bleomycin A5 (BioDeep_00000262042)
PANOMIX_OTCML-2023 Chemicals and Drugs Antibiotics
代谢物信息卡片
Pingyangmycin
化学式: C57H89N19O21S2 (1439.5921544000003)
中文名称: 对甲苯磺酸正丙酯
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O)OC4C(C(C(C(O4)CO)O)OC(=O)N)O)C(=O)NC(C)C(C(C)C(=O)NC(C(C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCCNCCCCN)O
InChI: InChI=1S/C57H89N19O21S2/c1-22-35(73-48(76-46(22)61)27(14-33(60)80)68-15-26(59)47(62)86)52(90)75-37(43(28-16-65-21-69-28)95-56-45(41(84)39(82)31(17-77)94-56)96-55-42(85)44(97-57(63)92)40(83)32(18-78)93-55)53(91)70-24(3)38(81)23(2)49(87)74-36(25(4)79)51(89)67-13-8-34-71-30(20-98-34)54-72-29(19-99-54)50(88)66-12-7-11-64-10-6-5-9-58/h16,19-21,23-27,31-32,36-45,55-56,64,68,77-79,81-85H,5-15,17-18,58-59H2,1-4H3,(H2,60,80)(H2,62,86)(H2,63,92)(H,65,69)(H,66,88)(H,67,89)(H,70,91)(H,74,87)(H,75,90)(H2,61,73,76)
描述信息
A member of the class of bleomycins that is used in sclerotherapy for cervicofacial lymphatic malformations.
D000970 - Antineoplastic Agents
Bleomycin A5 (Pingyangmycin) is an orally active glycopeptide antibiotics. Bleomycin A5 has a role as an antineoplastic agent, an apoptosis inducer and a bacterial metabolite[1][2].
同义名列表
2 个代谢物同义名
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:78160
- PubChem: 10057320
- PubChem: 84046
- ChEMBL: CHEMBL2002141
- KNApSAcK: C00027949
- CAS: 11116-32-8
- PMhub: MS000247718
- MetaboLights: MTBLC78160
- medchemexpress: HY-N10470
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xian-Zh Lin, Hao Hu, Xu Zhao, Yu-X Qian, Hui Wang, Hua Jiang, Lie Zhu. Animal experimental research of intralesional bleomycin and pingyangmycin in the treatment of xanthoma.
Journal of cosmetic dermatology.
2022 Jul; 21(7):2977-2983. doi:
10.1111/jocd.14500. [PMID: 34619007] - Jin Zhang, Jing Zhang, Qin Zhang. The effects of miR-27a-3p-mediated Smurf2 on bleomycin A5-induced pulmonary fibrosis in rats.
Cellular and molecular biology (Noisy-le-Grand, France).
2020 Jun; 66(3):79-84. doi:
. [PMID: 32538751] - Ling Zhang, Fen Chen, Jiatong Zheng, Hongwei Wang, Xingjun Qin, Weisan Pan. Chitosan-based liposomal thermogels for the controlled delivery of pingyangmycin: design, optimization and in vitro and in vivo studies.
Drug delivery.
2018 Nov; 25(1):690-702. doi:
10.1080/10717544.2018.1444684. [PMID: 29484910] - Aihua Wang, Fengqiang Wang, Yingqiu Yin, Min Zhang, Ping Chen. Dexamethasone reduces serum level of IL-17 in Bleomycin-A5-induced rats model of pulmonary fibrosis.
Artificial cells, nanomedicine, and biotechnology.
2018 Jun; 46(4):783-787. doi:
10.1080/21691401.2017.1339051. [PMID: 28608724] - Lijing Liu, Huiming Yin, Minjiang Huang, Jianbin He, Gaozhong Yi, Zaiyan Wang, Hong Qian. [miR-21 promotes pulmonary fibrosis in rats via down-regulating the expression of ADAMTS-1].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology.
2016 Dec; 32(12):1636-1640. doi:
NULL. [PMID: 27916096] - Jiongming Sui, Ya Wang, Peng Wang, Lixian Qiao, Shimeng Sun, Xiaohui Hu, Jing Chen, Jingshan Wang. Generation of peanut drought tolerant plants by pingyangmycin-mediated in vitro mutagenesis and hydroxyproline-resistance screening.
PloS one.
2015; 10(3):e0119240. doi:
10.1371/journal.pone.0119240. [PMID: 25826431] - Ming-Lei Sun, Wei-Hong Xie, Chang-Mei Wang, Yu-Ming Wen. [Lymphatic targeting study of pingyangmycin-activated carbon nanoparticles treating oral cancer lymph node metastasis].
Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology.
