Kinetensin (BioDeep_00000024694)

 

Secondary id: BioDeep_00001880075

human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


(2S)-2-{[(2S)-2-{[(2S)-2-({[(2S)-1-[(2S)-2-{[(2S)-2-{[(2S)-2-{[(2S)-2-{[(2S,3S)-2-amino-1-hydroxy-3-methylpentylidene]amino}-1-hydroxypropylidene]amino}-5-carbamimidamido-1-hydroxypentylidene]amino}-5-carbamimidamido-1-hydroxypentylidene]amino}-3-(1H-imidazol-5-yl)propanoyl]pyrrolidin-2-yl](hydroxy)methylidene}amino)-1-hydroxy-3-(4-hydroxyphenyl)propylidene]amino}-1-hydroxy-3-phenylpropylidene]amino}-4-methylpentanoate

  化学式: C56H85N17O11 (1171.6614)
中文名称: 升压素, 运动升压素
  谱图信息: 最多检出来源 () 0%

Reviewed

Last reviewed on 2024-07-09.

Cite this Page

Kinetensin. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/kinetensin (retrieved 2025-05-04) (BioDeep RN: BioDeep_00000024694). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CCC(C)C(C(=O)NC(C)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=C(C=C3)O)C(=O)NC(CC4=CC=CC=C4)C(=O)NC(CC(C)C)C(=O)O)N
InChI: InChI=1S/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/t32-,33+,38-,39+,40+,41-,42-,43+,44-,45-/m0/s1


描述信息

Kinetensin is a nonapeptide, originally isolated from pepsin-treated plasma that shares some sequence homology with the C-terminal end of neurotensin, serum albumin and angiotensin. It is a potent histamine releaser in rodents and may serve as an inflammatory mediator [HMDB]
Kinetensin is a nonapeptide, originally isolated from pepsin-treated plasma that shares some sequence homology with the C-terminal end of neurotensin, serum albumin, and angiotensin. It is a potent histamine releaser in rodents and may serve as an inflammatory mediator.
Kinetensin is a neurotensin-like peptide isolated from pepsin-treated human plasma.
Kinetensin is a neurotensin-like peptide isolated from pepsin-treated human plasma.

同义名列表

10 个代谢物同义名

(2S)-2-{[(2S)-2-{[(2S)-2-({[(2S)-1-[(2S)-2-{[(2S)-2-{[(2S)-2-{[(2S)-2-{[(2S,3S)-2-amino-1-hydroxy-3-methylpentylidene]amino}-1-hydroxypropylidene]amino}-5-carbamimidamido-1-hydroxypentylidene]amino}-5-carbamimidamido-1-hydroxypentylidene]amino}-3-(1H-imidazol-5-yl)propanoyl]pyrrolidin-2-yl](hydroxy)methylidene}amino)-1-hydroxy-3-(4-hydroxyphenyl)propylidene]amino}-1-hydroxy-3-phenylpropylidene]amino}-4-methylpentanoate; (2S)-2-[(2S)-2-[(2S)-2-{[(2S)-1-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S,3S)-2-amino-3-methylpentanamido]propanamido]-5-carbamimidamidopentanamido]-5-carbamimidamidopentanamido]-3-(1H-imidazol-4-yl)propanoyl]pyrrolidin-2-yl]formamido}-3-(4-hydroxyphenyl)propanamido]-3-phenylpropanamido]-4-methylpentanoic acid; L-Isoleucyl-L-alanyl-L-arginyl-L-arginyl-L-histidyl-L-prolyl-L-tyrosyl-L-phenylalanyl-L-leucine; L-Ile-L-ala-L-arg-L-arg-L-his-L-pro-L-tyr-L-phe-L-leu; H-Ile-ala-arg-arg-his-pro-tyr-phe-leu-OH; Ile-ala-arg-arg-his-pro-tyr-phe-leu; Kinetensin (human); I-a-R-R-H-p-y-F-L; Kinetensin; IARRHPYFL



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Marc Wichern, Claus Lindenblatt, Manfred Lübken, Harald Horn. Experimental results and mathematical modelling of an autotrophic and heterotrophic biofilm in a sand filter treating landfill leachate and municipal wastewater. Water research. 2008 Aug; 42(14):3899-909. doi: 10.1016/j.watres.2008.05.031. [PMID: 18708239]
  • S Renee Commerford, Leo Vargas, Suzanne E Dorfman, Nico Mitro, Erik C Rocheford, Puiying A Mak, Xue Li, Patrick Kennedy, Tara L Mullarkey, Enrique Saez. Dissection of the insulin-sensitizing effect of liver X receptor ligands. Molecular endocrinology (Baltimore, Md.). 2007 Dec; 21(12):3002-12. doi: 10.1210/me.2007-0156. [PMID: 17717069]
  • D Read, A Shulkes, D Fletcher, K Hardy. Pharmacokinetics and biological activity of kinetensin in conscious sheep. Agents and actions. 1993 Mar; 38(3-4):231-9. doi: 10.1007/bf01976215. [PMID: 8213349]
  • A Sydbom, J Ware, M H Mogard. Stimulation of histamine release by the peptide kinetensin. Agents and actions. 1989 Apr; 27(1-2):68-71. doi: 10.1007/bf02222201. [PMID: 2473637]
  • M H Mogard, R Kobayashi, T D Lee, C F Chen, M Hagiwara, F Leung, J R Reeve, J E Shively, J H Walsh. Neurotensin-like immunoreactivity generated by pepsin from human plasma and gastric tissue. Regulatory peptides. 1987 Aug; 18(3-4):221-32. doi: 10.1016/0167-0115(87)90010-3. [PMID: 3118424]
  • R E Carraway, S P Mitra, D E Cochrane. Structure of a biologically active neurotensin-related peptide obtained from pepsin-treated albumin(s). The Journal of biological chemistry. 1987 May; 262(13):5968-73. doi: NULL. [PMID: 2437111]
  • M H Mogard, R Kobayashi, C F Chen, T D Lee, J R Reeve, J E Shively, J H Walsh. The amino acid sequence of kinetensin, a novel peptide isolated from pepsin-treated human plasma: homology with human serum albumin, neurotensin and angiotensin. Biochemical and biophysical research communications. 1986 May; 136(3):983-8. doi: 10.1016/0006-291x(86)90429-8. [PMID: 3087352]