Antipain (BioDeep_00000260924)

   

natural product


代谢物信息卡片


Antipain (dihydrochloride)

化学式: C27H44N10O6 (604.3445)
中文名称: 抗痛素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)C(C(=O)NC(CCCN=C(N)N)C=O)NC(=O)C(CCCN=C(N)N)NC(=O)NC(CC1=CC=CC=C1)C(=O)O
InChI: InChI=1S/C27H44N10O6/c1-16(2)21(23(40)34-18(15-38)10-6-12-32-25(28)29)37-22(39)19(11-7-13-33-26(30)31)35-27(43)36-20(24(41)42)14-17-8-4-3-5-9-17/h3-5,8-9,15-16,18-21H,6-7,10-14H2,1-2H3,(H,34,40)(H,37,39)(H,41,42)(H4,28,29,32)(H4,30,31,33)(H2,35,36,43)

描述信息

D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors

同义名列表

2 个代谢物同义名

Antipain (dihydrochloride); Antipain



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Daniela Volonte, Morgan Sedorovitz, Victoria E Cespedes, Maria L Beecher, Ferruccio Galbiati. Cell autonomous angiotensin II signaling controls the pleiotropic functions of oncogenic K-Ras. The Journal of biological chemistry. 2021 Jan; 296(?):100242. doi: 10.1074/jbc.ra120.015188. [PMID: 33380422]
  • Alfredo Bottone, Antonietta Cerulli, Gilda DʼUrso, Milena Masullo, Paola Montoro, Assunta Napolitano, Sonia Piacente. Plant Specialized Metabolites in Hazelnut (Corylus avellana) Kernel and Byproducts: An Update on Chemistry, Biological Activity, and Analytical Aspects. Planta medica. 2019 Aug; 85(11-12):840-855. doi: 10.1055/a-0947-5725. [PMID: 31250412]
  • João Victor da Silva E Silva, Heliton Patrick Cordovil Brigido, Kelly Cristina Oliveira de Albuquerque, Josiwander Miranda Carvalho, Jordano Ferreira Reis, Lara Vinhal Faria, Márlia Coelho-Ferreira, Fernando Tobias Silveira, Agnaldo da Silva Carneiro, Sandro Percário, Andrey Moacir do Rosário Marinho, Maria Fâni Dolabela. Flavopereirine-An Alkaloid Derived from Geissospermum vellosii-Presents Leishmanicidal Activity In Vitro. Molecules (Basel, Switzerland). 2019 Feb; 24(4):. doi: 10.3390/molecules24040785. [PMID: 30795632]
  • Michio Iwaoka, Arisa Katakura, Jun Mishima, Yoshimi Ishihara, Amit Kunwar, Kavirayani Indira Priyadarsini. Mimicking the lipid peroxidation inhibitory activity of phospholipid hydroperoxide glutathione peroxidase (GPx4) by using fatty acid conjugates of a water-soluble selenolane. Molecules (Basel, Switzerland). 2015 Jul; 20(7):12364-75. doi: 10.3390/molecules200712364. [PMID: 26198222]
  • Franklin Souza-Silva, Saulo Cabral Bourguignon, Bernardo Acácio Santini Pereira, Luzia Monteiro de Castro Côrtes, Luiz Filipe Gonçalves de Oliveira, Andrea Henriques-Pons, Lea Cysne Finkelstein, Vitor Francisco Ferreira, Paula Fernandes Carneiro, Rosa Teixeira de Pinho, Ernesto Raul Caffarena, Carlos Roberto Alves. Epoxy-α-lapachone has in vitro and in vivo anti-leishmania (Leishmania) amazonensis effects and inhibits serine proteinase activity in this parasite. Antimicrobial agents and chemotherapy. 2015 Apr; 59(4):1910-8. doi: 10.1128/aac.04742-14. [PMID: 25583728]
  • Maksim Ionov, Nataliya V Gordiyenko, Izabela Zukowska, Elmira Tokhtaeva, Olga A Mareninova, Nina Baram, Khairulla Ziyaev, Kuralbay Rezhepov, Maria Zamaraeva. Stability and antioxidant activity of gossypol derivative immobilized on N-polyvinylpyrrolidone. International journal of biological macromolecules. 2012 Dec; 51(5):908-14. doi: 10.1016/j.ijbiomac.2012.08.005. [PMID: 22910577]
  • Anisuzzaman, M Khyrul Islam, M Abdul Alim, Takeharu Miyoshi, Takeshi Hatta, Kayoko Yamaji, Yasunobu Matsumoto, Kozo Fujisaki, Naotoshi Tsuji. Longistatin is an unconventional serine protease and induces protective immunity against tick infestation. Molecular and biochemical parasitology. 2012 Mar; 182(1-2):45-53. doi: 10.1016/j.molbiopara.2011.12.002. [PMID: 22206819]
