DG(8:0/8:0/0:0) (BioDeep_00000026996)

   

human metabolite Endogenous LipidSearch


代谢物信息卡片


Octanoic acid, 1-(hydroxymethyl)-1,2-ethanediyl ester

化学式: C19H36O5 (344.2563)
中文名称: 1,2-二辛酰基-sn-甘油, 二辛酸甘油酯
谱图信息: 最多检出来源 Homo sapiens(lipidsearch) 87.76%

分子结构信息

SMILES: CCCCCCCC(=O)OCC(CO)OC(=O)CCCCCCC
InChI: InChI=1S/C19H36O5/c1-3-5-7-9-11-13-18(21)23-16-17(15-20)24-19(22)14-12-10-8-6-4-2/h17,20H,3-16H2,1-2H3

描述信息

Diglycerides (DGs) are also known as diacylglycerols or diacylglycerides, meaning that they are glycerides consisting of two fatty acid chains covalently bonded to a glycerol molecule through ester linkages. DG(8:0/8:0/0:0), in particular, consists of one chain of caprylic acid at the C-1 position and one chain of caprylic acid at the C-2 position. Mono- and diacylglycerols are common food additives used to blend together certain ingredients, such as oil and water, which would not otherwise blend well. Diacylglycerols are often found in bakery products, beverages, ice cream, chewing gum, shortening, whipped toppings, margarine, and confections.
C78276 - Agent Affecting Digestive System or Metabolism

同义名列表

33 个代谢物同义名

Octanoic acid, 1-(hydroxymethyl)-1,2-ethanediyl ester; (2S)-1-hydroxy-3-(octanoyloxy)propan-2-yl octanoate; Octanoate, 1-(hydroxymethyl)-1,2-ethanediyl ester; 1-capryloyl-2-capryloyl-sn-glycerol; 1,2-Dioctanoylglycerol, (S)-isomer; 1,2-dicapryloyl-rac-glycerol; Diacylglycerol(8:0/8:0/0:0); 1,2-Dicapryloyl-sn-glycerol; 1,2-Octanoyl-sn-diglyceride; 1,2-Dioctanoyl-rac-glycerol; 1,2-dioctanoyl-sn-glycerol; sn-1,2-Dioctanoylglycerol; 1,2-Dicapryloylglycerol; Diacylglycerol(8:0/8:0); D-alpha,beta-Dicaprylin; 1,2-Dioctanoylglycerol; Diacylglycerol(16:0); sn-1,2-Dicaprilin; Dicaprylglyceride; D-a,b-Dicaprylin; Dag(8:0/8:0/0:0); D-Α,β-dicaprylin; UNII:SA9937IP23; DG(8:0/8:0/0:0); Diacylglycerol; DAG(8:0/8:0); Diglyceride; DG(8:0/8:0); Dioctanoin; Dag(16:0); DAG(16:0); DG(16:0); DiC8



