Dasatinib (BioDeep_00000026878)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


N-(2-CHLORO-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide

化学式: C22H26ClN7O2S (487.1557126000001)
中文名称: 达沙替尼
谱图信息: 最多检出来源 Homo sapiens(blood) 1.89%

分子结构信息

SMILES: CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=CC(=NC(=N3)C)N4CCN(CC4)CCO
InChI: InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)

描述信息

Dasatinib is only found in individuals that have used or taken this drug. It is an oral dual BCR/ABL and Src family tyrosine kinase inhibitor approved for use in patients with chronic myelogenous leukemia (CML). The main targets of Dasatinib, are BCRABL, SRC, Ephrins and GFR.Dasatinib, at nanomolar concentrations, inhibits the following kinases: BCR-ABL, SRC family (SRC, LCK, YES, FYN), c-KIT, EPHA2, and PDGFR&beta. Based on modeling studies, dasatinib is predicted to bind to multiple conformations of the ABL kinase. In vitro, dasatinib was active in leukemic cell lines representing variants of imatinib mesylate sensitive and resistant disease. Dasatinib inhibited the growth of chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL) cell lines overexpressing BCR-ABL. Under the conditions of the assays, dasatinib was able to overcome imatinib resistance resulting from BCR-ABL kinase domain mutations, activation of alternate signaling pathways involving the SRC family kinases (LYN, HCK), and multi-drug resistance gene overexpression.
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01E - Protein kinase inhibitors > L01EA - Bcr-abl tyrosine kinase inhibitors
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C1967 - Tyrosine Kinase Inhibitor
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C155700 - BCR-ABL Inhibitor
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor
D004791 - Enzyme Inhibitors > D047428 - Protein Kinase Inhibitors
D000970 - Antineoplastic Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

11 个代谢物同义名

N-(2-CHLORO-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide; (18F)-N-(2-Chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide; N-(2-Chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide; Anhydrous dasatinib; Dasatinib (anh.); Anh. dasatinib; BMS Dasatinib; Dasatinibum; BMS-354825; Dasatinib; Sprycel



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Lian Wang, Bing Xiong, Wei Lu, Yujie Cheng, Jihui Zhu, Guihai Ai, Xiaojie Zhang, Xiuni Liu, Zhongping Cheng. Senolytic drugs dasatinib and quercetin combined with Carboplatin or Olaparib reduced the peritoneal and adipose tissue metastasis of ovarian cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 May; 174(?):116474. doi: 10.1016/j.biopha.2024.116474. [PMID: 38518604]
  • Shangke Liu, Xiang Li, Can Chen, Xinyu Lin, Weifang Zuo, Cheng Peng, Qinglin Jiang, Wei Huang, Gu He. Design, synthesis, and biological evaluation of novel discoidin domain receptor inhibitors for the treatment of lung adenocarcinoma and pulmonary fibrosis. European journal of medicinal chemistry. 2024 Feb; 265(?):116100. doi: 10.1016/j.ejmech.2023.116100. [PMID: 38171149]
  • Cih-En Huang, Kuan-Der Lee, Jung-Jung Chang, Huey-En Tzeng, Shih-Hao Huang, Lennex Hsueh-Lin Yu, Min-Chi Chen. Association of Nilotinib With Cardiovascular Diseases in Patients With Chronic Myelogenous Leukemia: A National Population-Based Cohort Study. The oncologist. 2024 Jan; 29(1):e81-e89. doi: 10.1093/oncolo/oyad225. [PMID: 37561957]
