Lisuride (BioDeep_00000026846)

human metabolite blood metabolite Chemicals and Drugs

代谢物信息卡片

3,3-diethyl-1-[(4S,7R)-6-methyl-6,11-diazatetracyclo[7.6.1.0²,⁷.0¹²,¹⁶]hexadeca-1(16),2,9,12,14-pentaen-4-yl]urea

化学式: C20H26N4O (338.2106506)
中文名称: 利修来得
谱图信息: 最多检出来源 Homo sapiens(urine) 27.27%

分子结构信息

SMILES: CCN(CC)C(=O)NC1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C
InChI: InChI=1S/C20H26N4O/c1-4-24(5-2)20(25)22-14-10-16-15-7-6-8-17-19(15)13(11-21-17)9-18(16)23(3)12-14/h6-8,10-11,14,18,21H,4-5,9,12H2,1-3H3,(H,22,25)/t14-,18+/m0/s1

描述信息

Lisuride is only found in individuals that have used or taken this drug. It is used for the management of Parkinsons Disease.Lisuride is an anti-Parkinson drug chemically related to the dopaminergic ergoline Parkinsons drugs. Lisuride binds to the 5-HT(1A) and 5-HT(2A/2C) receptors. It is also thought to bind to the dopamine receptor and to act as a dopamine agonist. Evidence has also emerged that Lisuride also binds to the Histamine H1 receptor. Lisuride is also used to lower prolactin and, in low doses, to prevent migraine attacks.
G - Genito urinary system and sex hormones > G02 - Other gynecologicals > G02C - Other gynecologicals > G02CB - Prolactine inhibitors
D002491 - Central Nervous System Agents > D018726 - Anti-Dyskinesia Agents > D000978 - Antiparkinson Agents
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017366 - Serotonin Receptor Agonists
N - Nervous system > N02 - Analgesics > N02C - Antimigraine preparations > N02CA - Ergot alkaloids
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018491 - Dopamine Agonists
C78272 - Agent Affecting Nervous System > C38149 - Antiparkinsonian Agent

同义名列表

34 个代谢物同义名

3,3-diethyl-1-[(4S,7R)-6-methyl-6,11-diazatetracyclo[7.6.1.0²,⁷.0¹²,¹⁶]hexadeca-1(16),2,9,12,14-pentaen-4-yl]urea; N-((8alpha)-9,10-didehydro-6-methylergolin-8-yl)-N,N-diethylurea; N-((8a)-9,10-didehydro-6-methylergolin-8-yl)-N,N-diethylurea; N-((8α)-9,10-didehydro-6-methylergolin-8-yl)-N,N-diethylurea; Schering brand 2 OF lisuride maleate; Schering brand 1 OF lisuride maleate; Lisuride maleate, (8beta)-isomer; IPRAD brand OF lisuride maleate; Roche brand OF lisuride maleate; Lisuride, (8alpha)-(+-)-isomer; Hydrogen maleate, lysuride; Lysuride hydrogen maleate; Lisuride phosphate (1:1); Hydrochloride, lisuride; Carbamide, methylergol; Lisuride hydrochloride; Lisuride maleate (1:1); Methylergol carbamide; Mesylate, lisuride; Lisuride mesylate; Maleate, lisuride; Lisuride Maleate; SCHEMBL14507250; s-(-)-lisuride; Lisuridum; Dopergine; Lisurida; Dopergin; Lisuride; Lysurid; Revanil; Lysenyl; Cuvalit; Arolac

数据库引用编号

12 个数据库交叉引用编号

ChEBI: CHEBI:51164
PubChem: 28864
PubChem: 3938
HMDB: HMDB0014727
DrugBank: DB00589
ChEMBL: CHEMBL157138
Wikipedia: Lisuride
MeSH: Lisuride
chemspider: 26847
CAS: 140387-89-9
CAS: 18016-80-3
PMhub: MS000237534

分类词条

Indoloquinolines

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

9606 - Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Annika Gocht, Jörg H W Distler, Bernd Spriewald, Martina Ramsperger-Gleixner, Michael Weyand, Stephan M Ensminger, Christian Heim. Effects of different serotonin receptor subtype antagonists on the development of cardiac allograft vasculopathy in murine aortic allografts. Transplant immunology. 2018 08; 49(?):43-53. doi: 10.1016/j.trim.2018.04.002. [PMID: 29649585]
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Paolo Solla, Antonino Cannas, Francesco Marrosu, Maria Giovanna Marrosu. Therapeutic interventions and adjustments in the management of Parkinson disease: role of combined carbidopa/levodopa/entacapone (Stalevo). Neuropsychiatric disease and treatment. 2010 Sep; 6(?):483-90. doi: 10.2147/ndt.s5190. [PMID: 20856911]
Jessica A Knight, Carol Smith, Nicole Toohey, Michael T Klein, Milt Teitler. Pharmacological analysis of the novel, rapid, and potent inactivation of the human 5-Hydroxytryptamine7 receptor by risperidone, 9-OH-Risperidone, and other inactivating antagonists. Molecular pharmacology. 2009 Feb; 75(2):374-80. doi: 10.1124/mol.108.052084. [PMID: 18996971]
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Angelo Antonini, Giovanni Abbruzzese, Paolo Barone, Ubaldo Bonuccelli, Leonardo Lopiano, Marco Onofrj, Mario Zappia, Aldo Quattrone. COMT inhibition with tolcapone in the treatment algorithm of patients with Parkinson's disease (PD): relevance for motor and non-motor features. Neuropsychiatric disease and treatment. 2008 Feb; 4(1):1-9. doi: 10.2147/ndt.s2404. [PMID: 18728767]
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