Dronedarone (BioDeep_00000270928)
代谢物信息卡片
Dronedarone
化学式: C31H44N2O5S (556.2970774)
中文名称: 决奈达隆
谱图信息:
最多检出来源 Viridiplantae(plant) 2.96%
分子结构信息
SMILES: CCCCC1=C(C2=C(C=CC(NS(C)(=O)=O)=C2)O1)C(C3=CC=C(C=C3)OCCCN(CCCC)CCCC)=O
InChI: InChI=1S/C31H44N2O5S/c1-5-8-12-29-30(27-23-25(32-39(4,35)36)15-18-28(27)38-29)31(34)24-13-16-26(17-14-24)37-22-11-21-33(19-9-6-2)20-10-7-3/h13-18,23,32H,5-12,19-22H2,1-4H3
描述信息
C - Cardiovascular system > C01 - Cardiac therapy > C01B - Antiarrhythmics, class i and iii > C01BD - Antiarrhythmics, class iii
C78274 - Agent Affecting Cardiovascular System > C47793 - Antiarrhythmic Agent
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
CONFIDENCE standard compound; INTERNAL_ID 2181
CONFIDENCE standard compound; EAWAG_UCHEM_ID 2855
INTERNAL_ID 2181; CONFIDENCE standard compound
Dronedarone (SR 33589), a derivative of amiodarone (HY-14187), is a class III antiarrhythmic agent for the study of atrial fibrillation (AF) and atrial flutter. Dronedarone is a potent blocker of multiple ion currents, including potassium current, sodium current, and L-type calcium current, and exhibits antiadrenergic effects by noncompetitive binding to β-adrenergic receptors. Dronedarone is a substrate for and a moderate inhibitor of CYP3A4[1].
同义名列表
2 个代谢物同义名
数据库引用编号
42 个数据库交叉引用编号
- ChEBI: CHEBI:50659
- KEGGdrug: D02537
- PubChem: 208898
- DrugBank: DB04855
- ChEMBL: CHEMBL184412
- MeSH: Dronedarone
- CAS: 141626-36-0
- MoNA: AU218133
- MoNA: AU218132
- MoNA: AU218131
- MoNA: AU218130
- MoNA: AU218111
- MoNA: AU218110
- MoNA: AU218109
- MoNA: AU218108
- MoNA: AU218107
- MoNA: EA285514
- MoNA: EA285513
- MoNA: EA285512
- MoNA: EA285511
- MoNA: EA285510
- MoNA: EA285509
- MoNA: EA285508
- MoNA: EA285507
- MoNA: EA285506
- MoNA: EA285505
- MoNA: EA285504
- MoNA: EA285503
- MoNA: EA285502
- MoNA: EA285501
- MoNA: AU218155
- MoNA: AU218154
- MoNA: AU218153
- MoNA: AU218152
- MoNA: AU218151
- MoNA: AU218105
- MoNA: AU218104
- MoNA: AU218103
- MoNA: AU218102
- MoNA: AU218101
- PMhub: MS000000725
- medchemexpress: HY-A0016
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mate Vamos, Jonas Oldgren, Gi-Byoung Nam, Gregory Y H Lip, Hugh Calkins, Jun Zhu, Kwo-Chang Ueng, Ulf Ludwigs, Mattias Wieloch, John Stewart, Stefan H Hohnloser. Dronedarone vs. placebo in patients with atrial fibrillation or atrial flutter across a range of renal function: a post hoc analysis of the ATHENA trial.
European heart journal. Cardiovascular pharmacotherapy.
2022 Jun; 8(4):363-371. doi:
10.1093/ehjcvp/pvab090. [PMID: 34958366] - Munveer Thind, Wojciech Zareba, Dan Atar, Harry J G M Crijns, Jun Zhu, Hui-Nam Pak, James Reiffel, Ulf Ludwigs, Mattias Wieloch, John Stewart, Peter Kowey. Efficacy and safety of dronedarone versus placebo in patients with atrial fibrillation stratified according to renal function: Post hoc analyses of the EURIDIS-ADONIS trials.
Clinical cardiology.