  • Benjamin C Hawthorne, Ian J Wellington, Joshua T Sabitsky, Kyle V Murphy, Owen P Karsmarski, Rohin O Thomas, Matthew R LeVasseur, Michael R Mancini, Maxwell T Trudeau, Sagar Gulati, Mary Beth R McCarthy, Mark P Cote, Ming Xu, Augustus D Mazzocca. Human Rotator Cuff Tears Reveal an Age-Dependent Increase in Markers of Cellular Senescence and Selective Removal of Senescent Cells With Dasatinib + Quercetin Increases Genetic Expression of COL1A1 In Vitro. Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association. 2024 01; 40(1):34-44. doi: 10.1016/j.arthro.2023.05.036. [PMID: 37356505]
  • Juan Huang, Jianhao Zhou, Yujie Dai, Yuankai Liu, Fang Li, Shuaishuai Gong, Yuanyuan Zhang, Junping Kou. Ruscogenin ameliorates dasatinib-induced intestinal barrier dysfunction via ErbB4/YAP and ROCK/MLC pathways. Journal of natural medicines. 2023 Sep; 77(4):735-747. doi: 10.1007/s11418-023-01715-9. [PMID: 37347409]
  • Yue Gu, Elisa Avolio, Valeria V Alvino, Anita C Thomas, Andrew Herman, Poppy J Miller, Niall Sullivan, Ashton Faulkner, Paolo Madeddu. The tyrosine kinase inhibitor Dasatinib reduces cardiac steatosis and fibrosis in obese, type 2 diabetic mice. Cardiovascular diabetology. 2023 08; 22(1):214. doi: 10.1186/s12933-023-01955-9. [PMID: 37592236]
  • Bingye Shi, Wei Zhang, Tao Wang, Zhenyu Cui. The therapeutic and prognostic role of cuproptosis-related genes in triple negative breast cancer. BMC bioinformatics. 2023 May; 24(1):223. doi: 10.1186/s12859-023-05348-3. [PMID: 37259036]
  • Md Torikul Islam, Eric Tuday, Shanena Allen, John Kim, Daniel W Trott, William L Holland, Anthony J Donato, Lisa A Lesniewski. Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age. Aging cell. 2023 02; 22(2):e13767. doi: 10.1111/acel.13767. [PMID: 36637079]
  • Vikas Kumar, Raj Kumar, Shraddha Parate, Danishuddin, Gihwan Lee, Moonhyuk Kwon, Seong-Hee Jeong, Hyeon-Su Ro, Keun Woo Lee, Seon-Won Kim. Identification of Activated Cdc42-Associated Kinase Inhibitors as Potential Anticancer Agents Using Pharmacoinformatic Approaches. Biomolecules. 2023 01; 13(2):. doi: 10.3390/biom13020217. [PMID: 36830587]
  • Xinxin Zeng, Liyue Sun, Xiaomei Ling, Yuying Jiang, Ju Shen, Lei Liang, Xuhui Zhang. Comprehensive analysis identifies novel targets of gemcitabine to improve chemotherapy treatment strategies for colorectal cancer. Frontiers in endocrinology. 2023; 14(?):1170526. doi: 10.3389/fendo.2023.1170526. [PMID: 37664836]
  • Yujian Yang, Qiuchun Yu, Lean Hu, Botao Dai, Ruxi Qi, Yu Chang, Qingwen Zhang, Zhang Zhang, Yingjun Li, Xumu Zhang. Enantioselective semisynthesis of novel cephalotaxine esters with potent antineoplastic activities against leukemia. European journal of medicinal chemistry. 2022 Dec; 244(?):114731. doi: 10.1016/j.ejmech.2022.114731. [PMID: 36242991]
  • Valentin García-Gutiérrez, Massimo Breccia, Elias Jabbour, Michael Mauro, Jorge E Cortes. A clinician perspective on the treatment of chronic myeloid leukemia in the chronic phase. Journal of hematology & oncology. 2022 Jul; 15(1):90. doi: 10.1186/s13045-022-01309-0. [PMID: 35818053]
  • Yuna Fu, Jianhua Wang, Yan Wang, Heng Sun. Investigating the Effect of Tyrosine Kinase Inhibitors on the Interaction between Human Serum Albumin by Atomic Force Microscopy. Biomolecules. 2022 06; 12(6):. doi: 10.3390/biom12060819. [PMID: 35740944]
