Xanthopterin-B2 (BioDeep_00000270907)
natural product
代谢物信息卡片
Xanthopterin-B2
化学式: C6H5N5O2 (179.04432300000002)
中文名称: 迟效酵母粉
谱图信息:
最多检出来源 Viridiplantae(plant) 0.53%
分子结构信息
SMILES: C1=NC2=C(C(=O)NC(=N2)N)NC1=O
InChI: InChI=1S/C6H5N5O2/c7-6-10-4-3(5(13)11-6)9-2(12)1-8-4/h1H,(H,9,12)(H3,7,8,10,11,13)
数据库引用编号
30 个数据库交叉引用编号
- PubChem: 135403800
- Metlin: METLIN5672
- ChEMBL: CHEMBL1236854
- MeSH: Xanthopterin
- CAS: 119-44-8
- CAS: 14331-49-8
- MoNA: Bruker_HCD_library000173
- MoNA: VF-NPL-LTQ007518
- MoNA: VF-NPL-LTQ007517
- MoNA: VF-NPL-QEHF026238
- MoNA: VF-NPL-QEHF026237
- MoNA: VF-NPL-QEHF026236
- MoNA: VF-NPL-QEHF026235
- MoNA: VF-NPL-QEHF026234
- MoNA: VF-NPL-QEHF026233
- MoNA: VF-NPL-QEHF026232
- MoNA: VF-NPL-QEHF026231
- MoNA: VF-NPL-QEHF026230
- MoNA: VF-NPL-QEHF026229
- MoNA: VF-NPL-QEHF026228
- MoNA: VF-NPL-QEHF026227
- MoNA: VF-NPL-QEHF026226
- MoNA: VF-NPL-QEHF026225
- MoNA: VF-NPL-QEHF026224
- MoNA: KO004270
- MoNA: KO004269
- MoNA: KO004268
- MoNA: KO004267
- MoNA: KO004266
- PMhub: MS000000629
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xiaofeng Shi, Shuang Pan, Yongqi Li, Wei Ma, Han Wang, Caiming Xu, Lei Li. Xanthoplanine attenuates macrophage polarization towards M1 and inflammation response via disruption of CrkL-STAT5 complex.
Archives of biochemistry and biophysics.
2020 04; 683(?):108325. doi:
10.1016/j.abb.2020.108325. [PMID: 32142888] - Pei-Zhong Bao, Jun Ye, Lian-Shu Han, Wen-Juan Qiu, Hui-Wen Zhang, Yong-Guo Yu, Jian-Guo Wang, Xue-Fan Gu. Application of isoxanthopterin as a new pterin marker in the differential diagnosis of hyperphenylalaninemia.
World journal of pediatrics : WJP.
2019 Feb; 15(1):66-71. doi:
10.1007/s12519-018-0202-2. [PMID: 30443829] - Angus Lindsay, Preston M McCourt, Peter Karachunski, Dawn A Lowe, James M Ervasti. Xanthine oxidase is hyper-active in Duchenne muscular dystrophy.
Free radical biology & medicine.
2018 12; 129(?):364-371. doi:
10.1016/j.freeradbiomed.2018.10.404. [PMID: 30312761] - A Lindsay, J Healy, W Mills, J Lewis, N Gill, N Draper, S P Gieseg. Impact-induced muscle damage and urinary pterins in professional rugby: 7,8-dihydroneopterin oxidation by myoglobin.
Scandinavian journal of medicine & science in sports.
2016 Mar; 26(3):329-37. doi:
10.1111/sms.12436. [PMID: 25772829] - Lingling Huang, Lan Guo, Yiqun Wan, Pingping Pan, Lei Feng. Simultaneous determination of three potential cancer biomarkers in rat urine by synchronous fluorescence spectroscopy.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2014; 120(?):595-601. doi:
10.1016/j.saa.2013.12.001. [PMID: 24365397] - Gabriella Allegri, Heleno José Bezerra Costa Netto, Luiz Nelson Lopes Ferreira Gomes, Maria Lúcia Costa de Oliveira, Fernanda Bertão Scalco, Francisco Radler de Aquino Neto. Determination of six pterins in urine by LC-MS/MS.