2022 Jan; 45(1):101-109. doi:
10.1002/clc.23765. [PMID: 35019175] - Munveer Thind, David S McKindley, James A Reiffel, Gerald V Naccarelli, John Stewart, Peter R Kowey. Predictors of dronedarone plasma drug concentrations and effect on atrial fibrillation/atrial flutter recurrence: Analyses from the EURIDIS and ADONIS studies.
Clinical cardiology.
2022 Jan; 45(1):119-128. doi:
10.1002/clc.23768. [PMID: 35032136] - Chuntao Wu, Rania Boiron, Hayet Kechemir, Sampada Gandhi, Stephen Lin, Mattias Wieloch, Juhaeri Juhaeri. Evaluating the Risk of Digitalis Intoxication Associated With Concomitant Use of Dronedarone and Digoxin Using Real-World Data.
Clinical therapeutics.
2021 05; 43(5):852-858.e2. doi:
10.1016/j.clinthera.2021.03.014. [PMID: 33888353] - Laura Barrie Smith, Nihar R Desai, Bryan Dowd, Alexander Everhart, Jeph Herrin, Lucas Higuera, Molly Moore Jeffery, Anupam B Jena, Joseph S Ross, Nilay D Shah, Pinar Karaca-Mandic. Patient and provider-level factors associated with changes in utilization of treatments in response to evidence on ineffectiveness or harm.
International journal of health economics and management.
2020 Sep; 20(3):299-317. doi:
10.1007/s10754-020-09282-2. [PMID: 32350680] - Ryuichi Kambayashi, Mihoko Hagiwara-Nagasawa, Yoshiki Kondo, Zhi Jie Yeo, Ai Goto, Koki Chiba, Yoshio Nunoi, Hiroko Izumi-Nakaseko, Jacqueline Wen Hui Leow, Gopalakrishnan Venkatesan, Akio Matsumoto, Eric Chun Yong Chan, Atsushi Sugiyama. How the Deuteration of Dronedarone Can Modify Its Cardiovascular Profile: In Vivo Characterization of Electropharmacological Effects of Poyendarone, a Deuterated Analogue of Dronedarone.
Cardiovascular toxicology.
2020 08; 20(4):339-350. doi:
10.1007/s12012-019-09559-0. [PMID: 31898152] - Yiyan Yu, Dan Luo, Zhiyi Li, Juan Zhang, Fang Li, Jie Qiao, Fengxu Yu, Miaoling Li. Inhibitory Effects of Dronedarone on Small Conductance Calcium Activated Potassium Channels in Patients with Chronic Atrial Fibrillation: Comparison to Amiodarone.
Medical science monitor : international medical journal of experimental and clinical research.
2020 May; 26(?):e924215. doi:
10.12659/msm.924215. [PMID: 32470968] - Yousef A Bin Jardan, Ali Abdussalam, Ayman O S El-Kadi, Dion R Brocks. Dronedarone: the effect of diet-induced obesity on its metabolism and experimental hyperlipidemia on its metabolism and tissue distribution in the rat.
Canadian journal of physiology and pharmacology.
2020 Mar; 98(3):177-181. doi:
10.1139/cjpp-2019-0125. [PMID: 31614093] - Giuseppe Boriani, Carina Blomström-Lundqvist, Stefan H Hohnloser, Lennart Bergfeldt, Giovanni L Botto, Alessandro Capucci, Ignacio Fernández Lozano, Andreas Goette, Carsten W Israel, José L Merino, A John Camm. Safety and efficacy of dronedarone from clinical trials to real-world evidence: implications for its use in atrial fibrillation.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.
2019 12; 21(12):1764-1775. doi:
10.1093/europace/euz193. [PMID: 31324921] - Begoña Quintana-Villamandos, Laia Pazó-Sayós, Silvia Magdalena Arribas, Pilar Rodríguez-Rodríguez, Rainer H Böger, Nicole Lüneburg, Emilio Delgado-Baeza, Maria Carmen González. Dronedarone induces regression of coronary artery remodeling related to better global antioxidant status.
Hypertension research : official journal of the Japanese Society of Hypertension.
2019 10; 42(10):1485-1494. doi:
10.1038/s41440-019-0257-z. [PMID: 30992541] - In-Hwan Baek. Dose proportionality and pharmacokinetics of dronedarone following intravenous and oral administration to rat.
Xenobiotica; the fate of foreign compounds in biological systems.