  • Takahiro Sumimoto, Ryosuke Nakahara, Yosuke Suzuki, Ryota Tanaka, Natsumi Yoshida, Masao Ogata, Hiroki Itoh. Development of a Sensitive and High-Throughput Assay for Simultaneous Quantification of 5 Tyrosine Kinase Inhibitors and 2 Active Metabolites in Human Plasma Using Ultra-high Performance Liquid Chromatography Coupled to Tandem Mass Spectrometry. Therapeutic drug monitoring. 2022 06; 44(3):419-429. doi: 10.1097/ftd.0000000000000922. [PMID: 34469417]
  • Emily R Finch, Laura J Janke, Lie Li, Monique A Payton, David A Jenkins, Kristine R Crews, Mary V Relling, Seth E Karol. Dasatinib does not exacerbate dexamethasone-induced osteonecrosis in murine models of acute lymphoblastic leukemia therapy. Pediatric blood & cancer. 2022 04; 69(4):e29490. doi: 10.1002/pbc.29490. [PMID: 34866312]
  • Hassan Reda Hassan Elsayed, Randa El-Gamal, Mohammed R Rabei, Mona G Elhadidy, Shereen Hamed, Basma H Othman, Mohamed Mahmoud Abdelraheem Elshaer, Mostafa Khaled Sedky, Ahmed Tarek Abd Elbaset Hassan, Mohammad El-Nablaway. Enhanced Autophagic Flux, Suppressed Apoptosis and Reduced Macrophage Infiltration by Dasatinib in Kidneys of Obese Mice. Cells. 2022 02; 11(4):. doi: 10.3390/cells11040746. [PMID: 35203394]
  • Ali S Abdelhameed, Mohamed W Attwa, Mohamed I Attia, Amer M Alanazi, Obaid S Alruqi, Haitham AlRabiah. Development of novel univariate and multivariate validated chemometric methods for the analysis of dasatinib, sorafenib, and vandetanib in pure form, dosage forms and biological fluids. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2022 Jan; 264(?):120336. doi: 10.1016/j.saa.2021.120336. [PMID: 34481256]
  • Ruin Moaddel, Martina Rossi, Stephanie Rodriguez, Rachel Munk, Mohammed Khadeer, Kotb Abdelmohsen, Myriam Gorospe, Luigi Ferrucci. Identification of gingerenone A as a novel senolytic compound. PloS one. 2022; 17(3):e0266135. doi: 10.1371/journal.pone.0266135. [PMID: 35349590]
  • Ting Fan, Yi Du, Mingwan Zhang, Austin Rui Zhu, Jianjun Zhang. Senolytics Cocktail Dasatinib and Quercetin Alleviate Human Umbilical Vein Endothelial Cell Senescence via the TRAF6-MAPK-NF-κB Axis in a YTHDF2-Dependent Manner. Gerontology. 2022; 68(8):920-934. doi: 10.1159/000522656. [PMID: 35468611]
  • Omid Salaami, Chia-Ling Kuo, Matthew T Drake, George A Kuchel, James L Kirkland, Robert J Pignolo. Antidiabetic Effects of the Senolytic Agent Dasatinib. Mayo Clinic proceedings. 2021 12; 96(12):3021-3029. doi: 10.1016/j.mayocp.2021.06.025. [PMID: 34772496]
  • Paola Mantuano, Brigida Boccanegra, Elena Conte, Michela De Bellis, Santa Cirmi, Francesca Sanarica, Ornella Cappellari, Ilaria Arduino, Annalisa Cutrignelli, Angela Assunta Lopedota, Antonietta Mele, Nunzio Denora, Annamaria De Luca. β-Dystroglycan Restoration and Pathology Progression in the Dystrophic mdx Mouse: Outcome and Implication of a Clinically Oriented Study with a Novel Oral Dasatinib Formulation. Biomolecules. 2021 11; 11(11):. doi: 10.3390/biom11111742. [PMID: 34827740]
  • Ali S Abdelhameed, Eman S Hassan, Mohamed W Attwa, Nasser S Al-Shakliah, Amer M Alanazi, Haitham AlRabiah. Simple and efficient spectroscopic-based univariate sequential methods for simultaneous quantitative analysis of vandetanib, dasatinib, and sorafenib in pharmaceutical preparations and biological fluids. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2021 Nov; 260(?):119987. doi: 10.1016/j.saa.2021.119987. [PMID: 34082354]
  • Gangireddy Navitha Reddy, Chenkual Laltanpuii, Rajesh Sonti. Review on in vivo profiling of drug metabolites with LC-MS/MS in the past decade. Bioanalysis. 2021 Nov; 13(22):1697-1722. doi: 10.4155/bio-2021-0144. [PMID: 34696599]
