Neuromedin C (BioDeep_00000026771)

   

human metabolite Endogenous Volatile Flavor Compounds


代谢物信息卡片


(2R)-2-[(2-Amino-1-hydroxyethylidene)amino]-N-[(1S)-1-{[(1R)-1-{[(1S)-1-{[(1R)-1-[({[(1S)-1-[(1-{[(1R)-1-(C-hydroxycarbonimidoyl)-3-(methylsulphanyl)propyl]-C-hydroxycarbonimidoyl}-3-methylbutyl)-C-hydroxycarbonimidoyl]-2-(1H-imidazol-5-yl)ethyl]-C-hydroxycarbonimidoyl}methyl)-C-hydroxycarbonimidoyl]-2-methylpropyl]-C-hydroxycarbonimidoyl}ethyl]-C-hydroxycarbonimidoyl}-2-(1H-indol-3-yl)ethyl]-C-hydroxycarbonimidoyl}-2-(1H-imidazol-5-yl)ethyl]butanediimidic acid

化学式: C50H73N17O11S (1119.5395907999998)
中文名称: GRP (18-27) (HUMAN, PORCINE, CANINE)
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)C(CC1=CN=CN1)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(C)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C(CC4=CN=CN4)NC(=O)C(CC(=O)N)NC(=O)CN
InChI: InChI=1S/C50H73N17O11S/c1-25(2)13-34(46(74)63-33(43(53)71)11-12-79-6)64-47(75)36(15-29-20-54-23-58-29)62-41(70)22-57-50(78)42(26(3)4)67-44(72)27(5)60-45(73)35(14-28-19-56-32-10-8-7-9-31(28)32)65-48(76)37(16-30-21-55-24-59-30)66-49(77)38(17-39(52)68)61-40(69)18-51/h7-10,19-21,23-27,33-38,42,56H,11-18,22,51H2,1-6H3,(H2,52,68)(H2,53,71)(H,54,58)(H,55,59)(H,57,78)(H,60,73)(H,61,69)(H,62,70)(H,63,74)(H,64,75)(H,65,76)(H,66,77)(H,67,72)/t27-,33+,34?,35+,36-,37-,38+,42+/m0/s1

描述信息

Neuromedin c is a neuropeptide derived from the same precursor polypeptide as neurotensin, and with similar but subtly distinct expression and effect. Neurotensin is a 13 amino acid neuropeptide that is implicated in the regulation of luteinizing hormone and prolactin release and has significant interaction with the dopaminergic system. Neurotensin was first isolated from extracts of bovine hypothalamus based on its ability to cause a visible vasodilation in the exposed cutaneous regions of anesthetized rats. This structure shows neuromedin C.
Neuromedin C is a neuropeptide derived from the same precursor polypeptide as neurotensin, and with similar but subtly distinct expression and effect
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
D009676 - Noxae > D011042 - Poisons > D014688 - Venoms

