K252b (BioDeep_00000258019)
代谢物信息卡片
16-Hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8,10,12,20,22,24,26-nonaene-16-carboxylic acid
化学式: C26H19N3O5 (453.13246440000006)
中文名称: K-252B
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC12C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)O)O
InChI: InChI=1S/C26H19N3O5/c1-25-26(33,24(31)32)10-17(34-25)28-15-8-4-2-6-12(15)19-20-14(11-27-23(20)30)18-13-7-3-5-9-16(13)29(25)22(18)21(19)28/h2-9,17,33H,10-11H2,1H3,(H,27,30)(H,31,32)
描述信息
D004791 - Enzyme Inhibitors
同义名列表
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Noritaka Nakamichi, Shunsuke Nakao, Misa Nishiyama, Yuka Takeda, Takahiro Ishimoto, Yusuke Masuo, Satoshi Matsumoto, Makoto Suzuki, Yukio Kato. Oral Administration of the Food-Derived Hydrophilic Antioxidant Ergothioneine Enhances Object Recognition Memory in Mice.
Current molecular pharmacology.
2021; 14(2):220-233. doi:
10.2174/1874467213666200212102710. [PMID: 32048982] - Liz G Müller, Caroline Biojone, Amanda J Sales, Andresa H Betti, Vivian Herzfeldt, Sâmia R L Joca, Stela M K Rates. A valepotriate-enriched fraction from Valeriana glechomifolia decreases DNA methylation and up-regulate TrkB receptors in the hippocampus of mice.
Behavioural pharmacology.
2020 06; 31(4):333-342. doi:
10.1097/fbp.0000000000000534. [PMID: 31860564] - Julieta Saba, Juan Turati, Delia Ramírez, Lila Carniglia, Daniela Durand, Mercedes Lasaga, Carla Caruso. Astrocyte truncated tropomyosin receptor kinase B mediates brain-derived neurotrophic factor anti-apoptotic effect leading to neuroprotection.
Journal of neurochemistry.
2018 09; 146(6):686-702. doi:
10.1111/jnc.14476. [PMID: 29851427] - Yu-Fei Ni, Hao Wang, Qiu-Yan Gu, Fei-Ying Wang, Ying-Jie Wang, Jin-Liang Wang, Bo Jiang. Gemfibrozil has antidepressant effects in mice: Involvement of the hippocampal brain-derived neurotrophic factor system.
Journal of psychopharmacology (Oxford, England).
2018 04; 32(4):469-481. doi:
10.1177/0269881118762072. [PMID: 29534628] - Seigo Usuki, Noriko Tamura, Kohei Yuyama, Tomohiro Tamura, Katsuyuki Mukai, Yasuyuki Igarashi. Konjac Ceramide (kCer) Regulates NGF-Induced Neurite Outgrowth via the Sema3A Signaling Pathway.
Journal of oleo science.
2018 Jan; 67(1):77-86. doi:
10.5650/jos.ess17141. [PMID: 29238028] - Yeli Gong, Youhua Yang, Xiaoqing Chen, Min Yang, Dan Huang, Rong Yang, Lianying Zhou, Changlei Li, Qiuju Xiong, Zhe Xiong. Hyperoside protects against chronic mild stress-induced learning and memory deficits.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 Jul; 91(?):831-840. doi:
10.1016/j.biopha.2017.05.019. [PMID: 28501772] - Min-Wang Zhang, She-Feng Zhang, Zhen-Hua Li, Fang Han. 7,8-Dihydroxyflavone reverses the depressive symptoms in mouse chronic mild stress.
Neuroscience letters.
2016 Dec; 635(?):33-38. doi:
10.1016/j.neulet.2016.10.035. [PMID: 27773794] - Fan Xiao, Ping Zhang, Ai-Hua Chen, Chun-Yan Wang, Wei Zou, Hong-Feng Gu, Xiao-Qing Tang. Hydrogen sulfide inhibits MPP+-induced aldehyde stress and endoplasmic reticulum stress in PC12 cells: involving upregulation of BDNF.
Experimental cell research.