2011 Jun; 29(3):253-6, 263. doi:
NULL. [PMID: 21776848] - Jie Qi, Yanchao Liu, Qingjun Li, Xiaoling Chen. [Effect of ginkgo biloba extract against pulmonary fibrosis and its mechanisms].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2010 Nov; 35(22):3043-7. doi:
10.4268/cjcmm20102224. [PMID: 21355279] - Wei-liang Chen, Zhi-quan Huang, Da-ming Zhang, Qiang Chai. Percutaneous sclerotherapy of massive venous malformations of the face and neck using fibrin glue combined with OK-432 and pingyangmycin.
Head & neck.
2010 Apr; 32(4):467-72. doi:
10.1002/hed.21206. [PMID: 19672870] - Monika Zochowska, Agnieszka Paca, Guy Schoehn, Jean-Pierre Andrieu, Jadwiga Chroboczek, Bernard Dublet, Ewa Szolajska. Adenovirus dodecahedron, as a drug delivery vector.
PloS one.
2009; 4(5):e5569. doi:
10.1371/journal.pone.0005569. [PMID: 19440379] - Wei-Liang Chen, Zhao-Hui Yang, Zhi-Bao Bai, Yong-Yuan Wang, Zhi-Quan Huang, Yong-Jie Wang. A pilot study on combination compartmentalisation and sclerotherapy for the treatment of massive venous malformations of the face and neck.
Journal of plastic, reconstructive & aesthetic surgery : JPRAS.
2008 Dec; 61(12):1486-92. doi:
10.1016/j.bjps.2007.10.002. [PMID: 17993298] - Rui-qin Li, Hong Xiao, Rui Zhang, Wei Li, Jian-ping Song. [Effect of gualou xiebai (GLXB) decoction on platelet-derived growth factor BB (PDGF-BB) expression in lungs from bleomycin A5 induced pulmonary fibrosis in rats].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2008 Nov; 33(22):2666-70. doi:
". [PMID: 19216168] - Changguang Wang, Jie Liu, Weisan Pan, Xinchun Wang, Qinghong Gao, Shixiang Hou. Pingyangmycin loaded bovine serum albumin microspheres for chemoembolization therapy--in vitro and in vivo studies.
International journal of pharmaceutics.
2008 Mar; 351(1-2):219-26. doi:
10.1016/j.ijpharm.2007.09.045. [PMID: 18054185] - Changhua Zhou, Wei Han, Ping Zhang, Meiying Cai, Dapeng Wei, Chongjie Zhang. Lycopene from tomatoes partially alleviates the bleomycin-induced experimental pulmonary fibrosis in rats.
Nutrition research (New York, N.Y.).
2008 Feb; 28(2):122-30. doi:
10.1016/j.nutres.2007.12.008. [PMID: 19083398] - Jiangtao Liu, Zhongfang Liu, Xiaoli Hu, Ling Kong, Shaopu Liu. Fluorescence quenching method for the determination of bleomycins A5 and A2 with halofluorescein dyes.
Luminescence : the journal of biological and chemical luminescence.
2008 Jan; 23(1):1-6. doi:
10.1002/bio.1007. [PMID: 18167058] - Changguang Wang, Jie Liu, Qinghong Gao, Yueqi Bi, Liangchun Gan, Xinchun Wang, Shixiang Hou. Preparation and characterization of Pingyangmycin-loaded bovine serum albumin microspheres for embolization therapy.
International journal of pharmaceutics.
2007 May; 336(2):361-6. doi:
10.1016/j.ijpharm.2007.02.013. [PMID: 17360133] - Jiangtao Liu, Zhongfang Liu, Xiaoli Hu, Ling Kong, Shaopu Liu. A highly sensitive resonance Rayleigh scattering method for the determination of bleomycinA5 and bleomycinA2 with some halofluorescein dyes.
Journal of pharmaceutical and biomedical analysis.
2007 Mar; 43(4):1452-9. doi:
10.1016/j.jpba.2006.11.024. [PMID: 17174057] - Z B Gao, P T Ding, H Xu, L Zhang, J Wei, D W Chen. The determination of in vitro pingyangmycin hydrochloride plasma protein binding by microdialysis.
Die Pharmazie.
2007 Feb; 62(2):115-6. doi:
NULL. [PMID: 17341030] - Y-C Ho, K-W Tai, Y-C Chang. Synergistic effects of verapamil on pingyangmycin-induced cytotoxicity and apoptosis in KB cells.
Oral diseases.