  • Soyoung Lee, Yong Yu, Jakob Trimpert, Fahad Benthani, Mario Mairhofer, Paulina Richter-Pechanska, Emanuel Wyler, Dimitri Belenki, Sabine Kaltenbrunner, Maria Pammer, Lea Kausche, Theresa C Firsching, Kristina Dietert, Michael Schotsaert, Carles Martínez-Romero, Gagandeep Singh, Séverine Kunz, Daniela Niemeyer, Riad Ghanem, Helmut J F Salzer, Christian Paar, Michael Mülleder, Melissa Uccellini, Edward G Michaelis, Amjad Khan, Andrea Lau, Martin Schönlein, Anna Habringer, Josef Tomasits, Julia M Adler, Susanne Kimeswenger, Achim D Gruber, Wolfram Hoetzenecker, Herta Steinkellner, Bettina Purfürst, Reinhard Motz, Francesco Di Pierro, Bernd Lamprecht, Nikolaus Osterrieder, Markus Landthaler, Christian Drosten, Adolfo García-Sastre, Rupert Langer, Markus Ralser, Roland Eils, Maurice Reimann, Dorothy N Y Fan, Clemens A Schmitt. Virus-induced senescence is a driver and therapeutic target in COVID-19. Nature. 2021 11; 599(7884):283-289. doi: 10.1038/s41586-021-03995-1. [PMID: 34517409]
  • Bibian M E Tullemans, Alicia Veninga, Delia I Fernandez, Maureen J B Aarts, Johannes A Eble, Paola E J van der Meijden, Johan W M Heemskerk, Marijke J E Kuijpers. Multiparameter Evaluation of the Platelet-Inhibitory Effects of Tyrosine Kinase Inhibitors Used for Cancer Treatment. International journal of molecular sciences. 2021 Oct; 22(20):. doi: 10.3390/ijms222011199. [PMID: 34681859]
  • Lorena Vigón, Paula Martínez-Román, Sara Rodríguez-Mora, Montserrat Torres, María C Puertas, Elena Mateos, María Salgado, Antonio Navarro, Matilde Sánchez-Conde, Juan Ambrosioni, Miguel Cervero, Christoph Wyen, Christian Hoffmann, José M Miró, José Alcamí, Daniel Podzamczer, Valentín García-Gutiérrez, Javier Martínez-Picado, Verónica Briz, María Rosa López-Huertas, Vicente Planelles, Mayte Coiras. Provirus reactivation is impaired in HIV-1 infected individuals on treatment with dasatinib and antiretroviral therapy. Biochemical pharmacology. 2021 10; 192(?):114666. doi: 10.1016/j.bcp.2021.114666. [PMID: 34186065]
  • Sonja Suvakov, Ranine Ghamrawi, Hajrunisa Cubro, Haitao Tu, Wendy M White, Yvonne S Butler Tobah, Natasa M Milic, Joseph P Grande, Julie M Cunningham, Fouad T Chebib, Larissa G P Langhi Prata, Yi Zhu, Tamara Tchkonia, James L Kirkland, Karl A Nath, Aleksandar Milosavljevic, Vesna D Garovic. Epigenetic and senescence markers indicate an accelerated ageing-like state in women with preeclamptic pregnancies. EBioMedicine. 2021 Aug; 70(?):103536. doi: 10.1016/j.ebiom.2021.103536. [PMID: 34391091]
  • Tensei Hirasawa, Masafumi Kikuchi, Kensuke Shigeta, Shinya Takasaki, Yu Sato, Toshihiro Sato, Jiro Ogura, Koichi Onodera, Noriko Fukuhara, Yasushi Onishi, Masamitsu Maekawa, Nariyasu Mano. High-throughput liquid chromatography/electrospray ionization-tandem mass spectrometry method using in-source collision-induced dissociation for simultaneous quantification of imatinib, dasatinib, bosutinib, nilotinib, and ibrutinib in human plasma. Biomedical chromatography : BMC. 2021 Aug; 35(8):e5124. doi: 10.1002/bmc.5124. [PMID: 33772839]
  • Seo Rin Kim, Amrutesh S Puranik, Kai Jiang, Xiaojun Chen, Xiang-Yang Zhu, Ian Taylor, Alireza Khodadadi-Jamayran, Amir Lerman, LaTonya J Hickson, Bennett G Childs, Stephen C Textor, Tamara Tchkonia, Timothy B Niewold, James L Kirkland, Lilach O Lerman. Progressive Cellular Senescence Mediates Renal Dysfunction in Ischemic Nephropathy. Journal of the American Society of Nephrology : JASN. 2021 08; 32(8):1987-2004. doi: 10.1681/asn.2020091373. [PMID: 34135081]
