25-Hydroxyvitamin D2 (BioDeep_00000024731)
human metabolite Endogenous blood metabolite
代谢物信息卡片
化学式: C28H44O2 (412.3341124)
中文名称: 25-羟基维生素 D₂
谱图信息:
最多检出来源 Homo sapiens(urine) 2.63%
分子结构信息
SMILES: C=C1CCC(O)CC1=CC=C1CCCC2(C)C1CCC2C(C)C=CC(C)C(C)(C)O
InChI: InChI=1S/C28H44O2/c1-19-10-14-24(29)18-23(19)13-12-22-8-7-17-28(6)25(15-16-26(22)28)20(2)9-11-21(3)27(4,5)30/h9,11-13,20-21,24-26,29-30H,1,7-8,10,14-18H2,2-6H3/b11-9+,22-12+,23-13-/t20-,21+,24+,25?,26+,28-/m1/s1
描述信息
9,10-Secoergosta-5,7,10(19),22-tetraene-3,25-diol. Biologically active metabolite of vitamin D2 which is more active in curing rickets than its parent. The compound is believed to attach to the same receptor as vitamin D2 and 25-hydroxyvitamin D3. [HMDB]
9,10-Secoergosta-5,7,10(19),22-tetraene-3,25-diol. Biologically active metabolite of vitamin D2 which is more active in curing rickets than its parent. The compound is believed to attach to the same receptor as vitamin D2 and 25-hydroxyvitamin D3.
D018977 - Micronutrients > D014815 - Vitamins > D004872 - Ergocalciferols
D050071 - Bone Density Conservation Agents
同义名列表
14 个代谢物同义名
(1S,3Z)-3-{2-[(3aS,4E,7aR)-1-[(2R,3E,5S)-6-hydroxy-5,6-dimethylhept-3-en-2-yl]-7a-methyl-octahydro-1H-inden-4-ylidene]ethylidene}-4-methylidenecyclohexan-1-ol; 9,10-Secoergosta-5,7,10(19),22-tetraene-3 beta,25-diol; 9,10-Secoergosta-5,7,10(19),22-tetraene-3b,25-diol; 25-Hydroxyvitamin D2 (6,19,19-d3); 25 Hydroxyergocalciferol; 25-hydroxyergocalciferol; 25 Hydroxyvitamin D 2; 25-Hydroxyvitamin D 2; 25 Hydroxycalciferol; 25-Hydroxycalciferol; 25 Hydroxyvitamin D2; 25-hydroxyvitamin D2; 25-Hydroxyvitamin D; Ercalcidiol
数据库引用编号
9 个数据库交叉引用编号
- PubChem: 22833566
- PubChem: 585790
- HMDB: HMDB0001438
- MeSH: 25-Hydroxyvitamin D 2
- foodb: FDB022621
- chemspider: 17216121
- CAS: 21343-40-8
- PMhub: MS000164282
- RefMet: 25-Hydroxyvitamin D2
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Anja C Bailer, Sophie Philipp, Shabnam Staudt, Thomas Weidauer, Michael Kiehntopf, Stefan Lorkowski, Gabriele I Stangl, Christine Dawczynski. UVB-exposed wheat germ oil increases serum 25-hydroxyvitamin D2 without improving overall vitamin D status: a randomized controlled trial.
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Nutrients.
2018 Jul; 10(7):. doi:
10.3390/nu10070876
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Diabetic medicine : a journal of the British Diabetic Association.
2018 07; 35(7):972-979. doi:
10.1111/dme.13632
. [PMID: 29608221] - Janusz Popko, Michał Karpiński, Sylwia Chojnowska, Katarzyna Maresz, Robert Milewski, Vladimir Badmaev, Leon J Schurgers. Decreased Levels of Circulating Carboxylated Osteocalcin in Children with Low Energy Fractures: A Pilot Study.
Nutrients.
2018 Jun; 10(6):. doi:
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Nutrients.
2018 May; 10(6):. doi:
10.3390/nu10060680
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Endocrine research.
2018 May; 43(2):106-115. doi:
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European journal of nutrition.
2018 Apr; 57(3):1015-1023. doi:
10.1007/s00394-017-1385-3
. [PMID: 28224220] - Amanda C Cunha Figueiredo, Paula Guedes Cocate, Amanda R Amorim Adegboye, Ana Beatriz Franco-Sena, Dayana R Farias, Maria Beatriz Trindade de Castro, Alex Brito, Lindsay H Allen, Rana R Mokhtar, Michael F Holick, Gilberto Kac. Changes in plasma concentrations of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D during pregnancy: a Brazilian cohort.
