Ganoderic acid D (BioDeep_00000264961)

Main id: BioDeep_00000230374

 

natural product PANOMIX_OTCML-2023


代谢物信息卡片


7beta,12alpha-Dihydroxy-3,11,23-tetraoxo-5alpha-lanost-8-en-26-oic acid

化学式: C30H42O7 (514.2930382)
中文名称: 灵芝酸 D
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(=O)C([C@H]2[C@](C1)(C1=C([C@H](C2)O)[C@]2([C@@](CC1=O)(C)[C@H](CC2=O)[C@H](C)CC(=O)C[C@H](C(=O)O)C)C)C)(C)C
InChI: InChI=1S/C30H42O7/c1-15(10-17(31)11-16(2)26(36)37)18-12-23(35)30(7)25-19(32)13-21-27(3,4)22(34)8-9-28(21,5)24(25)20(33)14-29(18,30)6/h15-16,18-19,21,32H,8-14H2,1-7H3,(H,36,37)/t15-,16-,18-,19+,21+,28+,29-,30+/m1/s1

描述信息

Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells[1]. Ganoderic acid D induces HeLa human cervical carcinoma apoptosis[2].
Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells[1]. Ganoderic acid D induces HeLa human cervical carcinoma apoptosis[2].
Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells[1]. Ganoderic acid D induces HeLa human cervical carcinoma apoptosis[2].

同义名列表

3 个代谢物同义名

Ganoderic acid D; Ganoderic-acid-D; 7beta,12alpha-Dihydroxy-3,11,23-tetraoxo-5alpha-lanost-8-en-26-oic acid



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Chun-Ru Cheng, Min Yang, Shu-Hong Guan, Xiao-Hui Wu, Xiao-Yan Pang, Yang Wang, Yi Yang, Jie Ding, De-An Guo. Pharmacokinetics of ganoderic acid D and its main metabolite by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2013 Jul; 930(?):1-6. doi: 10.1016/j.jchromb.2013.04.015. [PMID: 23692850]
  • Chunru Cheng, Min Yang, Kate Yu, Shuhong Guan, Sijia Tao, Alan Millar, Xiaoyan Pang, Dean Guo. Identification of metabolites of ganoderic acid D by ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2307-14. doi: 10.1124/dmd.112.047506. [PMID: 22942320]
  • Ichiko Miyamoto, Jie Liu, Kuniyoshi Shimizu, Masao Sato, Akiko Kukita, Toshio Kukita, Ryuichiro Kondo. Regulation of osteoclastogenesis by ganoderic acid DM isolated from Ganoderma lucidum. European journal of pharmacology. 2009 Jan; 602(1):1-7. doi: 10.1016/j.ejphar.2008.11.005. [PMID: 19026632]
  • Qing-Xi Yue, Zhi-Wei Cao, Shu-Hong Guan, Xiao-Hui Liu, Lin Tao, Wan-Ying Wu, Yi-Xue Li, Peng-Yuan Yang, Xuan Liu, De-An Guo. Proteomics characterization of the cytotoxicity mechanism of ganoderic acid D and computer-automated estimation of the possible drug target network. Molecular & cellular proteomics : MCP. 2008 May; 7(5):949-61. doi: 10.1074/mcp.m700259-mcp200. [PMID: 18166740]