2016 Oct; 348(1):106-114. doi:
10.1016/j.yexcr.2016.09.006. [PMID: 27641114] - Rong-Hao Mu, Xiao-Yan Fang, Shuang-Shuang Wang, Cheng-Fu Li, Shao-Mei Chen, Xue-Mei Chen, Qing Liu, Yu-Cheng Li, Li-Tao Yi. Antidepressant-like effects of standardized gypenosides: involvement of brain-derived neurotrophic factor signaling in hippocampus.
Psychopharmacology.
2016 Sep; 233(17):3211-21. doi:
10.1007/s00213-016-4357-z. [PMID: 27385417] - Ouissame Mnie-Filali, Thorsten Lau, Friederike Matthaeus, Erika Abrial, Sarah Delcourte, Mostafa El Mansari, Alan Pershon, Patrick Schloss, Connie Sánchez, Nasser Haddjeri. Protein Kinases Alter the Allosteric Modulation of the Serotonin Transporter In Vivo and In Vitro.
CNS neuroscience & therapeutics.
2016 08; 22(8):691-9. doi:
10.1111/cns.12562. [PMID: 27171685] - Miguel A De la Cruz-Morcillo, Julien Berger, Ricardo Sánchez-Prieto, Sofiane Saada, Thomas Naves, Angélique Guillaudeau, Aurélie Perraud, Philippe Sindou, Aurélie Lacroix, Aurélien Descazeaud, Fabrice Lalloué, Marie-Odile Jauberteau. p75 neurotrophin receptor and pro-BDNF promote cell survival and migration in clear cell renal cell carcinoma.
Oncotarget.
2016 Jun; 7(23):34480-97. doi:
10.18632/oncotarget.8911. [PMID: 27120782] - Atsushi Takemiya, Ayaka Doi, Sayumi Yoshida, Koji Okajima, Satoru Tokutomi, Ken-Ichiro Shimazaki. Reconstitution of an Initial Step of Phototropin Signaling in Stomatal Guard Cells.
Plant & cell physiology.
2016 Jan; 57(1):152-9. doi:
10.1093/pcp/pcv180. [PMID: 26707730] - Hai Thi Do, Céline Bruelle, Dan Duc Pham, Matti Jauhiainen, Ove Eriksson, Laura T Korhonen, Dan Lindholm. Nerve growth factor (NGF) and pro-NGF increase low-density lipoprotein (LDL) receptors in neuronal cells partly by different mechanisms: role of LDL in neurite outgrowth.
Journal of neurochemistry.
2016 Jan; 136(2):306-15. doi:
10.1111/jnc.13397. [PMID: 26484803] - Ping He, Beiru Zhang, Dajun Liu, Xiaohui Bian, Detian Li, Yanqiu Wang, Guangping Sun, Guangyu Zhou. Hepatitis B Virus X Protein Modulates Apoptosis in NRK-52E Cells and Activates Fas/FasL Through the MLK3-MKK7-JNK3 Signaling Pathway.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2016; 39(4):1433-43. doi:
10.1159/000447846. [PMID: 27606894] - Tatsuo Hata, Naoaki Sakata, Gumpei Yoshimatsu, Haruyuki Tsuchiya, Masahiko Fukase, Masaharu Ishida, Takeshi Aoki, Yu Katayose, Shinichi Egawa, Michiaki Unno. Nerve Growth Factor Improves Survival and Function of Transplanted Islets Via TrkA-mediated β Cell Proliferation and Revascularization.
Transplantation.
2015 Jun; 99(6):1132-43. doi:
10.1097/tp.0000000000000655. [PMID: 25806408] - Sheng-Quan Hu, Wei Cui, Shing-Hung Mak, Chung-Lit Choi, Yuan-Jia Hu, Gang Li, Karl Wah-Keung Tsim, Yuan-Ping Pang, Yi-Fan Han. Robust Neuritogenesis-Promoting Activity by Bis(heptyl)-Cognitin Through the Activation of alpha7-Nicotinic Acetylcholine Receptor/ERK Pathway.
CNS neuroscience & therapeutics.