同义名列表

17 个代谢物同义名

(2R)-2-[(2-Amino-1-hydroxyethylidene)amino]-N-[(1S)-1-{[(1R)-1-{[(1S)-1-{[(1R)-1-[({[(1S)-1-[(1-{[(1R)-1-(C-hydroxycarbonimidoyl)-3-(methylsulphanyl)propyl]-C-hydroxycarbonimidoyl}-3-methylbutyl)-C-hydroxycarbonimidoyl]-2-(1H-imidazol-5-yl)ethyl]-C-hydroxycarbonimidoyl}methyl)-C-hydroxycarbonimidoyl]-2-methylpropyl]-C-hydroxycarbonimidoyl}ethyl]-C-hydroxycarbonimidoyl}-2-(1H-indol-3-yl)ethyl]-C-hydroxycarbonimidoyl}-2-(1H-imidazol-5-yl)ethyl]butanediimidic acid; (2R)-2-[(2-Amino-1-hydroxyethylidene)amino]-N-[(1S)-1-{[(1R)-1-{[(1S)-1-{[(1R)-1-[({[(1S)-1-[(1-{[(1R)-1-(C-hydroxycarbonimidoyl)-3-(methylsulphanyl)propyl]-C-hydroxycarbonimidoyl}-3-methylbutyl)-C-hydroxycarbonimidoyl]-2-(1H-imidazol-5-yl)ethyl]-C-hydroxycarbonimidoyl}methyl)-C-hydroxycarbonimidoyl]-2-methylpropyl]-C-hydroxycarbonimidoyl}ethyl]-C-hydroxycarbonimidoyl}-2-(1H-indol-3-yl)ethyl]-C-hydroxycarbonimidoyl}-2-(1H-imidazol-5-yl)ethyl]butanediimidate; (2R)-2-[(2-Amino-1-hydroxyethylidene)amino]-N-[(1S)-1-{[(1R)-1-{[(1S)-1-{[(1R)-1-[({[(1S)-1-[(1-{[(1R)-1-(C-hydroxycarbonimidoyl)-3-(methylsulfanyl)propyl]-C-hydroxycarbonimidoyl}-3-methylbutyl)-C-hydroxycarbonimidoyl]-2-(1H-imidazol-5-yl)ethyl]-C-hydroxycarbonimidoyl}methyl)-C-hydroxycarbonimidoyl]-2-methylpropyl]-C-hydroxycarbonimidoyl}ethyl]-C-hydroxycarbonimidoyl}-2-(1H-indol-3-yl)ethyl]-C-hydroxycarbonimidoyl}-2-(1H-imidazol-5-yl)ethyl]butanediimidate; (2R)-2-(2-aminoacetamido)-N-[(1S)-1-{[(1R)-1-{[(1S)-1-{[(1R)-1-[({[(1S)-1-[(1-{[(1R)-1-carbamoyl-3-(methylsulfanyl)propyl]carbamoyl}-3-methylbutyl)carbamoyl]-2-(1H-imidazol-5-yl)ethyl]carbamoyl}methyl)carbamoyl]-2-methylpropyl]carbamoyl}ethyl]carbamoyl}-2-(1H-indol-3-yl)ethyl]carbamoyl}-2-(1H-imidazol-5-yl)ethyl]butanediamide; (2R)-2-(2-aminoacetamido)-N-[(1S)-1-{[(1R)-1-{[(1S)-1-{[(1R)-1-[({[(1S)-1-[(1-{[(1R)-1-carbamoyl-3-(methylsulfanyl)propyl]carbamoyl}-3-methylbutyl)carbamoyl]-2-(3H-imidazol-4-yl)ethyl]carbamoyl}methyl)carbamoyl]-2-methylpropyl]carbamoyl}ethyl]carbamoyl}-2-(1H-indol-3-yl)ethyl]carbamoyl}-2-(3H-imidazol-4-yl)ethyl]succinamide; Gly-asn-his-TRP-ala-val-gly-his-leu-met-NH2; GRP (18-27) (human, porcine, canine); Canine gastrin-releasing peptide 10; Gastrin releasing peptide (18-27); Gastrin releasing peptide 10; Bombesin decapeptide; neuromedin C; NMC Peptide; GRP (18-27); GRP-10; NMC; Neuromedin C



