Dothiepin (BioDeep_00000270886)
代谢物信息卡片
(E)-Dosulepin
化学式: C19H21NS (295.13946260000006)
中文名称: 度硫平
谱图信息:
最多检出来源 Viridiplantae(plant) 85.71%
分子结构信息
SMILES: CN(C)CCC=C(c21)c(c3)c(ccc3)SCc(cccc2)1
InChI: InChI=1S/C19H21NS/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19/h3-6,8-12H,7,13-14H2,1-2H3
描述信息
N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants > N06AA - Non-selective monoamine reuptake inhibitors
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D018759 - Adrenergic Uptake Inhibitors
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents
D049990 - Membrane Transport Modulators
CONFIDENCE Reference Standard (Level 1); HBM4EU - science and policy for a healthy future (https://www.hbm4eu.eu); Flow Injection
Flow Injection; CONFIDENCE Reference Standard (Level 1); HBM4EU - science and policy for a healthy future (https://www.hbm4eu.eu)
CONFIDENCE Reference Standard (Level 1); HBM4EU - science and policy for a healthy future (https://www.hbm4eu.eu)
同义名列表
2 个代谢物同义名
数据库引用编号
58 个数据库交叉引用编号
- ChEBI: CHEBI:36802
- ChEBI: CHEBI:36798
- KEGGdrug: D07872
- PubChem: 5282426
- PubChem: 3155
- Metlin: METLIN2429
- ChEMBL: CHEMBL108947
- MeSH: Dothiepin
- CAS: 25627-38-7
- CAS: 113-53-1
- MoNA: HB002528
- MoNA: HB002527
- MoNA: HB002526
- MoNA: HB002525
- MoNA: HB002524
- MoNA: HB002523
- MoNA: HB002522
- MoNA: HB002521
- MoNA: HB002520
- MoNA: HB002519
- MoNA: HB002331
- MoNA: HB002330
- MoNA: HB002329
- MoNA: HB002328
- MoNA: HB002327
- MoNA: HB002326
- MoNA: HB002325
- MoNA: HB002324
- MoNA: HB002323
- MoNA: HB002322
- MoNA: HB002321
- MoNA: HB002320
- MoNA: HB002110
- MoNA: HB002109
- MoNA: HB002108
- MoNA: HB002107
- MoNA: HB002106
- MoNA: HB002105
- MoNA: HB002104
- MoNA: HB002103
- MoNA: HB002102
- MoNA: HB002101
- MoNA: HB002100
- MoNA: HB002099
- MoNA: HB002098
- MoNA: HB002097
- MoNA: HB002096
- MoNA: HB001984
- MoNA: HB001983
- MoNA: HB001982
- MoNA: HB001981
- MoNA: WA001296
- MoNA: WA001295
- MoNA: WA001294
- MoNA: WA001293
- MoNA: WA001292
- PMhub: MS000000576
- RefMet: Dothiepin
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yeran Hwang, Ju-Tae Sohn. Effect of lipid emulsion on neuropsychiatric drug-induced toxicity: A narrative review.
Medicine.
2024 Mar; 103(11):e37612. doi:
10.1097/md.0000000000037612. [PMID: 38489675] - Biswa Ranjan Mishra, Rituparna Maiti, Santanu Nath, Pallabi Sahoo, Monalisa Jena, Archana Mishra. Effect of Sertraline, Dosulepin, and Venlafaxine on Non-BDNF Neurotrophins in Patients With Depression: A Cohort Study.
Journal of clinical psychopharmacology.
2019 May; 39(3):220-225. doi:
10.1097/jcp.0000000000001022. [PMID: 30932945] - N Rajendiran, J Thulasidhasan. Spectroscopic, electrochemical and molecular docking studies of dothiepin and doxepin with bovine serum albumin and DNA base.
Luminescence : the journal of biological and chemical luminescence.
2016 Dec; 31(8):1438-1447. doi:
10.1002/bio.3126. [PMID: 26991906] - Michael Stephen Blaber, Jamal Nasir Khan, Judith Anne Brebner, Rachel McColm. 'Lipid rescue' for tricyclic antidepressant cardiotoxicity.
The Journal of emergency medicine.
2012 Sep; 43(3):465-7. doi:
10.1016/j.jemermed.2011.09.010. [PMID: 22244291] - María del Mar Ramírez Fernández, Sarah M R Wille, Nele Samyn. Quantitative method validation for the analysis of 27 antidepressants and metabolites in plasma with ultraperformance liquid chromatography-tandem mass spectrometry.
Therapeutic drug monitoring.
