7-Methoxyflavone (BioDeep_00000268502)

 

Secondary id: BioDeep_00000397201

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


7-Methoxyflavone

化学式: C16H12O3 (252.0786402)
中文名称: 7-甲氧基黄酮
谱图信息: 最多检出来源 Astragalus membranaceus(otcml) 50%

分子结构信息

SMILES: c1(ccc2c(c1)oc(cc2=O)c1ccccc1)OC
InChI: InChI=1S/C16H12O3/c1-18-12-7-8-13-14(17)10-15(19-16(13)9-12)11-5-3-2-4-6-11/h2-10H,1H3

描述信息

7-Methoxyflavone is a compound isolated from Zornia brasiliensis. 7-Methoxyflavone has peripheral antinociceptive activity. 7-Methoxyflavone inhibits paw-licking time in the neurogenic phase of the formalin pain response (65.6\%) and did not decrease the nociceptive response in the inflammatory phase[1].

同义名列表

1 个代谢物同义名

7-Methoxyflavone



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

19 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Qing He, Qi'er Mu, Zhongxun Wei, Bin Peng, Zhenni Lan, Yun Zhang, Weihao Yao, Jinfang Nie. Investigation of the binding behavior of bioactive 7-methoxyflavone to human serum albumin by coupling multi-spectroscopic with computational approaches. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2023 Jan; 285(?):121920. doi: 10.1016/j.saa.2022.121920. [PMID: 36201870]
  • Nadja Kampschulte, Tim Berking, Ibrahim E Çelik, Stefan F Kirsch, Nils Helge Schebb. Inhibition of cytochrome P450 monooxygenase-catalyzed oxylipin formation by flavonoids: Evaluation of structure-activity relationship towards CYP4F2-selective inhibitors. European journal of medicinal chemistry. 2022 Aug; 238(?):114332. doi: 10.1016/j.ejmech.2022.114332. [PMID: 35576701]
  • Achi Mahamat, Abel Joel Yaya Gbaweng, Maurice Tagatsing Fotsing, Emmanuel Talla, Fabrice Boyom Fekam, Celine Henoumont, Laurent Sophie, Joseph Tanyi Mbafor. Two new flavones glycosides with antimicrobial activities from Clerodendrum formicarum Gürke (Lamiaceae). Natural product research. 2021 Mar; 35(6):951-959. doi: 10.1080/14786419.2019.1613397. [PMID: 31148483]
  • Hye Lin Park, Jae Chul Lee, Kyungha Lee, Jeong Min Lee, Hyo Jeong Nam, Seong Hee Bhoo, Tae Hoon Lee, Sang-Won Lee, Man-Ho Cho. Biochemical Characterization of a Flavonoid O-methyltransferase from Perilla Leaves and Its Application in 7-Methoxyflavonoid Production. Molecules (Basel, Switzerland). 2020 Sep; 25(19):. doi: 10.3390/molecules25194455. [PMID: 32998370]
  • Zhao Qu, Yan Chen, Zhuo-Hui Luo, Xiao-Ling Shen, Ying-Jie Hu. 7-methoxyflavanone alleviates neuroinflammation in lipopolysaccharide-stimulated microglial cells by inhibiting TLR4/MyD88/MAPK signalling and activating the Nrf2/NQO-1 pathway. The Journal of pharmacy and pharmacology. 2020 Mar; 72(3):385-395. doi: 10.1111/jphp.13219. [PMID: 31867739]
  • Anne Dayse Soares da Silva, Luiz Henrique Agra Cavalcante-Silva, Carolina B Brito da Matta, Diego de Farias Silva, Morgana Vital de Araújo, Josean F Tavares, Marcelo S da Silva, Magna Suzana Alexandre-Moreira. Antinociceptive effect of 7-methoxyflavone isolated from Zornia brasiliensis. Natural product research. 2013; 27(18):1695-9. doi: 10.1080/14786419.2013.768988. [PMID: 23425114]
  • Prapapan Temkitthawon, Thomas R Hinds, Joseph A Beavo, Jarupa Viyoch, Khanit Suwanborirux, Wittaya Pongamornkul, Pattara Sawasdee, Kornkanok Ingkaninan. Kaempferia parviflora, a plant used in traditional medicine to enhance sexual performance contains large amounts of low affinity PDE5 inhibitors. Journal of ethnopharmacology. 2011 Oct; 137(3):1437-41. doi: 10.1016/j.jep.2011.08.025. [PMID: 21884777]
  • Tadayoshi Kaneko, Hiroshige Chiba, Norio Horie, Takao Kato, Masaki Kobayashi, Ken Hashimoto, Kaoru Kusama, Hiroshi Sakagami. Inhibition of prostaglandin E2 production by flavone and its related compounds. In vivo (Athens, Greece). 2010 Jan; 24(1):55-8. doi: ". [PMID: 20133976]
  • Xiang Li, Zhi Liu, Xin-feng Zhang, Li-juan Wang, Yi-nan Zheng, Chang-chun Yuan, Guang-zhi Sun. Isolation and characterization of phenolic compounds from the leaves of Salix matsudana. Molecules (Basel, Switzerland). 2008 Aug; 13(8):1530-7. doi: 10.3390/molecules13081530. [PMID: 18794770]
  • Supinya Tewtrakul, Sanan Subhadhirasakul, Sopa Kummee. Anti-allergic activity of compounds from Kaempferia parviflora. Journal of ethnopharmacology. 2008 Feb; 116(1):191-3. doi: 10.1016/j.jep.2007.10.042. [PMID: 18077118]
  • Alessandra Regina Pepe Ambrozin, Paulo Cezar Vieira, João Batista Fernandes, Maria Fátima das Graças Fernandes da Silva, Sérgio de Albuquerque. Trypanocidal activity of Meliaceae and Rutaceae plant extracts. Memorias do Instituto Oswaldo Cruz. 2004 Mar; 99(2):227-31. doi: 10.1590/s0074-02762004000200020. [PMID: 15250481]
  • R S Zand, D J Jenkins, E P Diamandis. Steroid hormone activity of flavonoids and related compounds. Breast cancer research and treatment. 2000 Jul; 62(1):35-49. doi: 10.1023/a:1006422302173. [PMID: 10989984]
  • L Costantino, G Rastelli, M C Gamberini, J A Vinson, P Bose, A Iannone, M Staffieri, L Antolini, A Del Corso, U Mura, A Albasini. 1-Benzopyran-4-one antioxidants as aldose reductase inhibitors. Journal of medicinal chemistry. 1999 Jun; 42(11):1881-93. doi: 10.1021/jm980441h. [PMID: 10354396]