Moronic acid (BioDeep_00000265011)
natural product
代谢物信息卡片
化学式: C30H46O3 (454.3447)
中文名称: 模绕酮酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C(=O)C([C@H]2[C@](C1)([C@@H]1[C@@](CC2)([C@]2([C@H](CC1)C1=CC(CC[C@@]1(CC2)C(=O)O)(C)C)C)C)C)(C)C
InChI: InChI=1S/C30H46O3/c1-25(2)14-16-30(24(32)33)17-15-28(6)19(20(30)18-25)8-9-22-27(5)12-11-23(31)26(3,4)21(27)10-13-29(22,28)7/h18-19,21-22H,8-17H2,1-7H3,(H,32,33)/t19-,21+,22-,27+,28-,29-,30+/m1/s1
描述信息
A pentacyclic triterpenoid that is olean-18-ene substituted at position 3 by an oxo group and position 28 by a carboxy group.
同义名列表
2 个代谢物同义名
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:30815
- PubChem: 489941
- Metlin: METLIN53770
- ChEMBL: CHEMBL472646
- LipidMAPS: LMPR0106150002
- KNApSAcK: C00034063
- CAS: 6713-27-5
- PMhub: MS000105359
- MetaboLights: MTBLC30815
- LOTUS: LTS0007832
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
41 个相关的物种来源信息
- 151787 - Acridocarpus: LTS0007832
- 4011 - Anacardiaceae: LTS0007832
- 68528 - Boronia: LTS0007832
- 1764338 - Boronia inornata: 10.1016/0031-9422(94)00567-D
- 1764338 - Boronia inornata: LTS0007832
- 43722 - Brucea: LTS0007832
- 210348 - Brucea javanica: 10.1002/JCCS.200500117
- 210348 - Brucea javanica: LTS0007832
- 155620 - Chisocheton: LTS0007832
- 155629 - Chisocheton macrophyllus: 10.1248/CPB.41.617
- 155629 - Chisocheton macrophyllus: LTS0007832
- 100370 - Croton: LTS0007832
- 2759 - Eukaryota: LTS0007832
- 3977 - Euphorbiaceae: LTS0007832
- 4136 - Lamiaceae: LTS0007832
- 4447 - Liliopsida: LTS0007832
- 3398 - Magnoliopsida: LTS0007832
- 4268 - Malpighiaceae: LTS0007832
- 3629 - Malvaceae: LTS0007832
- 43707 - Meliaceae: LTS0007832
- 289732 - Orthopterygium: 10.1016/S0031-9422(00)80284-8
- 289732 - Orthopterygium: LTS0007832
- 3967 - Phoradendron: LTS0007832
- 136774 - Phoradendron reichenbachianum: 10.1055/S-2001-15823
- 136774 - Phoradendron reichenbachianum: LTS0007832
- 4012 - Rhus: LTS0007832
- 289753 - Rhus chinensis: 10.1055/S-2007-967113
- 289753 - Rhus chinensis: LTS0007832
- 23513 - Rutaceae: LTS0007832
- 21880 - Salvia: LTS0007832
- 396869 - Salvia pomifera: 10.1016/S0031-9422(00)89809-X
- 396869 - Salvia pomifera: LTS0007832
- 3958 - Santalaceae: LTS0007832
- 23808 - Simaroubaceae: LTS0007832
- 35493 - Streptophyta: LTS0007832
- 58023 - Tracheophyta: LTS0007832
- 33090 - Viridiplantae: LTS0007832
- 1003255 - Viscaceae: LTS0007832
- 93803 - Waltheria: LTS0007832
- 75435 - Xyridaceae: LTS0007832
- 75440 - Xyris: LTS0007832
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
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文献列表
- Litzia Cerón-Romero, Paolo Paoli, Guido Camici, Virginia Flores-Morales, María Yolanda Rios, Juan J Ramírez-Espinosa, Sergio Hidalgo-Figueroa, Gabriel Navarrete-Vázquez, Samuel Estrada-Soto. In vitro and in silico PTP-1B inhibition and in vivo antidiabetic activity of semisynthetic moronic acid derivatives.
Bioorganic & medicinal chemistry letters.
2016 Apr; 26(8):2018-22. doi:
10.1016/j.bmcl.2016.02.082
. [PMID: 26961283] - Juan José Ramírez-Espinosa, Sara García-Jiménez, Maria Yolanda Rios, José L Medina-Franco, Fabián López-Vallejo, Scott P Webster, Margareth Binnie, Maximiliano Ibarra-Barajas, Rolffy Ortiz-Andrade, Samuel Estrada-Soto. Antihyperglycemic and sub-chronic antidiabetic actions of morolic and moronic acids, in vitro and in silico inhibition of 11β-HSD 1.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2013 May; 20(7):571-6. doi:
10.1016/j.phymed.2013.01.013
. [PMID: 23453304] - Kuo-Hsiung Lee. Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach.
Journal of natural products.
2010 Mar; 73(3):500-16. doi:
10.1021/np900821e
. [PMID: 20187635] - Qiong Gu, Rui-Rui Wang, Xue-Mei Zhang, Yun-Hua Wang, Yong-Tang Zheng, Jun Zhou, Ji-Jun Chen. A new benzofuranone and anti-HIV constituents from the stems of Rhus chinensis.
Planta medica.
2007 Mar; 73(3):279-82. doi:
10.1055/s-2007-967113
. [PMID: 17290322] - Sotirios Paraschos, Prokopios Magiatis, Sofia Mitakou, Kalliopi Petraki, Antonios Kalliaropoulos, Petros Maragkoudakis, Andreas Mentis, Dionyssios Sgouras, Alexios-Leandros Skaltsounis. In vitro and in vivo activities of Chios mastic gum extracts and constituents against Helicobacter pylori.
Antimicrobial agents and chemotherapy.
2007 Feb; 51(2):551-9. doi:
10.1128/aac.00642-06
. [PMID: 17116667] - Shugeng Cao, Rebecca Clare Guza, James S Miller, Rabodo Andriantsiferana, Vincent E Rasamison, David G I Kingston. Cytotoxic triterpenoids from Acridocarpus vivy from the Madagascar rain forest.
Journal of natural products.
2004 Jun; 67(6):986-9. doi:
10.1021/np040058h
. [PMID: 15217279] - Kuo-Hsiung Lee. Current developments in the discovery and design of new drug candidates from plant natural product leads.
Journal of natural products.
2004 Feb; 67(2):273-83. doi:
10.1021/np030373o
. [PMID: 14987069] - J Ito, F R Chang, H K Wang, Y K Park, M Ikegaki, N Kilgore, K H Lee. Anti-AIDS agents. 48.(1) Anti-HIV activity of moronic acid derivatives and the new melliferone-related triterpenoid isolated from Brazilian propolis.
Journal of natural products.
2001 Oct; 64(10):1278-81. doi:
10.1021/np010211x
. [PMID: 11678650] - M Y Rios, D Salina, M L Villarreal. Cytotoxic activity of moronic acid and identification of the new triterpene 3,4-seco-olean-18-ene-3,28-dioic acid from Phoradendron reichenbachianum.
Planta medica.
2001 Jul; 67(5):443-6. doi:
10.1055/s-2001-15823
. [PMID: 11488459] - M Kurokawa, P Basnet, M Ohsugi, T Hozumi, S Kadota, T Namba, T Kawana, K Shiraki. Anti-herpes simplex virus activity of moronic acid purified from Rhus javanica in vitro and in vivo.
The Journal of pharmacology and experimental therapeutics.
1999 Apr; 289(1):72-8. doi:
"
. [PMID: 10086989]