2,3-Dinor-TXB2 (BioDeep_00000025024)
human metabolite Endogenous
代谢物信息卡片
(3Z)-5-[(2R,3S,4S)-4,6-dihydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]oxan-3-yl]pent-3-enoic acid
化学式: C18H30O6 (342.204228)
中文名称: 2,3-二正凝血噁烷 B2
谱图信息:
最多检出来源 Homo sapiens(urine) 85.71%
分子结构信息
SMILES: CCCCCC(C=CC1C(C(CC(O1)O)O)CC=CCC(=O)O)O
InChI: InChI=1S/C18H30O6/c1-2-3-4-7-13(19)10-11-16-14(8-5-6-9-17(21)22)15(20)12-18(23)24-16/h5-6,10-11,13-16,18-20,23H,2-4,7-9,12H2,1H3,(H,21,22)/b6-5-,11-10+/t13-,14-,15-,16+,18?/m0/s1
描述信息
Fatty Acyl-Eicosanoid - metabolite of thromboxane. Found to be excreted via urinary tract at a higher level in diabetic rats. A study demonstrates that thromboxane as well as prostacyclin biosynthesis is increased in 2 murine models of atherogenesis and is secondary to increased in vivo platelet activation. Assessment of their generation in these models may afford the basis for future studies on the functional role of these eicosanoids in the evolution and progression of atherosclerosisThromboxanes are eicosanoids. The eicosanoids consist of the prostaglandins (PGs), thromboxanes (TXs), leukotrienes (LTs), and lipoxins (LXs). The PGs and TXs are collectively identified as prostanoids. Prostaglandins were originally shown to be synthesized in the prostate gland, thromboxanes from platelets (thrombocytes), and leukotrienes from leukocytes, hence the derivation of their names. All mammalian cells except erythrocytes synthesize eicosanoids. These molecules are extremely potent, able to cause profound physiological effects at very dilute concentrations. All eicosanoids function locally at the site of synthesis, through receptor-mediated G-protein linked signalling pathways.
Fatty Acyl-Eicosanoid - metabolite of thromboxane. Found to be excreted via urinary tract at a higher level in diabetic rats. A study demonstrates that thromboxane as well as prostacyclin biosynthesis is increased in 2 murine models of atherogenesis and is secondary to increased in vivo platelet activation. Assessment of their generation in these models may afford the basis for future studies on the functional role of these eicosanoids in the evolution and progression of atherosclerosis
同义名列表
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:89991
- PubChem: 5283138
- PubChem: 1477
- HMDB: HMDB0002904
- foodb: FDB023080
- chemspider: 4446262
- CAS: 63250-09-9
- PMhub: MS000173493
- RefMet: 2,3-Dinor-TXB2
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
1 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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Cardiovascular research.
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1995 Dec; 53(6):419-21. doi:
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Perfusion.
1995 Nov; 10(6):403-13. doi:
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Prostaglandins.
1995 Nov; 50(5-6):331-40. doi:
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Obstetrics and gynecology.
1995 Jun; 85(6):1027-30. doi:
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Prostaglandins.
1995 Apr; 49(4):247-53. doi:
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Prostaglandins, leukotrienes, and essential fatty acids.
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Journal of internal medicine.
1994 Feb; 235(2):153-61. doi:
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Arthritis and rheumatism.
1994 Jan; 37(1):93-7. doi:
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Circulation.
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Prostaglandins.
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British heart journal.
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Nihon rinsho. Japanese journal of clinical medicine.
1992 Feb; 50(2):349-54. doi:
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Transactions of the Association of American Physicians.
1992; 105(?):149-56. doi:
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American journal of obstetrics and gynecology.
1992 Jan; 166(1 Pt 1):150-4. doi:
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Clinical and investigative medicine. Medecine clinique et experimentale.
1991 Dec; 14(6):518-24. doi:
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Cancer research.
1991 Aug; 51(16):4146-8. doi:
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British journal of clinical pharmacology.
1991 Jul; 32(1):127-9. doi:
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British journal of pharmacology.
1991 Jul; 103(3):1663-8. doi:
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Circulation.
1991 May; 83(5):1698-704. doi:
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Lancet (London, England).
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Arthritis and rheumatism.
1991 Apr; 34(4):481-5. doi:
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1990 Dec; 79(6):639-45. doi:
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Lancet (London, England).
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1990 Jan; 39(1):47-51. doi:
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1990 Jan; 39(1):99-107. doi:
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Biochimica et biophysica acta.
1989 Dec; 993(2-3):259-65. doi:
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British journal of clinical pharmacology.
1989 Nov; 28(5):573-9. doi:
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British journal of cancer.
1989 Nov; 60(5):785-8. doi:
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The American review of respiratory disease.
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Biochimica et biophysica acta.
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Archives of disease in childhood.
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British journal of haematology.
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