Flumethasone Pivalate (BioDeep_00000026769)

   

human metabolite blood metabolite


代谢物信息卡片


2-[(1R,2S,8S,10S,11S,13R,14R,15S,17S)-1,8-difluoro-14,17-dihydroxy-2,13,15-trimethyl-5-oxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-dien-14-yl]-2-oxoethyl 2,2-dimethylpropanoate

化学式: C27H36F2O6 (494.24798200000004)
中文名称: 特戊酸氟米松
谱图信息: 最多检出来源 Homo sapiens(blood) 46.88%

分子结构信息

SMILES: CC1CC2C3CC(C4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COC(=O)C(C)(C)C)O)C)O)F)C)F
InChI: InChI=1S/C27H36F2O6/c1-14-9-16-17-11-19(28)18-10-15(30)7-8-24(18,5)26(17,29)20(31)12-25(16,6)27(14,34)21(32)13-35-22(33)23(2,3)4/h7-8,10,14,16-17,19-20,31,34H,9,11-13H2,1-6H3/t14-,16+,17+,19+,20+,24+,25+,26+,27+/m1/s1

描述信息

Flumethasone pivalate is a moderately potent difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. As it is a privalate salt, its anti-inflammatory action is concentrated at the site of application. This local effect on diseased areas results in a prompt decrease in inflammation, exudation and itching.
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D005938 - Glucocorticoids
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid

同义名列表

11 个代谢物同义名

2-[(1R,2S,8S,10S,11S,13R,14R,15S,17S)-1,8-difluoro-14,17-dihydroxy-2,13,15-trimethyl-5-oxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-dien-14-yl]-2-oxoethyl 2,2-dimethylpropanoate; Novartis brand OF flumethasone pivalate; Flumethasone dimethylpropionate; Flumethasone pivalic acid; Flumethasone 21-pivalate; Flumetasone pivalic acid; Flumethasone Pivalate; Flumetasone pivalate; Locacorten; Locorten; Cerson



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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INOH(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Sonja Hoeller, Andrea Sperger, Claudia Valenta. Lecithin based nanoemulsions: A comparative study of the influence of non-ionic surfactants and the cationic phytosphingosine on physicochemical behaviour and skin permeation. International journal of pharmaceutics. 2009 Mar; 370(1-2):181-6. doi: 10.1016/j.ijpharm.2008.11.014. [PMID: 19073240]
  • P Jassar, J Jose, J J Homer. Otic drops used to clear a blocked grommet: an in vitro prospective randomized controlled study with blinded assessment. Clinical otolaryngology and allied sciences. 2004 Dec; 29(6):602-5. doi: 10.1111/j.1365-2273.2004.00880.x. [PMID: 15533145]
  • M Shohat, M Mimouni, A Shuper, I Varsano. Adrenocortical suppression by topical application of glucocorticosteroids in infants with seborrheic dermatitis. Clinical pediatrics. 1986 Apr; 25(4):209-12. doi: 10.1177/000992288602500407. [PMID: 2936538]