Validamycin A (BioDeep_00000002578)

 

Secondary id: BioDeep_00000840331, BioDeep_00001871766

human metabolite Chemicals and Drugs


代谢物信息卡片


2-(hydroxymethyl)-6-[(2,3,5-trihydroxy-6-methyl-4-{[4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}cyclohexyl)oxy]oxane-3,4,5-triol

化学式: C20H35NO13 (497.21083000000004)
中文名称: 井冈霉素A
谱图信息: 最多检出来源 Macaca mulatta(otcml) 0.45%

分子结构信息

SMILES: CC1C(C(C(C(C1OC2C(C(C(C(O2)CO)O)O)O)O)O)NC3C=C(C(C(C3O)O)O)CO)O
InChI: InChI=1S/C20H35NO13/c1-5-10(24)9(21-7-2-6(3-22)11(25)15(29)12(7)26)14(28)17(31)19(5)34-20-18(32)16(30)13(27)8(4-23)33-20/h2,5,7-32H,3-4H2,1H3

描述信息

Validamycin A is used in control of fungal infection in rice, potatoes, strawberries and other crops.
It is used in control of fungal infection in rice, potatoes, strawberries and other crops
Validamycin A, a fungicidal, is an agricultural antibiotic. Validamycin A is originally isolated from Streptomyces hygroscopicus var. limoneus. Validamycin A inhibits the growth of A. flavus, with a MIC of 1?μg/mL[1]. Validamycin A shows potent inhibitory activity against trehalase of Rhizoctonia solani, with an IC50 of 72 μM[2]. Validamycin A is a reversible tyrosinase inhibitor, with a Ki of 5.893 mM[3].

同义名列表

12 个代谢物同义名

2-(hydroxymethyl)-6-[(2,3,5-trihydroxy-6-methyl-4-{[4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}cyclohexyl)oxy]oxane-3,4,5-triol; Cepex 10SL; Validacin; Antibiotic T 7545a; Validamycin, jmaf; Validamycin A; Validamycin; Validacin; Rhizocin; Solacol; T 7545a; Valimon; Mycin



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Weihua Chen, Zhongjun Qin. Development of a gene cloning system in a fast-growing and moderately thermophilic Streptomyces species and heterologous expression of Streptomyces antibiotic biosynthetic gene clusters. BMC microbiology. 2011 Oct; 11(?):243. doi: 10.1186/1471-2180-11-243. [PMID: 22032628]
  • Antoine Gravot, Louis Grillet, Geoffrey Wagner, Mélanie Jubault, Christine Lariagon, Cécile Baron, Carole Deleu, Régine Delourme, Alain Bouchereau, Maria J Manzanares-Dauleux. Genetic and physiological analysis of the relationship between partial resistance to clubroot and tolerance to trehalose in Arabidopsis thaliana. The New phytologist. 2011 Sep; 191(4):1083-1094. doi: 10.1111/j.1469-8137.2011.03751.x. [PMID: 21599669]
  • Venencia Albert, Arulselvi Subramanian, Kanchana Rangarajan, Ravindra Mohan Pandey. Agreement of two different laboratory methods used to measure electrolytes. Journal of laboratory physicians. 2011 Jul; 3(2):104-9. doi: 10.4103/0974-2727.86843. [PMID: 22219564]
  • Amjad Masood Husaini. Pre- and post-agroinfection strategies for efficient leaf disk transformation and regeneration of transgenic strawberry plants. Plant cell reports. 2010 Jan; 29(1):97-110. doi: 10.1007/s00299-009-0801-4. [PMID: 19956955]
  • Gabriel Iturriaga, Ramón Suárez, Barbara Nova-Franco. Trehalose metabolism: from osmoprotection to signaling. International journal of molecular sciences. 2009 Sep; 10(9):3793-3810. doi: 10.3390/ijms10093793. [PMID: 19865519]
  • Miguel López, Noel A Tejera, Carmen Lluch. Validamycin A improves the response of Medicago truncatula plants to salt stress by inducing trehalose accumulation in the root nodules. Journal of plant physiology. 2009 Jul; 166(11):1218-22. doi: 10.1016/j.jplph.2008.12.011. [PMID: 19232773]
  • Hui Xu, Kazuyuki Minagawa, Linquan Bai, Zixin Deng, Taifo Mahmud. Catalytic analysis of the validamycin glycosyltransferase (ValG) and enzymatic production of 4''-epi-validamycin A. Journal of natural products. 2008 Jul; 71(7):1233-6. doi: 10.1021/np800185k. [PMID: 18563934]
  • Ryo Ishikawa, Kentaro Shirouzu, Hideo Nakashita, Han-Young Lee, Takayuki Motoyama, Isamu Yamaguchi, Tohru Teraoka, Tsutomu Arie. Foliar spray of validamycin a or validoxylamine a controls tomato fusarium wilt. Phytopathology. 2005 Oct; 95(10):1209-16. doi: 10.1094/phyto-95-1209. [PMID: 18943474]
  • Noel A Tejera García, Carmen Iribarne, Miguel López, José A Herrera-Cervera, Carmen Lluch. Physiological implications of trehalase from Phaseolus vulgaris root nodules: partial purification and characterization. Plant physiology and biochemistry : PPB. 2005 Apr; 43(4):355-61. doi: 10.1016/j.plaphy.2005.02.013. [PMID: 15907687]
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