2015 Jun; 21(6):520-9. doi:
10.1111/cns.12401. [PMID: 25917415] - Peng Zhong, Yong Liu, Ying Hu, Tong Wang, Yong-ping Zhao, Qing-song Liu. BDNF interacts with endocannabinoids to regulate cocaine-induced synaptic plasticity in mouse midbrain dopamine neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2015 Mar; 35(10):4469-81. doi:
10.1523/jneurosci.2924-14.2015. [PMID: 25762688] - Yu Fukuda, Takao Fukui, Chika Hikichi, Tomomasa Ishikawa, Kenichiro Murate, Takeshi Adachi, Hideki Imai, Koki Fukuhara, Akihiro Ueda, Allen P Kaplan, Tatsuro Mutoh. Neurotropin promotes NGF signaling through interaction of GM1 ganglioside with Trk neurotrophin receptor in PC12 cells.
Brain research.
2015 Jan; 1596(?):13-21. doi:
10.1016/j.brainres.2014.11.041. [PMID: 25454796] - Xian-zhe Dong, Cui-li Huang, Bing-ying Yu, Yuan Hu, Li-hua Mu, Ping Liu. Effect of Tenuifoliside A isolated from Polygala tenuifolia on the ERK and PI3K pathways in C6 glioma cells.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2014 Sep; 21(10):1178-88. doi:
10.1016/j.phymed.2014.04.022. [PMID: 24877714] - Yonglu Meng, Nan Ma, Qian Zhang, Qi You, Na Li, Muhammad Ali Khan, Xiaojing Liu, Lin Wu, Zhen Su, Junping Gao. Precise spatio-temporal modulation of ACC synthase by MPK6 cascade mediates the response of rose flowers to rehydration.
The Plant journal : for cell and molecular biology.
2014 Sep; 79(6):941-50. doi:
10.1111/tpj.12594. [PMID: 24942184] - Kazuhiro Kawamura, Nanami Kawamura, Yuta Kawagoe, Jin Kumagai, Toshio Fujimoto, Yukihiro Terada. Suppression of hydatidiform molar growth by inhibiting endogenous brain-derived neurotrophic factor/tyrosine kinase B signaling.
Endocrinology.
2012 Aug; 153(8):3972-81. doi:
10.1210/en.2012-1167. [PMID: 22719055] - Mohammad Anowar Hossain, Shintaro Munemasa, Yoshimasa Nakamura, Izumi C Mori, Yoshiyuki Murata. K252a-sensitive protein kinases but not okadaic acid-sensitive protein phosphatases regulate methyl jasmonate-induced cytosolic Ca2+ oscillation in guard cells of Arabidopsis thaliana.
Journal of plant physiology.
2011 Nov; 168(16):1901-8. doi:
10.1016/j.jplph.2011.05.004. [PMID: 21665326] - Jana Balbuena, Gisela Pachon, Guillermo Lopez-Torrents, Josep M Aran, Javier S Castresana, Jordi Petriz. ABCG2 is required to control the sonic hedgehog pathway in side population cells with stem-like properties.
Cytometry. Part A : the journal of the International Society for Analytical Cytology.
2011 Sep; 79(9):672-83. doi:
10.1002/cyto.a.21103. [PMID: 21774076] - Hussein Akil, Aurélie Perraud, Carole Mélin, Marie-Odile Jauberteau, Muriel Mathonnet. Fine-tuning roles of endogenous brain-derived neurotrophic factor, TrkB and sortilin in colorectal cancer cell survival.
PloS one.
2011; 6(9):e25097. doi:
10.1371/journal.pone.0025097. [PMID: 21966426] - Ali Jalili, Neeta Shirvaikar, Leah A Marquez-Curtis, A Robert Turner, Anna Janowska-Wieczorek. The HGF/c-Met axis synergizes with G-CSF in the mobilization of hematopoietic stem/progenitor cells.
Stem cells and development.
2010 Aug; 19(8):1143-51. doi:
10.1089/scd.2009.0376. [PMID: 20021260] - Yuki Hayashi, Suguru Nakamura, Atsushi Takemiya, Yohei Takahashi, Ken-Ichiro Shimazaki, Toshinori Kinoshita. Biochemical characterization of in vitro phosphorylation and dephosphorylation of the plasma membrane H+-ATPase.
Plant & cell physiology.