European journal of nutrition.
2018 Apr; 57(3):1059-1072. doi:
10.1007/s00394-017-1389-z
. [PMID: 28353072] - Joseph Jamnik, David Ja Jenkins, Ahmed El-Sohemy. Biomarkers of cardiometabolic health and nutritional status in individuals with positive celiac disease serology.
Nutrition and health.
2018 Mar; 24(1):37-45. doi:
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. [PMID: 29249178] - Carol Ní Chaoimh, Elaine K McCarthy, Jonathan O'B Hourihane, Louise C Kenny, Alan D Irvine, Deirdre M Murray, Mairead E Kiely. Low vitamin D deficiency in Irish toddlers despite northerly latitude and a high prevalence of inadequate intakes.
European journal of nutrition.
2018 Mar; 57(2):783-794. doi:
10.1007/s00394-016-1368-9
. [PMID: 28025694] - Silvia Barja-Fernández, Concepción M Aguilera, Isabel Martínez-Silva, Rocío Vazquez, Mercedes Gil-Campos, Josune Olza, Juan Bedoya, Carmen Cadarso-Suárez, Ángel Gil, Luisa M Seoane, Rosaura Leis. 25-Hydroxyvitamin D levels of children are inversely related to adiposity assessed by body mass index.
Journal of physiology and biochemistry.
2018 Feb; 74(1):111-118. doi:
10.1007/s13105-017-0581-1
. [PMID: 28744831] - Seyedeh Forough Sajjadi, Khadijeh Mirzaei, Leila Khorrami-Nezhad, Zhila Maghbooli, Seyed Ali Keshavarz. Vitamin D Status and Resting Metabolic Rate May Modify through Expression of Vitamin D Receptor and Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Gene in Overweight and Obese Adults.
Annals of nutrition & metabolism.
2018; 72(1):43-49. doi:
10.1159/000485662
. [PMID: 29258108] - King-Wah Chiu, Toshiaki Nakano, Tsung-Hui Hu, Kuang-Den Chen, Li-Wen Hsu, Hock-Liew Eng, Yu-Fan Cheng, Shigeru Goto, Chao-Long Chen. Association between Subclinical Low Serum 25(OH)D in Donors and Fatty Liver Disease in Recipients after Living Donor Liver Transplantation.
BioMed research international.
2018; 2018(?):4508085. doi:
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Blood purification.
2018; 46(2):103-110. doi:
10.1159/000488637
. [PMID: 29672317] - Khulood Othman Alyahya. Vitamin D levels in schoolchildren: a cross-sectional study in Kuwait.
BMC pediatrics.
2017 12; 17(1):213. doi:
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. [PMID: 29273017] - O V Kaminskyi, O V Kopylova, D Ye Afanasyev, O V Mazurenko, S Ya Berezovskyi. Pilot study of parathyroid glands in adult and pediatric subjects exposed to ionizing radiation after the ChNPP accident, methodology of parathyroid diagnostic ultrasound.
Problemy radiatsiinoi medytsyny ta radiobiolohii.
2017 Dec; 22(?):382-394. doi:
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- Luana Cupertino Milagres, Naruna Pereira Rocha, Mariana de Santis Filgueiras, Fernanda Martins de Albuquerque, Ana Paula Pereira Castro, Milene Cristine Pessoa, Maria do Carmo Gouveia Peluzio, Juliana Farias de Novaes. Vitamin D insufficiency/deficiency is associated with insulin resistance in Brazilian children, regardless of body fat distribution.
Public health nutrition.
2017 Nov; 20(16):2878-2886. doi:
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. [PMID: 28829285] - Bahareh Nikooyeh, Siamak M Samiee, Marjan R Farzami, Hamid Alavimajd, Maliheh Zahedirad, Ali Kalayi, Nastaran Shariatzadeh, Nasrin Boroumand, Elham Golshekan, Yalda Gholamian, Tirang R Neyestani. Harmonization of serum 25-hydroxycalciferol assay results from high-performance liquid chromatography, enzyme immunoassay, radioimmunoassay, and immunochemiluminescence systems: A multicenter study.
Journal of clinical laboratory analysis.
