Neuromedin B (BioDeep_00000026831)

   

human metabolite Endogenous


代谢物信息卡片


(2R)-2-[(2-Amino-1-hydroxyethylidene)amino]-N-[(1S)-1-{[(1R)-1-{[(1R)-1-{[(1S,2R)-2-hydroxy-1-[({[(1S)-1-{[(1R)-1-{[(1S)-1-(C-hydroxycarbonimidoyl)-3-(methylsulphanyl)propyl]-C-hydroxycarbonimidoyl}-2-phenylethyl]-C-hydroxycarbonimidoyl}-2-(1H-imidazol-5-yl)ethyl]-C-hydroxycarbonimidoyl}methyl)-C-hydroxycarbonimidoyl]propyl]-C-hydroxycarbonimidoyl}ethyl]-C-hydroxycarbonimidoyl}-2-(1H-indol-3-yl)ethyl]-C-hydroxycarbonimidoyl}-3-methylbutyl]butanediimidic acid

化学式: C52H73N15O12S (1131.5283577999999)
中文名称: Neuromedin B.
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)CC(C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(C)C(=O)NC(C(C)O)C(=O)NCC(=O)NC(CC3=CN=CN3)C(=O)NC(CC4=CC=CC=C4)C(=O)NC(CCSC)C(=O)N)NC(=O)C(CC(=O)N)NC(=O)CN
InChI: InChI=1S/C52H73N15O12S/c1-27(2)17-36(64-51(78)40(21-41(54)69)61-42(70)22-53)48(75)66-38(19-31-23-57-34-14-10-9-13-33(31)34)47(74)60-28(3)46(73)67-44(29(4)68)52(79)58-25-43(71)62-39(20-32-24-56-26-59-32)50(77)65-37(18-30-11-7-6-8-12-30)49(76)63-35(45(55)72)15-16-80-5/h6-14,23-24,26-29,35-40,44,57,68H,15-22,25,53H2,1-5H3,(H2,54,69)(H2,55,72)(H,56,59)(H,58,79)(H,60,74)(H,61,70)(H,62,71)(H,63,76)(H,64,78)(H,65,77)(H,66,75)(H,67,73)/t28-,29-,35+,36+,37-,38-,39+,40-,44+/m1/s1

描述信息

NMB acts by binding to its high affinity cell surface receptor, neuromedin B receptor (NMBR). This receptor is a G protein-coupled receptor with seven transmembrane spanning regions, hence the receptor is also denoted as a 7 transmembrane receptor (7-TMR). Upon binding several intracellular signaling pathways are triggered (see Figure 2).; Neuromedin B (NMB) is a bombesin-related peptide in mammals. It was originally purified from pig spinal cord, and later shown to be present in human central nervous system and gastrointestinal tract. [HMDB]
NMB acts by binding to its high affinity cell surface receptor, neuromedin B receptor (NMBR). This receptor is a G protein-coupled receptor with seven transmembrane spanning regions, hence the receptor is also denoted as a 7 transmembrane receptor (7-TMR). Upon binding several intracellular signaling pathways are triggered (see Figure 2). Neuromedin B (NMB) is a bombesin-related peptide in mammals. It was originally purified from pig spinal cord, and later shown to be present in human central nervous system and gastrointestinal tract.
D018377 - Neurotransmitter Agents > D015320 - Tachykinins