2010 Jul; 51(7):1186-96. doi:
10.1093/pcp/pcq078. [PMID: 20516032] - Nanami Kawamura, Kazuhiro Kawamura, Motomu Manabe, Toshinobu Tanaka. Inhibition of brain-derived neurotrophic factor/tyrosine kinase B signaling suppresses choriocarcinoma cell growth.
Endocrinology.
2010 Jul; 151(7):3006-14. doi:
10.1210/en.2009-1378. [PMID: 20463055] - Toyoaki Ohbuchi, Toru Yokoyama, Takeshi Saito, Hirofumi Hashimoto, Hitoshi Suzuki, Hiroki Otsubo, Hiroaki Fujihara, Hideaki Suzuki, Yoichi Ueta. Brain-derived neurotrophic factor inhibits spontaneous inhibitory postsynaptic currents in the rat supraoptic nucleus.
Brain research.
2009 Mar; 1258(?):34-42. doi:
10.1016/j.brainres.2008.12.057. [PMID: 19150437] - Simone D Guerios, Zun-Yi Wang, Kyle Boldon, Wade Bushman, Dale E Bjorling. Blockade of NGF and trk receptors inhibits increased peripheral mechanical sensitivity accompanying cystitis in rats.
American journal of physiology. Regulatory, integrative and comparative physiology.
2008 Jul; 295(1):R111-22. doi:
10.1152/ajpregu.00728.2007. [PMID: 18448607] - Frank C Lanfermeijer, Marten Staal, Robert Malinowski, Johannes W Stratmann, J Theo M Elzenga. Micro-electrode flux estimation confirms that the Solanum pimpinellifolium cu3 mutant still responds to systemin.
Plant physiology.
2008 Jan; 146(1):129-39. doi:
10.1104/pp.107.110643. [PMID: 18055585] - Yun-Lian Lin, Yi-Chao Lee, Chuen-Lin Huang, Wen-Lin Lai, Yen-Ru Lin, Nai-Kuei Huang. Ligusticum chuanxiong prevents rat pheochromocytoma cells from serum deprivation-induced apoptosis through a protein kinase A-dependent pathway.
Journal of ethnopharmacology.
2007 Feb; 109(3):428-34. doi:
10.1016/j.jep.2006.08.012. [PMID: 16973320] - Natsumi Yamamoto, Gunay Mammadova, Robert X-D Song, Yasuo Fukami, Ken-ichi Sato. Tyrosine phosphorylation of p145met mediated by EGFR and Src is required for serum-independent survival of human bladder carcinoma cells.
Journal of cell science.
2006 Nov; 119(Pt 22):4623-33. doi:
10.1242/jcs.03236. [PMID: 17062641] - Sergei Sokolovski, Adrian Hills, Rob Gay, Carlos Garcia-Mata, Lorenzo Lamattina, Michael R Blatt. Protein phosphorylation is a prerequisite for intracellular Ca2+ release and ion channel control by nitric oxide and abscisic acid in guard cells.
The Plant journal : for cell and molecular biology.
2005 Aug; 43(4):520-9. doi:
10.1111/j.1365-313x.2005.02471.x. [PMID: 16098106] - Caterina Di Ciano-Oliveira, Monika Lodyga, Lingzhi Fan, Katalin Szászi, Hiroshi Hosoya, Ori D Rotstein, András Kapus. Is myosin light-chain phosphorylation a regulatory signal for the osmotic activation of the Na+-K+-2Cl- cotransporter?.
American journal of physiology. Cell physiology.
2005 Jul; 289(1):C68-81. doi:
10.1152/ajpcell.00631.2004. [PMID: 15728707] - Jin-Young Ahn, Lami Kang, Hyun-Jeong Kim, Hyejin Kang, Sung-Hoon Kim, Je-Yong Kim, Seung Ki Kim, Kyu-Chang Wang, Byung Kyu Cho, Kwang-Woo Lee, Jae-Kyu Roh, Manho Kim. Induction method of tyrosine kinase A-mediated cell death in rat pheochromocytoma.
Biotechnology letters.
