Fluorocitric acid (BioDeep_00000026713)
human metabolite
代谢物信息卡片
Fluorocitric acid
化学式: C6H7FO7 (210.01758039999999)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(C(=O)O)C(C(C(=O)O)F)(C(=O)O)O
InChI: InChI=1S/C6H7FO7/c7-3(4(10)11)6(14,5(12)13)1-2(8)9/h3,14H,1H2,(H,8,9)(H,10,11)(H,12,13)
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ik-Rak Jung, Sung-E Choi, Seung A Hong, Yoonjung Hwang, Yup Kang. Sodium fluorocitrate having protective effect on palmitate-induced beta cell death improves hyperglycemia in diabetic db/db mice.
Scientific reports.
2017 10; 7(1):12916. doi:
10.1038/s41598-017-13365-5. [PMID: 29018279] - Expedito K A Camboim, Michelle Z Tadra-Sfeir, Emanuel M de Souza, Fabio de O Pedrosa, Paulo P Andrade, Chris S McSweeney, Franklin Riet-Correa, Marcia A Melo. Defluorination of sodium fluoroacetate by bacteria from soil and plants in Brazil.
TheScientificWorldJournal.
2012; 2012(?):149893. doi:
10.1100/2012/149893. [PMID: 22619595] - Keisuke Shibata, Takeshi Sugawara, Kayoko Fujishita, Youichi Shinozaki, Takashi Matsukawa, Tsutomu Suzuki, Schuichi Koizumi. The astrocyte-targeted therapy by Bushi for the neuropathic pain in mice.
PloS one.
2011; 6(8):e23510. doi:
10.1371/journal.pone.0023510. [PMID: 21876755] - Kazuhide Hayakawa, Keiichi Irie, Kazunori Sano, Takuya Watanabe, Sei Higuchi, Makiko Enoki, Takafumi Nakano, Kazuhiko Harada, Shin Ishikane, Tomoaki Ikeda, Masayuki Fujioka, Kensuke Orito, Katsunori Iwasaki, Kenichi Mishima, Michihiro Fujiwara. Therapeutic time window of cannabidiol treatment on delayed ischemic damage via high-mobility group box1-inhibiting mechanism.
Biological & pharmaceutical bulletin.
2009 Sep; 32(9):1538-44. doi:
10.1248/bpb.32.1538. [PMID: 19721229] - Ildikó Toma, Jung Julie Kang, Arnold Sipos, Sarah Vargas, Eric Bansal, Fiona Hanner, Elliott Meer, János Peti-Peterdi. Succinate receptor GPR91 provides a direct link between high glucose levels and renin release in murine and rabbit kidney.
The Journal of clinical investigation.
2008 Jul; 118(7):2526-34. doi:
10.1172/jci33293. [PMID: 18535668] - Emilie Muller, Hervé Le-Corronc, Pascal Legendre. Extrasynaptic and postsynaptic receptors in glycinergic and GABAergic neurotransmission: a division of labor?.
Frontiers in molecular neuroscience.
2008; 1(?):3. doi:
10.3389/neuro.02.003.2008. [PMID: 18946536] - Ludmila A Voloboueva, Sang Won Suh, Raymond A Swanson, Rona G Giffard. Inhibition of mitochondrial function in astrocytes: implications for neuroprotection.
Journal of neurochemistry.
2007 Aug; 102(4):1383-94. doi:
10.1111/j.1471-4159.2007.04634.x. [PMID: 17488276] - Shinichiro Hirose, Yukiko Umetani, Misato Amitani, Rie Hosoi, Sotaro Momosaki, Jun Hatazawa, Antony Gee, Osamu Inoue. Role of NMDA receptors in the increase of glucose metabolism in the rat brain induced by fluorocitrate.
Neuroscience letters.
2007 Mar; 415(3):259-63. doi:
10.1016/j.neulet.2007.01.031. [PMID: 17280781] - V P Zinchenko, N V Goncharov, V V Teplova, V A Kasymov, O I Petrova, A V Berezhnov, E V Senchenkov, I V Mindukshev, R O Jenkins, A S Radilov. [Studies of interaction of intracellular signalling and metabolic pathways under inhibition of mitochondrial aconitase with fluoroacetate].
Tsitologiia.
2007; 49(12):1023-31. doi:
NULL. [PMID: 18318221] - Osamu Inoue, Rie Hosoi, Sotaro Momosaki, Keisuke Yamamoto, Misato Amitani, Masatoshi Yamaguchi, Antony Gee. Evaluation of [14C]phenylacetate as a prototype tracer for the measurement of glial metabolism in the rat brain.
Nuclear medicine and biology.
