Iminostilbene (BioDeep_00000270905)

   


代谢物信息卡片


Iminostilbene

化学式: C14H11N (193.0891446)
中文名称: 亚氨基芪
谱图信息: 最多检出来源 Viridiplantae(plant) 20.36%

分子结构信息

SMILES: C1=Cc2ccccc2Nc2ccccc21
InChI: InChI=1S/C14H11N/c1-3-7-13-11(5-1)9-10-12-6-2-4-8-14(12)15-13/h1-10,15H

描述信息

D004791 - Enzyme Inhibitors > D000091062 - Gamma Secretase Inhibitors and Modulators
CONFIDENCE standard compound; INTERNAL_ID 2461
CONFIDENCE standard compound; INTERNAL_ID 8780
CONFIDENCE standard compound; INTERNAL_ID 4133
CONFIDENCE standard compound; EAWAG_UCHEM_ID 992
CONFIDENCE standard compound; INTERNAL_ID 2048

同义名列表

1 个代谢物同义名

Iminostilbene



数据库引用编号

32 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Shan Lu, Yu Tian, Yun Luo, Xudong Xu, Wenxiu Ge, Guibo Sun, Xiaobo Sun. Iminostilbene, a novel small-molecule modulator of PKM2, suppresses macrophage inflammation in myocardial ischemia-reperfusion injury. Journal of advanced research. 2021 03; 29(?):83-94. doi: 10.1016/j.jare.2020.09.001. [PMID: 33842007]
  • Wei Jiang, Tianyi Xia, Yunlei Yun, Mingming Li, Feng Zhang, Shouhong Gao, Wansheng Chen. UHPLC-MS/MS method for simultaneous determination of carbamazepine and its seven major metabolites in serum of epileptic patients. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2019 Feb; 1108(?):17-24. doi: 10.1016/j.jchromb.2018.12.016. [PMID: 30660838]
  • Lu Jiandong, Yilong Yang, Jinting Peng, Min Xiang, Dongcai Wang, Guoliang Xiong, Shunmin Li. Trichosanthes kirilowii lectin ameliorates streptozocin-induced kidney injury via modulation of the balance between M1/M2 phenotype macrophage. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Jan; 109(?):93-102. doi: 10.1016/j.biopha.2018.10.060. [PMID: 30396096]
  • Ishfaq Ahmed, Badal C Roy, Rita-Marie T Raach, Sarah M Owens, Lijun Xia, Shrikant Anant, Venkatesh Sampath, Shahid Umar. Enteric infection coupled with chronic Notch pathway inhibition alters colonic mucus composition leading to dysbiosis, barrier disruption and colitis. PloS one. 2018; 13(11):e0206701. doi: 10.1371/journal.pone.0206701. [PMID: 30383855]
  • Pengpeng Bi, Feng Yue, Anju Karki, Beatriz Castro, Sara E Wirbisky, Chao Wang, Abigail Durkes, Bennett D Elzey, Ourania M Andrisani, Christopher A Bidwell, Jennifer L Freeman, Stephen F Konieczny, Shihuan Kuang. Notch activation drives adipocyte dedifferentiation and tumorigenic transformation in mice. The Journal of experimental medicine. 2016 09; 213(10):2019-37. doi: 10.1084/jem.20160157. [PMID: 27573812]
  • Zhicheng Xiao, Jing Zhang, Xiaogang Peng, Yanjun Dong, Lixin Jia, Huihua Li, Jie Du. The Notch γ-secretase inhibitor ameliorates kidney fibrosis via inhibition of TGF-β/Smad2/3 signaling pathway activation. The international journal of biochemistry & cell biology. 2014 Oct; 55(?):65-71. doi: 10.1016/j.biocel.2014.08.009. [PMID: 25150830]
  • Toshiharu Ueno, Namiko Kobayashi, Makiko Nakayama, Yasutoshi Takashima, Takamoto Ohse, Ira Pastan, Jeffrey W Pippin, Stuart J Shankland, Noriko Uesugi, Taiji Matsusaka, Michio Nagata. Aberrant Notch1-dependent effects on glomerular parietal epithelial cells promotes collapsing focal segmental glomerulosclerosis with progressive podocyte loss. Kidney international. 2013 Jun; 83(6):1065-75. doi: 10.1038/ki.2013.48. [PMID: 23447065]