2005 Apr; 27(8):583-7. doi:
10.1007/s10529-005-2884-5. [PMID: 15973493] - Anna Kulma, Dorthe Villadsen, David G Campbell, Sarah E M Meek, Jean E Harthill, Tom H Nielsen, Carol MacKintosh. Phosphorylation and 14-3-3 binding of Arabidopsis 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.
The Plant journal : for cell and molecular biology.
2004 Mar; 37(5):654-67. doi:
10.1111/j.1365-313x.2003.01992.x. [PMID: 14871307] - Hong Shen, Ayalew Ligaba, Mineo Yamaguchi, Hiroki Osawa, Koichi Shibata, Xiaolong Yan, Hideaki Matsumoto. Effect of K-252a and abscisic acid on the efflux of citrate from soybean roots.
Journal of experimental botany.
2004 Mar; 55(397):663-71. doi:
10.1093/jxb/erh058. [PMID: 14754917] - Aziz Aziz, Alain Heyraud, Bernard Lambert. Oligogalacturonide signal transduction, induction of defense-related responses and protection of grapevine against Botrytis cinerea.
Planta.
2004 Mar; 218(5):767-74. doi:
10.1007/s00425-003-1153-x. [PMID: 14618326] - Jing Du, Linyin Feng, Eugene Zaitsev, Hyun-Soo Je, Xu-Wen Liu, Bai Lu. Regulation of TrkB receptor tyrosine kinase and its internalization by neuronal activity and Ca2+ influx.
The Journal of cell biology.
2003 Oct; 163(2):385-95. doi:
10.1083/jcb.200305134. [PMID: 14581459] - E Yokota, T Izeki, T Shimmen. Possible involvement of energy metabolism in the change of cytoplasm organization induced by a protein phosphatase inhibitor, calyculin A, in root hair cells of Limnobium stoloniferum.
Protoplasma.
2003 Jun; 221(3-4):217-26. doi:
10.1007/s00709-002-0055-2. [PMID: 12802629] - Backil Sung, Grewo Lim, Jianren Mao. Altered expression and uptake activity of spinal glutamate transporters after nerve injury contribute to the pathogenesis of neuropathic pain in rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2003 Apr; 23(7):2899-910. doi:
10.1523/jneurosci.23-07-02899.2003. [PMID: 12684477] - Sonja Stoelzle, Takatoshi Kagawa, Masamitsu Wada, Rainer Hedrich, Petra Dietrich. Blue light activates calcium-permeable channels in Arabidopsis mesophyll cells via the phototropin signaling pathway.
Proceedings of the National Academy of Sciences of the United States of America.
2003 Feb; 100(3):1456-61. doi:
10.1073/pnas.0333408100. [PMID: 12540824] - Bing Zhang, Katrina Ramonell, Shauna Somerville, Gary Stacey. Characterization of early, chitin-induced gene expression in Arabidopsis.
Molecular plant-microbe interactions : MPMI.
2002 Sep; 15(9):963-70. doi:
10.1094/mpmi.2002.15.9.963. [PMID: 12236603] - Maki Katsuhara, Yoshiko Akiyama, Kazuki Koshio, Mineo Shibasaka, Kunihiro Kasamo. Functional analysis of water channels in barley roots.
Plant & cell physiology.
2002 Aug; 43(8):885-93. doi:
10.1093/pcp/pcf102. [PMID: 12198191] - Alessandro Morotti, Silvia Mila, Paolo Accornero, Emma Tagliabue, Carola Ponzetto. K252a inhibits the oncogenic properties of Met, the HGF receptor.
Oncogene.
2002 Jul; 21(32):4885-93. doi:
10.1038/sj.onc.1205622. [PMID: 12118367] - Yuki Fujiki, Masaki Ito, Takashi Itoh, Ikuo Nishida, Akira Watanabe. Activation of the promoters of Arabidopsis genes for the branched-chain alpha-keto acid dehydrogenase complex in transgenic tobacco BY-2 cells under sugar starvation.
Plant & cell physiology.
2002 Mar; 43(3):275-80. doi:
10.1093/pcp/pcf032. [PMID: 11917081] - Ilana Kronfeld, Gila Kazimirsky, Erwin W Gelfand, Chaya Brodie. NGF rescues human B lymphocytes from anti-IgM induced apoptosis by activation of PKCzeta.