  • Christina D Camell, Matthew J Yousefzadeh, Yi Zhu, Larissa G P Langhi Prata, Matthew A Huggins, Mark Pierson, Lei Zhang, Ryan D O'Kelly, Tamar Pirtskhalava, Pengcheng Xun, Keisuke Ejima, Ailing Xue, Utkarsh Tripathi, Jair Machado Espindola-Netto, Nino Giorgadze, Elizabeth J Atkinson, Christina L Inman, Kurt O Johnson, Stephanie H Cholensky, Timothy W Carlson, Nathan K LeBrasseur, Sundeep Khosla, M Gerard O'Sullivan, David B Allison, Stephen C Jameson, Alexander Meves, Ming Li, Y S Prakash, Sergio E Chiarella, Sara E Hamilton, Tamara Tchkonia, Laura J Niedernhofer, James L Kirkland, Paul D Robbins. Senolytics reduce coronavirus-related mortality in old mice. Science (New York, N.Y.). 2021 07; 373(6552):. doi: 10.1126/science.abe4832. [PMID: 34103349]
  • Xiaoyuan Gong, Le Li, Hui Wei, Bingcheng Liu, Chunlin Zhou, Guangji Zhang, Kaiqi Liu, Dong Lin, Benfa Gong, Shuning Wei, Yan Li, Yingchang Mi, Ying Wang, Jianxiang Wang. A Higher Dose of Dasatinib May Increase the Possibility of Crossing the Blood-brain Barrier in the Treatment of Patients With Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia. Clinical therapeutics. 2021 07; 43(7):1265-1271.e1. doi: 10.1016/j.clinthera.2021.05.009. [PMID: 34120773]
  • Yuji Mukai, Yuka Yoshida, Tatsunari Yoshida, Takeshi Kondo, Nobuo Inotsume, Takaki Toda. Simultaneous Quantification of BCR-ABL and Bruton Tyrosine Kinase Inhibitors in Dried Plasma Spots and Its Application to Clinical Sample Analysis. Therapeutic drug monitoring. 2021 06; 43(3):386-393. doi: 10.1097/ftd.0000000000000825. [PMID: 33065614]
  • Hui-Wen Lue, Daniel S Derrick, Soumya Rao, Ahna Van Gaest, Larry Cheng, Jennifer Podolak, Samantha Lawson, Changhui Xue, Devin Garg, Ralph White, Christopher W Ryan, Justin M Drake, Anna Ritz, Laura M Heiser, George V Thomas. Cabozantinib and dasatinib synergize to induce tumor regression in non-clear cell renal cell carcinoma. Cell reports. Medicine. 2021 05; 2(5):100267. doi: 10.1016/j.xcrm.2021.100267. [PMID: 34095877]
  • Nick Verougstraete, Veronique Stove, Alain G Verstraete, Christophe Stove. Quantification of eight hematological tyrosine kinase inhibitors in both plasma and whole blood by a validated LC-MS/MS method. Talanta. 2021 May; 226(?):122140. doi: 10.1016/j.talanta.2021.122140. [PMID: 33676691]
  • Nabila M E Hassan, George S G Shehatou, Hany Ibrahim Kenawy, Eman Said. Dasatinib mitigates renal fibrosis in a rat model of UUO via inhibition of Src/STAT-3/NF-κB signaling. Environmental toxicology and pharmacology. 2021 May; 84(?):103625. doi: 10.1016/j.etap.2021.103625. [PMID: 33617955]
  • Dingding Gao, Nan Jin, Yixian Fu, Yueyue Zhu, Yujie Wang, Ting Wang, Yuehong Chen, Mingming Zhang, Qiang Xiao, Min Huang, Yingxia Li. Rational drug design of benzothiazole-based derivatives as potent signal transducer and activator of transcription 3 (STAT3) signaling pathway inhibitors. European journal of medicinal chemistry. 2021 Apr; 216(?):113333. doi: 10.1016/j.ejmech.2021.113333. [PMID: 33689932]
  • Qingqing Li, Xianwei Yang, Peipei Zhang, Fei Mo, Peiru Si, Ximeng Kang, Menghan Wang, Jiye Zhang. Dasatinib loaded nanostructured lipid carriers for effective treatment of corneal neovascularization. Biomaterials science. 2021 Apr; 9(7):2571-2583. doi: 10.1039/d0bm01599g. [PMID: 33589891]