Bioanalysis.
2012 Jul; 4(14):1739-46. doi:
10.4155/bio.12.131. [PMID: 22877220] - M J Culzoni, A Mancha de Llanos, M M De Zan, A Espinosa-Mansilla, F Cañada-Cañada, A Muñoz de la Peña, H C Goicoechea. Enhanced MCR-ALS modeling of HPLC with fast scan fluorimetric detection second-order data for quantitation of metabolic disorder marker pteridines in urine.
Talanta.
2011 Oct; 85(5):2368-74. doi:
10.1016/j.talanta.2011.07.086. [PMID: 21962655] - A Mancha de Llanos, M M De Zan, M J Culzoni, A Espinosa-Mansilla, F Cañada-Cañada, A Muñoz de la Peña, H C Goicoechea. Determination of marker pteridines in urine by HPLC with fluorimetric detection and second-order multivariate calibration using MCR-ALS.
Analytical and bioanalytical chemistry.
2011 Feb; 399(6):2123-35. doi:
10.1007/s00216-010-4071-3. [PMID: 20711774] - Sanjeewa Gamagedara, Stephen Gibbons, Yinfa Ma. Investigation of urinary pteridine levels as potential biomarkers for noninvasive diagnosis of cancer.
Clinica chimica acta; international journal of clinical chemistry.
2011 Jan; 412(1-2):120-8. doi:
10.1016/j.cca.2010.09.015. [PMID: 20869359] - Yi-Qun Wan, Li-Juan Tang, Ting Tan. Simultaneous determination of xanthopterin and isoxanthopterin in human urine by synchronous fluorescence spectroscopy.
Journal of fluorescence.
2010 Nov; 20(6):1191-8. doi:
10.1007/s10895-010-0667-4. [PMID: 20419340] - Lei Feng, Aiping Yan, Lin Chen, Yiqun Wan. [Determination of isoxanthopterin in human urine by solid phase extraction-high performance anion-exchange chromatography coupled with integrated pulsed amperometric detection].
Se pu = Chinese journal of chromatography.
2010 Apr; 28(4):408-12. doi:
10.3724/sp.j.1123.2010.00408. [PMID: 20712126] - D Qujeq, H Ahmadi. Determination of xanthopterin in patients with renal insufficiency.
American journal of nephrology.
2001 Jul; 21(4):340-2. doi:
10.1159/000046271. [PMID: 11509808] - R Walter, N Blau, A Schaffner, M Schneemann, R Speich, R Stocker, B Naujeck, G Schoedon. Inhalation of the nitric oxide synthase cofactor tetrahydrobiopterin in healthy volunteers.
American journal of respiratory and critical care medicine.
1997 Dec; 156(6):2006-10. doi:
10.1164/ajrccm.156.6.96-12084. [PMID: 9412588] - N Blau, J B de Klerk, B Thöny, C W Heizmann, L Kierat, J A Smeitink, M Duran. Tetrahydrobiopterin loading test in xanthine dehydrogenase and molybdenum cofactor deficiencies.
Biochemical and molecular medicine.
1996 Aug; 58(2):199-203. doi:
10.1006/bmme.1996.0049. [PMID: 8812740] - T Yamamoto, Y Moriwaki, S Takahashi, Z Tsutsumi, J Yamakita, Y Nasako, K Hiroishi, K Higashino. Determination of human plasma xanthine oxidase activity by high-performance liquid chromatography.
Journal of chromatography. B, Biomedical applications.
1996 Jun; 681(2):395-400. doi:
10.1016/0378-4347(96)00071-0. [PMID: 8811453] - S L Garber, J Salmassi, J A Arruda, G Dunea. Xanthopterin-induced renal dysfunction: a reversible model of crystal nephropathy.
Nephron.
