7-Hydroxymatairesinol (BioDeep_00000269058)
Main id: BioDeep_00000269041
PANOMIX_OTCML-2023
代谢物信息卡片
(-)-7-hydroxymatairesinol
化学式: C20H22O7 (374.1365462)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1(=O)[C@@H]([C@H](CO1)[C@H](c1ccc(c(c1)OC)O)O)Cc1cc(c(cc1)O)OC
InChI: InChI=1S/C20H22O7/c1-25-17-8-11(3-5-15(17)21)7-13-14(10-27-20(13)24)19(23)12-4-6-16(22)18(9-12)26-2/h3-6,8-9,13-14,19,21-23H,7,10H2,1-2H3/t13-,14+,19+/m1/s1
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Giorgio Biasiotto, Isabella Zanella, Federica Predolini, Ivonne Archetti, Moris Cadei, Eugenio Monti, Marcello Luzzani, Barbara Pacchetti, Paola Mozzoni, Roberta Andreoli, Giuseppe De Palma, Federico Serana, Annika Smeds, Diego Di Lorenzo. 7-Hydroxymatairesinol improves body weight, fat and sugar metabolism in C57BJ/6 mice on a high-fat diet.
The British journal of nutrition.
2018 10; 120(7):751-762. doi:
10.1017/s0007114518001824. [PMID: 30105962] - Di Yang, Chen-Xi Xiao, Zheng-Hua Su, Meng-Wei Huang, Ming Qin, Wei-Jun Wu, Wan-Wan Jia, Yi-Zhun Zhu, Jin-Feng Hu, Xin-Hua Liu. (-)-7(S)-hydroxymatairesinol protects against tumor necrosis factor-α-mediated inflammation response in endothelial cells by blocking the MAPK/NF-κB and activating Nrf2/HO-1.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2017 Aug; 32(?):15-23. doi:
10.1016/j.phymed.2017.04.005. [PMID: 28732803] - Annika I Smeds, Patrik C Eklund, Stefan M Willför. Chemical characterization of high-molar-mass fractions in a Norway spruce knotwood ethanol extract.
Phytochemistry.
2016 Oct; 130(?):207-17. doi:
10.1016/j.phytochem.2016.05.006. [PMID: 27256310] - Nathalie Jullian-Pawlicki, Michelle Lequart-Pillon, Luyen Huynh-Cong, David Lesur, Dominique Cailleu, François Mesnard, Jean Claude Laberche, Eric Gontier, Michèle Boitel-Conti. Arylnaphthalene and aryltetralin-type lignans in hairy root cultures of Linum perenne, and the stereochemistry of 6-methoxypodophyllotoxin and one diastereoisomer by HPLC-MS and NMR spectroscopy.
Phytochemical analysis : PCA.
2015 Sep; 26(5):310-9. doi:
10.1002/pca.2565. [PMID: 25982186] - Eliana Spilioti, Bjarne Holmbom, Athanasios G Papavassiliou, Paraskevi Moutsatsou. Lignans 7-hydroxymatairesinol and 7-hydroxymatairesinol 2 exhibit anti-inflammatory activity in human aortic endothelial cells.
Molecular nutrition & food research.
2014 Apr; 58(4):749-59. doi:
10.1002/mnfr.201300318. [PMID: 24311533] - Jay K Udani, Donald J Brown, Maria Olivia C Tan, Mary Hardy. Pharmacokinetics and bioavailability of plant lignan 7-hydroxymatairesinol and effects on serum enterolactone and clinical symptoms in postmenopausal women: a single-blinded, parallel, dose-comparison study.
Journal of the American College of Nutrition.
2013; 32(6):428-35. doi:
10.1080/07315724.2013.849578. [PMID: 24606716] - Alexandrine During, Céline Debouche, Thomas Raas, Yvan Larondelle. Among plant lignans, pinoresinol has the strongest antiinflammatory properties in human intestinal Caco-2 cells.
The Journal of nutrition.
2012 Oct; 142(10):1798-805. doi:
10.3945/jn.112.162453. [PMID: 22955517] - Marco Cosentino, Franca Marino, Ramòna Consuélo Maio, Marco Gioacchino Delle Canne, Marcello Luzzani, Silvano Paracchini, Sergio Lecchini. Immunomodulatory activity of the lignan 7-hydroxymatairesinol potassium acetate (HMR/lignan) extracted from the heartwood of Norway spruce (Picea abies).
International immunopharmacology.
2010 Mar; 10(3):339-43. doi:
10.1016/j.intimp.2009.12.005. [PMID: 20005303] - Kanae Yamashita, Yasushi Yamada, Shiho Kitou, Saiko Ikeda, Chisato Abe, Niina M Saarinen, Risto Santti. Hydroxymatairesinol and sesaminol act differently on tocopherol concentrations in rats.
Journal of nutritional science and vitaminology.