  • Olivier Mathieu, Marie-Christine Picot, Philippe Gelisse, Hélène Breton, Pascal Demoly, Dominique Hillaire-Buys. Effects of carbamazepine and metabolites on IL-2, IL-5, IL-6, IL-10 and IFN-γ secretion in epileptic patients: the influence of co-medication. Pharmacological reports : PR. 2011; 63(1):86-94. doi: 10.1016/s1734-1140(11)70402-9. [PMID: 21441615]
  • H Vijay Kumar, Nagaraja Naik. Synthesis and antioxidant properties of some novel 5H-dibenz[b,f]azepine derivatives in different in vitro model systems. European journal of medicinal chemistry. 2010 Jan; 45(1):2-10. doi: 10.1016/j.ejmech.2009.09.016. [PMID: 19846240]
  • Parvana Hajieva, Justyna B Mocko, Bernd Moosmann, Christian Behl. Novel imine antioxidants at low nanomolar concentrations protect dopaminergic cells from oxidative neurotoxicity. Journal of neurochemistry. 2009 Jul; 110(1):118-32. doi: 10.1111/j.1471-4159.2009.06114.x. [PMID: 19486265]
  • Marie Leclercq, Olivier Mathieu, Elena Gomez, Claude Casellas, Hélène Fenet, Dominique Hillaire-Buys. Presence and fate of carbamazepine, oxcarbazepine, and seven of their metabolites at wastewater treatment plants. Archives of environmental contamination and toxicology. 2009 Apr; 56(3):408-15. doi: 10.1007/s00244-008-9202-x. [PMID: 18779941]
  • Thiruvur Niranjan, Bernhard Bielesz, Antje Gruenwald, Manish P Ponda, Jeffrey B Kopp, David B Thomas, Katalin Susztak. The Notch pathway in podocytes plays a role in the development of glomerular disease. Nature medicine. 2008 Mar; 14(3):290-8. doi: 10.1038/nm1731. [PMID: 18311147]
  • Hélène Breton, Marylène Cociglio, Françoise Bressolle, Hélène Peyriere, Jean Pierre Blayac, Dominique Hillaire-Buys. Liquid chromatography-electrospray mass spectrometry determination of carbamazepine, oxcarbazepine and eight of their metabolites in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2005 Dec; 828(1-2):80-90. doi: 10.1016/j.jchromb.2005.09.019. [PMID: 16203183]
  • Ihsan Ergün, M Cenk Akbostanci, Başol Canbakan, Bilge Koçer, Arzu Ensari, Gökhan Nergizoglu, Kenan Keven. Minimal change nephrotic syndrome with stiff-person syndrome: is there a link?. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2005 Jul; 46(1):e11-4. doi: 10.1053/j.ajkd.2005.03.009. [PMID: 15983949]
  • Pamela Gallant, Tabita Malutan, Heather McLean, LouAnn Verellen, Stanley Caveney, Cam Donly. Functionally distinct dopamine and octopamine transporters in the CNS of the cabbage looper moth. European journal of biochemistry. 2003 Feb; 270(4):664-74. doi: 10.1046/j.1432-1033.2003.03417.x. [PMID: 12581206]
  • B Moosmann, T Skutella, K Beyer, C Behl. Protective activity of aromatic amines and imines against oxidative nerve cell death. Biological chemistry. 2001 Nov; 382(11):1601-12. doi: 10.1515/bc.2001.195. [PMID: 11767950]
  • T M Li, J E Miller, F E Ward, J F Burd. Homogeneous substrate-labeled fluorescent immunoassay for carbamazepine. Epilepsia. 1982 Aug; 23(4):391-8. doi: 10.1111/j.1528-1157.1982.tb05425.x. [PMID: 7047157]