  • Keisuke Takeuchi, Tomohisa Sakaue, Yoshio Yamamoto, Katsuji Nishi, Iwao Ohkubo. Shedding of gACE from residual body membrane of rat sperm. Legal medicine (Tokyo, Japan). 2009 Apr; 11 Suppl 1(?):S309-10. doi: 10.1016/j.legalmed.2009.02.074. [PMID: 19375970]
  • Zheming Wang, Christian Gu, Tom Colby, Takayuki Shindo, Rengarajan Balamurugan, Herbert Waldmann, Markus Kaiser, Renier A L van der Hoorn. Beta-lactone probes identify a papain-like peptide ligase in Arabidopsis thaliana. Nature chemical biology. 2008 Sep; 4(9):557-63. doi: 10.1038/nchembio.104. [PMID: 18660805]
  • W F Kean, K D Rainsford, I R L Kean. Management of chronic musculoskeletal pain in the elderly: opinions on oral medication use. Inflammopharmacology. 2008 Apr; 16(2):53-75. doi: 10.1007/s10787-008-1623-7. [PMID: 18389178]
  • André L S Santos, Claudia M d'Avila-Levy, Felipe A Dias, Rachel O Ribeiro, Fernanda M Pereira, Camila G R Elias, Thaïs Souto-Padrón, Angela H C S Lopes, Celuta S Alviano, Marta H Branquinha, Rosangela M A Soares. Phytomonas serpens: cysteine peptidase inhibitors interfere with growth, ultrastructure and host adhesion. International journal for parasitology. 2006 Jan; 36(1):47-56. doi: 10.1016/j.ijpara.2005.09.004. [PMID: 16310789]
  • Alexander Belenky, Andrew Smith, Bin Zhang, Spencer Lin, Normand Despres, Alan H B Wu, Barry I Bluestein. The effect of class-specific protease inhibitors on the stabilization of B-type natriuretic peptide in human plasma. Clinica chimica acta; international journal of clinical chemistry. 2004 Feb; 340(1-2):163-72. doi: 10.1016/j.cccn.2003.10.026. [PMID: 14734208]
  • Malay Mandai, Sudip Das, Tapati Chakraborti, Sajal Chakraborti. Matrix metalloprotease 2-mediated activation of Ca(2+)-ATPase by superoxide radical (O2*-) in plasma membrane of bovine pulmonary vascular smooth muscle. Indian journal of biochemistry & biophysics. 2002 Dec; 39(6):390-6. doi: . [PMID: 22905396]
  • Claudia R Moreira, Alvin H Schmaier, Fakhri Mahdi, Guacyara da Motta, Helena B Nader, Zia Shariat-Madar. Identification of prolylcarboxypeptidase as the cell matrix-associated prekallikrein activator. FEBS letters. 2002 Jul; 523(1-3):167-70. doi: 10.1016/s0014-5793(02)02980-0. [PMID: 12123826]
  • Y Zhao, Q Qiu, F Mahdi, Z Shariat-Madar, R Røjkjaer, A H Schmaier. Assembly and activation of HK-PK complex on endothelial cells results in bradykinin liberation and NO formation. American journal of physiology. Heart and circulatory physiology. 2001 Apr; 280(4):H1821-9. doi: 10.1152/ajpheart.2001.280.4.h1821. [PMID: 11247797]
  • H Wan, H L Winton, C Soeller, E R Tovey, D C Gruenert, P J Thompson, G A Stewart, G W Taylor, D R Garrod, M B Cannell, C Robinson. Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions. The Journal of clinical investigation. 1999 Jul; 104(1):123-33. doi: 10.1172/jci5844. [PMID: 10393706]
  • V M Gordon, R Benz, K Fujii, S H Leppla, R K Tweten. Clostridium septicum alpha-toxin is proteolytically activated by furin. Infection and immunity. 1997 Oct; 65(10):4130-4. doi: 10.1128/iai.65.10.4130-4134.1997. [PMID: 9317018]
  • X Yang, R G Schnellmann. Proteinases in renal cell death. Journal of toxicology and environmental health. 1996 Jul; 48(4):319-32. doi: 10.1080/009841096161221. [PMID: 8691504]
  • B A Fritz, A W Lowe. Polarized GP2 secretion in MDCK cells via GPI targeting and apical membrane-restricted proteolysis. The American journal of physiology. 1996 Jan; 270(1 Pt 1):G176-83. doi: 10.1152/ajpgi.1996.270.1.g176. [PMID: 8772516]
  • N Arakaki, S Kawakami, O Nakamura, T Ohnishi, H Miyazaki, T Ishii, H Tsubouchi, Y Daikuhara. Evidence for the presence of an inactive precursor of human hepatocyte growth factor in plasma and sera of patients with liver diseases. Hepatology (Baltimore, Md.). 1995 Dec; 22(6):1728-34. doi: NULL. [PMID: 7489981]