同义名列表

8 个代谢物同义名

(2R)-2-[(2-Amino-1-hydroxyethylidene)amino]-N-[(1S)-1-{[(1R)-1-{[(1R)-1-{[(1S,2R)-2-hydroxy-1-[({[(1S)-1-{[(1R)-1-{[(1S)-1-(C-hydroxycarbonimidoyl)-3-(methylsulphanyl)propyl]-C-hydroxycarbonimidoyl}-2-phenylethyl]-C-hydroxycarbonimidoyl}-2-(1H-imidazol-5-yl)ethyl]-C-hydroxycarbonimidoyl}methyl)-C-hydroxycarbonimidoyl]propyl]-C-hydroxycarbonimidoyl}ethyl]-C-hydroxycarbonimidoyl}-2-(1H-indol-3-yl)ethyl]-C-hydroxycarbonimidoyl}-3-methylbutyl]butanediimidic acid; (2R)-2-[(2-Amino-1-hydroxyethylidene)amino]-N-[(1S)-1-{[(1R)-1-{[(1R)-1-{[(1S,2R)-2-hydroxy-1-[({[(1S)-1-{[(1R)-1-{[(1S)-1-(C-hydroxycarbonimidoyl)-3-(methylsulphanyl)propyl]-C-hydroxycarbonimidoyl}-2-phenylethyl]-C-hydroxycarbonimidoyl}-2-(1H-imidazol-5-yl)ethyl]-C-hydroxycarbonimidoyl}methyl)-C-hydroxycarbonimidoyl]propyl]-C-hydroxycarbonimidoyl}ethyl]-C-hydroxycarbonimidoyl}-2-(1H-indol-3-yl)ethyl]-C-hydroxycarbonimidoyl}-3-methylbutyl]butanediimidate; (2R)-2-[(2-Amino-1-hydroxyethylidene)amino]-N-[(1S)-1-{[(1R)-1-{[(1R)-1-{[(1S,2R)-2-hydroxy-1-[({[(1S)-1-{[(1R)-1-{[(1S)-1-(C-hydroxycarbonimidoyl)-3-(methylsulfanyl)propyl]-C-hydroxycarbonimidoyl}-2-phenylethyl]-C-hydroxycarbonimidoyl}-2-(1H-imidazol-5-yl)ethyl]-C-hydroxycarbonimidoyl}methyl)-C-hydroxycarbonimidoyl]propyl]-C-hydroxycarbonimidoyl}ethyl]-C-hydroxycarbonimidoyl}-2-(1H-indol-3-yl)ethyl]-C-hydroxycarbonimidoyl}-3-methylbutyl]butanediimidate; (2S)-2-[(2R)-2-[(2S)-2-{2-[(2S,3R)-2-[(2R)-2-[(2R)-2-[(2S)-2-[(2R)-2-(2-aminoacetamido)-3-(C-hydroxycarbonimidoyl)propanamido]-4-methylpentanamido]-3-(1H-indol-3-yl)propanamido]propanamido]-3-hydroxybutanamido]acetamido}-3-(1H-imidazol-4-yl)propanamido]-3-phenylpropanamido]-4-(methylsulfanyl)butanimidic acid; Glycyl-arginyl-leucyl-tryptophyl-alanyl-threonyl-glycyl-histidyl-phenylalanyl-methioninamide; Gly-asn-leu-TRP-ala-THR-gly-his-phe-met-NH2; Neuromedin B trifluoroacetate salt; Neuromedin B



