5,15-DiHETE (BioDeep_00000026969)

   

human metabolite Endogenous blood metabolite


代谢物信息卡片


(5S,6E,8Z,11Z,13E,15S)-5,15-dihydroxyicosa-6,8,11,13-tetraenoic acid

化学式: C20H32O4 (336.2300472)
中文名称: 5(S),15(S)-二羟化二十烷四烯酸
谱图信息: 最多检出来源 Homo sapiens(blood) 1.3%

分子结构信息

SMILES: CCCCCC(/C=C/C=C\C/C=C\C=C\C(CCCC(=O)O)O)O
InChI: InChI=1S/C20H32O4/c1-2-3-9-13-18(21)14-10-7-5-4-6-8-11-15-19(22)16-12-17-20(23)24/h5-8,10-11,14-15,18-19,21-22H,2-4,9,12-13,16-17H2,1H3,(H,23,24)/b7-5-,8-6-,14-10+,15-11+/t18-,19+/m0/s1

描述信息

5,15-DiHETE or 5,15-dihydroxyeicosatetraenoic acid is a double oxidation product of arachadonic acid. (PMID: 6817003). It is produced by the action of lipoxygenases (specifically 5-lipoxygenase and 15 lipoxygenase) in the liver and in neutrophils. [HMDB]
5,15-DiHETE or 5,15-dihydroxyeicosatetraenoic acid is a double oxidation product of arachadonic acid. (PMID: 6817003). It is produced by the action of lipoxygenases (specifically 5-lipoxygenase and 15 lipoxygenase) in the liver and in neutrophils.

同义名列表

18 个代谢物同义名

(5S,6E,8Z,11Z,13E,15S)-5,15-dihydroxyicosa-6,8,11,13-tetraenoic acid; 5(S),15(S)-Dihydroxy-6,13-trans-8,11-cis-eicosatetraenoic acid; 5(S),15(S)-Dihydroxy-6,13-trans-8,11-cis-eicosatetraenoate; (5S,6E,8Z,11Z,13E,15S)-5,15-Dihydroxyicosatetraenoic acid; (5S,15S)-Dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoic acid; (5S,15S)-Dihydroxy-(6E,8Z,11Z,13E)-icosatetraenoic acid; (5S,6E,8Z,11Z,13E,15S)-5,15-Dihydroxyicosatetraenoate; (5S,15S)-Dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate; 5S,15S-dihydroxy-6E,8Z,11Z,13E-eicosatetraenoic acid; (5S,15S)-Dihydroxy-(6E,8Z,11Z,13E)-icosatetraenoate; 5S,15S-Dihydroxy-6E,8Z,11Z,13E-eicosatetraenoate; 5,15-Dihydroxy-6,8,11,13-eicosatetraenoic acid; 5,15-Dihydroxy-6,8,11,13-eicosatetraenoate; 5,15-Dihydroxyeicosatetraenoic acid; 5,15-Dihydroxyeicosatetraenoate; 5(S),15(S)-DIHETE; 5S,15S-DiHETE; 5,15-Dihete



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Abigail R Green, Cody Freedman, Jennyfer Tena, Benjamin E Tourdot, Benjamin Liu, Michael Holinstat, Theodore R Holman. 5 S,15 S-Dihydroperoxyeicosatetraenoic Acid (5,15-diHpETE) as a Lipoxin Intermediate: Reactivity and Kinetics with Human Leukocyte 5-Lipoxygenase, Platelet 12-Lipoxygenase, and Reticulocyte 15-Lipoxygenase-1. Biochemistry. 2018 12; 57(48):6726-6734. doi: 10.1021/acs.biochem.8b00889. [PMID: 30407793]
  • Xingyang Yi, Lang Wu, Duanxiu Liao, Chun Wang, Biao Zhang. Interactions Among CYP2C8, EPHX2, and CYP4A11 Variants and CYP Plasma Metabolite Levels in Ischemic Stroke. Journal of atherosclerosis and thrombosis. 2016 Nov; 23(11):1286-1293. doi: 10.5551/jat.35279. [PMID: 27087514]
  • Noemi Tejera, William E Boeglin, Takashi Suzuki, Claus Schneider. COX-2-dependent and -independent biosynthesis of dihydroxy-arachidonic acids in activated human leukocytes. Journal of lipid research. 2012 Jan; 53(1):87-94. doi: 10.1194/jlr.m017822. [PMID: 22068350]
  • Charles N Serhan, Ashish Jain, Sylvie Marleau, Clary Clish, Alpdogan Kantarci, Balsam Behbehani, Sean P Colgan, Gregory L Stahl, Aksam Merched, Nicos A Petasis, Lawrence Chan, Thomas E Van Dyke. Reduced inflammation and tissue damage in transgenic rabbits overexpressing 15-lipoxygenase and endogenous anti-inflammatory lipid mediators. Journal of immunology (Baltimore, Md. : 1950). 2003 Dec; 171(12):6856-65. doi: 10.4049/jimmunol.171.12.6856. [PMID: 14662892]
  • M Dadaian, P Westlund. Albumin modifies the metabolism of hydroxyeicosatetraenoic acids via 12-lipoxygenase in human platelets. Journal of lipid research. 1999 May; 40(5):940-7. doi: . [PMID: 10224163]
  • P P McDonald, S R McColl, P H Naccache, P Borgeat. Activation of the human neutrophil 5-lipoxygenase by leukotriene B4. British journal of pharmacology. 1992 Sep; 107(1):226-32. doi: 10.1111/j.1476-5381.1992.tb14491.x. [PMID: 1330161]
  • S R McColl, E Krump, P P McDonald, M Braquet, P H Naccache, P Borgeat. Enhancement of platelet-activating factor-induced leukotriene synthesis in neutrophils by granulocyte-macrophage colony-stimulating factor (GM-CSF): studies on the mechanism of action of GM-CSF. Journal of lipid mediators. 1990; 2 Suppl(?):S119-27. doi: ". [PMID: 1966811]
  • S R McColl, E Krump, P H Naccache, A C Caon, P Borgeat. Activation of the human neutrophil 5-lipoxygenase by exogenous arachidonic acid: involvement of pertussis toxin-sensitive guanine nucleotide-binding proteins. British journal of pharmacology. 1989 Aug; 97(4):1265-73. doi: 10.1111/j.1476-5381.1989.tb12588.x. [PMID: 2507084]