2012 Feb; 34(1):11-24. doi:
10.1097/ftd.0b013e31823bf0fd. [PMID: 22210095] - Paul W Andrews, J Anderson Thomson, Ananda Amstadter, Michael C Neale. Primum non nocere: an evolutionary analysis of whether antidepressants do more harm than good.
Frontiers in psychology.
2012; 3(?):117. doi:
10.3389/fpsyg.2012.00117. [PMID: 22536191] - David Hendron, Gareth Menagh, Euan A Sandilands, Damian Scullion. Tricyclic antidepressant overdose in a toddler treated with intravenous lipid emulsion.
Pediatrics.
2011 Dec; 128(6):e1628-32. doi:
10.1542/peds.2011-0867. [PMID: 22065274] - Soeren Boegevig, Anders Rothe, Jacob Tfelt-Hansen, Lotte C G Hoegberg. Successful reversal of life threatening cardiac effect following dosulepin overdose using intravenous lipid emulsion.
Clinical toxicology (Philadelphia, Pa.).
2011 Apr; 49(4):337-9. doi:
10.3109/15563650.2011.566880. [PMID: 21563912] - Vera Maresova, Jiri Chadt, Eva Novakova. Screening and semiquantitative analysis of drugs and drugs of abuse in human serum samples using gas chromatography-mass spectrometry.
Neuro endocrinology letters.
2008 Oct; 29(5):749-54. doi:
NULL. [PMID: 18987582] - E E Roelofsen, A J Wilhelm, A Sinjewel, E J F Franssen. Toxicokinetics of dothiepin: 2 case reports.
Therapeutic drug monitoring.
2008 Oct; 30(5):638-41. doi:
10.1097/ftd.0b013e318184525b. [PMID: 18695634] - Rasha M El-Nashar. Flow injection potentiometric assay of hexoprenaline in its pure state, pharmaceutical preparations, and biological samples.
Journal of automated methods & management in chemistry.
2008; 2008(?):586310. doi:
10.1155/2008/586310. [PMID: 18483573] - Tatsuo Shinozuka, Masaru Terada, Einosuke Tanaka. Solid-phase extraction and analysis of 20 antidepressant drugs in human plasma by LC/MS with SSI method.
Forensic science international.
2006 Oct; 162(1-3):108-12. doi:
10.1016/j.forsciint.2006.03.038. [PMID: 16859851] - Zdenek Fisar, Kvetoslava Fuksová, Jan Sikora, Lucie Kalisová, Marie Velenovská, Michaela Novotná. Distribution of antidepressants between plasma and red blood cells.
Neuro endocrinology letters.
2006 Jun; 27(3):307-13. doi:
NULL. [PMID: 16816836] - F L Sauvage, J M Gaulier, G Lachâtre, P Marquet. A fully automated turbulent-flow liquid chromatography-tandem mass spectrometry technique for monitoring antidepressants in human serum.
Therapeutic drug monitoring.
2006 Feb; 28(1):123-30. doi:
10.1097/01.ftd.0000194026.04483.c3. [PMID: 16418706] - H K Ruben Thanacoody, Simon H L Thomas. Tricyclic antidepressant poisoning : cardiovascular toxicity.
Toxicological reviews.
2005; 24(3):205-14. doi:
10.2165/00139709-200524030-00013. [PMID: 16390222] - Pierre Baumann, Sven Ulrich, Gabriel Eckermann, Manfred Gerlach, Hans-Joachim Kuss, Gerd Laux, Bruno Müller-Oerlinghausen, Marie Luise Rao, Peter Riederer, Gerald Zernig, Christoph Hiemke. The AGNP-TDM Expert Group Consensus Guidelines: focus on therapeutic monitoring of antidepressants.
Dialogues in clinical neuroscience.
2005; 7(3):231-47. doi:
NULL. [PMID: 16156382] - S Havránek, M Micek, I Paclt, J Slavícek, O Kittnar, A Dohnalová, E Brizman, P Hála, E Kittzlerová, K Pisvejcová. QT dispersion estimated from 80 body surface potential map leads and from standard 12-leads ECG in psychiatric patients treated with dosulepin.
Prague medical report.
2004; 105(1):53-63. doi:
NULL. [PMID: 15354946] - O Kittnar, M Mlcek. [Dispersion of QT intervals--a myth or a diagnostic symptom?].
Casopis lekaru ceskych.
2004; 143(9):604-7. doi:
NULL. [PMID: 15532899] - O Kittnar, I Paclt, M Mlcek, J Slavícek, A Dohnalová, S Havránek, E Brizman, E Kitzlerová, K Pisvejcová. QT dispersion and electrical heart field morphology in patients treated with dosulepin.
Physiological research.