数据库引用编号

8 个数据库交叉引用编号

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代谢反应

0 个相关的代谢反应过程信息。

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Hyun-Joo Park, Mi-Kyoung Kim, Yeon Kim, Hyung Joon Kim, Soo-Kyung Bae, Moon-Kyoung Bae. Neuromedin B modulates phosphate-induced vascular calcification. BMB reports. 2021 Nov; 54(11):569-574. doi: NULL. [PMID: 34674793]
  • Guihong Yang, Huipeng Huang, Mengyao Tang, Zifeng Cai, Cuiqin Huang, Baomin Qi, Ji-Long Chen. Role of neuromedin B and its receptor in the innate immune responses against influenza A virus infection in vitro and in vivo. Veterinary research. 2019 Oct; 50(1):80. doi: 10.1186/s13567-019-0695-2. [PMID: 31601264]
  • G S M Paula, L L Souza, N O S Bressane, R Maravalhas, M Wilieman, T Bento-Bernardes, K R Silva, L S Mendonca, K J Oliveira, C C Pazos-Moura. Mice with Deletion of Neuromedin B Receptor Exhibit Decreased Oral Glucose-Stimulated Insulin Release. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2016 Dec; 48(12):854-861. doi: 10.1055/s-0042-115643. [PMID: 27756093]
  • H Q Zhao, G Yao, S Yannaing, S ThanThan, H Kuwayama. Insulinotropic action of bombesin-like peptides mediated by gastrin-releasing peptide receptors in steers. Journal of animal science. 2016 Jan; 94(1):58-64. doi: 10.2527/jas.2015-9495. [PMID: 26812312]
  • Hiraku Kameda, Hideaki Miyoshi, Chikara Shimizu, So Nagai, Akinobu Nakamura, Takuma Kondo, Dai Chida, Tatsuya Atsumi. Expression and regulation of neuromedin B in pituitary corticotrophs of male melanocortin 2 receptor-deficient mice. Endocrinology. 2014 Jul; 155(7):2492-9. doi: 10.1210/en.2013-2077. [PMID: 24742195]
  • C K Boughton, S A Patel, E L Thompson, M Patterson, A E Curtis, A Amin, K Chen, M A Ghatei, S R Bloom, K G Murphy. Neuromedin B stimulates the hypothalamic-pituitary-gonadal axis in male rats. Regulatory peptides. 2013 Nov; 187(?):6-11. doi: 10.1016/j.regpep.2013.10.002. [PMID: 24120470]
  • Nicole Wege, Alexandra Schutkowski, Bettina König, Corinna Brandsch, Matthias Weiwad, Gabriele I Stangl. PPARα modulates the TSH β-subunit mRNA expression in thyrotrope TαT1 cells and in a mouse model. Molecular nutrition & food research. 2013 Mar; 57(3):376-89. doi: 10.1002/mnfr.201200409. [PMID: 23255496]
  • Tetsuya Tachibana, Kiyoko Matsuda, Sakirul Islam Khan, Hiroshi Ueda, Mark A Cline. Feeding and drinking response following central administrations of bombesin-like peptides in chicks. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 2010 Aug; 156(4):394-9. doi: 10.1016/j.cbpa.2010.03.008. [PMID: 20233609]
  • R T Jensen, J F Battey, E R Spindel, R V Benya. International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states. Pharmacological reviews. 2008 Mar; 60(1):1-42. doi: 10.1124/pr.107.07108. [PMID: 18055507]
  • Priyanka Prakash, Ramasubbu Sankararamakrishnan. Molecular dynamics simulations of C-terminal decapeptide of gastrin-releasing peptide in DMPC bilayers: structure, stability and orientation of the peptide hormone within the bilayers. Protein and peptide letters. 2007; 14(6):590-6. doi: 10.2174/092986607780989868. [PMID: 17627601]
  • Subbaya Subramanian, Robert B West, Robert J Marinelli, Torsten O Nielsen, Brian P Rubin, John R Goldblum, Rajiv M Patel, Shirley Zhu, Kelli Montgomery, Tony L Ng, Christopher L Corless, Michael C Heinrich, Matt van de Rijn. The gene expression profile of extraskeletal myxoid chondrosarcoma. The Journal of pathology. 2005 Aug; 206(4):433-44. doi: 10.1002/path.1792. [PMID: 15920699]
