Carboxytolbutamide (BioDeep_00000027017)

   

human metabolite Endogenous


代谢物信息卡片


4-{[(butyl-C-hydroxycarbonimidoyl)amino]sulphonyl}benzoic acid

化学式: C12H16N2O5S (300.0779886)
中文名称: 羧基甲苯磺丁脲
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCN=C(NS(=O)(=O)c1ccc(cc1)C(=O)O)O
InChI: InChI=1S/C12H16N2O5S/c1-2-3-8-13-12(17)14-20(18,19)10-6-4-9(5-7-10)11(15)16/h4-7H,2-3,8H2,1H3,(H,15,16)(H2,13,14,17)

描述信息

Carboxytolbutamide belongs to the family of Sulfanylbenzoic Acid Derivatives. These are benzoic acid derivatives which bear a sulfanyl group (R-SH) attached to the benzene ring.

同义名列表

10 个代谢物同义名

4-{[(butyl-C-hydroxycarbonimidoyl)amino]sulphonyl}benzoic acid; 4-{[(butyl-C-hydroxycarbonimidoyl)amino]sulfonyl}benzoic acid; 4-[(butyl-C-hydroxycarbonimidoyl)aminosulfonyl]benzoic acid; 4-{[(butyl-C-hydroxycarbonimidoyl)amino]sulphonyl}benzoate; 4-{[(butyl-C-hydroxycarbonimidoyl)amino]sulfonyl}benzoate; 4-(((Butylamino)carbonyl)amino)sulfonylbenzoic acid; 1-Butyl-3-(4-carboxyphenyl)sulfonylurea; Tolbutamide carboxylic acid; 4-Carboxy Tolbutamide; Carboxytolbutamide



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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INOH(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Shaoyu Zhang, Naining Song, Quansheng Li, Huirong Fan, Changxiao Liu. Liquid chromatography/tandem mass spectrometry method for simultaneous evaluation of activities of five cytochrome P450s using a five-drug cocktail and application to cytochrome P450 phenotyping studies in rats. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2008 Aug; 871(1):78-89. doi: 10.1016/j.jchromb.2008.06.034. [PMID: 18614408]
  • Alexander Jetter, Martina Kinzig-Schippers, Andreas Skott, Andreas Lazar, Dorota Tomalik-Scharte, Julia Kirchheiner, Monika Walchner-Bonjean, Ursula Hering, Verena Jakob, Michael Rodamer, Wafaâ Jabrane, Dirk Kasel, Jürgen Brockmöller, Uwe Fuhr, Fritz Sörgel. Cytochrome P450 2C9 phenotyping using low-dose tolbutamide. European journal of clinical pharmacology. 2004 May; 60(3):165-71. doi: 10.1007/s00228-004-0754-z. [PMID: 15045499]
  • L L Hansen, K Brøsen. Quantitative determination of tolbutamide and its metabolites in human plasma and urine by high-performance liquid chromatography and UV detection. Therapeutic drug monitoring. 1999 Dec; 21(6):664-71. doi: 10.1097/00007691-199912000-00015. [PMID: 10604830]
  • A S Gross, S Bridge, G M Shenfield. Pharmacokinetics of tolbutamide in ethnic Chinese. British journal of clinical pharmacology. 1999 Feb; 47(2):151-6. doi: 10.1046/j.1365-2125.1999.00868.x. [PMID: 10190649]
  • M E Veronese, J O Miners, D L Rees, D J Birkett. Tolbutamide hydroxylation in humans: lack of bimodality in 106 healthy subjects. Pharmacogenetics. 1993 Apr; 3(2):86-93. doi: 10.1097/00008571-199304000-00004. [PMID: 8518838]
  • K Washio, O Makaya, H Sasaki, K Nishida, J Nakamura, J Shibasaki. A new aspect of tolbutamide metabolism in the rabbit: the role of 1-butyl-3-(p-formylphenyl)sulphonylurea. The Journal of pharmacy and pharmacology. 1993 Mar; 45(3):231-3. doi: 10.1111/j.2042-7158.1993.tb05541.x. [PMID: 8483106]
  • M A Page, J S Boutagy, G M Shenfield. A screening test for slow metabolisers of tolbutamide. British journal of clinical pharmacology. 1991 Jun; 31(6):649-54. doi: 10.1111/j.1365-2125.1991.tb05587.x. [PMID: 1867959]
  • M E Veronese, J O Miners, D Randles, D Gregov, D J Birkett. Validation of the tolbutamide metabolic ratio for population screening with use of sulfaphenazole to produce model phenotypic poor metabolizers. Clinical pharmacology and therapeutics. 1990 Mar; 47(3):403-11. doi: 10.1038/clpt.1990.46. [PMID: 2311340]
  • A K Miller, J Adir, R E Vestal. Excretion of tolbutamide metabolites in young and old subjects. European journal of clinical pharmacology. 1990; 38(5):523-4. doi: 10.1007/bf02336696. [PMID: 2379540]
  • S St-Hilaire, P M Belanger. Simultaneous determinations of tolbutamide and its hydroxy and carboxy metabolites in serum and urine: application to pharmacokinetic studies of tolbutamide in the rat. Journal of pharmaceutical sciences. 1989 Oct; 78(10):863-6. doi: 10.1002/jps.2600781017. [PMID: 2600795]
  • J Keal, C Stockley, A Somogyi. Simultaneous determination of tolbutamide and its hydroxy and carboxy metabolites in plasma and urine by high-performance liquid chromatography. Journal of chromatography. 1986 May; 378(1):237-41. doi: 10.1016/s0378-4347(00)80719-7. [PMID: 3733977]
  • E W Cate, J F Rogers, J R Powell. Inhibition of tolbutamide elimination by cimetidine but not ranitidine. Journal of clinical pharmacology. 1986 May; 26(5):372-7. doi: 10.1002/j.1552-4604.1986.tb03540.x. [PMID: 3700691]
  • D L Vesely. The comparative effects of tolbutamide and the non-hypoglycemic analog carboxytolbutamide on guanylate cyclase activity. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 1986 Jan; 18(1):10-3. doi: 10.1055/s-2007-1012213. [PMID: 2868985]
  • G Raghow, M C Meyer. High-performance liquid chromatographic assay of tolbutamide and carboxytolbutamide in human plasma. Journal of pharmaceutical sciences. 1981 Oct; 70(10):1166-8. doi: 10.1002/jps.2600701022. [PMID: 7299655]
  • P Pecorari, A Albasini, M Melegari, G Vampa, F Manenti. An HPLC method for the simultaneous determination of tolbutamide and its metabolites in plasma. Il Farmaco; edizione pratica. 1981 Jan; 36(1):7-12. doi: NULL. [PMID: 7227495]
  • E NELSON, I O'REILLY. Kinetics of carboxytolbutamide excretion following tolbutamide and carboxytolbutamide administration. The Journal of pharmacology and experimental therapeutics. 1961 Apr; 132(?):103-9. doi: NULL. [PMID: 13728274]
  • E NELSON, I O'REILLY, T CHULSKI. Determination of carboxytolbutamide in urine. Clinica chimica acta; international journal of clinical chemistry. 1960 Sep; 5(?):774-6. doi: 10.1016/0009-8981(60)90026-7. [PMID: 13728273]