Tafluprost (BioDeep_00000027089)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


1-Methylethyl (5Z)-7-((1R,2R, 3R,5S)-2-((1E)-3,3-difluoro-4-phenoxy -1-butenyl)-3,5-dihydroxycyclopentyl)-5-heptenoate

化学式: C25H34F2O5 (452.23741780000006)
中文名称: 他氟前列素
谱图信息: 最多检出来源 Homo sapiens(blood) 2.5%

分子结构信息

SMILES: CC(C)OC(=O)CCCC=CCC1C(CC(C1C=CC(COC2=CC=CC=C2)(F)F)O)O
InChI: InChI=1S/C25H34F2O5/c1-18(2)32-24(30)13-9-4-3-8-12-20-21(23(29)16-22(20)28)14-15-25(26,27)17-31-19-10-6-5-7-11-19/h3,5-8,10-11,14-15,18,20-23,28-29H,4,9,12-13,16-17H2,1-2H3/b8-3-,15-14+/t20-,21-,22+,23-/m1/s1

描述信息

Tafluprost is only found in individuals that have used or taken this drug. It is a prostaglandin analogue used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. Tafluprost was approved for use in the U.S. on February 10, 2012.Tafluprost is a prostaglandin F2a analogue. Specifically, Tafluprost is a prostanoid selective FP receptor agonist that is believed to reduce the intraocular pressure (IOP) by increasing the outflow of aqueous humor. Studies in animals and man suggest that the main mechanism of action is increased uveoscleral outflow.
S - Sensory organs > S01 - Ophthalmologicals > S01E - Antiglaucoma preparations and miotics > S01EE - Prostaglandin analogues
C78568 - Prostaglandin Analogue

同义名列表

7 个代谢物同义名

1-Methylethyl (5Z)-7-((1R,2R, 3R,5S)-2-((1E)-3,3-difluoro-4-phenoxy -1-butenyl)-3,5-dihydroxycyclopentyl)-5-heptenoate; propan-2-yl (5Z)-7-[(1R,2R,3R,5S)-2-[(1E)-3,3-difluoro-4-phenoxybut-1-en-1-yl]-3,5-dihydroxycyclopentyl]hept-5-enoate; AFP-168;MK2452; Tafluprost; Saflutan; Zioptan; AFP-168



数据库引用编号

10 个数据库交叉引用编号

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相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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1 个相关的物种来源信息

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  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Kai Kaarniranta, Kirsi Ikäheimo, Eliisa Mannermaa, Auli Ropo. Pharmacokinetics, Efficacy, and Safety of the Preservative-free Fixed Combination of Tafluprost 0.0015\% and Timolol 0.5\% in Healthy Volunteers: A Phase I Comparison vs. the Corresponding Preservative-free Monotherapies. Clinical pharmacokinetics. 2016 Apr; 55(4):485-94. doi: 10.1007/s40262-015-0331-x. [PMID: 26391697]
  • Iwona Dams, Jaromir Wasyluk, Marek Prost, Andrzej Kutner. Therapeutic uses of prostaglandin F(2α) analogues in ocular disease and novel synthetic strategies. Prostaglandins & other lipid mediators. 2013 Jul; 104-105(?):109-21. doi: 10.1016/j.prostaglandins.2013.01.001. [PMID: 23353557]
  • Hee Young Choi, Ji Eun Lee, Ji Woong Lee, Hyun Jun Park, Ji Eun Lee, Jae Ho Jung. In vitro study of antiadipogenic profile of latanoprost, travoprost, bimatoprost, and tafluprost in human orbital preadiopocytes. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 2012 Apr; 28(2):146-52. doi: 10.1089/jop.2011.0160. [PMID: 22107041]
  • Yasufumi Fukano, Kouichi Kawazu, Takahiro Akaishi, Padma Bezwada, Pertti Pellinen. Metabolism and ocular tissue distribution of an antiglaucoma prostanoid, tafluprost, after ocular instillation to monkeys. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 2011 Jun; 27(3):251-9. doi: 10.1089/jop.2010.0178. [PMID: 21491995]
  • Akiyasu Kanamori, Maiko Naka, Masahide Fukuda, Makoto Nakamura, Akira Negi. Tafluprost protects rat retinal ganglion cells from apoptosis in vitro and in vivo. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. 2009 Oct; 247(10):1353-60. doi: 10.1007/s00417-009-1122-6. [PMID: 19551401]
  • Y Fukano, K Kawazu. Disposition and metabolism of a novel prostanoid antiglaucoma medication, tafluprost, following ocular administration to rats. Drug metabolism and disposition: the biological fate of chemicals. 2009 Aug; 37(8):1622-34. doi: 10.1124/dmd.108.024885. [PMID: 19477946]
  • Hannu Uusitalo, Kai Kaarniranta, Auli Ropo. Pharmacokinetics, efficacy and safety profiles of preserved and preservative-free tafluprost in healthy volunteers. Acta ophthalmologica. Supplement. 2008; 242(?):7-13. doi: 10.1111/j.1755-3768.2008.01380.x. [PMID: 18752509]