1995; 69(1):71-8. doi:
10.1159/000188363. [PMID: 7891801] - M Rubenstein, S Muchnik, S L Garber, J A Arruda, G Dunea. Differential effect of xanthopterin and biopterin on cell growth.
The International journal of biochemistry.
1993 Dec; 25(12):1873-80. doi:
10.1016/0020-711x(88)90319-9. [PMID: 8138025] - A Fukuda, T Mazda, W L Gyure, T Iino, H Harada, M Yakura, H Kamitsukasa, A Ohbayashi, T Oka, M Tsusué. A comparative study of urinary xanthopterin and neopterin in liver diseases.
European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies.
1993 Mar; 31(3):129-34. doi:
10.1515/cclm.1993.31.3.129. [PMID: 8490058] - T Iino, H Watanabe, W L Gyure, T Mazda, H Mieno, M Tsusué. An example of the detection of an esophageal carcinoma in its very early stage by urinary xanthopterin determination.
Advances in experimental medicine and biology.
1993; 338(?):243-6. doi:
10.1007/978-1-4615-2960-6_49. [PMID: 8304117] - A A Bakir, M Shaykh, R H Williams, S Ahmed, G Dunea. A study of xanthopterin in chronic renal failure.
American journal of nephrology.
1992; 12(4):224-8. doi:
10.1159/000168450. [PMID: 1481869] - M Goldberg, H Eichinger, W Otten, M Merkenschlager. [Pteridine pattern in the urine of swine of different breeds and halothane genotypes in relation to nutrition and stress].
Tierarztliche Praxis.
1991 Oct; 19(5):493-6. doi:
NULL. [PMID: 1759264] - R H Williams, M Shaykh, S Ahmed, T Musiala, N Bazilinski, G Dunea, A Dubin. Purification and biochemical characterization of xanthopterin from patients with chronic renal failure. I. Isolation, purification and preliminary characterization.
Clinical biochemistry.
1991 Oct; 24(5):399-406. doi:
10.1016/s0009-9120(05)80015-3. [PMID: 1760878] - R H Williams, M Shaykh, S Ahmed, T Musiala, N Bazilinski, G Dunea, A Dubin. Purification and biochemical characterization of xanthopterin from patients with chronic renal failure. II. Biochemical elucidation and structural analysis.
Clinical biochemistry.
1991 Oct; 24(5):407-15. doi:
10.1016/s0009-9120(05)80016-5. [PMID: 1760879] - T Sasaoka, N Kaneda, T Nagatsu. Highly sensitive assay for xanthine oxidase activity by high-performance liquid chromatography with fluorescence detection.
Journal of chromatography.
1988 Feb; 424(2):392-7. doi:
10.1016/s0378-4347(00)81118-4. [PMID: 3372632] - J H Woolf, C A Nichol, D S Duch. Determination of biopterin and other pterins in tissues and body fluids by high-performance liquid chromatography.
Journal of chromatography.
1983 May; 274(?):398-402. doi:
10.1016/s0378-4347(00)84451-5. [PMID: 6874847] - B Stea, R A Smith. Urinary unconjugated pteridines: general considerations.
Survey of immunologic research.
1982; 1(4):357-64. doi:
10.1007/bf02918548. [PMID: 6764849] - B Stea, R M Halpern, B C Halpern, R A Smith. Urinary excretion levels of unconjugated pterins in cancer patients and normal individuals.
Clinica chimica acta; international journal of clinical chemistry.
1981 Jul; 113(3):231-42. doi:
10.1016/0009-8981(81)90277-1. [PMID: 7261396] - J L Dhondt, J P Farriaux, C Largilliere, M Dautrevaux, P Ardouin. Pterin metabolism in normal subjects and hyperphenylalaninaemic patients.
Journal of inherited metabolic disease.
1981; 4(2):47-8. doi:
10.1007/bf02263584. [PMID: 6790841] - H Rokos, K Rokos, H Frisius, H J Kirstaedter. Altered urinary excretion of pteridines in neoplastic disease. Determination of biopterin, neopterin, xanthopterin, and pterin.
