hydroxychlorpromazine (BioDeep_00000026919)
human metabolite Endogenous blood metabolite Chemicals and Drugs
代谢物信息卡片
化学式: C17H19ClN2OS (334.0907)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(urine) 25.4%
分子结构信息
SMILES: CN(C)CCCN1C2=C(C=C(C=C2)O)SC3=C1C=C(C=C3)Cl
InChI: InChI=1S/C17H19ClN2OS/c1-19(2)8-3-9-20-14-6-5-13(21)11-17(14)22-16-7-4-12(18)10-15(16)20/h4-7,10-11,21H,3,8-9H2,1-2H3
描述信息
hydroxychlorpromazine is a metabolite of chlorpromazine. Chlorpromazine (as chlorpromazine hydrochloride, abbreviated CPZ; marketed in the United States as Thorazine and elsewhere as Largactil) is a typical antipsychotic. First synthesized on December 11, 1950, chlorpromazine was the first drug developed with specific antipsychotic action, and would serve as the prototype for the phenothiazine class of drugs, which later grew to comprise several other agents. (Wikipedia)
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:125475
- PubChem: 16414
- HMDB: HMDB0060991
- ChEMBL: CHEMBL909
- CAS: 2095-62-7
- PMhub: MS000238985
分类词条
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Cho-Ming Loi, Dennis A Smith, Deepak Dalvie. Which metabolites circulate?.
Drug metabolism and disposition: the biological fate of chemicals.
2013 May; 41(5):933-51. doi:
10.1124/dmd.112.050278. [PMID: 23454828] - M Chetty, R Miller. Effect of storage on the plasma concentration of chlorpromazine and six of its metabolites.
Therapeutic drug monitoring.
1991 Jul; 13(4):350-5. doi:
10.1097/00007691-199107000-00012. [PMID: 1780969] - P K Yeung, J W Hubbard, E D Korchinski, K K Midha. Radioimmunoassay for the N-oxide metabolite of chlorpromazine in human plasma and its application to a pharmacokinetic study in healthy humans.
Journal of pharmaceutical sciences.
1987 Oct; 76(10):803-8. doi:
10.1002/jps.2600761011. [PMID: 3430345] - K K Midha, J W Hubbard, J K Cooper, T Gurnsey, E M Hawes, G McKay, B S Chakraborty, P K Yeung. Therapeutic monitoring of chlorpromazine. IV: Comparison of a new high-performance liquid chromatographic method with radioimmunoassays for parent drug and some of its major metabolites.
Therapeutic drug monitoring.
1987 Sep; 9(3):358-65. doi:
. [PMID: 3672582] - L D Gruenke, J C Craig, F D Klein, T L Nguyen, B A Hitzemann, J W Holaday, H H Loh, L Braff, A Fischer, I D Glick. Determination of chlorpromazine and its major metabolites by gas chromatography/mass spectrometry: application to biological fluids.
Biomedical mass spectrometry.
1985 Dec; 12(12):707-13. doi:
10.1002/bms.1200121207. [PMID: 2936401] - P K Yeung, G McKay, I A Ramshaw, J W Hubbard, K K Midha. A comparison of two radioimmunoassays for 7-hydroxychlorpromazine: rabbit polyclonal antibodies vs. mouse monoclonal antibodies.
The Journal of pharmacology and experimental therapeutics.
1985 Jun; 233(3):816-22. doi:
NULL. [PMID: 4009490] - G Alfredsson, L Bjerkenstedt, G Edman, C Härnryd, G Oxenstierna, G Sedvall, F A Wiesel. Relationships between drug concentrations in serum and CSF, clinical effects and monoaminergic variables in schizophrenic patients treated with sulpiride or chlorpromazine.
Acta psychiatrica Scandinavica. Supplementum.
1984; 311(?):49-74. doi:
10.1111/j.1600-0447.1984.tb06859.x. [PMID: 6199949] - G Alfredsson, M Lindberg, G Sedvall. The presence of 7-hydroxychlorpromazine in CSF of chloropromazine-treated patients.
Psychopharmacology.
1982; 77(4):376-8. doi:
10.1007/bf00432774. [PMID: 6813900] - B Wode-Helgodt, G Alfredsson. Concentrations of chlorpromazine and two of its active metabolites in plasma and cerebrospinal fluid of psychotic patients treated with fixed drug doses.
Psychopharmacology.
1981; 73(1):55-62. doi:
10.1007/bf00431102. [PMID: 6785790] - H GOLDENBERG, V FISHMAN. (COMMENTS ON '7-HYDROXYCHLORPROMAZINE IN THE URINES OF SCHIZOPHRENICS RECEIVING CHLORPROMAZINE'.).
Biochemical pharmacology.
1965 Mar; 14(?):365-8. doi:
10.1016/0006-2952(65)90206-6. [PMID: 14314336] - T L PERRY, C F CULLING, K BERRY, S HANSEN. 7-HYDROXYCHLORPROMAZINE: POTENTIAL TOXIC DRUG METABOLITE IN PSYCHIATRIC PATIENTS.
Science (New York, N.Y.).
1964 Oct; 146(3640):81-3. doi:
10.1126/science.146.3640.81. [PMID: 14173037] - S PRICE, H F MARTIN, B J GUDZINOWICZ. 7-HYDROXYCHLORPROMAZINE IN THE URINES OF SCHIZOPHRENICS RECEIVING CHLROPROMAZINE.
Biochemical pharmacology.
1964 Apr; 13(?):659-62. doi:
10.1016/0006-2952(64)90052-8. [PMID: 14191872]
