N,N-Dimethyl-3-(naphthalen-1-yloxy)-1-phenylpropan-1-amine (BioDeep_00000270878)
代谢物信息卡片
N,N-Dimethyl-alpha-[2-(1-naphthalenyloxy)ethyl]-benzenemethanamine
化学式: C21H23NO (305.1779548)
中文名称: 消旋达泊西汀游离碱
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(C)C(CCOC1=CC=CC2=CC=CC=C21)C3=CC=CC=C3
InChI: InChI=1S/C21H23NO/c1-22(2)20(18-10-4-3-5-11-18)15-16-23-21-14-8-12-17-9-6-7-13-19(17)21/h3-14,20H,15-16H2,1-2H3
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xin Zhang, Zhanwang Gao, Fei Qin, Kehan Chen, Jiansong Wang, Lingli Wang. Determination of Dapoxetine Hydrochloride in Human Plasma by HPLC-MS/MS and Its Application in a Bioequivalence Study.
Molecules (Basel, Switzerland).
2022 Apr; 27(9):. doi:
10.3390/molecules27092707. [PMID: 35566058] - Jingyan Liu, Zhihui Li, Keyu Yan, Gehang Ju, Wen Qiu. Pharmacokinetics and Safety of Dapoxetine Hydrochloride in Healthy Chinese Men: Impact of Dose and High-Fat Meal.
Clinical pharmacology in drug development.
2021 10; 10(10):1216-1224. doi:
10.1002/cpdd.919. [PMID: 33528113] - Yuanyuan Huang, Jingjing Gao, Pan Gao, Dangwei Peng, Yutian Dai, Hui Jiang, Xiansheng Zhang. A comprehensive assessment of genetic variation in serotonin transporter gene (5-HTTLPR+rs25531) and the response to dapoxetine in Chinese patients with premature ejaculation.
Andrologia.
2021 Sep; 53(8):e14141. doi:
10.1111/and.14141. [PMID: 34118072] - Ibrahim A El-Said, Ahmed A Aboelwafa, Omaima N ElGazayerly. Optimization of taste-masked dapoxetine oral thin films using factorial design: in vitro and in vivo evaluation.
Pharmaceutical development and technology.
2021 Jun; 26(5):522-538. doi:
10.1080/10837450.2021.1894445. [PMID: 33663316] - Keyu Yan, Gehang Ju, Qiong Tan, Lijiao Zeng, Wen Qiu. Bioequivalence Analysis of 2 Dapoxetine Hydrochloride Formulations in Healthy Chinese Male Volunteers Under Fed and Fasting Conditions: A Randomized, Open-Label, 2-Sequence, 2-Period, 2-Way Crossover Study.
Clinical pharmacology in drug development.
2021 04; 10(4):384-392. doi:
10.1002/cpdd.866. [PMID: 33385318] - Ahmed A Abu-Hassan, Ramadan Ali, Sayed M Derayea. One-pot micellar augmented native fluorescence for facile fluorimetric assay of dapoxetine hydrochloride in biological plasma and tablets.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2020 Oct; 239(?):118512. doi:
10.1016/j.saa.2020.118512. [PMID: 32470817] - Rana Said, Basel Arafat, Tawfiq Arafat. High performance liquid chromatography - Mass spectrometric bioanalytical method for the determination of dapoxetine in human plasma: Application for bioequivalence study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2020 Jul; 1149(?):122154. doi:
10.1016/j.jchromb.2020.122154. [PMID: 32485631] - Hong-Chang Yuan, Zhi-Jian Deng, Xin-Min Liu, Ting-Fang Dong, Xiang-Jun Qiu, Zeng Nan. Effect of Wuziyanzong pill on metabolism of dapoxetine in vivo and in vitro.
Journal of pharmaceutical and biomedical analysis.
2019 Mar; 166(?):119-127. doi:
10.1016/j.jpba.2018.12.022. [PMID: 30639931] - Mohammed As Abourehab, Osama Aa Ahmed, Gehan F Balata, Waleed H Almalki. Self-assembled biodegradable polymeric micelles to improve dapoxetine delivery across the blood-brain barrier.
International journal of nanomedicine.
2018; 13(?):3679-3687. doi:
10.2147/ijn.s168148. [PMID: 29983562] - Khaled S Abdlekawy, Ahmed M Donia, Fawzy Elbarbry. Effects of Grapefruit and Pomegranate Juices on the Pharmacokinetic Properties of Dapoxetine and Midazolam in Healthy Subjects.
European journal of drug metabolism and pharmacokinetics.