  • Takahiro Shimizu, Shoshiro Okada, Naoko Yamaguchi, Junichi Arai, Hiroshi Wakiguchi, Kunihiko Yokotani. Brain phospholipase C/diacylglycerol lipase are involved in bombesin BB2 receptor-mediated activation of sympatho-adrenomedullary outflow in rats. European journal of pharmacology. 2005 May; 514(2-3):151-8. doi: 10.1016/j.ejphar.2005.03.033. [PMID: 15910801]
  • Luigi Bouchard, Vicky Drapeau, Véronique Provencher, Simone Lemieux, Yvon Chagnon, Treva Rice, D C Rao, Marie-Claude Vohl, Angelo Tremblay, Claude Bouchard, Louis Pérusse. Neuromedin beta: a strong candidate gene linking eating behaviors and susceptibility to obesity. The American journal of clinical nutrition. 2004 Dec; 80(6):1478-86. doi: 10.1093/ajcn/80.6.1478. [PMID: 15585758]
  • Tânia Maria Ortiga-Carvalho, Karen de Jesus Oliveira, Marcelo Marcos Morales, Viviane Pinto Martins, Carmen Cabanelas Pazos-Moura. Thyrotropin secretagogues reduce rat pituitary neuromedin B, a local thyrotropin release inhibitor. Experimental biology and medicine (Maywood, N.J.). 2003 Oct; 228(9):1083-8. doi: 10.1177/153537020322800916. [PMID: 14530520]
  • Rachel Moraes Moreira, Flavio Henrique Curty, Patricia Cristina Lisboa, Daniele Amaral, Tania Maria Ortiga-Carvalho, Carmen C Pazos-Moura. Estrogen modulates neuromedin B effects on thyrotropin and prolactin release in vitro. Life sciences. 2003 Jan; 72(8):917-23. doi: 10.1016/s0024-3205(02)02351-2. [PMID: 12493572]
  • P G Du, S Kato, Y H Li, T Maeda, T Yamane, S Yamamoto, M Fujiwara, Y Yamamoto, K Nishi, I Ohkubo. Rat tripeptidyl peptidase I: molecular cloning, functional expression, tissue localization and enzymatic characterization. Biological chemistry. 2001 Dec; 382(12):1715-25. doi: 10.1515/bc.2001.207. [PMID: 11843185]
  • G Cassano, N Resta, G Gasparre, C Lippe, G Guanti. The proliferative response of HT-29 human colon adenocarcinoma cells to bombesin-like peptides. Cancer letters. 2001 Oct; 172(2):151-7. doi: 10.1016/s0304-3835(01)00642-5. [PMID: 11566490]
  • F H Curty, P C Lisbôa, T M Ortiga-Carvalho, C C Pazos-Moura. The somatostatin analogue octreotide modulates Iodothyronine deiodinase activity and pituitary neuromedin B. Thyroid : official journal of the American Thyroid Association. 2000 Aug; 10(8):647-52. doi: 10.1089/10507250050137716. [PMID: 11014308]
  • R R Ryan, T Katsuno, S A Mantey, T K Pradhan, H C Weber, D H Coy, J F Battey, R T Jensen. Comparative pharmacology of the nonpeptide neuromedin B receptor antagonist PD 168368. The Journal of pharmacology and experimental therapeutics. 1999 Sep; 290(3):1202-11. doi: NULL. [PMID: 10454496]
  • J M Siegfried, N Krishnamachary, A Gaither Davis, C Gubish, J D Hunt, S P Shriver. Evidence for autocrine actions of neuromedin B and gastrin-releasing peptide in non-small cell lung cancer. Pulmonary pharmacology & therapeutics. 1999; 12(5):291-302. doi: 10.1006/pupt.1999.0210. [PMID: 10545285]
  • W Hou, T Tsuda, R T Jensen. Neuromedin B activates phospholipase D through both PKC-dependent and PKC-independent mechanisms. Biochimica et biophysica acta. 1998 Apr; 1391(3):337-50. doi: 10.1016/s0005-2760(98)00014-9. [PMID: 9555086]