2019 Jun; 49(6):734-739. doi:
10.1080/00498254.2018.1496369. [PMID: 29962267] - Begoña Quintana-Villamandos, María Jesús Delgado-Martos, Emilio Delgado-Baeza. Impact of a Multichannel Blocker in Attenuating Intramyocardial Artery Remodeling in Hypertensive Rats through Increased Nitric Oxide Bioavailability.
BioMed research international.
2019; 2019(?):6374582. doi:
10.1155/2019/6374582. [PMID: 31355272] - Vaishali M Gambhire, Makarand S Gambhire, Nisharani S Ranpise. Solid Lipid Nanoparticles of Dronedarone Hydrochloride for Oral Delivery: Optimization, In Vivo Pharmacokinetics and Uptake Studies.
Pharmaceutical nanotechnology.
2019; 7(5):375-388. doi:
10.2174/2211738507666190802140607. [PMID: 31376827] - Yoshiyuki Motokawa, Yuji Nakamura, Mihoko Hagiwara-Nagasawa, Ai Goto, Koki Chiba, Nur Jaharat Lubna, Hiroko Izumi-Nakaseko, Kentaro Ando, Atsuhiko T Naito, Hiroshi Yamazaki, Atsushi Sugiyama. In vivo Analysis of the Anti-atrial Fibrillatory, Proarrhythmic and Cardiodepressive Profiles of Dronedarone as a Guide for Safety Pharmacological Evaluation of Antiarrhythmic Drugs.
Cardiovascular toxicology.
2018 06; 18(3):242-251. doi:
10.1007/s12012-017-9434-y. [PMID: 29139031] - Min-Soo Kim, In-Hwan Baek. Effect of dronedarone on the pharmacokinetics of carvedilol following oral administration to rats.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2018 Jan; 111(?):13-19. doi:
10.1016/j.ejps.2017.09.029. [PMID: 28942006] - Renu Chadha, Alka Bali, Gulshan Bansal. Bioanalytical Method Validation for Dronedarone and Duloxetine in Blood Serum.
Journal of AOAC International.
2017 Jan; 100(1):45-50. doi:
10.5740/jaoacint.16-0204. [PMID: 27760589] - Yousef A Bin Jardan, Dion R Brocks. The pharmacokinetics of dronedarone in normolipidemic and hyperlipidemic rats.
Biopharmaceutics & drug disposition.
2016 Sep; 37(6):345-51. doi:
10.1002/bdd.2016. [PMID: 27194397] - Dingxin Qin, George Leef, Mian Bilal Alam, Rohit Rattan, Mohamad Bilal Munir, Divyang Patel, Furqan Khattak, Evan Adelstein, Sandeep K Jain, Samir Saba. Comparative effectiveness of antiarrhythmic drugs for rhythm control of atrial fibrillation.
Journal of cardiology.
2016 May; 67(5):471-6. doi:
10.1016/j.jjcc.2015.07.001. [PMID: 26233885] - Li-Qin Jiang, Shan-Jiang Chen, Jian-Jiang Xu, Zhang Ran, Wang Ying, Sheng-Gang Zhao. Dronedarone and Amiodarone Induce Dyslipidemia and Thyroid Dysfunction in Rats.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2016; 38(6):2311-22. doi:
10.1159/000445585. [PMID: 27197836] - Valentino Conti, Chiara Biagi, Mauro Melis, Ida Fortino, Monia Donati, Alberto Vaccheri, Mauro Venegoni, Domenico Motola. Acute renal failure in patients treated with dronedarone or amiodarone: a large population-based cohort study in Italy.
European journal of clinical pharmacology.
2015 Sep; 71(9):1147-53. doi:
10.1007/s00228-015-1903-2. [PMID: 26174115] - Natalia Mochalina, Tord Juhlin, Pyotr G Platonov, Peter J Svensson, Mattias Wieloch. Concomitant use of dronedarone with dabigatran in patients with atrial fibrillation in clinical practice.
Thrombosis research.
2015 Jun; 135(6):1070-4. doi:
10.1016/j.thromres.2015.03.015. [PMID: 25842008] - Sang Duk Han, Sang Won Jung, Sun Woo Jang, Miwon Son, Byoung Moon Kim, Myung Joo Kang. Reduced Food-Effect on Intestinal Absorption of Dronedarone by Self-microemulsifying Drug Delivery System (SMEDDS).
