Antrafenine (BioDeep_00000026034)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


2-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}ethyl 2-{[7-(trifluoromethyl)quinolin-4-yl]amino}benzoate

化学式: C30H26F6N4O2 (588.1959848)
中文名称: 安曲非宁
谱图信息: 最多检出来源 Mentha canadensis(plant) 50%

分子结构信息

SMILES: c1ccc(c(c1)C(=O)OCCN1CCN(CC1)c1cccc(c1)C(F)(F)F)Nc1ccnc2cc(ccc12)C(F)(F)F
InChI: InChI=1S/C30H26F6N4O2/c31-29(32,33)20-4-3-5-22(18-20)40-14-12-39(13-15-40)16-17-42-28(41)24-6-1-2-7-25(24)38-26-10-11-37-27-19-21(30(34,35)36)8-9-23(26)27/h1-11,18-19H,12-17H2,(H,37,38)

描述信息

Antrafenine is only found in individuals that have used or taken this drug. It is a piperazine derivative drug that acts as an analgesic and anti-inflammatory drug with similar efficacy to naproxen. It is not widely used as it has largely been replaced by newer drugs.Antrafenine is believed to be associated with the inhibition of cyclooxygenase activity. Two unique cyclooxygenases have been described in mammals. The constitutive cyclooxygenase, COX-1, synthesizes prostaglandins necessary for normal gastrointestinal and renal function. The inducible cyclooxygenase, COX-2, generates prostaglandins involved in inflammation. Inhibition of COX-1 is thought to be associated with gastrointestinal and renal toxicity while inhibition of COX-2 provides anti-inflammatory activity.
C78272 - Agent Affecting Nervous System > C245 - Anesthetic Agent

同义名列表

5 个代谢物同义名

2-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}ethyl 2-{[7-(trifluoromethyl)quinolin-4-yl]amino}benzoate; 2-(4-(m-Trifluoromethyl-phenyl)-1-piperazinyl)ethyl 2-(7-trifluoromethyl-4-quinolinylamino)benzoate; Antrafenine dihydrochloride; Antrafenine; Stakane



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • G Nicot, L Merle, J P Coquelin, J P Valette, G Lachatre. [Proteins and urinary enzymes following administration of antrafenine in healthy volunteers]. Therapie. 1983 Jul; 38(4):379-86. doi: NULL. [PMID: 6648882]
  • S M Hassan, A Olivesi, A Fish, P Turner. A comparison of antrafenine and aspirin on platelet aggregation and frusemide-induced diuresis. Postgraduate medical journal. 1982 Jan; 58(675):17-9. doi: 10.1136/pgmj.58.675.17. [PMID: 7088753]
  • C Bressot, M Dechavanne, D Ville, P J Meunier. [Analgesic effect and fecal blood loss induced by antrafenine. A double-blind comparison with aspirin]. Revue du rhumatisme et des maladies osteo-articulaires. 1981 Jul; 48(7-9):601-4. doi: NULL. [PMID: 7027425]
  • P R Guinebault, M Broquaire, M Sanjuan, V Rovei, R A Braithwaite. Determination of antrafenine and its main acid metabolite, 2-{[7-(trifluoromethyl)-4-quinolinyl]amino}-benzoic acid, in biological fluids using high-performance liquid chromatography with large volume automatic injection and gas-liquid chromatography with derivative formation. Journal of chromatography. 1981 Apr; 223(1):103-10. doi: 10.1016/s0378-4347(00)80072-9. [PMID: 7251752]
  • V Rovei, A Leroy, J P Sauvanet, R Braithwaite, J P Coquelin, R Gomeni, P L Morselli, J P Fillastre. [Comparative pharmacokinetics of antrafenine in healthy volunteers and in patients with chronic renal failure (author's transl)]. Therapie. 1981 Jan; 36(1):21-6. doi: NULL. [PMID: 7233368]
  • H L Boiteau, A Prost, F Rossel-Renac, M Audran, J P Hamelin, N Carlier. [Ionized fluorine in the plasma and urine of subjects treated with organofluorine drugs prescribed in rheumatology]. Revue du rhumatisme et des maladies osteo-articulaires. 1979 Feb; 46(2):123-32. doi: NULL. [PMID: 34870]