23-Hydroxyursolic acid (BioDeep_00000265155)
代谢物信息卡片
化学式: C30H48O4 (472.3552408)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)CO)O)C)C)C2C1C)C)C(=O)O
InChI: InChI=1S/C30H48O4/c1-18-9-14-30(25(33)34)16-15-28(5)20(24(30)19(18)2)7-8-22-26(3)12-11-23(32)27(4,17-31)21(26)10-13-29(22,28)6/h7,18-19,21-24,31-32H,8-17H2,1-6H3,(H,33,34)/t18-,19+,21-,22-,23+,24+,26+,27+,28-,29-,30+/m1/s1
描述信息
A pentacyclic triterpenoid that is ursolic acid substituted by an additional hydroxy group at position 23. It has been isolated from Lagerstroemia speciosa and Juglans sinensis.
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:67896
- PubChem: 14136881
- ChEMBL: CHEMBL523622
- KNApSAcK: C00050661
- CAS: 94414-19-4
- MetaboLights: MTBLC67896
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yan-Gang Cao, Yan-Li Zhang, Meng-Nan Zeng, Man Qi, Ying-Jie Ren, Yan-Ling Liu, Xuan Zhao, Xiao-Ke Zheng, Wei-Sheng Feng. Renoprotective Mono- and Triterpenoids from the Fruit of Gardenia jasminoides.
Journal of natural products.
2020 04; 83(4):1118-1130. doi:
10.1021/acs.jnatprod.9b01119. [PMID: 32141747] - Evelyn Afua Mireku, Abraham Yeboah Mensah, Isaac Kingsley Amponsah, Cynthia Amaning Danquah, Daniel Anokwah, Michael Kwesi Baah. Antimicrobial pentacyclic triterpenes and glycosides from the stem bark of Cussonia bancoensis.
Natural product research.
2020 Mar; 34(6):859-862. doi:
10.1080/14786419.2018.1503262. [PMID: 30289000] - Jong-Heon Won, Kyung-Sook Chung, Eun-Young Park, Jeong-Hun Lee, Jung-Hye Choi, Leon Azefack Tapondjou, Hee-Juhn Park, Masaaki Nomura, Ahmed H E Hassan, Kyung-Tae Lee. 23-Hydroxyursolic Acid Isolated from the Stem Bark of Cussonia bancoensis Induces Apoptosis through Fas/Caspase-8-Dependent Pathway in HL-60 Human Promyelocytic Leukemia Cells.
Molecules (Basel, Switzerland).
2018 Dec; 23(12):. doi:
10.3390/molecules23123306. [PMID: 30551620] - Huynh Nga Nguyen, Yong Joo Ahn, Edward Antonio Medina, Reto Asmis. Dietary 23-hydroxy ursolic acid protects against atherosclerosis and obesity by preventing dyslipidemia-induced monocyte priming and dysfunction.
Atherosclerosis.
2018 08; 275(?):333-341. doi:
10.1016/j.atherosclerosis.2018.06.882. [PMID: 30015296] - Quan Wen, Yan Lu, Zhi Chao, Dao-Feng Chen. Anticomplement triterpenoids from the roots of Ilex asprella.
Bioorganic & medicinal chemistry letters.
2017 02; 27(4):880-886. doi:
10.1016/j.bmcl.2017.01.007. [PMID: 28094185] - Sileshi G Wubshet, Yousof Tahtah, Allison M Heskes, Kenneth T Kongstad, Irini Pateraki, Björn Hamberger, Birger L Møller, Dan Staerk. Identification of PTP1B and α-Glucosidase Inhibitory Serrulatanes from Eremophila spp. by Combined use of Dual High-Resolution PTP1B and α-Glucosidase Inhibition Profiling and HPLC-HRMS-SPE-NMR.
Journal of natural products.
2016 Apr; 79(4):1063-72. doi:
10.1021/acs.jnatprod.5b01128. [PMID: 26960032] - Cun-qin Wang, Hong-ting Wang, Hao Xu, Yan-ping Shi. [Triterpenoids from Leaves of Ilex latifolia].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2015 Aug; 38(8):1653-5. doi:
". [PMID: 26983238] - Yeon Ho Choi, Wei Zhou, Joonseok Oh, Sanggil Choe, Dong Woo Kim, Seung Ho Lee, Minkyun Na. Rhododendric acid A, a new ursane-type PTP1B inhibitor from the endangered plant Rhododendron brachycarpum G. Don.
Bioorganic & medicinal chemistry letters.
2012 Oct; 22(19):6116-9. doi:
10.1016/j.bmcl.2012.08.029. [PMID: 22940448] - Heejung Yang, Eun Ju Jeong, Jinwoong Kim, Sang Hyun Sung, Young Choong Kim. Antiproliferative triterpenes from the leaves and twigs of Juglans sinensis on HSC-T6 cells.
Journal of natural products.
2011 Apr; 74(4):751-6. doi:
10.1021/np1008202. [PMID: 21309591] - Kyung-Min Shin, Rung-Kyu Kim, Tapondjou Leon Azefack, Lontsi David, Sondengam Beibam Luc, Muhammad Iqbal Choudhary, Hee-Juhn Park, Jong-Won Choi, Kyung-Tae Lee. In vitro anti-inflammatory activity of 23-hydroxyursolic acid isolated from Cussonia bancoensis in murine macrophage RAW 264.7 cells.
Planta medica.
2004 Sep; 70(9):803-7. doi:
10.1055/s-2004-827226. [PMID: 15386188] - Leon A Tapondjou, David Lontsi, Beibam L Sondengam, Fazarna Shaheen, Mohammad I Choudhary, Atta-ur-Rahman, Fanie R van Heerden, Hee-Juhn Park, Kyung-Tae Lee. Saponins from Cussonia bancoensis and their inhibitory effects on nitric oxide production.
Journal of natural products.
2003 Sep; 66(9):1266-9. doi:
10.1021/np020412g. [PMID: 14510614] - L A Tapondjou, David Lontsi, Beibam Luc Sondengam, Jongwon Choi, Kyung-Tae Lee, Hyun-Ju Jung, Hee-Juhn Park. In vivo anti-nociceptive and anti-inflammatory effect of the two triterpenes, ursolic acid and 23-hydroxyursolic acid, from Cussonia bancoensis.
Archives of pharmacal research.
2003 Feb; 26(2):143-6. doi:
10.1007/bf02976660. [PMID: 12643591] - K Nishimura, T Fukuda, T Miyase, H Noguchi, X M Chen. Activity-guided isolation of triterpenoid acyl CoA cholesteryl acyl transferase (ACAT) inhibitors from Ilex kudincha.
Journal of natural products.
1999 Jul; 62(7):1061-4. doi:
10.1021/np990019j. [PMID: 10425145]