Biological & pharmaceutical bulletin.
2015; 38(7):1026-32. doi:
10.1248/bpb.b15-00110. [PMID: 26133712] - Stefan H Hohnloser, Jonathan L Halperin, A John Camm, Peggy Gao, David Radzik, Stuart J Connolly. Interaction between digoxin and dronedarone in the PALLAS trial.
Circulation. Arrhythmia and electrophysiology.
2014 Dec; 7(6):1019-25. doi:
10.1161/circep.114.002046. [PMID: 25378467] - Mónica Marin-Casino, Maria J Pérez-Sáez, Marta Crespo, Daniel Echeverría, Marisa Mir, Julio Pascual. Significant tacrolimus and dronedarone interaction in a kidney transplant recipient.
Transplantation.
2014 Aug; 98(4):e33-4. doi:
10.1097/tp.0000000000000280. [PMID: 25243519] - Yousef A Bin Jardan, Raniah Q Gabr, Dion R Brocks. Pharmacokinetics of dronedarone in rat using a newly developed high-performance liquid chromatographic assay method.
Biomedical chromatography : BMC.
2014 Aug; 28(8):1070-4. doi:
10.1002/bmc.3121. [PMID: 25165788] - Gerrit Gehring, Katrin Rohrmann, Nkacheh Atenchong, Eva Mittler, Stephan Becker, Franziska Dahlmann, Stefan Pöhlmann, Florian W R Vondran, Sascha David, Michael P Manns, Sandra Ciesek, Thomas von Hahn. The clinically approved drugs amiodarone, dronedarone and verapamil inhibit filovirus cell entry.
The Journal of antimicrobial chemotherapy.
2014 Aug; 69(8):2123-31. doi:
10.1093/jac/dku091. [PMID: 24710028] - Jignesh M Parekh, Mallika Sanyal, Manish Yadav, Pranav S Shrivastav. Systematic evaluation of plasma phospholipids for reliable and precise determination of dronedarone and desbutyldronedarone by LC-MS/MS.
Bioanalysis.
2014; 6(19):2635-50. doi:
10.4155/bio.14.123. [PMID: 25411706] - Ajay Vallakati, Preeti A Chandra, Manali Pednekar, Robert Frankel, Jacob Shani. Dronedarone-induced digoxin toxicity: new drug, new interactions.
American journal of therapeutics.
2013 Nov; 20(6):e717-9. doi:
10.1097/mjt.0b013e31821106c9. [PMID: 21519214] - Richard L Verrier, Marcel F Sobrado, Vitor P F Pagotto, Alexandre F Kanas, Ananda D Machado, Bruno B Varone, Lucas F Sobrado, Bruce D Nearing, Dewan Zeng, Luiz Belardinelli. Inhibition of I(f) in the atrioventricular node as a mechanism for dronedarone's reduction in ventricular rate during atrial fibrillation.
Heart rhythm.
2013 Nov; 10(11):1692-7. doi:
10.1016/j.hrthm.2013.08.007. [PMID: 23933296] - Lucas F Sobrado, Bruno B Varone, Ananda D Machado, Bruce D Nearing, Dewan Zeng, Luiz Belardinelli, Richard L Verrier. Dronedarone's inhibition of If current is the primary mechanism responsible for its bradycardic effect.
Journal of cardiovascular electrophysiology.
2013 Aug; 24(8):914-8. doi:
10.1111/jce.12155. [PMID: 23647933] - Iordanis Mourouzis, Erietta Kostakou, Georgios Galanopoulos, Polixeni Mantzouratou, Constantinos Pantos. Inhibition of thyroid hormone receptor α1 impairs post-ischemic cardiac performance after myocardial infarction in mice.
Molecular and cellular biochemistry.
2013 Jul; 379(1-2):97-105. doi:
10.1007/s11010-013-1631-9. [PMID: 23532677] - Chiara Biagi, Mauro Venegoni, Mauro Melis, Elena Buccellato, Nicola Montanaro, Domenico Motola. Dronedarone-associated acute renal failure: evidence coming from the Italian spontaneous ADR reporting database.
British journal of clinical pharmacology.
