raddeanoside R13 (BioDeep_00000253733)

   

PANOMIX_OTCML-2023


代谢物信息卡片


(4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-[(2S,3R,4S,5S)-4-hydroxy-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid

化学式: C47H76O16 (896.5133096)
中文名称: 革叶常春藤皂苷 A1, 黑海常春藤苷A1
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1(CC[C@]2([C@@H](C1)C1=CC[C@H]3[C@]([C@@]1(CC2)C)(CC[C@@H]1[C@@]3(CC[C@@H](C1(C)C)O[C@@H]1OC[C@@H]([C@@H]([C@H]1O[C@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)C)O)O)O)O)O[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O)C)C)C(=O)O)(C)C
InChI: InChI=1S/C47H76O16/c1-22-30(49)33(52)35(54)38(59-22)63-37-32(51)26(61-39-36(55)34(53)31(50)25(20-48)60-39)21-58-40(37)62-29-12-13-44(6)27(43(29,4)5)11-14-46(8)28(44)10-9-23-24-19-42(2,3)15-17-47(24,41(56)57)18-16-45(23,46)7/h9,22,24-40,48-55H,10-21H2,1-8H3,(H,56,57)/t22-,24-,25+,26-,27-,28+,29-,30-,31+,32-,33+,34-,35+,36+,37+,38-,39-,40-,44-,45+,46+,47-/m0/s1

描述信息

Hederacolchiside A1 is a natural product found in Serjania salzmanniana with data available.
Hederacolchiside A1, isolated from Pulsatilla chinensis, suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/mTOR signaling pathway[1]. Hederacolchiside A1 has antischistosomal activity, affecting parasite viability both in vivo and in vitro[2].
Hederacolchiside A1, isolated from Pulsatilla chinensis, suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/mTOR signaling pathway[1]. Hederacolchiside A1 has antischistosomal activity, affecting parasite viability both in vivo and in vitro[2].
Hederacolchiside A1, isolated from Pulsatilla chinensis, suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/mTOR signaling pathway[1]. Hederacolchiside A1 has antischistosomal activity, affecting parasite viability both in vivo and in vitro[2].

同义名列表

6 个代谢物同义名

(4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-[(2S,3R,4S,5S)-4-hydroxy-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid; Hederacolchiside A1; raddeanoside R13; Oleanolic acid 3-O-alpha-L-rhamnopyranosyl-(1-; 4)-alpha-L-arabinopyranoside; 2)-beta-D-glucopyranosyl-(1-



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Dan Su, Tingting Wang, Chen Jin, Yali Liu, Abid Naeem, Zhou Liao, Mingyue Zhou, Changlian Chen, Yonggui Song, Zhifu Ai. Pulchinenosides: Correlation of surface activity-cytotoxicity and hepatocyte apoptosis mechanism study. Bioorganic & medicinal chemistry letters. 2021 07; 43(?):128080. doi: 10.1016/j.bmcl.2021.128080. [PMID: 33964439]
  • Le Ba Vinh, Hyun-Jae Jang, Nguyen Viet Phong, Kyoungwon Cho, Sung Sun Park, Jong Seong Kang, Young Ho Kim, Seo Young Yang. Isolation, structural elucidation, and insights into the anti-inflammatory effects of triterpene saponins from the leaves of Stauntonia hexaphylla. Bioorganic & medicinal chemistry letters. 2019 04; 29(8):965-969. doi: 10.1016/j.bmcl.2019.02.022. [PMID: 30808589]
  • Yuanying Fang, Rikang Wang, Mingzhen He, Hesong Huang, Qi Wang, Zunhua Yang, Yan Li, Shilin Yang, Yi Jin. Nitric oxide-donating derivatives of hederacolchiside A1: Synthesis and biological evaluation in vitro and in vivo as potential anticancer agents. Bioorganic & medicinal chemistry letters. 2017 01; 27(1):98-101. doi: 10.1016/j.bmcl.2016.11.021. [PMID: 27866816]
  • Yuanying Fang, Zunhua Yang, Hui Ouyang, Rikang Wang, Jun Li, Hesong Huang, Yi Jin, Yulin Feng, Shilin Yang. Synthesis and biological evaluation of Hederacolchiside A1 derivatives as anticancer agents. Bioorganic & medicinal chemistry letters. 2016 10; 26(19):4576-4579. doi: 10.1016/j.bmcl.2016.08.077. [PMID: 27592134]
  • Y Mimaki, M Kuroda, T Asano, Y Sashida. Triterpene saponins and lignans from the roots of Pulsatilla chinensis and their cytotoxic activity against HL-60 cells. Journal of natural products. 1999 Sep; 62(9):1279-83. doi: 10.1021/np9901837. [PMID: 10514313]
  • O A Ekabo, N R Farnsworth, T O Henderson, G Mao, R Mukherjee. Antifungal and molluscicidal saponins from Serjania salzmanniana. Journal of natural products. 1996 Apr; 59(4):431-5. doi: 10.1021/np960208r. [PMID: 8699187]