L-Thyronine (BioDeep_00000026907)
human metabolite Endogenous blood metabolite
代谢物信息卡片
(2S)-2-amino-3-[4-(4-hydroxyphenoxy)phenyl]propanoic acid
化学式: C15H15NO4 (273.100103)
中文名称: L-甲状腺原氨酸, 甲状腺原氨酸
谱图信息:
最多检出来源 Homo sapiens(blood) 0.1%
分子结构信息
SMILES: C1=CC(=CC=C1CC(C(=O)O)N)OC2=CC=C(C=C2)O
InChI: InChI=1S/C15H15NO4/c16-14(15(18)19)9-10-1-5-12(6-2-10)20-13-7-3-11(17)4-8-13/h1-8,14,17H,9,16H2,(H,18,19)/t14-/m0/s1
描述信息
Thyronine (T0) is a de-iodinated form of thyroxine. Thyronine are a group of metabolites derived from thyroxine and triiodothyronine via the peripheral enzymatic removal of iodines from the thyroxine nucleus. Thyronine is the thyroxine nucleus devoid of its four iodine atoms. Thyronine (T0) has been identified in human urine. In 22 normal individuals urinary thyronine concentrations were found to range between 8-25 nmol‚ÅÑ24h (PMID: 479355). Thyronine is thought to be a byproduct of thyroxine metabolism and arises through the action of thyroxine deiodinases.
Iodide is actively absorbed from the bloodstream and concentrated in the thyroid follicles. (If there is a deficiency of dietary iodine, the thyroid enlarges in an attempt to trap more iodine, resulting in goitre.) Via a reaction with the enzyme thyroperoxidase, iodine is covalently bound to tyrosine residues in the thyroglobulin molecules, forming monoiodotyrosine (MIT) and diiodotyrosine (DIT). Linking two moieties of DIT produces thyroxine. Combining one particle of MIT and one particle of DIT produces triiodothyronine.
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
同义名列表
12 个代谢物同义名
(2S)-2-amino-3-[4-(4-hydroxyphenoxy)phenyl]propanoic acid; beta-(p-Hydroxyphenoxy)phenylalanine; 4-(4-Hydroxyphenoxy)-L-phenylalanine; b-(p-Hydroxyphenoxy)phenylalanine; O-(4-Hydroxyphenyl)-L-tyrosine; O-(4-Hydroxyphenyl)tyrosine; Desiodothyroxine; DL-THYRONINE; L-Thyronine; Thyronines; thyronine; Thyronine
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:30662
- PubChem: 5461103
- HMDB: HMDB0000667
- Wikipedia: Thyronine
- MeSH: Thyronines
- foodb: FDB022172
- chemspider: 4574450
- CAS: 1596-67-4
- PMhub: MS000238794
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
1 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(1)
- thyroid hormone metabolism I (via deiodination):
3,5,3'-triiodo-L-thyronine + A + H+ + iodide ⟶ A(H2) + L-thyroxine
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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10.1016/j.jchromb.2021.122553. [PMID: 33503577] - Carla Moran, Christoph Seger, Kevin Taylor, Susan Oddy, Keith Burling, Odelia Rajanayagam, Louise Fairall, Anne McGowan, Greta Lyons, David Halsall, Mark Gurnell, John Schwabe, Krishna Chatterjee, Christopher Strey. Hyperthyroxinemia and Hypercortisolemia due to Familial Dysalbuminemia.
Thyroid : official journal of the American Thyroid Association.
2020 11; 30(11):1681-1684. doi:
10.1089/thy.2020.0315. [PMID: 32669045] - Riccardo Zucchi. Thyroid Hormone Analogues: An Update.
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2020 08; 30(8):1099-1105. doi:
10.1089/thy.2020.0071. [PMID: 32098589] - M Kim, K Park, I Choi. The metabolic suppressor 3-iodothyronamine enhances lipolysis in 3T3-L1 adipocytes via activation of the adenosine monophosphate-activated protein kinase/forkhead box O1 signaling pathway.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2020 Jun; 71(3):. doi:
10.26402/jpp.2020.3.12. [PMID: 33077693] - Haiyan Zhou, Bailong Hu, Xingde Liu. Thyroid Hormone Metabolite 3-Iodothyronamine (T1AM) Alleviates Hypoxia/Reoxygenation-Induced Cardiac Myocyte Apoptosis via Akt/FoxO1 Pathway.
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BioMed research international.
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Molecular vision.
2010 Feb; 16(?):283-93. doi:
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Pharmacognosy reviews.
2010 Jan; 4(7):95-105. doi:
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Journal of cellular and molecular medicine.
2009 Sep; 13(9B):3082-90. doi:
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The Journal of endocrinology.
2009 Jun; 201(3):377-86. doi:
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Endocrinology.
2009 Apr; 150(4):1991-9. doi:
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Chembiochem : a European journal of chemical biology.
2009 Jan; 10(2):361-5. doi:
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2008 Nov; 1210(1):55-9. doi:
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2008 Oct; 32(10):1566-75. doi:
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Thyroid : official journal of the American Thyroid Association.
2008 Feb; 18(2):239-53. doi:
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Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology.
2008 Feb; 178(2):167-77. doi:
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Pediatric research.
2008 Feb; 63(2):149-53. doi:
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The Journal of experimental biology.
2007 Nov; 210(Pt 22):4005-15. doi:
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Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2007 Aug; 48(8):1338-47. doi:
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The British journal of nutrition.
2007 Aug; 98(2):310-9. doi:
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Environmental health perspectives.
2007 Jul; 115(7):1052-8. doi:
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ACS chemical biology.
2007 Jun; 2(6):390-8. doi:
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The Journal of clinical investigation.
2007 Mar; 117(3):627-35. doi:
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The Journal of membrane biology.
2007 Feb; 215(2-3):135-45. doi:
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Wei sheng yan jiu = Journal of hygiene research.
2006 Mar; 35(2):194-5. doi:
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Thyroid : official journal of the American Thyroid Association.
2005 Aug; 15(8):943-58. doi:
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Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology.
2005 Jul; 191(7):649-57. doi:
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Journal of dairy science.
2003 Jan; 86(1):152-8. doi:
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Endocrinology.
2002 Mar; 143(3):814-9. doi:
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Endocrinology.
2002 Mar; 143(3):764-74. doi:
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Clinical chemistry and laboratory medicine.
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Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
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The American journal of physiology.
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