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

108 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(108)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Michelle A Lum, Carter J Barger, Alice H Hsu, Olga V Leontieva, Adrian R Black, Jennifer D Black. Protein Kinase Cα (PKCα) Is Resistant to Long Term Desensitization/Down-regulation by Prolonged Diacylglycerol Stimulation. The Journal of biological chemistry. 2016 Mar; 291(12):6331-46. doi: 10.1074/jbc.m115.696211. [PMID: 26769967]
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  • Christian Winter, Nicole B Kampik, Luca Vedovelli, Florina Rothenberger, Teodor G Paunescu, Paul A Stehberger, Dennis Brown, Hubert John, Carsten A Wagner. Aldosterone stimulates vacuolar H(+)-ATPase activity in renal acid-secretory intercalated cells mainly via a protein kinase C-dependent pathway. American journal of physiology. Cell physiology. 2011 Nov; 301(5):C1251-61. doi: 10.1152/ajpcell.00076.2011. [PMID: 21832245]
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  • Shinichi Meguro, Noriko Osaki, Koji Onizawa, Noriyuki Yajima, Tadashi Hase, Noboru Matsuo, Ichiro Tokimitsu. Comparison of dietary triacylglycerol oil and diacylglycerol oil in protein kinase C activation. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2007 Jul; 45(7):1165-72. doi: 10.1016/j.fct.2006.12.024. [PMID: 17306914]
  • Paola Capuano, Desa Bacic, Marcel Roos, Serge M Gisler, Gerti Stange, Jürg Biber, Brigitte Kaissling, Edward J Weinman, Shirish Shenolikar, Carsten A Wagner, Heini Murer. Defective coupling of apical PTH receptors to phospholipase C prevents internalization of the Na+-phosphate cotransporter NaPi-IIa in Nherf1-deficient mice. American journal of physiology. Cell physiology. 2007 Feb; 292(2):C927-34. doi: 10.1152/ajpcell.00126.2006. [PMID: 16987995]
  • Johnny Näsman, Genevieve Bart, Kim Larsson, Lauri Louhivuori, Hanna Peltonen, Karl E O Akerman. The orexin OX1 receptor regulates Ca2+ entry via diacylglycerol-activated channels in differentiated neuroblastoma cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006 Oct; 26(42):10658-66. doi: 10.1523/jneurosci.2609-06.2006. [PMID: 17050705]
  • Christina Hörnig, Dana Albert, Lutz Fischer, Michael Hörnig, Olof Rådmark, Dieter Steinhilber, Oliver Werz. 1-Oleoyl-2-acetylglycerol stimulates 5-lipoxygenase activity via a putative (phospho)lipid binding site within the N-terminal C2-like domain. The Journal of biological chemistry. 2005 Jul; 280(29):26913-21. doi: 10.1074/jbc.m500068200. [PMID: 15923196]
  • Helena Stensman, Arathi Raghunath, Christer Larsson. Autophosphorylation suppresses whereas kinase inhibition augments the translocation of protein kinase Calpha in response to diacylglycerol. The Journal of biological chemistry. 2004 Sep; 279(39):40576-83. doi: 10.1074/jbc.m405560200. [PMID: 15277524]
  • Philippe Lucas, Kyrill Ukhanov, Trese Leinders-Zufall, Frank Zufall. A diacylglycerol-gated cation channel in vomeronasal neuron dendrites is impaired in TRPC2 mutant mice: mechanism of pheromone transduction. Neuron. 2003 Oct; 40(3):551-61. doi: 10.1016/s0896-6273(03)00675-5. [PMID: 14642279]
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  • Desa Bacic, Nicole Schulz, Jürg Biber, Brigitte Kaissling, Heini Murer, Carsten A Wagner. Involvement of the MAPK-kinase pathway in the PTH-mediated regulation of the proximal tubule type IIa Na+/Pi cotransporter in mouse kidney. Pflugers Archiv : European journal of physiology. 2003 Apr; 446(1):52-60. doi: 10.1007/s00424-002-0969-8. [PMID: 12690463]
  • Johannes C Lenz, H Peter Reusch, Nadine Albrecht, Günter Schultz, Michael Schaefer. Ca2+-controlled competitive diacylglycerol binding of protein kinase C isoenzymes in living cells. The Journal of cell biology. 2002 Oct; 159(2):291-302. doi: 10.1083/jcb.200203048. [PMID: 12391024]
  • Carole L Baron, Vivek Malhotra. Role of diacylglycerol in PKD recruitment to the TGN and protein transport to the plasma membrane. Science (New York, N.Y.). 2002 Jan; 295(5553):325-8. doi: 10.1126/science.1066759. [PMID: 11729268]
  • P Masiello, M Novelli, M Bombara, V Fierabracci, S Vittorini, M Prentki, E Bergamini. The antilipolytic agent 3,5-dimethylpyrazole inhibits insulin release in response to both nutrient secretagogues and cyclic adenosine monophosphate agonists in isolated rat islets. Metabolism: clinical and experimental. 2002 Jan; 51(1):110-4. doi: 10.1053/meta.2002.28969. [PMID: 11782881]
  • A Y Andreeva, E Krause, E C Müller, I E Blasig, D I Utepbergenov. Protein kinase C regulates the phosphorylation and cellular localization of occludin. The Journal of biological chemistry. 2001 Oct; 276(42):38480-6. doi: 10.1074/jbc.m104923200. [PMID: 11502742]
  • Y Tesfai, H M Brereton, G J Barritt. A diacylglycerol-activated Ca2+ channel in PC12 cells (an adrenal chromaffin cell line) correlates with expression of the TRP-6 (transient receptor potential) protein. The Biochemical journal. 2001 Sep; 358(Pt 3):717-26. doi: 10.1042/0264-6021:3580717. [PMID: 11535132]
  • G Pietig, T Mehrens, J R Hirsch, I Cetinkaya, H Piechota, E Schlatter. Properties and regulation of organic cation transport in freshly isolated human proximal tubules. The Journal of biological chemistry. 2001 Sep; 276(36):33741-6. doi: 10.1074/jbc.m104617200. [PMID: 11447227]
  • L Sek, C J Porter, W N Charman. Characterisation and quantification of medium chain and long chain triglycerides and their in vitro digestion products, by HPTLC coupled with in situ densitometric analysis. Journal of pharmaceutical and biomedical analysis. 2001 Jun; 25(3-4):651-61. doi: 10.1016/s0731-7085(00)00528-8. [PMID: 11377046]
  • P S Lorenzo, J W Kung, D A Bottorff, S H Garfield, J C Stone, P M Blumberg. Phorbol esters modulate the Ras exchange factor RasGRP3. Cancer research. 2001 Feb; 61(3):943-9. doi: NULL. [PMID: 11221888]
  • B Haidar, S Mott, B Boucher, C Y Lee, M Marcil, J Genest. Cellular cholesterol efflux is modulated by phospholipid-derived signaling molecules in familial HDL deficiency/Tangier disease fibroblasts. Journal of lipid research. 2001 Feb; 42(2):249-57. doi: 10.1016/s0022-2275(20)31686-2. [PMID: 11181755]
  • J K Jackon, C Tudan, H M Burt. The involvement of phospholipase C in crystal induced human neutrophil activation. The Journal of rheumatology. 2000 Dec; 27(12):2877-85. doi: NULL. [PMID: 11128680]
  • T Okada, R Inoue, K Yamazaki, A Maeda, T Kurosaki, T Yamakuni, I Tanaka, S Shimizu, K Ikenaka, K Imoto, Y Mori. Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7. Ca(2+)-permeable cation channel that is constitutively activated and enhanced by stimulation of G protein-coupled receptor. The Journal of biological chemistry. 1999 Sep; 274(39):27359-70. doi: 10.1074/jbc.274.39.27359. [PMID: 10488066]
  • M Gekle, S Mildenberger, C Sauvant, D Bednarczyk, S H Wright, W H Dantzler. Inhibition of initial transport rate of basolateral organic anion carrier in renal PT by BK and phenylephrine. The American journal of physiology. 1999 08; 277(2):F251-6. doi: 10.1152/ajprenal.1999.277.2.f251. [PMID: 10444580]
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  • A T Tool, M Blom, D Roos, A J Verhoeven. Phospholipase D-derived phosphatidic acid is involved in the activation of the CD11b/CD18 integrin in human eosinophils. The Biochemical journal. 1999 May; 340 ( Pt 1)(?):95-101. doi: 10.1042/bj3400095. [PMID: 10229663]
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