 10.1007/bf00315516. [PMID: 8112374]
  • E Zylber-Katz, L Granit, M Levy. Formation and excretion of dipyrone metabolites in man. European journal of clinical pharmacology. 1992; 42(2):187-91. doi: 10.1007/bf00278482. [PMID: 1618251]
  • V Vlahov, M Badian, M Verho, N Bacracheva. Pharmacokinetics of metamizol metabolites in healthy subjects after a single oral dose of metamizol sodium. European journal of clinical pharmacology. 1990; 38(1):61-5. doi: 10.1007/bf00314805. [PMID: 2328750]
  • E Neddermann, P Rohdewald. Dose-dependent pharmacokinetics of metabolites of dipyrone in saliva. European journal of drug metabolism and pharmacokinetics. 1988 Apr; 13(2):105-11. doi: 10.1007/bf03191311. [PMID: 3208789]
  • E Zylber-Katz, L Granit, M Levy. Plasma protein binding of dipyrone metabolites in man. European journal of clinical pharmacology. 1985; 29(1):67-71. doi: 10.1007/bf00547371. [PMID: 4054207]
  • Y Matzner, R Drexler, M Levy. Effect of dipyrone, acetylsalicylic acid and acetaminophen on human neutrophil chemotaxis. European journal of clinical investigation. 1984 Dec; 14(6):440-3. doi: 10.1111/j.1365-2362.1984.tb01210.x. [PMID: 6441720]
  • M Levy, D Flusser, E Zylber-Katz, L Granit. Plasma kinetics of dipyrone metabolites in rapid and slow acetylators. European journal of clinical pharmacology. 1984; 27(4):453-8. doi: 10.1007/bf00549594. [PMID: 6519153]
  • H Wolhoff, G Altrogge, W Pola, N Sistovaris. [Metamizol--acute overdose with suicidal intent]. Deutsche medizinische Wochenschrift (1946). 1983 Nov; 108(46):1761-4. doi: 10.1055/s-2008-1069822. [PMID: 6641523]
  • N Sistovaris, W Pola, H Wolhoff. Thin-layer chromatographic determination of major metamizole metabolites in serum and urine. Journal of chromatography. 1983 May; 274(?):289-98. doi: 10.1016/s0378-4347(00)84432-1. [PMID: 6874829]