  • Valeria Cagno, Gaelle Magliocco, Caroline Tapparel, Youssef Daali. The tyrosine kinase inhibitor nilotinib inhibits SARS-CoV-2 in vitro. Basic & clinical pharmacology & toxicology. 2021 Apr; 128(4):621-624. doi: 10.1111/bcpt.13537. [PMID: 33232578]
  • Hassan Reda Hassan Elsayed, Mohammad El-Nablaway, Basma H Othman, Asim Mohammed Abdalla, Eman Mohammad El Nashar, Mostafa Mohammed Abd-Elmonem, Randa El-Gamal. Can Dasatinib Ameliorate the Hepatic changes, Induced by Long Term Western Diet, in Mice?. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. 2021 Mar; 234(?):151626. doi: 10.1016/j.aanat.2020.151626. [PMID: 33144268]
  • Ezgi Ersoy Yesil, Dede Sit, Hasan Kayabasi, Fatima Zerenler Gursoy, Mustafa Behcet Demirbas, Sibel Ocak Serin. A case of dasatinib-induced focal segmental glomerulosclerosis in a patient with Philadelphia chromosome positive chronic myeloid leukemia. Nephrologie & therapeutique. 2021 Feb; 17(1):53-56. doi: 10.1016/j.nephro.2020.09.007. [PMID: 33431310]
  • Kavya Annu, Kazuto Yasuda, William V Caufield, Burgess B Freeman, Erin G Schuetz. Vitamin D levels do not cause vitamin-drug interactions with dexamethasone or dasatinib in mice. PloS one. 2021; 16(10):e0258579. doi: 10.1371/journal.pone.0258579. [PMID: 34669728]
  • Suili Yang, Xiaoshan Zhang, Yuzhen Wang, Congcong Wen, Chenxiang Wang, Ziye Zhou, Guanyang Lin. Development of UPLC-MS/MS Method for Studying the Pharmacokinetic Interaction Between Dasatinib and Posaconazole in Rats. Drug design, development and therapy. 2021; 15(?):2171-2178. doi: 10.2147/dddt.s301241. [PMID: 34079220]
  • Raji E Joseph, Neha Amatya, D Bruce Fulton, John R Engen, Thomas E Wales, Amy Andreotti. Differential impact of BTK active site inhibitors on the conformational state of full-length BTK. eLife. 2020 11; 9(?):. doi: 10.7554/elife.60470. [PMID: 33226337]
  • Kana Koinuma, Toru Sakairi, Yoshikazu Watanabe, Azusa IIzuka, Mitsuharu Watanabe, Hiroko Hamatani, Masao Nakasatomi, Takuma Ishizaki, Hidekazu Ikeuchi, Yoriaki Kaneko, Keiju Hiromura. A case of long-term dasatinib-induced proteinuria and glomerular injury. CEN case reports. 2020 11; 9(4):359-364. doi: 10.1007/s13730-020-00484-8. [PMID: 32388829]
  • Simone Krebs, Darren R Veach, Lukas M Carter, Milan Grkovski, Monica Fornier, Michael J Mauro, Martin H Voss, Daniel C Danila, Eva Burnazi, Manda Null, Kevin Staton, Christina Pressl, Bradley J Beattie, Pat Zanzonico, Wolfgang A Weber, Serge K Lyashchenko, Jason S Lewis, Steven M Larson, Mark P S Dunphy. First-in-Humans Trial of Dasatinib-Derivative Tracer for Tumor Kinase-Targeted PET. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2020 11; 61(11):1580-1587. doi: 10.2967/jnumed.119.234864. [PMID: 32169913]
  • Yasuhiro Taniguchi, Naoto Takahashi, Masatomo Miura, Chikara Hirase, Sanae Sueda, Jorge Luis Espinoza, Shinya Rai, Shoko Nakayama, Kentaro Serizawa, Takahiro Kumode, Yosaku Watatani, Yasuyoshi Morita, Hirokazu Tanaka, Itaru Matsumura. The Impact of Hemodialysis and Liver Cirrhosis on the Plasma Concentrations of Tyrosine Kinase Inhibitors in a Patient with Chronic Myeloid Leukemia. Internal medicine (Tokyo, Japan). 2020 Nov; 59(21):2745-2749. doi: 10.2169/internalmedicine.4871-20. [PMID: 32641651]
  • Qiu-Jin Yang, Jie Zheng, Fu-Tao Dang, Yue-Meng Wan, Jing Yang. Acute pancreatitis induced by combination chemotherapy used for the treatment of acute myeloid leukemia: A case report. Medicine. 2020 Aug; 99(35):e21848. doi: 10.1097/md.0000000000021848. [PMID: 32871908]
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