数据库引用编号

10 个数据库交叉引用编号

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代谢反应

0 个相关的代谢反应过程信息。

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jeppe H Ekberg, Maria Hauge, Line V Kristensen, Andreas N Madsen, Maja S Engelstoft, Anna-Sofie Husted, Rasmus Sichlau, Kristoffer L Egerod, Pascal Timshel, Timothy J Kowalski, Fiona M Gribble, Frank Reiman, Harald S Hansen, Andrew D Howard, Birgitte Holst, Thue W Schwartz. GPR119, a Major Enteroendocrine Sensor of Dietary Triglyceride Metabolites Coacting in Synergy With FFA1 (GPR40). Endocrinology. 2016 Dec; 157(12):4561-4569. doi: 10.1210/en.2016-1334. [PMID: 27779915]
  • H Q Zhao, G Yao, S Yannaing, S ThanThan, H Kuwayama. Insulinotropic action of bombesin-like peptides mediated by gastrin-releasing peptide receptors in steers. Journal of animal science. 2016 Jan; 94(1):58-64. doi: 10.2527/jas.2015-9495. [PMID: 26812312]
  • Berthold A Nock, Renzo Cescato, Eleni Ketani, Beatrice Waser, Jean Claude Reubi, Theodosia Maina. [(99m)Tc]Demomedin C, a radioligand based on human gastrin releasing peptide(18-27): synthesis and preclinical evaluation in gastrin releasing peptide receptor-expressing models. Journal of medicinal chemistry. 2012 Oct; 55(19):8364-74. doi: 10.1021/jm300741f. [PMID: 22966957]
  • Hongqiong Zhao, Seinosuke Matsuda, Sint Thanthan, Swe Yannaing, Hideto Kuwayama. Bombesin-like peptides stimulate growth hormone secretion mediated by the gastrin-releasing peptide receptor in cattle. Peptides. 2012 Oct; 37(2):194-9. doi: 10.1016/j.peptides.2012.07.018. [PMID: 22868212]
  • Tetsuya Tachibana, Kiyoko Matsuda, Sakirul Islam Khan, Hiroshi Ueda, Mark A Cline. Feeding and drinking response following central administrations of bombesin-like peptides in chicks. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 2010 Aug; 156(4):394-9. doi: 10.1016/j.cbpa.2010.03.008. [PMID: 20233609]
  • G Cassano, N Resta, G Gasparre, C Lippe, G Guanti. The proliferative response of HT-29 human colon adenocarcinoma cells to bombesin-like peptides. Cancer letters. 2001 Oct; 172(2):151-7. doi: 10.1016/s0304-3835(01)00642-5. [PMID: 11566490]
  • J C Whitley, A Shulkes, L A Salamonsen, D Vogiagis, M Familari, A S Giraud. Temporal expression and cellular localization of a gastrin-releasing peptide-related gene in ovine uterus during the oestrous cycle and pregnancy. The Journal of endocrinology. 1998 Apr; 157(1):139-48. doi: 10.1677/joe.0.1570139. [PMID: 9614367]
  • D H Nichols, S Lovas, T E Adrian, C A Miller, R F Murphy. Peptides bind to eosinophils in the rat stomach. The Anatomical record. 1998 02; 250(2):172-81. doi: 10.1002/(sici)1097-0185(199802)250:2<172::aid-ar7>3.0.co;2-5. [PMID: 9489778]
  • G Gasmi, A Singer, J Forman-Kay, B Sarkar. NMR structure of neuromedin C, a neurotransmitter with an amino terminal CuII-, NiII-binding (ATCUN) motif. The journal of peptide research : official journal of the American Peptide Society. 1997 Jun; 49(6):500-9. doi: 10.1111/j.1399-3011.1997.tb01157.x. [PMID: 9266477]
  • E Polverini, P Neyroz, P Fariselli, R Casadio, L Masotti. The effect of membranes on the conformation of neuromedin C. Biochemical and biophysical research communications. 1995 Sep; 214(2):663-8. doi: 10.1006/bbrc.1995.2337. [PMID: 7677779]
  • B Walker, J Gray, D M Burns, Q Wang, T E Adrian, D H Nichols, R F Murphy, J Nelson. Carboxyfluorescein and biotin neuromedin C analogues: synthesis and applications. Peptides. 1995; 16(2):255-61. doi: 10.1016/0196-9781(94)00174-x. [PMID: 7540292]
