2,4-Dihydroxychalcone (BioDeep_00000266787)

   

natural product PANOMIX_OTCML-2023


代谢物信息卡片


2-Propen-1-one,1-(2-hydroxyphenyl)-3-(4-hydroxyphenyl)-

化学式: C15H12O3 (240.0786402)
中文名称: 2,4-二羟查耳酮, 2’,4-二羟基查耳酮, 2',4'-二羟查耳酮
谱图信息: 最多检出来源 Viridiplantae(plant) 1.31%

分子结构信息

SMILES: c1(cc(c(cc1)C(=O)/C=C/c1ccccc1)O)O
InChI: InChI=1S/C15H12O3/c16-12-7-8-13(15(18)10-12)14(17)9-6-11-4-2-1-3-5-11/h1-10,16,18H/b9-6+

描述信息

relative retention time with respect to 9-anthracene Carboxylic Acid is 1.137
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.136
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.140

同义名列表

6 个代谢物同义名

2,4-Dihydroxychalcone; 2-Propen-1-one,1-(2,4-dihydroxyphenyl)-3-phenyl-; (2E)-3-(2,4-dihydroxyphenyl)-1-phenylprop-2-en-1-one; 3-(2,4-Dihydroxyphenyl)-1-phenyl-2-propen-1-one; 2-Propen-1-one,1-(2-hydroxyphenyl)-3-(4-hydroxyphenyl)-; 1-(2-Hydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one