Clinica chimica acta; international journal of clinical chemistry.
1980 Aug; 105(2):275-86. doi:
10.1016/0009-8981(80)90470-2. [PMID: 7398095] - D M Danks, R G Cotton, P Schlesinger. Diagnosis of malignant hyperphenylalaninaemia.
Archives of disease in childhood.
1979 May; 54(5):329-30. doi:
10.1136/adc.54.5.329. [PMID: 475407] - P Schlesinger, B M Watson, R G Cotton, D M Danks. Urinary dihydroxanthopterin in the diagnosis of malignant hyperphenylalaninemia and phenylketonuria.
Clinica chimica acta; international journal of clinical chemistry.
1979 Mar; 92(2):187-95. doi:
10.1016/0009-8981(79)90113-x. [PMID: 487572] - B M Watson, P Schlesinger, R G Cotton. Dihydroxanthopterinuria in phenylketonuria and lethal hyperphenylalaninemia patients.
Clinica chimica acta; international journal of clinical chemistry.
1977 Aug; 78(3):417-23. doi:
10.1016/0009-8981(77)90075-4. [PMID: 884867] - A E Auletta, A M Gery, A Parmar, J Davis, L Mishra, J A Mead. The effect of folate and folate analogs upon dihydrofolate reductase and DNA synthesis in kidneys of normal mice.
Life sciences.
1974 Apr; 14(8):1541-53. doi:
10.1016/0024-3205(74)90165-9. [PMID: 4829544] - A Haddow, W C Ross, G M Timmis. The chain of unexpected discovery: xanthopterin-stimulated renal mitosis.
Perspectives in biology and medicine.
1972; 15(2):177-217. doi:
10.1353/pbm.1972.0039. [PMID: 4551972] - H Rembold, V Chandrashekar, P Sudershan. Catabolism of pteridine cofactors. IV. In vivo catabolism of reduced pterins in rats.
Biochimica et biophysica acta.
1971 May; 237(2):365-8. doi:
10.1016/0304-4165(71)90332-1. [PMID: 5571427] - W Brade, P Propping. [Acute renal failure after pteridine administration].
Klinische Wochenschrift.
1970 Oct; 48(20):1209-16. doi:
10.1007/bf01487128. [PMID: 5477373] - W Brade, P Propping. [Regeneration of the kidney after tubular damage by pteridine derivatives].
Naunyn-Schmiedebergs Archiv fur Pharmakologie.
1969; 264(3):222. doi:
NULL. [PMID: 4242375] - D M Taylor, G Threlfall, A T Buck. Chemically-induced renal hypertrophy in the rat.
Biochemical pharmacology.
1968 Aug; 17(8):1567-74. doi:
10.1016/0006-2952(68)90216-5. [PMID: 5672817] - T A Hyde. The effect of nephrectomy and renal ischaemia on liver regeneration.
The Journal of pathology and bacteriology.
1968 Jul; 96(1):131-6. doi:
10.1002/path.1700960114. [PMID: 5667843] - F J Roe, E Boyland, C E Dukes, B C Mitchley. Failure of testosterone or xanthopterin to influence the induction of renal neoplasms by lead in rats.
British journal of cancer.
1965 Dec; 19(4):860-6. doi:
10.1038/bjc.1965.99. [PMID: 5862663] - J A BLAIR. Isolation of isoxanthopterin from human urine.
The Biochemical journal.
1958 Mar; 68(3):385-7. doi:
10.1042/bj0680385a. [PMID: 13522634] - H D PURVES. Recovery of radioactive iodine from urine.
Nature.
1952 Jan; 169(4290):111-2. doi:
10.1038/169111a0. [PMID: 14910697] - H M RAUEN, C von HALLER. [Relation of urine xanthopterin to protein metabolism].
Hoppe-Seyler's Zeitschrift fur physiologische Chemie.
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