2013 May; 75(5):1351-5. doi:
10.1111/bcp.12005. [PMID: 23072519] - David Duncker, Hanno Oswald, Ajmal Gardiwal, Ulrich Lüsebrink, Thorben König, Hendrik Schreyer, Gunnar Klein. Stable cystatin C serum levels confirm normal renal function in patients with dronedarone-associated increase in serum creatinine.
Journal of cardiovascular pharmacology and therapeutics.
2013 Mar; 18(2):109-12. doi:
10.1177/1074248412453873. [PMID: 22837540] - C Young, M Maruthappu, R P Wayne, L Leaver. Reversible acute kidney injury requiring haemodialysis five days after starting dronedarone in a stable 71-year-old man at risk of cardiovascular polypharmacy.
The journal of the Royal College of Physicians of Edinburgh.
2013; 43(2):122-5. doi:
10.4997/jrcpe.2013.207. [PMID: 23734353] - Richard L Verrier, Vitor P F Pagotto, Alexandre F Kanas, Marcel F Sobrado, Bruce D Nearing, Dewan Zeng, Luiz Belardinelli. Low doses of ranolazine and dronedarone in combination exert potent protection against atrial fibrillation and vulnerability to ventricular arrhythmias during acute myocardial ischemia.
Heart rhythm.
2013 Jan; 10(1):121-7. doi:
10.1016/j.hrthm.2012.09.015. [PMID: 22985658] - Allan C Skanes, Jeff S Healey, John A Cairns, Paul Dorian, Anne M Gillis, M Sean McMurtry, L Brent Mitchell, Atul Verma, Stanley Nattel. Focused 2012 update of the Canadian Cardiovascular Society atrial fibrillation guidelines: recommendations for stroke prevention and rate/rhythm control.
The Canadian journal of cardiology.
2012 Mar; 28(2):125-36. doi:
10.1016/j.cjca.2012.01.021. [PMID: 22433576] - Elena Piccoli, Matteo Nadai, Carla Mucignat Caretta, Valeria Bergonzini, Claudia Del Vecchio, Huy Riem Ha, Laurent Bigler, Daniele Dal Zoppo, Elisabetta Faggin, Andrea Pettenazzo, Rocco Orlando, Cristiano Salata, Arianna Calistri, Giorgio Palù, Aldo Baritussio. Amiodarone impairs trafficking through late endosomes inducing a Niemann-Pick C-like phenotype.
Biochemical pharmacology.
2011 Nov; 82(9):1234-49. doi:
10.1016/j.bcp.2011.07.090. [PMID: 21878321] - Cen Xie, Shilei Yang, Dafang Zhong, Xiaojian Dai, Xiaoyan Chen. Simultaneous determination of dronedarone and its active metabolite debutyldronedarone in human plasma by liquid chromatography-tandem mass spectrometry: application to a pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2011 Oct; 879(28):3071-5. doi:
10.1016/j.jchromb.2011.09.004. [PMID: 21937291] - Thomas Meinertz, Wilhelm Kirch, Ludger Rosin, David Pittrow, Stefan N Willich, Paulus Kirchhof. Management of atrial fibrillation by primary care physicians in Germany: baseline results of the ATRIUM registry.
Clinical research in cardiology : official journal of the German Cardiac Society.
2011 Oct; 100(10):897-905. doi:
10.1007/s00392-011-0320-5. [PMID: 21533828] - Vera H M Deneer, Norbert M van Hemel. Is antiarrhythmic treatment in the elderly different? a review of the specific changes.
Drugs & aging.
2011 Aug; 28(8):617-33. doi:
10.2165/11591680-000000000-00000. [PMID: 21812498] - Michele Marzocchi, Federico Lombardi. Dronedarone for atrial fibrillation therapy.
Expert review of cardiovascular therapy.
2011 Jun; 9(6):675-83. doi:
10.1586/erc.11.58. [PMID: 21714598] - Saurabh Malhotra, Mithilesh K Das. Delayed and indirect effects of antiarrhythmic drugs in reducing sudden cardiac death.
Future cardiology.
2011 Mar; 7(2):203-17. doi:
10.2217/fca.11.3. [PMID: 21453027] - Patrina Gunness, Katarina Aleksa, Gideon Koren. The effect of acyclovir on the tubular secretion of creatinine in vitro.
Journal of translational medicine.