2007 Oct; 53(5):393-9. doi:
10.3177/jnsv.53.393. [PMID: 18079605] - Marco Cosentino, Franca Marino, Marco Ferrari, Emanuela Rasini, Raffaella Bombelli, Alessandra Luini, Massimiliano Legnaro, Marco Gioacchino Delle Canne, Marcello Luzzani, Francesca Crema, Silvano Paracchini, Sergio Lecchini. Estrogenic activity of 7-hydroxymatairesinol potassium acetate (HMR/lignan) from Norway spruce (Picea abies) knots and of its active metabolite enterolactone in MCF-7 cells.
Pharmacological research.
2007 Aug; 56(2):140-7. doi:
10.1016/j.phrs.2007.05.001. [PMID: 17572100] - Annika Bylund, Niina Saarinen, Jie-Xian Zhang, Anders Bergh, Anders Widmark, Anders Johansson, Eva Lundin, Herman Adlercreutz, Göran Hallmans, Pär Stattin, Sari Mäkela. Anticancer effects of a plant lignan 7-hydroxymatairesinol on a prostate cancer model in vivo.
Experimental biology and medicine (Maywood, N.J.).
2005 Mar; 230(3):217-23. doi:
10.1177/153537020523000308. [PMID: 15734725] - Annika I Smeds, Niina M Saarinen, Patrik C Eklund, Rainer E Sjöholm, Sari I Mäkelä. New lignan metabolites in rat urine.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2005 Feb; 816(1-2):87-97. doi:
10.1016/j.jchromb.2004.11.017. [PMID: 15664338] - B Lina, H Korte, L Nyman, M Unkila. A thirteen week dietary toxicity study with 7-hydroxymatairesinol potassium acetate (HMRlignan) in rats.
Regulatory toxicology and pharmacology : RTP.
2005 Feb; 41(1):28-38. doi:
10.1016/j.yrtph.2004.09.001. [PMID: 15649825] - N M Saarinen, P E Penttinen, A I Smeds, T T Hurmerinta, S I Mäkelä. Structural determinants of plant lignans for growth of mammary tumors and hormonal responses in vivo.
The Journal of steroid biochemistry and molecular biology.
2005 Feb; 93(2-5):209-19. doi:
10.1016/j.jsbmb.2004.12.004. [PMID: 15860264] - A P M Wolterbeek, A Roberts, H Korte, M Unkila, D H Waalkens-Berendsen. Prenatal developmental toxicity study with 7-hydroxymatairesinol potassium acetate (HMRlignan) in rats.
Regulatory toxicology and pharmacology : RTP.
2004 Aug; 40(1):1-8. doi:
10.1016/j.yrtph.2004.04.001. [PMID: 15265601] - Annika Smeds, Kristo Hakala. Liquid chromatographic-tandem mass spectrometric method for the plant lignan 7-hydroxymatairesinol and its potential metabolites in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2003 Aug; 793(2):297-308. doi:
10.1016/s1570-0232(03)00330-1. [PMID: 12906904] - Lauri Kangas, Niina Saarinen, Marja Mutanen, Markku Ahotupa, Riikka Hirsinummi, Mikko Unkila, Merja Perälä, Pasi Soininen, Reino Laatikainen, Helena Korte, Risto Santti. Antioxidant and antitumor effects of hydroxymatairesinol (HM-3000, HMR), a lignan isolated from the knots of spruce.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP).
2002 Aug; 11 Suppl 2(?):S48-57. doi:
. [PMID: 12570335] - T H Mäkelä, S A Kaltia, K T Wähälä, T A Hase. alpha,beta-Dibenzyl-gamma-butyrolactone lignan alcohols: total synthesis of (+/-)-7'-hydroxyenterolactone, (+/-)-7'-hydroxymatairesinol and (+/-)-8-hydroxyenterolactone.
Steroids.
2001 Oct; 66(10):777-84. doi:
10.1016/s0039-128x(01)00107-6. [PMID: 11522341] - N M Saarinen, R Huovinen, A Wärri, S I Mäkelä, L Valentín-Blasini, L Needham, C Eckerman, Y U Collan, R Santti. Uptake and metabolism of hydroxymatairesinol in relation to its anticarcinogenicity in DMBA-induced rat mammary carcinoma model.
Nutrition and cancer.
2001; 41(1-2):82-90. doi:
10.1080/01635581.2001.9680616. [PMID: 12094633] - N M Saarinen, A Wärri, S I Mäkelä, C Eckerman, M Reunanen, M Ahotupa, S M Salmi, A A Franke, L Kangas, R Santti. Hydroxymatairesinol, a novel enterolactone precursor with antitumor properties from coniferous tree (Picea abies).
Nutrition and cancer.
2000; 36(2):207-16. doi:
10.1207/s15327914nc3602_10. [PMID: 10890032]