  • E Polverini, R Casadio, P Neyroz, L Masotti. Conformational changes of neuromedin B and delta sleep-inducing peptide induced by their interaction with lipid membranes as revealed by spectroscopic techniques and molecular dynamics simulation. Archives of biochemistry and biophysics. 1998 Jan; 349(2):225-35. doi: 10.1006/abbi.1997.0395. [PMID: 9448709]
  • T Tsuda, T Kusui, R T Jensen. Neuromedin B receptor activation causes tyrosine phosphorylation of p125FAK by a phospholipase C independent mechanism which requires p21rho and integrity of the actin cytoskeleton. Biochemistry. 1997 Dec; 36(51):16328-37. doi: 10.1021/bi971448o. [PMID: 9405068]
  • H A Ferris, R E Carroll, M M Rasenick, R V Benya. Constitutive activation of the gastrin-releasing peptide receptor expressed by the nonmalignant human colon epithelial cell line NCM460. The Journal of clinical investigation. 1997 Nov; 100(10):2530-7. doi: 10.1172/jci119795. [PMID: 9366567]
  • T M Ortiga-Carvalho, F H Curty, C C Nascimento-Saba, E G Moura, J Polak, C C Pazos-Moura. Pituitary neuromedin B content in experimental fasting and diabetes mellitus and correlation with thyrotropin secretion. Metabolism: clinical and experimental. 1997 Feb; 46(2):149-53. doi: 10.1016/s0026-0495(97)90293-6. [PMID: 9030820]
  • T M Ortiga-Carvalho, J Polak, S McCann, C C Pazos-Moura. Effect of thyroid hormones on pituitary neuromedin B and possible interaction between thyroid hormones and neuromedin B on thyrotropin secretion. Regulatory peptides. 1996 Nov; 67(1):47-53. doi: 10.1016/s0167-0115(96)00106-1. [PMID: 8952005]
  • L K Malendowicz, C Macchi, G G Nussdorfer, M Nowak. The role of neuromedin B in the regulation of rat pituitary-adrenocortical function. Histology and histopathology. 1996 Oct; 11(4):895-7. doi: NULL. [PMID: 8930632]
  • C C Pazos-Moura, E G Moura, V Rettori, J Polak, S M McCann. Role of neuromedin B in the in vitro thyrotropin release in response to thyrotropin-releasing hormone from anterior pituitaries of eu-, hypo-, and hyperthyroid rats. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1996 Apr; 211(4):353-8. doi: 10.3181/00379727-211-43980. [PMID: 8618941]
  • H Shapira, M Lupu-Meiri, D Lipinsky, Y Oron. Agonist-evoked calcium efflux from a functionally discrete compartment in Xenopus oocytes. Cell calcium. 1996 Mar; 19(3):201-10. doi: 10.1016/s0143-4160(96)90021-4. [PMID: 8732260]
  • J T Lin, D H Coy, S A Mantey, R T Jensen. Comparison of the peptide structural requirements for high affinity interaction with bombesin receptors. European journal of pharmacology. 1995 Dec; 294(1):55-69. doi: 10.1016/0014-2999(95)00510-2. [PMID: 8788416]
  • J T Lin, D H Coy, S A Mantey, R T Jensen. Peptide structural requirements for antagonism differ between the two mammalian bombesin receptor subtypes. The Journal of pharmacology and experimental therapeutics. 1995 Oct; 275(1):285-95. doi: NULL. [PMID: 7562561]
  • T Kusui, M R Hellmich, L H Wang, R L Evans, R V Benya, J F Battey, R T Jensen. Characterization of gastrin-releasing peptide receptor expressed in Sf9 insect cells by baculovirus. Biochemistry. 1995 Jun; 34(25):8061-75. doi: 10.1021/bi00025a012. [PMID: 7794919]
  • T M Ortiga-Carvalho, F H Curty, C C Pazos-Moura. Acute effect of thyroxine on pituitary neuromedin B content of hypothyroid rats and its correlation with TSH secretion. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 1995 Jun; 28(6):715-9. doi: NULL. [PMID: 8547858]
  • R V Benya, T Kusui, T K Pradhan, J F Battey, R T Jensen. Expression and characterization of cloned human bombesin receptors. Molecular pharmacology. 1995 Jan; 47(1):10-20. doi: . [PMID: 7838118]