2010 Dec; 8(?):139. doi:
10.1186/1479-5876-8-139. [PMID: 21192814] - Paul Dorian. Clinical pharmacology of dronedarone: implications for the therapy of atrial fibrillation.
Journal of cardiovascular pharmacology and therapeutics.
2010 Dec; 15(4 Suppl):15S-8S. doi:
10.1177/1074248410367792. [PMID: 20472816] - James C Coons, Kara M Plauger, Amy L Seybert, George G Sokos. Worsening heart failure in the setting of dronedarone initiation.
The Annals of pharmacotherapy.
2010 Sep; 44(9):1496-500. doi:
10.1345/aph.1p075. [PMID: 20628043] - Eric M Tichy, Andrew J Medwid, Elizabeth A Mills, Richard N Formica, Sanjay Kulkarni. Significant sirolimus and dronedarone interaction in a kidney transplant recipient.
The Annals of pharmacotherapy.
2010 Jul; 44(7-8):1338-41. doi:
10.1345/aph.1p114. [PMID: 20484171] - Robert W Bolderman, J J Rob Hermans, Jos G Maessen. Determination of the class III antiarrhythmic drugs dronedarone and amiodarone, and their principal metabolites in plasma and myocardium by high-performance liquid chromatography and UV-detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2009 Jun; 877(18-19):1727-31. doi:
10.1016/j.jchromb.2009.04.029. [PMID: 19427276] - Yvonne Tschuppert, Thierry Buclin, Laura E Rothuizen, Laurent A Decosterd, Jacques Galleyrand, Christine Gaud, Jérôme Biollaz. Effect of dronedarone on renal function in healthy subjects.
British journal of clinical pharmacology.
2007 Dec; 64(6):785-91. doi:
10.1111/j.1365-2125.2007.02998.x. [PMID: 17662087] - Takahiro Iwamoto, Yasuhide Watanabe, Satomi Kita, Mordecai P Blaustein. Na+/Ca2+ exchange inhibitors: a new class of calcium regulators.
Cardiovascular & hematological disorders drug targets.
2007 Sep; 7(3):188-98. doi:
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Endocrinology.
2006 Jun; 147(6):2936-43. doi:
10.1210/en.2005-1246. [PMID: 16527845] - John M Ridley, James T Milnes, Harry J Witchel, Jules C Hancox. High affinity HERG K(+) channel blockade by the antiarrhythmic agent dronedarone: resistance to mutations of the S6 residues Y652 and F656.
Biochemical and biophysical research communications.
2004 Dec; 325(3):883-91. doi:
10.1016/j.bbrc.2004.10.127. [PMID: 15541373] - Thibaud Damy, Françoise Pousset, Henri Caplain, Jean-Sébastien Hulot, Philippe Lechat. Pharmacokinetic and pharmacodynamic interactions between metoprolol and dronedarone in extensive and poor CYP2D6 metabolizers healthy subjects.
Fundamental & clinical pharmacology.
2004 Feb; 18(1):113-23. doi:
10.1046/j.1472-8206.2003.00216.x. [PMID: 14748763] - H C Van Beeren, W M C Jong, E Kaptein, T J Visser, O Bakker, W M Wiersinga. Dronerarone acts as a selective inhibitor of 3,5,3'-triiodothyronine binding to thyroid hormone receptor-alpha1: in vitro and in vivo evidence.
Endocrinology.
2003 Feb; 144(2):552-8. doi:
10.1210/en.2002-220604. [PMID: 12538616] - Constantinos Pantos, Iordanis Mourouzis, Martine Delbruyère, Vassiliki Malliopoulou, Stylianos Tzeis, Demosthenis D Cokkinos, Nikos Nikitas, Hariclia Carageorgiou, Dennis Varonos, Dennis Cokkinos, Dino Nisato. Effects of dronedarone and amiodarone on plasma thyroid hormones and on the basal and postischemic performance of the isolated rat heart.
European journal of pharmacology.
2002 May; 444(3):191-6. doi:
10.1016/s0014-2999(02)01624-2. [PMID: 12063079] - P Chatelain, L Meysmans, J R Mattéazzi, P Beaufort, M Clinet. Interaction of the antiarrhythmic agents SR 33589 and amiodarone with the beta-adrenoceptor and adenylate cyclase in rat heart.
British journal of pharmacology.
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