European journal of immunology.
2002 01; 32(1):136-43. doi:
10.1002/1521-4141(200201)32:1<136::aid-immu136>3.0.co;2-t. [PMID: 11754354] - A Haapasalo, E Koponen, E Hoppe, G Wong, E Castrén. Truncated trkB.T1 is dominant negative inhibitor of trkB.TK+-mediated cell survival.
Biochemical and biophysical research communications.
2001 Feb; 280(5):1352-8. doi:
10.1006/bbrc.2001.4296. [PMID: 11162678] - C D Horton, Y Qi, D Chikaraishi, J K Wang. Neurotrophin-3 mediates the autocrine survival of the catecholaminergic CAD CNS neuronal cell line.
Journal of neurochemistry.
2001 Jan; 76(1):201-9. doi:
10.1046/j.1471-4159.2001.00017.x. [PMID: 11145993] - N Wagner, K D Wagner, M Sefton, A Rodríguez-Tébar, R Grantyn. An abnormal response of retinoblastoma cells (Y-79) to neurotrophins.
Investigative ophthalmology & visual science.
2000 Jun; 41(7):1932-9. doi:
NULL. [PMID: 10845619] - S Rhee, K H Lee, D Kim, Y K Kwon, M S Kang, H Kwon. Sustained formation of focal adhesions with paxillin in morphological differentiation of PC12 cells.
Molecules and cells.
2000 Apr; 10(2):169-79. doi:
10.1007/s10059-000-0169-3. [PMID: 10850658] - P Hassa, J Granado, E Freydl, U Wäspi, R Dudler. Syringolin-mediated activation of the Pir7b esterase gene in rice cells is suppressed by phosphatase inhibitors.
Molecular plant-microbe interactions : MPMI.
2000 Mar; 13(3):342-6. doi:
10.1094/mpmi.2000.13.3.342. [PMID: 10707360] - L Tong, K Werrbach-Perez, J R Perez-Polo. Prolonged activation of transcription factor AP-1 during NGF-mediated rescue from apoptotic cell death in PC12 cells.
Neurochemical research.
1999 Nov; 24(11):1431-41. doi:
10.1023/a:1022540925099. [PMID: 10555784] - H S Singer, B Hansen, D Martinie, C L Karp. Mitogenesis in glioblastoma multiforme cell lines: a role for NGF and its TrkA receptors.
Journal of neuro-oncology.
1999; 45(1):1-8. doi:
10.1023/a:1006323523437. [PMID: 10728904] - P M Vilalta, L Zhang, S F Hamm-Alvarez. A novel taxol-induced vimentin phosphorylation and stabilization revealed by studies on stable microtubules and vimentin intermediate filaments.
Journal of cell science.
1998 Jul; 111 ( Pt 13)(?):1841-52. doi:
10.1242/jcs.111.13.1841. [PMID: 9625747] - F A Redegeld, P Smith, S Apasov, M V Sitkovsky. Phosphorylation of T-lymphocyte plasma membrane-associated proteins by ectoprotein kinases: implications for a possible role for ectophosphorylation in T-cell effector functions.
Biochimica et biophysica acta.
1997 Sep; 1328(2):151-65. doi:
10.1016/s0005-2736(97)00082-5. [PMID: 9315612] - R B Lotto, J A Clausen, D J Price. A role for neurotrophins in the survival of murine embryonic thalamic neurons.
The European journal of neuroscience.
1997 Sep; 9(9):1940-9. doi:
10.1111/j.1460-9568.1997.tb00761.x. [PMID: 9383217] - D A Christopher, X Li, M Kim, J E Mullet. Involvement of protein kinase and extraplastidic serine/threonine protein phosphatases in signaling pathways regulating plastid transcription and the psbD blue light-responsive promoter in barley.
Plant physiology.
1997 Apr; 113(4):1273-82. doi:
10.1104/pp.113.4.1273. [PMID: 9112776] - M Kubokawa, Y Mori, T Kubota. Modulation of inwardly rectifying ATP-regulated K+ channel by phosphorylation process in opossum kidney cells.
