Bouchardatine (BioDeep_00000247709)
代谢物信息卡片
化学式: C17H11N3O2 (289.0851)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: O=Cc1c(-c2nc(=O)c3ccccc3[nH]2)[nH]c2ccccc12
InChI:
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
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文献列表
- Yong Rao, Zhao Xu, Yu-Tao Hu, Chan Li, Yao-Hao Xu, Qin-Qin Song, Hong Yu, Bing-Bing Song, Shuo-Bin Chen, Qing-Jiang Li, Shi-Liang Huang, Jia-Heng Tan, Tian-Miao Ou, Hong-Gen Wang, Guo-Ping Zhong, Ji-Ming Ye, Zhi-Shu Huang. Discovery of a promising agent IQZ23 for the treatment of obesity and related metabolic disorders.
European journal of medicinal chemistry.
2020 Apr; 192(?):112172. doi:
10.1016/j.ejmech.2020.112172
. [PMID: 32163815] - Yong Rao, Yu-Ting Lu, Chan Li, Qin-Qin Song, Yao-Hao Xu, Zhao Xu, Yu-Tao Hu, Hong Yu, Lin Gao, Lian-Quan Gu, Ji-Ming Ye, Zhi-Shu Huang. Bouchardatine analogue alleviates non-alcoholic hepatic fatty liver disease/non-alcoholic steatohepatitis in high-fat fed mice by inhibiting ATP synthase activity.
British journal of pharmacology.
2019 08; 176(16):2877-2893. doi:
10.1111/bph.14713
. [PMID: 31113010] - Yao-Hao Xu, Qin-Qin Song, Chan Li, Yu-Tao Hu, Bing-Bing Song, Ji-Ming Ye, Yong Rao, Zhi-Shu Huang. Bouchardatine suppresses rectal cancer in mice by disrupting its metabolic pathways via activating the SIRT1-PGC-1α-UCP2 axis.
European journal of pharmacology.
2019 Jul; 854(?):328-337. doi:
10.1016/j.ejphar.2019.04.029
. [PMID: 31028741] - Lin Gao, Zhao Xu, Yong Rao, Yu-Ting Lu, Yu-Tao Hu, Hong Yu, Yao-Hao Xu, Qing-Qing Song, Ji-Ming Ye, Zhi-Shu Huang. Design, synthesis and biological evaluation of novel bouchardatine analogs as potential inhibitors of adipogenesis/lipogenesis in 3T3-L1 adipocytes.
European journal of medicinal chemistry.
2018 Mar; 147(?):90-101. doi:
10.1016/j.ejmech.2018.01.089
. [PMID: 29425817] - Yong Rao, Hong Yu, Lin Gao, Yu-Ting Lu, Zhao Xu, Hong Liu, Lian-Quan Gu, Ji-Ming Ye, Zhi-Shu Huang. Natural alkaloid bouchardatine ameliorates metabolic disorders in high-fat diet-fed mice by stimulating the sirtuin 1/liver kinase B-1/AMPK axis.
British journal of pharmacology.
2017 08; 174(15):2457-2470. doi:
10.1111/bph.13855
. [PMID: 28493443] - Yong Rao, Hong Liu, Lin Gao, Hong Yu, Tian-Miao Ou, Jia-Heng Tan, Shi-Liang Huang, Hong-Gen Wang, Ding Li, Lian-Quan Gu, Ji-Ming Ye, Zhi-Shu Huang. Synthesis and Biological Evaluation of Novel Bouchardatine Derivatives as Potential Adipogenesis/Lipogenesis Inhibitors for Antiobesity Treatment.
Journal of medicinal chemistry.
2015 Dec; 58(23):9395-413. doi:
10.1021/acs.jmedchem.5b01566
. [PMID: 26572282] - Yong Rao, Hong Liu, Lin Gao, Hong Yu, Jia-Heng Tan, Tian-Miao Ou, Shi-Liang Huang, Lian-Quan Gu, Ji-Ming Ye, Zhi-Shu Huang. Discovery of natural alkaloid bouchardatine as a novel inhibitor of adipogenesis/lipogenesis in 3T3-L1 adipocytes.
Bioorganic & medicinal chemistry.
2015 Aug; 23(15):4719-4727. doi:
10.1016/j.bmc.2015.05.057
. [PMID: 26088335]