Phenylpropionylglycine (BioDeep_00000026776)

   

human metabolite Endogenous blood metabolite


代谢物信息卡片


2-[(1-Hydroxy-3-phenylpropylidene)amino]acetate

化学式: C11H13NO3 (207.0895388)
中文名称: N-(3-苯基丙酰基)甘氨酸
谱图信息: 最多检出来源 Homo sapiens(feces) 0.16%

分子结构信息

SMILES: C1=CC=C(C=C1)CCC(=O)NCC(=O)O
InChI: InChI=1S/C11H13NO3/c13-10(12-8-11(14)15)7-6-9-4-2-1-3-5-9/h1-5H,6-8H2,(H,12,13)(H,14,15)

描述信息

Phenylpropionylglycine is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids. However, the excretion of certain acyl glycines is increased in several inborn errors of metabolism. In certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Acyl glycines are produced through the action of glycine N-acyltransferase (EC 2.3.1.13) which is an enzyme that catalyzes the chemical reaction: acyl-CoA + glycine < -- > CoA + N-acylglycine. The detection of phenylpropionylglycine in urine after an oral load of phenylpropionic acid can be used to diagnose deficiency of medium-chain acyl-CoA dehydrogenase, a frequent and treatable metabolic defect. (PMID 9234867).
Phenylpropionylglycine is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids. However, the excretion of certain acyl glycines is increased in several inborn errors of metabolism. In certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Acyl glycines are produced through the action of glycine N-acyltransferase (EC 2.3.1.13) which is an enzyme that catalyzes the chemical reaction:

同义名列表

9 个代谢物同义名

2-[(1-Hydroxy-3-phenylpropylidene)amino]acetate; (3-Phenyl-propionylamino)-acetic acid; 2-(3-phenylpropanamido)acetic acid; (3-Phenyl-propionylamino)-acetate; N-(3-Phenyl-propionyl)-glycine; N-(3-Phenylpropanoyl)glycine; (3-Phenylpropionyl)glycine; 3-Phenylpropionylglycine; Phenylpropionylglycine



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

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Plant Reactome(0)

INOH(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Avalyn Stanislaus, Kevin Guo, Liang Li. Development of an isotope labeling ultra-high performance liquid chromatography mass spectrometric method for quantification of acylglycines in human urine. Analytica chimica acta. 2012 Oct; 750(?):161-72. doi: 10.1016/j.aca.2012.05.006. [PMID: 23062437]
  • Jun Niu, Zifeng Pi, Hao Yue, Yang Wang, Qing Yu, Shuying Liu. Effect of ginseng polysaccharide on the urinary excretion of type 2 diabetic rats studied by liquid chromatography-mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Oct; 907(?):7-12. doi: 10.1016/j.jchromb.2012.08.012. [PMID: 22998979]
  • Yuanyuan Zhang, Fei Li, Andrew D Patterson, Yao Wang, Kristopher W Krausz, Geoffrey Neale, Sarah Thomas, Deepa Nachagari, Peter Vogel, Mary Vore, Frank J Gonzalez, John D Schuetz. Abcb11 deficiency induces cholestasis coupled to impaired β-fatty acid oxidation in mice. The Journal of biological chemistry. 2012 Jul; 287(29):24784-94. doi: 10.1074/jbc.m111.329318. [PMID: 22619174]
  • Yueying Zhen, Kristopher W Krausz, Chi Chen, Jeffrey R Idle, Frank J Gonzalez. Metabolomic and genetic analysis of biomarkers for peroxisome proliferator-activated receptor alpha expression and activation. Molecular endocrinology (Baltimore, Md.). 2007 Sep; 21(9):2136-51. doi: 10.1210/me.2007-0150. [PMID: 17550978]
  • D R de Assis, R C Maria, G C Ferreira, P F Schuck, A Latini, C S Dutra-Filho, C M D Wannmacher, A T S Wyse, M Wajner. Na+, K+ ATPase activity is markedly reduced by cis-4-decenoic acid in synaptic plasma membranes from cerebral cortex of rats. Experimental neurology. 2006 Jan; 197(1):143-9. doi: 10.1016/j.expneurol.2005.09.002. [PMID: 16203000]