The Japanese journal of physiology.
1997 Feb; 47(1):111-9. doi:
10.2170/jjphysiol.47.111. [PMID: 9159650] - B C Fowler, P K Carmines, L D Nelson, P D Bell. Characterization of sodium-calcium exchange in rabbit renal arterioles.
Kidney international.
1996 Dec; 50(6):1856-62. doi:
10.1038/ki.1996.506. [PMID: 8943467] - X Liang, N F Shen, A Theologis. Li(+)-regulated 1-aminocyclopropane-1-carboxylate synthase gene expression in Arabidopsis thaliana.
The Plant journal : for cell and molecular biology.
1996 Dec; 10(6):1027-36. doi:
10.1046/j.1365-313x.1996.10061027.x. [PMID: 9011084] - R Delsite, D Djakiew. Anti-proliferative effect of the kinase inhibitor K252a on human prostatic carcinoma cell lines.
Journal of andrology.
1996 Sep; 17(5):481-90. doi:
NULL. [PMID: 8957691] - Z Jian, I Nonaka, S Hattori, S Nakamura. Activation of Ras and protection from apoptotic cell death by BDNF in PC12 cells expressing TrkB.
Cellular signalling.
1996 Aug; 8(5):365-70. doi:
10.1016/0898-6568(96)00069-1. [PMID: 8911685] - G Taglialatela, C J Hibbert, L A Hutton, K Werrbach-Perez, J R Perez-Polo. Suppression of p140trkA does not abolish nerve growth factor-mediated rescue of serum-free PC12 cells.
Journal of neurochemistry.
1996 May; 66(5):1826-35. doi:
10.1046/j.1471-4159.1996.66051826.x. [PMID: 8780007] - C Feldherr, D Akin. Stimulation of nuclear import by simian virus 40-transformed cell extracts is dependent on protein kinase activity.
Molecular and cellular biology.
1995 Dec; 15(12):7043-9. doi:
10.1128/mcb.15.12.7043. [PMID: 8524271] - H Karchi, D Miron, S Ben-Yaacov, G Galili. The lysine-dependent stimulation of lysine catabolism in tobacco seed requires calcium and protein phosphorylation.
The Plant cell.
1995 Nov; 7(11):1963-70. doi:
10.1105/tpc.7.11.1963. [PMID: 8535146] - S M Wolniak, P M Larsen. The timing of protein kinase activation events in the cascade that regulates mitotic progression in Tradescantia stamen hair cells.
The Plant cell.
1995 Apr; 7(4):431-45. doi:
10.1105/tpc.7.4.431. [PMID: 7539650] - I Melamed, C E Turner, K Aktories, D R Kaplan, E W Gelfand. Nerve growth factor triggers microfilament assembly and paxillin phosphorylation in human B lymphocytes.
The Journal of experimental medicine.
1995 Mar; 181(3):1071-9. doi:
10.1084/jem.181.3.1071. [PMID: 7869029] - M Edbladh, D Tonge, J Golding, A R Ekström, A Edström. Early regeneration in vitro of adult mouse sciatic axons is dependent on local protein synthesis but may not involve neurotrophins.
Neuroscience letters.
1994 Feb; 168(1-2):37-40. doi:
10.1016/0304-3940(94)90410-3. [PMID: 7518065] - K Ohmi, S Yamashita, Y Hashimoto, Y Nonomura. Induction of giant endothelial cells in culture by K-252a, a protein kinase inhibitor.
Japanese journal of pharmacology.
1993 Oct; 63(2):195-202. doi:
10.1254/jjp.63.195. [PMID: 8283830] - H Bergstrand, T Eriksson, A Hallberg, B Johansson, K Karabelas, P Michelsen, A Nybom. Modulation of neutrophil superoxide generation by inhibitors of protein kinase C, calmodulin, diacylglycerol and myosin light chain kinases, and peptidyl prolyl cis-trans isomerase.
The Journal of pharmacology and experimental therapeutics.
1992 Dec; 263(3):1334-46. doi:
. [PMID: 1281879] - I Holen, P B Gordon, P O Seglen. Protein kinase-dependent effects of okadaic acid on hepatocytic autophagy and cytoskeletal integrity.