  • K Okubo, K Miyasaka, M Matsumoto, A Funakoshi. Mechanisms of stimulatory effect of neuromedin C on pancreatic exocrine secretion in conscious rats. Pancreas. 1994 Sep; 9(5):585-90. doi: 10.1097/00006676-199409000-00008. [PMID: 7809013]
  • K Okubo, M Masuda, K Miyasaka, A Funakoshi. Secretory capacity of pancreatic protein during luminal feedback regulation in conscious rats. The Japanese journal of physiology. 1994; 44(2):205-19. doi: 10.2170/jjphysiol.44.205. [PMID: 7967222]
  • H Houben, C Denef. Negative regulation by dexamethasone of the potentiation of neuromedin C-induced growth hormone and prolactin release by estradiol in anterior pituitary cell aggregates. Life sciences. 1992; 50(11):775-80. doi: 10.1016/0024-3205(92)90182-o. [PMID: 1740962]
  • H Houben, C Denef. Effect of the bombesin receptor blockers [Leu13, psi CH2NH-Leu14]bombesin and N-pivaloyl GRP(20-25) alkylamide (L 686,095-001C002) on basal and neuromedin C-stimulated PRL and GH release in pituitary cell aggregates. Peptides. 1991 Mar; 12(2):371-4. doi: 10.1016/0196-9781(91)90028-n. [PMID: 1648716]
  • S C Huang, D H Yu, S A Wank, J D Gardner, R T Jensen. Characterization of the bombesin receptor on mouse pancreatic acini by chemical cross-linking. Peptides. 1990 Nov; 11(6):1143-50. doi: 10.1016/0196-9781(90)90144-t. [PMID: 1708135]
  • A J Vangsted, T W Schwartz. Production of gastrin-releasing peptide-(18-27) and a stable fragment of its precursor in small cell lung carcinoma cells. The Journal of clinical endocrinology and metabolism. 1990 Jun; 70(6):1586-93. doi: 10.1210/jcem-70-6-1586. [PMID: 1693372]
  • H Houben, C Denef. Stimulation of growth hormone and prolactin release from rat pituitary cell aggregates by bombesin- and ranatensin-like peptides is potentiated by estradiol, 5 alpha-dihydrotestosterone, and dexamethasone. Endocrinology. 1990 May; 126(5):2257-66. doi: 10.1210/endo-126-5-2257. [PMID: 2328688]
  • M Takeyama, K Kondo, Y Hayashi, H Yajima. Enzyme immunoassay of gastrin releasing peptide (GRP)-like immunoreactivity in milk. International journal of peptide and protein research. 1989 Jul; 34(1):70-4. doi: 10.1111/j.1399-3011.1989.tb01011.x. [PMID: 2507458]
  • T Von Schrenck, P Heinz-Erian, T Moran, S A Mantey, J D Gardner, R T Jensen. Neuromedin B receptor in esophagus: evidence for subtypes of bombesin receptors. The American journal of physiology. 1989 Apr; 256(4 Pt 1):G747-58. doi: 10.1152/ajpgi.1989.256.4.g747. [PMID: 2539739]
  • N W Bunnett, A J Turner, J Hryszko, R Kobayashi, J H Walsh. Isolation of endopeptidase-24.11 (EC 3.4.24.11, "enkephalinase") from the pig stomach. Hydrolysis of substance P, gastrin-releasing peptide 10, [Leu5] enkephalin, and [Met5] enkephalin. Gastroenterology. 1988 Oct; 95(4):952-7. doi: 10.1016/0016-5085(88)90168-0. [PMID: 2457534]
  • Y Haraguchi, A Sakamoto, T Yoshida, K Tanaka. Plasma GRP-like immunoreactivity in healthy and diseased subjects. Gastroenterologia Japonica. 1988 Jun; 23(3):247-50. doi: 10.1007/bf02779466. [PMID: 3402699]
  • K Kawai, Y Chiba, H Mukai, E Munekata, K Yamashita. Effects of neuromedin B, gastrin-releasing peptide-10 and their fragment peptides on secretion of gastrointestinal and pancreatic hormones in dogs. Acta endocrinologica. 1988 Feb; 117(2):205-13. doi: 10.1530/acta.0.1170205. [PMID: 3289296]
  • M Namba, M A Ghatei, M Ghiglione, S R Bloom. Effects of decapeptide of mammalian bombesin and neuromedin B on pancreatic exocrine secretion in the rat. Digestion. 1986; 34(2):105-14. doi: 10.1159/000199318. [PMID: 3755409]