2017 Nov; 31(6):. doi:
10.1002/jcla.22117
. [PMID: 28169461] - Laura Bertoccini, Federica Sentinelli, Frida Leonetti, Diego Bailetti, Danila Capoccia, Flavia A Cimini, Ilaria Barchetta, Michela Incani, Andrea Lenzi, Efisio Cossu, M Gisella Cavallo, Marco G Baroni. The vitamin D receptor functional variant rs2228570 (C>T) does not associate with type 2 diabetes mellitus.
Endocrine research.
2017 Nov; 42(4):331-335. doi:
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. [PMID: 28388281] - Konstantin Horas, Gerrit Maier, Franz Jakob, Uwe Maus, Andreas Kurth, Axel Jakuscheit, Maximilian Rudert, Boris Michael Holzapfel. High Prevalence of Vitamin D Deficiency in Patients with Bone Tumors.
Cancer investigation.
2017 Sep; 35(8):562-568. doi:
10.1080/07357907.2017.1351985
. [PMID: 28799812] - Susan S-C Tai, Michael A Nelson, Mary Bedner, Brian E Lang, Karen W Phinney, Lane C Sander, James H Yen, Joseph M Betz, Christopher T Sempos, Stephen A Wise. Development of Standard Reference Material (SRM) 2973 Vitamin D Metabolites in Frozen Human Serum (High Level).
Journal of AOAC International.
2017 Sep; 100(5):1294-1303. doi:
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. [PMID: 28917261] - Stephen A Wise, Susan S-C Tai, Carolyn Q Burdette, Johanna E Camara, Mary Bedner, Katrice A Lippa, Michael A Nelson, Federica Nalin, Karen W Phinney, Lane C Sander, Joseph M Betz, Christopher T Sempos, Paul M Coates. Role of the National Institute of Standards and Technology (NIST) in Support of the Vitamin D Initiative of the National Institutes of Health, Office of Dietary Supplements.
Journal of AOAC International.
2017 Sep; 100(5):1260-1276. doi:
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. [PMID: 28863788] - Sung E Cho, Sollip Kim, Young D Kim, Hyojung Lee, Dong H Seo, Junghan Song, Tae H Um, Chong R Cho, Nam H Kim, Jong H Hwang. Measurement of serum 3-epi-25-hydroxyvitamin D3, 25-hydroxyvitamin D3 and 25-hydroxyvitamin D2 in infant, paediatric and adolescent populations of Korea using ultra-performance liquid chromatography-tandem mass spectrometry.
Annals of clinical biochemistry.
2017 Sep; 54(5):530-538. doi:
10.1177/0004563216671009
. [PMID: 27614352] - Alessio Paffoni, Stefania Ferrari, Alice Mangiarini, Stefania Noli, Alessandro Bulfoni, Paola Vigano, Fabio Parazzini, Edgardo Somigliana. Concordance of vitamin D peripheral levels in infertile couples' partners.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2017 Aug; 33(8):649-652. doi:
10.1080/09513590.2017.1306737
. [PMID: 28466668] - Siddhnath Sudhanshu, Pramod Upadhyay, Monashish Sahu, Vinita Rawat, Vijayalakshmi Bhatia. Sun exposure, UV irradiance and serum 25-hydroxycholecalciferol in pregnant women in rural north India.
Public health nutrition.
2017 Jul; 20(10):1755-1759. doi:
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. [PMID: 27989262] - Ivayla Uzunova, Georgi Kirilov, Sabina Zacharieva, Naydenka Zlatareva, Krasimir Kalinov. Does Vitamin D Status Correlate with Cardiometabolic Risk Factors in Adults with Growth Hormone Deficiency?.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2017 Jul; 49(7):499-506. doi:
10.1055/s-0043-100114
. [PMID: 28493240] - Carol A Fritz, Kimberly A Navetta, David P Wolford, Jennifer L Colangelo. Assessment of endogenous 25-hydroxyvitamin D serum concentrations by liquid chromatography-tandem mass spectrometry in various animal species.
Veterinary clinical pathology.