2004; 53(4):379-86. doi:
NULL. [PMID: 15311996] - V Trcka. [50 years of the Institute for Research in Pharmacy and Biochemistry].
Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti.
2003 May; 52(3):107-14. doi:
". [PMID: 12789769] - P Milkiewicz, A P Chilton, S G Hubscher, E Elias. Antidepressant induced cholestasis: hepatocellular redistribution of multidrug resistant protein (MRP2).
Gut.
2003 Feb; 52(2):300-3. doi:
10.1136/gut.52.2.300. [PMID: 12524417] - I Paclt, J Slavícek, A Dohnalová, E Kitzlerová, K Pisvejcová. Electrocardiographic dose-dependent changes in prophylactic doses of dosulepine, lithium and citalopram.
Physiological research.
2003; 52(3):311-7. doi:
NULL. [PMID: 12790762] - E Kitzlerová, J Slavícek, K Pisvejcová, M Anders, A Dohnalová, M Balíková. Plasma levels of dosulepine and heart electric field.
Physiological research.
2003; 52(3):319-25. doi:
NULL. [PMID: 12790763] - Manfred Kollroser, Caroline Schober. Simultaneous determination of seven tricyclic antidepressant drugs in human plasma by direct-injection HPLC-APCI-MS-MS with an ion trap detector.
Therapeutic drug monitoring.
2002 Aug; 24(4):537-44. doi:
10.1097/00007691-200208000-00013. [PMID: 12142640] - J Bickeboeller-Friedrich, H H Maurer. Screening for detection of new antidepressants, neuroleptics, hypnotics, and their metabolites in urine by GC-MS developed using rat liver microsomes.
Therapeutic drug monitoring.
2001 Feb; 23(1):61-70. doi:
10.1097/00007691-200102000-00012. [PMID: 11206046] - T Sen, C A Abdul Salam, S Pal, S Sen, A K Nag Chaudhuri. Effect of dothiepin on gastric ulceration mediated by lipid derived eicosanoids.
Life sciences.
2000; 66(23):PL325-30. doi:
10.1016/s0024-3205(00)00561-0. [PMID: 10855953] - C Sánchez, J Hyttel. Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding.
Cellular and molecular neurobiology.
1999 Aug; 19(4):467-89. doi:
10.1023/a:1006986824213. [PMID: 10379421] - J Slavícek, I Paclt, J Hamplová, O Kittnar, Z Trefný, B M Horácek. Antidepressant drugs and heart electrical field.
Physiological research.
1998; 47(4):297-300. doi:
NULL. [PMID: 9803478] - M Tatsumi, K Groshan, R D Blakely, E Richelson. Pharmacological profile of antidepressants and related compounds at human monoamine transporters.
European journal of pharmacology.
1997 Dec; 340(2-3):249-58. doi:
10.1016/s0014-2999(97)01393-9. [PMID: 9537821] - M Schulz, A Schmoldt. Successful physostigmine treatment of acute dothiepin intoxication.
Die Pharmazie.
1994 Aug; 49(8):614. doi:
NULL. [PMID: 7938152] - K F Ilett, T H Blythe, L P Hackett, R T Ong, D A Tannenbaum, T M Clarke. Plasma concentrations of dothiepin and its metabolites are not correlated with clinical efficacy in major depressive illness.
Therapeutic drug monitoring.
1993 Oct; 15(5):351-7. doi:
10.1097/00007691-199310000-00001. [PMID: 8249040] - P J Taylor, B G Charles, R Norris, P Salm, P J Ravenscroft. Measurement of dothiepin and its major metabolites in plasma by high-performance liquid chromatography.
Journal of chromatography.
1992 Oct; 581(1):152-5. doi:
10.1016/0378-4347(92)80460-8. [PMID: 1430000] - K F Ilett, T H Lebedevs, R E Wojnar-Horton, P Yapp, M J Roberts, L J Dusci, L P Hackett. The excretion of dothiepin and its primary metabolites in breast milk.
British journal of clinical pharmacology.
1992 Jun; 33(6):635-9. doi:
10.1111/j.1365-2125.1992.tb04093.x. [PMID: 1389937] - K F Ilett, L P Hackett, L J Dusci, J W Paterson. Disposition of dothiepin after overdose: effects of repeated-dose activated charcoal.
Therapeutic drug monitoring.
1991 Nov; 13(6):485-9. doi:
10.1097/00007691-199111000-00003. [PMID: 1771645] - D K Yu, D C Dimmitt, R C Lanman, D H Giesing. Pharmacokinetics of dothiepin in humans: a single dose dose-proportionality study.
Journal of pharmaceutical sciences.