2007 Jan; 13(1):40-4. doi:
10.1111/j.1601-0825.2006.01242.x. [PMID: 17241428] - J R Spermon, L Ramos, A M M Wetzels, C G J Sweep, D D M Braat, L A L M Kiemeney, J A Witjes. Sperm integrity pre- and post-chemotherapy in men with testicular germ cell cancer.
Human reproduction (Oxford, England).
2006 Jul; 21(7):1781-6. doi:
10.1093/humrep/del084. [PMID: 16601009] - Reinhold Schmidt, Clemens Ruppert, Philipp Markart, Norbert Lübke, Leander Ermert, Norbert Weissmann, Andreas Breithecker, Monika Ermert, Werner Seeger, Andreas Günther. Changes in pulmonary surfactant function and composition in bleomycin-induced pneumonitis and fibrosis.
Toxicology and applied pharmacology.
2004 Mar; 195(2):218-31. doi:
10.1016/j.taap.2003.11.011. [PMID: 14998687] - Dong-wei Zhang, Ji-feng Wang, Jian-zhao Niu, Mei-juan Yang, Ling-qiao Wang, Huan Jin, Lian-qi Liu, Bao-hua Gao. [Influence of compound biejia ruangan prescription on extracelluar matrix in bleomycin induced pulmonary fibrosis rats].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2004 Jan; 29(1):62-6. doi:
NULL. [PMID: 15709386] - Xiao-Ling Chen, Wen-Bin Li, Ai-Min Zhou, Jie Ai, Shan-Sheng Huang. Role of endogenous peroxynitrite in pulmonary injury and fibrosis induced by bleomycin A5 in rats.
Acta pharmacologica Sinica.
2003 Jul; 24(7):697-702. doi:
". [PMID: 12852838] - A Serrano-Mollar, D Closa, N Prats, S Blesa, M Martinez-Losa, J Cortijo, J M Estrela, E J Morcillo, O Bulbena. In vivo antioxidant treatment protects against bleomycin-induced lung damage in rats.
British journal of pharmacology.
2003 Mar; 138(6):1037-48. doi:
10.1038/sj.bjp.0705138. [PMID: 12684259] - L Zhao, M Zhao, Q Fang. [Spironolactone ameliorates rat pulmonary fibrosis induced by bleomycin A5].
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases.
1998 May; 21(5):300-2. doi:
NULL. [PMID: 11326957] - C M Wang, Q Z He, R X Zhang. [Effects of tanshionone to bleomycin induced pulmonary fibrosis of rats on histological changes and production of lipid peroxides and hydroxyproline].
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases.
1994 Oct; 17(5):308-10, 320. doi:
". [PMID: 7536136] - G A Tikhomirov, V M Bukhman, M M Prigozhina, S T Filippos'iants. [An in vivo experiment on the antitumor action of bleomycin bound to an ion exchange carrier].
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic].
1994 Aug; 39(8):27-9. doi:
NULL. [PMID: 7535042] - Y E Zhang, Z D Xu, X H Wang. [Dynamic changes in extracellular matrix and related interstitial cells in experimental organ sclerosis].
Zhonghua bing li xue za zhi = Chinese journal of pathology.
1994 Apr; 23(2):111-4. doi:
NULL. [PMID: 7521799] - I E Matkhanov, Galanova YuV, E I Voschinnikov, A I Archakov. Cytotoxic effect of free bleomycin A5-iron (II) complex and its conjugates with concanavalin A, insulin and calcitonin on mouse thymocytes.
Biochemical and biophysical research communications.
1993 Nov; 197(1):85-91. doi:
10.1006/bbrc.1993.2444. [PMID: 7504486] - X Z Wang. [The role of oxygen radicals in bleomycin-induced pulmonary fibrosis].
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases.
1992 Jun; 15(3):158-60, 191. doi:
NULL. [PMID: 1282089] - F S Tadzhiev, L N Danilov, E S Lebedeva, N A Panichev, M Sou. [Content of trace elements and steroid hormones in blood and tissues of internal organs in experimental pulmonary fibrosis induced by intratracheal administration of bleomycetin].
Patologicheskaia fiziologiia i eksperimental'naia terapiia.
1992 May; ?(3):5-7. doi:
NULL. [PMID: 1282698] - X Y Chen. [Protective effect of dan-shen on bleomycin A5-induced lung fibrosis in mice].
Zhong yao tong bao (Beijing, China : 1981).
1987 Feb; 12(2):46-8. doi:
". [PMID: 2440598] - V M Petriev, A E Vatin, R M Prusova, P P Filatov, D G Khachirov. [57Co-bleomycetin pharmacokinetics in the body of mice with LIO-1 lymphosarcoma].
Antibiotiki.
1982 Aug; 27(8):623-6. doi:
NULL. [PMID: 6181732]