2017 Jun; 46(2):371-379. doi:
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. [PMID: 28403556] - Adriana J van Ballegooijen, Leila Zelnick, Andrew N Hoofnagle, Naomi M Hamburg, Cassiane Robinson-Cohen, Prabir Roy-Chaudhury, Alfred K Cheung, Yan-Ting Shiu, Ian H de Boer, Jonathan Himmelfarb, Gerald Beck, Peter B Imrey, John W Kusek, Bryan Kestenbaum. Association of Vitamin D Metabolites With Arterial Function in the Hemodialysis Fistula Maturation Study.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2017 Jun; 69(6):805-814. doi:
10.1053/j.ajkd.2017.01.049
. [PMID: 28359657] - Karen W Phinney, Susan S-C Tai, Mary Bedner, Johanna E Camara, Rosalind R C Chia, Lane C Sander, Katherine E Sharpless, Stephen A Wise, James H Yen, Rosemary L Schleicher, Madhulika Chaudhary-Webb, Khin L Maw, Yasamin Rahmani, Joseph M Betz, Joyce Merkel, Christopher T Sempos, Paul M Coates, Ramón A Durazo-Arvizu, Kurtis Sarafin, Stephen P J Brooks. Development of an Improved Standard Reference Material for Vitamin D Metabolites in Human Serum.
Analytical chemistry.
2017 05; 89(9):4907-4913. doi:
10.1021/acs.analchem.6b05168
. [PMID: 28375002] - Olusola Funmilayo Sotunde, Herculina Salome Kruger, Hattie H Wright, Lize Havemann-Nel, Carina M C Mels, Chrisna Ravyse, Marlien Pieters. Association of 25-hydroxyvitamin D and parathyroid hormone with the metabolic syndrome in black South African women.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.
2017 Apr; 42(4):413-419. doi:
10.1139/apnm-2016-0257
. [PMID: 28177729] - Manal Al Masri, Ahmed Jerome Romain, Catherine Boegner, Laurent Maimoun, Denis Mariano-Goulart, Vincent Attalin, Elodie Leprieur, Marion Picandet, Antoine Avignon, Ariane Sultan. Vitamin D status is not related to insulin resistance in different phenotypes of moderate obesity.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.
2017 Apr; 42(4):438-442. doi:
10.1139/apnm-2016-0298
. [PMID: 28177726] - Mark Pretzel Zumaraga, Paul Julius Medina, Juan Miguel Recto, Lauro Abrahan, Edelyn Azurin, Celeste C Tanchoco, Cecilia A Jimeno, Cynthia Palmes-Saloma. Targeted next generation sequencing of the entire vitamin D receptor gene reveals polymorphisms correlated with vitamin D deficiency among older Filipino women with and without fragility fracture.
The Journal of nutritional biochemistry.
2017 03; 41(?):98-108. doi:
10.1016/j.jnutbio.2016.12.003
. [PMID: 28068558] - M M Almurdhi, N D Reeves, F L Bowling, A J M Boulton, M Jeziorska, R A Malik. Distal lower limb strength is reduced in subjects with impaired glucose tolerance and is related to elevated intramuscular fat level and vitamin D deficiency.
Diabetic medicine : a journal of the British Diabetic Association.
2017 03; 34(3):356-363. doi:
10.1111/dme.13163
. [PMID: 27278802] - Hyun Yoon, Dae Keun Jeong, Chang Eun Park, Hye Jong Oh, Sung Gil Kim. The association between gender difference with metabolic syndrome, metabolic syndrome score and serum vitamin D levels in Korean adults.
International journal of food sciences and nutrition.
2017 Feb; 68(1):121-129. doi:
10.1080/09637486.2016.1221899
. [PMID: 27580963] - Dimitrios Palaiogiannis, Evangelia Bekou, Kalliopi Pazaitou-Panayiotou, Victoria Samanidou, Andreas Tsakalof. On-line SPE sample treatment as a tool for method automatization and detection limits reduction: Quantification of 25-hydroxyvitamin D3/D2.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 Feb; 1043(?):219-227. doi:
10.1016/j.jchromb.2016.10.006
. [PMID: 27756628] - Yeon-Kyeong Choi, Sang-Wook Song, Bo-Ra Shin, Jeong-Ah Kim, Ha-Na Kim. Serum vitamin D level is negatively associated with carotid atherosclerosis in Korean adults.
International journal of food sciences and nutrition.
2017 Feb; 68(1):90-96. doi:
10.1080/09637486.2016.1216526
. [PMID: 27537342] - Maria Inês Barreto Silva, Vanessa Vicente de Souza Cavalieri, Carla Cavalheiro da Silva Lemos, Márcia Regina Simas Torres Klein, Rachel Bregman. Body adiposity predictors of vitamin D status in nondialyzed patients with chronic kidney disease: A cross-sectional analysis in a tropical climate city.
Nutrition (Burbank, Los Angeles County, Calif.).
