cudratricusxanthone A (BioDeep_00000265980)
Cytotoxicity natural product
代谢物信息卡片
化学式: C23H24O6 (396.1573)
中文名称: 柘树口山酮 A
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: c12c(oc3c(c1=O)c(c(c(c3)O)O)CC=C(C)C)c(c(cc2O)O)C(C)(C=C)C
InChI: InChI=1S/C23H24O6/c1-6-23(4,5)19-14(25)9-13(24)18-21(28)17-12(8-7-11(2)3)20(27)15(26)10-16(17)29-22(18)19/h6-7,9-10,24-27H,1,8H2,2-5H3
描述信息
A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 2, 3, 6 and 8, an isoprenyl group at position 1 and a 2-methylbut-3-en-2-yl group at position 5. It is isolated from the root barks of Cudrania tricuspidata and exhibits cytotoxicity towards human cancer cell lines.
同义名列表
1 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:65686
- PubChem: 11153672
- ChEMBL: CHEMBL200640
- KNApSAcK: C00038875
- CAS: 740810-42-8
- PMhub: MS000100007
- MetaboLights: MTBLC65686
- LOTUS: LTS0157888
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
16 个相关的物种来源信息
- 2759 - Eukaryota: LTS0157888
- 3495 - Maclura: 10.1055/S-2008-1081315
- 3495 - Maclura: LTS0157888
- 210328 - Maclura tricuspidata:
- 210328 - Maclura tricuspidata: 10.1016/J.BMC.2004.01.030
- 210328 - Maclura tricuspidata: 10.1016/J.BMCL.2005.08.099
- 210328 - Maclura tricuspidata: 10.1016/J.BMCL.2007.10.007
- 210328 - Maclura tricuspidata: 10.1021/NP030481A
- 210328 - Maclura tricuspidata: 10.1021/NP070059K
- 210328 - Maclura tricuspidata: 10.1248/BPB.30.805
- 210328 - Maclura tricuspidata: LTS0157888
- 3398 - Magnoliopsida: LTS0157888
- 3487 - Moraceae: LTS0157888
- 35493 - Streptophyta: LTS0157888
- 58023 - Tracheophyta: LTS0157888
- 33090 - Viridiplantae: LTS0157888
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
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文献列表
- Hyo-Shin Kwon, Gil-Saeng Jeong, Byeong-Churl Jang. Cudratricusxanthone A Inhibits Lipid Accumulation and Expression of Inducible Nitric Oxide Synthase in 3T3-L1 Preadipocytes.
International journal of molecular sciences.
2021 Jan; 22(2):. doi:
10.3390/ijms22020505
. [PMID: 33419132] - In-Chul Lee, Jong-Sup Bae. Hepatoprotective effects of vicenin-2 and scolymoside through the modulation of inflammatory pathways.
Journal of natural medicines.
2020 Jan; 74(1):90-97. doi:
10.1007/s11418-019-01348-x
. [PMID: 31350693] - Lincheng Li, Mingchuan Liu, Mengyuan Cao, Ting He, Xiaozhi Bai. Research progress on SIRT1 and sepsis.
Histology and histopathology.
2019 Nov; 34(11):1205-1215. doi:
10.14670/hh-18-146
. [PMID: 31282985] - Yuri Lee, Gil-Saeng Jeong, Kyung-Min Kim, Wonhwa Lee, Jong-Sup Bae. Cudratricusxanthone A attenuates sepsis-induced liver injury via SIRT1 signaling.
Journal of cellular physiology.
2018 07; 233(7):5441-5446. doi:
10.1002/jcp.26390
. [PMID: 29226969] - Eun-Hwa Choi, Eun-Nam Kim, Gil-Saeong Jeong. Inhibitory effect of Cudratricusxanthone A on osteoclast differentiation and function.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2018 Apr; 43(?):86-91. doi:
10.1016/j.phymed.2018.03.060
. [PMID: 29747758] - Wonhwa Lee, Yuri Lee, Gil-Saeng Jeong, Sae-Kwang Ku, Jong-Sup Bae. Cudratricusxanthone A attenuates renal injury in septic mice.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2017 Aug; 106(Pt A):404-410. doi:
10.1016/j.fct.2017.06.009
. [PMID: 28595959] - Soo-Myeong Jeon, Dong-Sung Lee, Gil-Saeong Jeong. Cudraticusxanthone A isolated from the roots of Cudrania tricuspidata inhibits metastasis and induces apoptosis in breast cancer cells.
Journal of ethnopharmacology.
2016 Dec; 194(?):57-62. doi:
10.1016/j.jep.2016.08.042
. [PMID: 27586822] - Juhee Sim, Eunhwa Choi, You-Mie Lee, Gil-Saeng Jeong, Sangkyu Lee. In vitro inhibition of human cytochrome P450 by cudratricusxanthone A.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2015 Jul; 81(?):171-175. doi:
10.1016/j.fct.2015.04.024
. [PMID: 25936586] - Hayoung Yoo, Sae-Kwang Ku, Wonhwa Lee, Soyoung Kwak, Young-Doo Baek, Byung-Woon Min, Gil-Saeng Jeong, Jong-Sup Bae. Antiplatelet, anticoagulant, and profibrinolytic activities of cudratricusxanthone A.
Archives of pharmacal research.
2014 Aug; 37(8):1069-78. doi:
10.1007/s12272-013-0290-4
. [PMID: 24234914] - Young Bae Ryu, Marcus J Curtis-Long, Ji Won Lee, Jin Hyo Kim, Jun Young Kim, Kyu Young Kang, Woo Song Lee, Ki Hun Park. Characteristic of neuraminidase inhibitory xanthones from Cudrania tricuspidata.
Bioorganic & medicinal chemistry.
2009 Apr; 17(7):2744-50. doi:
10.1016/j.bmc.2009.02.042
. [PMID: 19285413] - Gil-Saeng Jeong, Ren-Bo An, Hyun-Ock Pae, Hun-Taeg Chung, Kwon-Ha Yoon, Dae-Gill Kang, Ho-Sub Lee, Youn-Chul Kim. Cudratricusxanthone A protects mouse hippocampal cells against glutamate-induced neurotoxicity via the induction of heme oxygenase-1.
Planta medica.
2008 Sep; 74(11):1368-73. doi:
10.1055/s-2008-1081315
. [PMID: 18683128] - Eun Jin Seo, Marcus J Curtis-Long, Byong Won Lee, Hoi Young Kim, Young Bae Ryu, Tae-Sook Jeong, Woo Song Lee, Ki Hun Park. Xanthones from Cudrania tricuspidata displaying potent alpha-glucosidase inhibition.
Bioorganic & medicinal chemistry letters.
2007 Dec; 17(23):6421-4. doi:
10.1016/j.bmcl.2007.10.007
. [PMID: 17950599] - Ji Hye Hwang, Seong Su Hong, Xiang Hua Han, Ji Sang Hwang, Dongho Lee, Heesoon Lee, Yeo Pyo Yun, Youngsoo Kim, Jai Seup Ro, Bang Yeon Hwang. Prenylated xanthones from the root bark of Cudrania tricuspidata.
Journal of natural products.
2007 Jul; 70(7):1207-9. doi:
10.1021/np070059k
. [PMID: 17608532] - Byong Won Lee, Sang Wan Gal, Ki-Min Park, Ki Hun Park. Cytotoxic xanthones from Cudrania tricuspidata.
Journal of natural products.
2005 Mar; 68(3):456-8. doi:
10.1021/np030481a
. [PMID: 15787460]