相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yang Liu, Xiaojing Zhang, Norbo Kelsang, Guangzhong Tu, Dexin Kong, Jianghai Lu, Yingtao Zhang, Hong Liang, Pengfei Tu, Qingying Zhang. Structurally Diverse Cytotoxic Dimeric Chalcones from Oxytropis chiliophylla. Journal of natural products. 2018 02; 81(2):307-315. doi: 10.1021/acs.jnatprod.7b00736. [PMID: 29400468]
  • Zhaodi Xie, Xiaoting Luo, Zhuan Zou, Xiao Zhang, Feifei Huang, Ruishan Li, Shijie Liao, Yun Liu. Synthesis and evaluation of hydroxychalcones as multifunctional non-purine xanthine oxidase inhibitors for the treatment of hyperuricemia. Bioorganic & medicinal chemistry letters. 2017 08; 27(15):3602-3606. doi: 10.1016/j.bmcl.2017.01.053. [PMID: 28655421]
  • Haoxin Li, Stéphanie Jean, Duncan Webster, Gilles A Robichaud, Larry A Calhoun, John A Johnson, Christopher A Gray. Dibenz[b,f]oxepin and Antimycobacterial Chalcone Constituents of Empetrum nigrum. Journal of natural products. 2015 Nov; 78(11):2837-40. doi: 10.1021/acs.jnatprod.5b00627. [PMID: 26473275]
  • Cristina M Jimenez, Diego A Sampietro, Melina A Sgariglia, José R Soberón, Marta A Vattuone. Isolation, identification and usefulness of antifungal compounds from Zuccagnia punctata for control of toxigenic ear rot pathogens. Natural product communications. 2014 Oct; 9(10):1461-4. doi: ". [PMID: 25522536]
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  • Shan-Shan Wang, Xiao-Jing Zhang, Sheng Que, Guang-Zhong Tu, Dan Wan, Wei Cheng, Hong Liang, Jia Ye, Qing-Ying Zhang. 3-Hydroxy-3-methylglutaryl flavonol glycosides from Oxytropis falcata. Journal of natural products. 2012 Jul; 75(7):1359-64. doi: 10.1021/np300292f. [PMID: 22775441]
  • Rolando A Curvale, Nora B Debattista, Nora B Pappano. Interaction between 2',4-dihydroxychalcone and the N, f, e conformers of bovine serum albumin: influence of temperature and ionic strength. The protein journal. 2012 Apr; 31(4):293-9. doi: 10.1007/s10930-012-9404-y. [PMID: 22450828]
  • R M Ordóñez, I C Zampini, M I Nieva Moreno, M I Isla. Potential application of Northern Argentine propolis to control some phytopathogenic bacteria. Microbiological research. 2011 Oct; 166(7):578-84. doi: 10.1016/j.micres.2010.11.006. [PMID: 21237629]
  • Wei-Dong Li, Zhi-Peng Chen, Min-Ming Qu, Dan Liu, Yan-Yu Xiao, Bao-Chang Cai. [Study on the pharmacokinetics Oxytropis falcate total flavonoids ointment in rats]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2011 Sep; 34(9):1396-8. doi: NULL. [PMID: 22260009]
  • Zhi-peng Chen, Min-ming Qu, Hong-xuan Chen, Dan Liu, Yan-yu Xiao, Jun Chen, Tu-lin Lu, Bao-chang Cai. The studies of anti-inflammatory and analgesic activities and pharmacokinetics of Oxytropis falcate Bunge extraction after transdermal administration in rats. Fitoterapia. 2011 Apr; 82(3):426-33. doi: 10.1016/j.fitote.2010.11.026. [PMID: 21156196]
  • Chenghua Lou, Guangming Yang, Hao Cai, Mingchang Zou, Zisheng Xu, Yu Li, Fengming Zhao, Weidong Li, Li Tong, Mingyan Wang, Baochang Cai. 2',4'-Dihydroxychalcone-induced apoptosis of human gastric cancer MGC-803 cells via down-regulation of survivin mRNA. Toxicology in vitro : an international journal published in association with BIBRA. 2010 Aug; 24(5):1333-7. doi: 10.1016/j.tiv.2010.05.003. [PMID: 20471467]
  • Sannah P N Mativandlela, Tshilidzi Muthivhi, Haruhisa Kikuchi, Yoshiteru Oshima, Chris Hamilton, Ahmed A Hussein, Martha L van der Walt, Peter J Houghton, Namrita Lall. Antimycobacterial flavonoids from the leaf extract of Galenia africana. Journal of natural products. 2009 Dec; 72(12):2169-71. doi: 10.1021/np800778b. [PMID: 20035557]
  • Suresh Awale, Tatsuya Miyamoto, Thein Zaw Linn, Feng Li, Nwet Nwet Win, Yasuhiro Tezuka, Hiroyasu Esumi, Shigetoshi Kadota. Cytotoxic constituents of Soymida febrifuga from Myanmar. Journal of natural products. 2009 Sep; 72(9):1631-6. doi: 10.1021/np9003323. [PMID: 19689125]
  • Iris Catiana Zampini, Milena Villarini, Massimo Moretti, Luca Dominici, María Inés Isla. Evaluation of genotoxic and antigenotoxic effects of hydroalcoholic extracts of Zuccagnia punctata Cav. Journal of ethnopharmacology. 2008 Jan; 115(2):330-5. doi: 10.1016/j.jep.2007.10.007. [PMID: 18023546]
  • Suresh Awale, Feng Li, Hiroko Onozuka, Hiroyasu Esumi, Yasuhiro Tezuka, Shigetoshi Kadota. Constituents of Brazilian red propolis and their preferential cytotoxic activity against human pancreatic PANC-1 cancer cell line in nutrient-deprived condition. Bioorganic & medicinal chemistry. 2008 Jan; 16(1):181-9. doi: 10.1016/j.bmc.2007.10.004. [PMID: 17950610]
  • Mauricio Cabrera, Macarena Simoens, Gabriela Falchi, M Laura Lavaggi, Oscar E Piro, Eduardo E Castellano, Anabel Vidal, Amaia Azqueta, Antonio Monge, Adela López de Ceráin, Gabriel Sagrera, Gustavo Seoane, Hugo Cerecetto, Mercedes González. Synthetic chalcones, flavanones, and flavones as antitumoral agents: biological evaluation and structure-activity relationships. Bioorganic & medicinal chemistry. 2007 May; 15(10):3356-67. doi: 10.1016/j.bmc.2007.03.031. [PMID: 17383189]
  • Laura Svetaz, Alejandro Tapia, Silvia N López, Ricardo L E Furlán, Elisa Petenatti, Rosanna Pioli, Guillermo Schmeda-Hirschmann, Susana A Zacchino. Antifungal chalcones and new caffeic acid esters from Zuccagnia punctata acting against soybean infecting fungi. Journal of agricultural and food chemistry. 2004 Jun; 52(11):3297-300. doi: 10.1021/jf035213x. [PMID: 15161186]
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  • S Sogawa, Y Nihro, H Ueda, A Izumi, T Miki, H Matsumoto, T Satoh. 3,4-Dihydroxychalcones as potent 5-lipoxygenase and cyclooxygenase inhibitors. Journal of medicinal chemistry. 1993 Nov; 36(24):3904-9. doi: 10.1021/jm00076a019. [PMID: 8254620]