2017 Jan; 33(?):240-247. doi:
10.1016/j.nut.2016.06.012
. [PMID: 27692990] - Michal Karpiński, Anna Galicka, Robert Milewski, Janusz Popko, Vladimir Badmaev, Sidney J Stohs. Association between Vitamin D Receptor Polymorphism and Serum Vitamin D Levels in Children with Low-Energy Fractures.
Journal of the American College of Nutrition.
2017 01; 36(1):64-71. doi:
10.1080/07315724.2016.1218803
. [PMID: 28067591] - Hossein Khosravi-Boroujeni, Nizal Sarrafzadegan, Masoumeh Sadeghi, Hamidreza Roohafza, Shu-Kay Ng, Ali Pourmogaddas, Faruk Ahmed. Prevalence and Trends of Vitamin D Deficiency among Iranian Adults: A Longitudinal Study from 2001-2013.
Journal of nutritional science and vitaminology.
2017; 63(5):284-290. doi:
10.3177/jnsv.63.284
. [PMID: 29225312] - James B Wetmore, Cassandra Kimber, Jonathan D Mahnken, Jason R Stubbs. Cholecalciferol v. ergocalciferol for 25-hydroxyvitamin D (25(OH)D) repletion in chronic kidney disease: a randomised clinical trial.
The British journal of nutrition.
2016 Dec; 116(12):2074-2081. doi:
10.1017/s000711451600427x
. [PMID: 28065190] - Raquel Revuelta Iniesta, Ilenia Paciarotti, Isobel Davidson, Jane M McKenzie, Celia Brand, Richard F M Chin, Mark F H Brougham, David C Wilson. 5-Hydroxyvitamin D concentration in paediatric cancer patients from Scotland: a prospective cohort study.
The British journal of nutrition.
2016 Dec; 116(11):1926-1934. doi:
10.1017/s0007114516004074
. [PMID: 27974067] - Sanghoo Lee, Joo-Hoon Kim, Seol-A Kim, Yeoun-Soo Sun, Anna Lee, Seo-Jin Park, Yun-Tae Kim, Kyoung-Ryul Lee, Young-Jin Kim. A Rapid and Simple Liquid-Chromatography-Tandem Mass Spectrometry Method for Measuring 25-Hydroxyvitamin D2 and 25-Hydroxyvitamin D3 in Human Serum: Comparison with Two Automated Immunoassays.
Annals of clinical and laboratory science.
2016 Dec; 46(6):645-653. doi:
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. [PMID: 27993879] - Ikram Bezrati, Raouf Hammami, Mohamed Kacem Ben Fradj, Domenico Martone, Johnny Padulo, Moncef Feki, Anis Chaouachi, Naziha Kaabachi. Association of plasma 25-hydroxyvitamin D with physical performance in physically active children.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.
2016 Nov; 41(11):1124-1128. doi:
10.1139/apnm-2016-0097
. [PMID: 27764544] - Mamoru Satoh, Takayuki Ishige, Shoujiro Ogawa, Motoi Nishimura, Kazuyuki Matsushita, Tatsuya Higashi, Fumio Nomura. Development and validation of the simultaneous measurement of four vitamin D metabolites in serum by LC-MS/MS for clinical laboratory applications.
Analytical and bioanalytical chemistry.
2016 Nov; 408(27):7617-7627. doi:
10.1007/s00216-016-9821-4
. [PMID: 27526091] - Jennifer L Willcox, Catherine Hammett-Stabler, Marlene L Hauck. Serum 25-hydroxyvitamin D concentrations in dogs with osteosarcoma do not differ from those of age- and weight-matched control dogs.
Veterinary journal (London, England : 1997).
2016 Nov; 217(?):132-133. doi:
10.1016/j.tvjl.2016.10.005
. [PMID: 27810204] - Niek F Dirks, Hubert W Vesper, Antonius E van Herwaarden, Jody M W van den Ouweland, Ido P Kema, Johannes G Krabbe, Annemieke C Heijboer. Various calibration procedures result in optimal standardization of routinely used 25(OH)D ID-LC-MS/MS methods.
Clinica chimica acta; international journal of clinical chemistry.
2016 Nov; 462(?):49-54. doi:
10.1016/j.cca.2016.08.016
. [PMID: 27570062] - Steven A Abrams. What does it mean to target specific serum 25-hydroxyvitamin D concentrations in children and adolescents?.
The American journal of clinical nutrition.
2016 11; 104(5):1193-1194. doi:
10.3945/ajcn.116.144758
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