1986 Jun; 75(6):582-5. doi:
10.1002/jps.2600750612. [PMID: 3735103] - K Kawahara, T Awaji, K Uda, Y Sakai, Y Hashimoto. Urinary excretion of conjugates of dothiepin and northiaden (mono-N-demethyl-dothiepin) after an oral dose of dothiepin to humans.
European journal of drug metabolism and pharmacokinetics.
1986 Jan; 11(1):29-32. doi:
10.1007/bf03189772. [PMID: 3720795] - M G Bramble, A H Lishman, J Purdon, B L Diffey, R J Hall. An analysis of plasma levels and 24-hour ECG recordings in tricyclic antidepressant poisoning: implications for management.
The Quarterly journal of medicine.
1985 Jul; 56(219):357-66. doi:
NULL. [PMID: 4095248] - K W Woodhouse, D N Bateman. Delayed gastric emptying with dothiepin.
Human toxicology.
1985 Jan; 4(1):67-70. doi:
10.1177/096032718500400108. [PMID: 3988307] - L Bloodworth, A Wilson, P Collins, D J Rainford. Severe dothiepin intoxication--a report of two cases.
Postgraduate medical journal.
1984 Jun; 60(704):442-4. doi:
10.1136/pgmj.60.704.442. [PMID: 6462990] - K P Maguire, T R Norman, I McIntyre, G D Burrows. Clinical pharmacokinetics of dothiepin. Single-dose kinetics in patients and prediction of steady-state concentrations.
Clinical pharmacokinetics.
1983 Mar; 8(2):179-85. doi:
10.2165/00003088-198308020-00004. [PMID: 6851370] - C Ogura, A Kishimoto, R Mizukawa, H Hazama, H Honma, K Kawahara. Age differences in effects on blood pressure, flicker fusion frequency, salivation and pharmacokinetics of single oral doses of dothiepin and amitriptyline.
European journal of clinical pharmacology.
1983; 25(6):811-4. doi:
10.1007/bf00542525. [PMID: 6662179] - K P Maguire, T R Norman, I McIntyre, G D Burrows, B Davies. Blood and plasma concentrations of dothiepin and its major metabolites and clinical response.
Journal of affective disorders.
1982 Mar; 4(1):41-8. doi:
10.1016/0165-0327(82)90018-0. [PMID: 6461686] - K P Maguire, G D Burrows, T R Norman, B A Scoggins. Metabolism and pharmacokinetics of dothiepin.
British journal of clinical pharmacology.
1981 Sep; 12(3):405-9. doi:
10.1111/j.1365-2125.1981.tb01235.x. [PMID: 7295471] - K P Maguire, T R Norman, G D Burrows, B A Scoggins. Simultaneous measurement of dothiepin and its major metabolites in plasma and whole blood by gas chromatography-mass fragmentography.
Journal of chromatography.
1981 Mar; 222(3):399-408. doi:
10.1016/s0378-4347(00)84140-7. [PMID: 7228947] - J A Rees. Clinical interpretation of pharmacokinetic data on dothiepin hydrochloride (Dosulepin, Prothiaden).
The Journal of international medical research.
1981; 9(2):98-102. doi:
10.1177/030006058100900202. [PMID: 7227628] - E L Crampton, R C Glass, B Marchant, J A Rees. Chemical ionisation mass fragmentographic measurement of dothiepin plasma concentrations following a single oral dose in man.
Journal of chromatography.
1980 Aug; 183(2):141-48. doi:
10.1016/s0378-4347(00)81687-4. [PMID: 7400272] - J Mendlewicz, P Linkowski, J A Rees. A double-blind comparison of dothiepin and amitriptyline in patients with primary affective disorder: serum levels and clinical response.
The British journal of psychiatry : the journal of mental science.
1980 Feb; 136(?):154-60. doi:
10.1192/bjp.136.2.154. [PMID: 6989426] - B R Nakra, R C Glass, J A Rees. Steady-state serum concentrations of dothiepin and northiaden after two dosage regimens of dothiepin hydrochloride (Prothiaden).
The Journal of international medical research.
1977; 5(6):391-7. doi:
10.1177/030006057300100202. [PMID: 590597] - R R Brodie, L F Chasseaud, E L Crampton, D R Hawkins, P C Risdall. High performance liquid chromatographic determination of dothiepin and northiaden in human plasma and serum.
The Journal of international medical research.
1977; 5(6):387-90. doi:
10.1177/030006057300100201. [PMID: 590596] - M Queisnerová, E Svátek, V Mansfeld. To the metabolism of dosulepin in man.
Activitas nervosa superior.
1974 Aug; 16(3):179. doi:
NULL. [PMID: 4420748]