  • H Aoki, T Akaike, K Abe, M Kuroda, S Arai, R Okamura, A Negi, H Maeda. Antiviral effect of oryzacystatin, a proteinase inhibitor in rice, against herpes simplex virus type 1 in vitro and in vivo. Antimicrobial agents and chemotherapy. 1995 Apr; 39(4):846-9. doi: 10.1128/aac.39.4.846. [PMID: 7785982]
  • S J Duthie, W T Melvin, M D Burke. Bromobenzene detoxification in the human liver-derived HepG2 cell line. Xenobiotica; the fate of foreign compounds in biological systems. 1994 Mar; 24(3):265-79. doi: 10.3109/00498259409043238. [PMID: 8009889]
  • K A Elliget, P C Phelps, B F Trump. Cytosolic Ca2+ elevation and calpain inhibitors in HgCl2 injury to rat kidney proximal tubule epithelial cells. Pathobiology : journal of immunopathology, molecular and cellular biology. 1994; 62(5-6):298-310. doi: 10.1159/000163923. [PMID: 7598799]
  • I Virgin, A H Salter, D F Ghanotakis, B Andersson. Light-induced D1 protein degradation is catalyzed by a serine-type protease. FEBS letters. 1991 Aug; 287(1-2):125-8. doi: 10.1016/0014-5793(91)80031-w. [PMID: 1715282]
  • M L Davenport, D R Clemmons, M V Miles, C Camacho-Hubner, A J D'Ercole, L E Underwood. Regulation of serum insulin-like growth factor-I (IGF-I) and IGF binding proteins during rat pregnancy. Endocrinology. 1990 Sep; 127(3):1278-86. doi: 10.1210/endo-127-3-1278. [PMID: 1696882]
  • M Caggana, A R Kennedy. c-fos mRNA levels are reduced in the presence of antipain and Bowman-Birk inhibitor. Carcinogenesis. 1989 Nov; 10(11):2145-8. doi: 10.1093/carcin/10.11.2145. [PMID: 2509094]
  • J D Chang, A R Kennedy. Cell cycle progression of C3H 10T1/2 and 3T3 cells in the absence of an increase in c-myc RNA levels. Carcinogenesis. 1988 Jan; 9(1):17-20. doi: 10.1093/carcin/9.1.17. [PMID: 2446795]
  • M L Scott, P K Phillips. Sensitive two-stage papain technique without cell washing. Vox sanguinis. 1987; 52(1-2):67-70. doi: 10.1111/j.1423-0410.1987.tb02992.x. [PMID: 3604169]
  • W H Gibson, S L Burack, A Picciano. The effects of serine protease inhibitors on morphological differentiation of murine neuroblastoma cells (NB15). Journal of cellular physiology. 1984 Apr; 119(1):119-26. doi: 10.1002/jcp.1041190119. [PMID: 6323488]
  • D R Clemmons, L E Underwood, P G Chatelain, J J Van Wyk. Liberation of immunoreactive somatomedin-C from its binding proteins by proteolytic enzymes and heparin. The Journal of clinical endocrinology and metabolism. 1983 Feb; 56(2):384-9. doi: 10.1210/jcem-56-2-384. [PMID: 6185523]
  • V S Ohl, M Mayer, B C Sekula, G Litwack. Receptor properties of corticosteroid binder IB. Archives of biochemistry and biophysics. 1982 Aug; 217(1):162-73. doi: 10.1016/0003-9861(82)90490-8. [PMID: 6215001]
  • J Hermon-Taylor, A I Magee, D A Grant, P A Jones, C E Marshall, J Dunham. Cleavage of peptide hormones by alpha 2-macroglobulin-trypsin complex and its relation to the pathogenesis and chemotherapy of acute pancreatitis. Clinica chimica acta; international journal of clinical chemistry. 1981 Jan; 109(2):203-9. doi: 10.1016/0009-8981(81)90335-1. [PMID: 6162593]
  • K B Hellman, A Hellman. Induction of type-C retrovirus by the tumor promotor TPA. International journal of cancer. 1981 Jan; 27(1):95-9. doi: 10.1002/ijc.2910270115. [PMID: 6265387]
  • N T Neff, G N DeMartino, A L Goldberg. The effect of protease inhibitors and decreased temperature on the degradation of different classes of proteins in cultured hepatocytes. Journal of cellular physiology. 1979 Dec; 101(3):439-57. doi: 10.1002/jcp.1041010311. [PMID: 528571]
  • I D Algranati, D D Sabatini. Effect of protease inhibitors on albumin secretion in hepatoma cells. Biochemical and biophysical research communications. 1979 Sep; 90(1):220-6. doi: 10.1016/0006-291x(79)91613-9. [PMID: 496972]