2006 Nov; 33(8):985-9. doi:
10.1016/j.nucmedbio.2006.08.007. [PMID: 17127171] - R C Collicchio-Zuanaze, M Sakate, D S Schwartz, E Trezza, A J Crocci. Calcium gluconate and sodium succinate for therapy of sodium fluoroacetate experimental intoxication in cats: clinical and electrocardiographic evaluation.
Human & experimental toxicology.
2006 Apr; 25(4):175-82. doi:
10.1191/0960327106ht609oa. [PMID: 16696292] - Nikolay V Goncharov, Richard O Jenkins, Andrey S Radilov. Toxicology of fluoroacetate: a review, with possible directions for therapy research.
Journal of applied toxicology : JAT.
2006 Mar; 26(2):148-61. doi:
10.1002/jat.1118. [PMID: 16252258] - Y Yamada, T Hamaguchi, M Goto, K Muro, Y Matsumura, Y Shimada, K Shirao, S Nagayama. Plasma concentrations of 5-fluorouracil and F-beta-alanine following oral administration of S-1, a dihydropyrimidine dehydrogenase inhibitory fluoropyrimidine, as compared with protracted venous infusion of 5-fluorouracil.
British journal of cancer.
2003 Sep; 89(5):816-20. doi:
10.1038/sj.bjc.6601224. [PMID: 12942110] - K I Menon, M G Feldwick, P S Noakes, R J Mead. The mode of toxic action of the pesticide gliftor: the metabolism of 1,3-difluoroacetone to (-)-erythro-fluorocitrate.
Journal of biochemical and molecular toxicology.
2001; 15(1):47-54. doi:
10.1002/1099-0461(2001)15:1<47::aid-jbt6>3.0.co;2-e. [PMID: 11170315] - D A Keller, D C Roe, P H Lieder. Fluoroacetate-mediated toxicity of fluorinated ethanes.
Fundamental and applied toxicology : official journal of the Society of Toxicology.
1996 Apr; 30(2):213-9. doi:
10.1006/faat.1996.0058. [PMID: 8812268] - B Tecle, J E Casida. Enzymatic defluorination and metabolism of fluoroacetate, fluoroacetamide, fluoroethanol, and (-)-erythro-fluorocitrate in rats and mice examined by 19F and 13C NMR.
Chemical research in toxicology.
1989 Nov; 2(6):429-35. doi:
10.1021/tx00012a012. [PMID: 2519733] - A Fine. The effects of fluorocitrate on renal glutamine, lactate, alanine, and oxygen metabolism in the dog.
Canadian journal of physiology and pharmacology.
1989 Jun; 67(6):641-4. doi:
10.1139/y89-102. [PMID: 2776079] - L Boquist, S Boquist, U Alehagen. Mitochondrial changes and associated alterations induced in mice by streptozotocin administered in vivo and in vitro.
Diabetes research and clinical practice.
1987 Jul; 3(4):179-90. doi:
10.1016/s0168-8227(87)80037-2. [PMID: 2887408] - T Bosakowski, A A Levin. Comparative acute toxicity of chlorocitrate and fluorocitrate in dogs.
Toxicology and applied pharmacology.
1987 Jun; 89(1):97-104. doi:
10.1016/0041-008x(87)90180-3. [PMID: 3590193] - T Bosakowski, A A Levin. Serum citrate as a peripheral indicator of fluoroacetate and fluorocitrate toxicity in rats and dogs.
Toxicology and applied pharmacology.
1986 Sep; 85(3):428-36. doi:
10.1016/0041-008x(86)90350-9. [PMID: 3764925] - E Bourke, V Delaney, A Risquez, H G Preuss. Effects of inhibitors of the tricarboxylic acid cycle on glutamine utilization in the intact dog kidney. Renal glutamine utilization following TCA cycle blockade.
Contributions to nephrology.
1985; 47(?):28-35. doi:
NULL. [PMID: 4064698] - R T Bogusky, T T Aoki. Early events in the initiation of ammonia formation in kidney.
The Journal of biological chemistry.
1983 Mar; 258(5):2795-801. doi:
10.1016/s0021-9258(18)32788-1. [PMID: 6131071] - R B Franklin, L C Costello. Isocitrate uptake and citrate production by rat ventral prostate fragments.
Investigative urology.
1978 Jul; 16(1):44-7. doi:
NULL. [PMID: 689836] - D H TREBLE, D T LAMPORT, R A PETERS. The inhibition of plant aconitate hydratase (aconitase) by fluorocitrate.
The Biochemical journal.
1962 Oct; 85(?):113-5. doi:
10.1042/bj0850113. [PMID: 13994045] - D B CATER, R A PETERS. The occurrence of renal changes, resembling nephrosis, in rats poisoned with fluorocitrate.
British journal of experimental pathology.
1961 Jun; 42(?):278-89. doi:
NULL. [PMID: 13691556]