The Biochemical journal.
1992 Jun; 284 ( Pt 3)(?):633-6. doi:
10.1042/bj2840633. [PMID: 1320371] - M Nishiyama, K Aogi, S Saeki, R Kim, K Kuroi, Y Yamaguchi, T Toge. A role for plasma membrane potential in doxorubicin--induced cytotoxicity.
Anticancer research.
1992 May; 12(3):849-52. doi:
NULL. [PMID: 1622144] - M K Bach, J R Brashler, E N Petzold, M E Sanders. Superoxide production by human eosinophils can be inhibited in an agonist-selective manner.
Agents and actions.
1992 Jan; 35(1-2):1-11. doi:
10.1007/bf01990944. [PMID: 1324597] - T Usui, M Yoshida, K Abe, H Osada, K Isono, T Beppu. Uncoupled cell cycle without mitosis induced by a protein kinase inhibitor, K-252a.
The Journal of cell biology.
1991 Dec; 115(5):1275-82. doi:
10.1083/jcb.115.5.1275. [PMID: 1955475] - D M Loeb, J Maragos, D Martin-Zanca, M V Chao, L F Parada, L A Greene. The trk proto-oncogene rescues NGF responsiveness in mutant NGF-nonresponsive PC12 cell lines.
Cell.
1991 Sep; 66(5):961-6. doi:
10.1016/0092-8674(91)90441-z. [PMID: 1653650] - A Rukenstein, R E Rydel, L A Greene. Multiple agents rescue PC12 cells from serum-free cell death by translation- and transcription-independent mechanisms.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
1991 Aug; 11(8):2552-63. doi:
10.1523/jneurosci.11-08-02552.1991. [PMID: 1714494] - U Zor, E Her, T Harell, G Fischer, Z Naor, P Braquet, E Ferber, N Reiss. Arachidonic acid release by basophilic leukemia cells and macrophages stimulated by Ca2+ ionophores, antigen and diacylglycerol: essential role for protein kinase C and prevention by glucocorticosteroids.
Biochimica et biophysica acta.
1991 Feb; 1091(3):385-92. doi:
10.1016/0167-4889(91)90204-b. [PMID: 2001419] - K Ohmi, S Yamashita, Y Nonomura. Effect of K252a, a protein kinase inhibitor, on the proliferation of vascular smooth muscle cells.
Biochemical and biophysical research communications.
1990 Dec; 173(3):976-81. doi:
10.1016/s0006-291x(05)80881-2. [PMID: 2268357] - D G Grosskopf, G Felix, T Boller. K-252a inhibits the response of tomato cells to fungal elicitors in vivo and their microsomal protein kinase in vitro.
FEBS letters.
1990 Nov; 275(1-2):177-80. doi:
10.1016/0014-5793(90)81466-2. [PMID: 2261987] - J R White, D Zembryki, N Hanna, S Mong. Differential inhibition of histamine release from mast cells by protein kinase C inhibitors: staurosporine and K-252a.
Biochemical pharmacology.
1990 Aug; 40(3):447-56. doi:
10.1016/0006-2952(90)90542-s. [PMID: 1696482] - D Wion, D Mac Grogan, R Houlgatte, P Brachet. Phorbol 12-myristate 13-acetate (PMA) increases the expression of the nerve growth factor (NGF) gene in mouse L-929 fibroblasts.
FEBS letters.
1990 Mar; 262(1):42-4. doi:
10.1016/0014-5793(90)80149-d. [PMID: 2318311] - R J Smith, J M Justen, L M Sam. Effects of a protein kinase C inhibitor, K-252a, on human polymorphonuclear neutrophil responsiveness.
Biochemical and biophysical research communications.
1988 May; 152(3):1497-503. doi:
10.1016/s0006-291x(88)80455-8. [PMID: 2837190] - Y Matsuda, J Fukuda. Inhibition by K-252a, a new inhibitor of protein kinase, of nerve growth factor-induced neurite outgrowth of chick embryo dorsal root ganglion cells.
Neuroscience letters.
1988 Apr; 87(1-2):11-7. doi:
10.1016/0304-3940(88)90137-1. [PMID: 3380330]