  • L K Malendowicz, G G Nussdorfer. Investigations on the acute effects of neuropeptides on the pituitary-adrenocortical function in normal and cold-stressed rats. I. Bombesin and neuromedin B. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 1995 Jan; 47(1):31-4. doi: 10.1016/s0940-2993(11)80279-4. [PMID: 7719118]
  • R V Benya, M Akeson, J Mrozinski, R T Jensen, J F Battey. Internalization of the gastrin-releasing peptide receptor is mediated by both phospholipase C-dependent and -independent processes. Molecular pharmacology. 1994 Sep; 46(3):495-501. doi: NULL. [PMID: 7935330]
  • R V Benya, T Kusui, F Shikado, J F Battey, R T Jensen. Desensitization of neuromedin B receptors (NMB-R) on native and NMB-R-transfected cells involves down-regulation and internalization. The Journal of biological chemistry. 1994 Apr; 269(16):11721-8. doi: . [PMID: 8163469]
  • H Plamondon, Z Merali. Effects of central neuromedin B and related peptides on blood glucose. Regulatory peptides. 1993 Sep; 47(2):133-40. doi: 10.1016/0167-0115(93)90417-7. [PMID: 8234899]
  • L H Wang, S A Mantey, J T Lin, H Frucht, R T Jensen. Ligand binding, internalization, degradation and regulation by guanine nucleotides of bombesin receptor subtypes: a comparative study. Biochimica et biophysica acta. 1993 Jan; 1175(2):232-42. doi: 10.1016/0167-4889(93)90028-n. [PMID: 8380344]
  • V Rettori, C C Pazos-Moura, E G Moura, J Polak, S M McCann. Role of neuromedin B in control of the release of thyrotropin in hypothyroid and hyperthyroid rats. Proceedings of the National Academy of Sciences of the United States of America. 1992 Apr; 89(7):3035-9. doi: 10.1073/pnas.89.7.3035. [PMID: 1557409]
  • S C Huang, D H Yu, S A Wank, J D Gardner, R T Jensen. Characterization of the bombesin receptor on mouse pancreatic acini by chemical cross-linking. Peptides. 1990 Nov; 11(6):1143-50. doi: 10.1016/0196-9781(90)90144-t. [PMID: 1708135]
  • H Houben, C Denef. Stimulation of growth hormone and prolactin release from rat pituitary cell aggregates by bombesin- and ranatensin-like peptides is potentiated by estradiol, 5 alpha-dihydrotestosterone, and dexamethasone. Endocrinology. 1990 May; 126(5):2257-66. doi: 10.1210/endo-126-5-2257. [PMID: 2328688]
  • V Rettori, L Milenkovic, A M Fahim, J Polak, S R Bloom, S M McCann. Role of neuromedin B in the control of the release of thyrotropin in the rat. Proceedings of the National Academy of Sciences of the United States of America. 1989 Jun; 86(12):4789-92. doi: 10.1073/pnas.86.12.4789. [PMID: 2499891]
  • T Von Schrenck, P Heinz-Erian, T Moran, S A Mantey, J D Gardner, R T Jensen. Neuromedin B receptor in esophagus: evidence for subtypes of bombesin receptors. The American journal of physiology. 1989 Apr; 256(4 Pt 1):G747-58. doi: 10.1152/ajpgi.1989.256.4.g747. [PMID: 2539739]
  • K Kawai, Y Chiba, H Mukai, E Munekata, K Yamashita. Effects of neuromedin B, gastrin-releasing peptide-10 and their fragment peptides on secretion of gastrointestinal and pancreatic hormones in dogs. Acta endocrinologica. 1988 Feb; 117(2):205-13. doi: 10.1530/acta.0.1170205. [PMID: 3289296]
  • M Namba, M A Ghatei, M Ghiglione, S R Bloom. Effects of decapeptide of mammalian bombesin and neuromedin B on pancreatic exocrine secretion in the rat. Digestion. 1986; 34(2):105-14. doi: 10.1159/000199318. [PMID: 3755409]