2017 Jun; 42(3):397-405. doi:
10.1007/s13318-016-0352-3. [PMID: 27294349] - Wei-min Zhang, Wu Qiang, Wang Ying-Fei, Sun Ming, Rong Wang. Development and validation of a sensitive UPLC-MS/MS method for the simultaneous determination of dapoxetine and its two metabolites in human plasma.
Journal of pharmaceutical and biomedical analysis.
2016 Feb; 119(?):45-9. doi:
10.1016/j.jpba.2015.11.018. [PMID: 26641706] - Rui-fang Li, Jun-min Fu, Xing-zhi Lv, Dong-tao Zhang, Yong-yang Pan, Da-pang Rao, Kai-yuan Yu. Effects of Evodiamine on the Pharmacokinetics of Dapoxetine and Its Metabolite Desmethyl Dapoxetine in Rats.
Pharmacology.
2016; 97(1-2):43-7. doi:
10.1159/000441568. [PMID: 26588583] - Hegazy Maha, Kessiba Amira, Abdelkawy Mohamed, El Gindy Ahmed Emad. A novel liquid chromatographic method with fluorescence detection for quantitation of tadalafil and dapoxetine hydrochloride in pharmaceutical dosage form and human plasma.
Se pu = Chinese journal of chromatography.
2015 Jul; 33(7):765-70. doi:
10.3724/sp.j.1123.2015.02063. [PMID: 26672207] - Yo Han Kim, Hee Youn Choi, Shi Hyang Lee, Hae Sun Jeon, Hyeong-Seok Lim, Mi Young Bahng, Kyun-Seop Bae. Pharmacokinetic interaction between udenafil and dapoxetine: a randomized, open-labeled crossover study in healthy male volunteers.
Drug design, development and therapy.
2015; 9(?):1209-16. doi:
10.2147/dddt.s78713. [PMID: 25759565] - Tae Kon Kim, In Sook Kim, Seok Hyun Hong, Yun Kyoung Choi, Hohyun Kim, Hye Hyun Yoo. Determination of dapoxetine in rat plasma by ultra-performance liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2013 May; 926(?):42-6. doi:
10.1016/j.jchromb.2013.03.002. [PMID: 23542722] - An Thyssen, Om Sharma, Si Tianmei, Joseph W Aquilina, An Vandebosch, Shean-Sheng Wang, Ramagopal Mudumbi, Hsiu-Ling Hsiao. Pharmacokinetics of dapoxetine hydrochloride in healthy Chinese, Japanese, and Caucasian men.
Journal of clinical pharmacology.
2010 Dec; 50(12):1450-60. doi:
10.1177/0091270009359183. [PMID: 20097934] - N B Modi, S Kell, J Aquilina, D Rivas. Effect of dapoxetine on the pharmacokinetics and hemodynamic effects of tamsulosin in men on a stable dose of tamsulosin.
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2008 Dec; 48(12):1438-50. doi:
10.1177/0091270008324695. [PMID: 18832488] - Mark J Dresser, Dongwoo Kang, Peter Staehr, Shalini Gidwani, Cindy Guo, John P Mulhall, Nishit B Modi. Pharmacokinetics of dapoxetine, a new treatment for premature ejaculation: Impact of age and effects of a high-fat meal.
Journal of clinical pharmacology.
2006 Sep; 46(9):1023-9. doi:
10.1177/0091270006291033. [PMID: 16920897] - Nishit B Modi, Mark J Dresser, Mary Simon, Denise Lin, Dhaval Desai, Suneel Gupta. Single- and multiple-dose pharmacokinetics of dapoxetine hydrochloride, a novel agent for the treatment of premature ejaculation.
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2006 Mar; 46(3):301-9. doi:
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Expert opinion on emerging drugs.
2006 Mar; 11(1):99-109. doi:
10.1517/14728214.11.1.99. [PMID: 16503829] - Karl-Erik Andersson, John P Mulhall, Michael G Wyllie. Pharmacokinetic and pharmacodynamic features of dapoxetine, a novel drug for 'on-demand' treatment of premature ejaculation.
BJU international.
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10.1111/j.1464-410x.2006.05911.x. [PMID: 16430636] - M J Dresser, D Desai, S Gidwani, A D Seftel, N B Modi. Dapoxetine, a novel treatment for premature ejaculation, does not have pharmacokinetic interactions with phosphodiesterase-5 inhibitors.
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BJU international.
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10.1111/j.1464-410x.2005.05659.x. [PMID: 15963145] - J R Bernstein, B M Manzione, R C Pohland, R B Franklin. Disposition of 14C-dapoxetine in rats: complementary experiments with whole-body autoradiographic and tissue dissection techniques.
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