Cudraisoflavone A (BioDeep_00000268676)

   

PANOMIX_OTCML-2023


代谢物信息卡片


7- (3,4-Dihydroxyphenyl) -5-hydroxy-2,2-dimethyl-10- (3-methyl-2-butenyl) -2H,6H-benzo [ 1,2-b:5,4-b ] dipyran-6-one

化学式: C25H24O6 (420.1572804)
中文名称: 昆明鸡血藤素, 昆明鸡血藤素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(=C3c(c4)cc(c(O)c4)O)Oc(c2C3=O)c(CC=C(C)C)c(c1c(O)2)OC(C=C1)(C)C
InChI: InChI=1S/C25H24O6/c1-13(2)5-7-16-23-15(9-10-25(3,4)31-23)21(28)20-22(29)17(12-30-24(16)20)14-6-8-18(26)19(27)11-14/h5-6,8-12,26-28H,7H2,1-4H3

描述信息

同义名列表

3 个代谢物同义名

AURICULASIN; Cudraisoflavone A; 7- (3,4-Dihydroxyphenyl) -5-hydroxy-2,2-dimethyl-10- (3-methyl-2-butenyl) -2H,6H-benzo [ 1,2-b:5,4-b ] dipyran-6-one



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Malik S Mohamed, Karim Abdelkader, Hesham A M Gomaa, Afnan S Batubara, Mohammed Gamal, Ahmed M Sayed. Mechanistic study of the antibacterial potential of the prenylated flavonoid auriculasin against Escherichia coli. Archiv der Pharmazie. 2022 Dec; 355(12):e2200360. doi: 10.1002/ardp.202200360. [PMID: 36029269]
  • Chun-Xiao Wang, Li-Hua Chen, Hai-Bin Zhuang, Ze-Sheng Shi, Zhi Chuan Chen, Jian-Peng Pan, Zhong-Shi Hong. Auriculasin enhances ROS generation to regulate colorectal cancer cell apoptosis, ferroptosis, oxeiptosis, invasion and colony formation. Biochemical and biophysical research communications. 2022 01; 587(?):99-106. doi: 10.1016/j.bbrc.2021.11.101. [PMID: 34872005]
  • Bingyu Sun, Yongqiang Liu, Danhua He, Jinke Li, Jiawei Wang, Wulin Wen, Ming Hong. Traditional Chinese medicines and their active ingredients sensitize cancer cells to TRAIL-induced apoptosis. Journal of Zhejiang University. Science. B. 2021 Mar; 22(3):190-203. doi: 10.1631/jzus.b2000497. [PMID: 33719224]
  • Xianbao Shi, Gang Zhang, Guangbo Ge, Zhe Guo, Yonggui Song, Dan Su, Lina Shan. In Vitro Metabolism of Auriculasin and Its Inhibitory Effects on Human Cytochrome P450 and UDP-Glucuronosyltransferase Enzymes. Chemical research in toxicology. 2019 10; 32(10):2125-2134. doi: 10.1021/acs.chemrestox.9b00307. [PMID: 31515991]
  • Tuoyi Wang, Yang Liu, Huazhen Liu, Chunyan Li, Yan Wang. Auriculasin from Flemingia philippinensis roots shows good therapeutic indexes on hyperactive behavior in zebrafish. Biochemical and biophysical research communications. 2018 09; 503(3):1254-1259. doi: 10.1016/j.bbrc.2018.07.033. [PMID: 30025896]
  • Achara Raksat, Wisanu Maneerat, Raymond J Andersen, Stephen G Pyne, Surat Laphookhieo. Antibacterial Prenylated Isoflavonoids from the Stems of Millettia extensa. Journal of natural products. 2018 08; 81(8):1835-1840. doi: 10.1021/acs.jnatprod.8b00321. [PMID: 30106294]
  • Hyun-Dong Cho, Ju-Hye Lee, Kwang-Deog Moon, Ki-Hun Park, Mi-Kyung Lee, Kwon-Il Seo. Auriculasin-induced ROS causes prostate cancer cell death via induction of apoptosis. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2018 Jan; 111(?):660-669. doi: 10.1016/j.fct.2017.12.007. [PMID: 29217266]
  • Yan Wang, Marcus J Curtis-Long, Heung Joo Yuk, Dae Wook Kim, Xue Fei Tan, Ki Hun Park. Bacterial neuraminidase inhibitory effects of prenylated isoflavones from roots of Flemingia philippinensis. Bioorganic & medicinal chemistry. 2013 Nov; 21(21):6398-404. doi: 10.1016/j.bmc.2013.08.049. [PMID: 24054487]
  • Esra Kupeli, Ilkay Orhan, Gulnur Toker, Erdem Yesilada. Anti-inflammatory and antinociceptive potential of Maclura pomifera (Rafin.) Schneider fruit extracts and its major isoflavonoids, scandenone and auriculasin. Journal of ethnopharmacology. 2006 Sep; 107(2):169-74. doi: 10.1016/j.jep.2006.02.021. [PMID: 16600547]
  • Chihiro Ito, Masataka Itoigawa, Naoki Kojima, Harukuni Tokuda, Tetsurou Hirata, Hoyoku Nishino, Hiroshi Furukawa. Chemical constituents of Millettia taiwaniana: structure elucidation of five new isoflavonoids and their cancer chemopreventive activity. Journal of natural products. 2004 Jul; 67(7):1125-30. doi: 10.1021/np030554q. [PMID: 15270565]