murrayafoline A (BioDeep_00000246254)

   

natural product


代谢物信息卡片


1-Methoxy-3-methyl-9H-carbazole

化学式: C14H13NO (211.0997)
中文名称: 1-甲氧基-3-甲基-9H-咔唑
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=CC2=C(C(=C1)OC)NC3=CC=CC=C32
InChI: InChI=1S/C14H13NO/c1-9-7-11-10-5-3-4-6-12(10)15-14(11)13(8-9)16-2/h3-8,15H,1-2H3

描述信息

同义名列表

2 个代谢物同义名

1-Methoxy-3-methyl-9H-carbazole; murrayafoline A



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

30 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Renren Bai, Chuansheng Yao, Zhichao Zhong, Jiamin Ge, Ziqiang Bai, Xiangyang Ye, Tian Xie, Yuanyuan Xie. Discovery of natural anti-inflammatory alkaloids: Potential leads for the drug discovery for the treatment of inflammation. European journal of medicinal chemistry. 2021 Mar; 213(?):113165. doi: 10.1016/j.ejmech.2021.113165. [PMID: 33454546]
  • Joon-Chul Kim, Jun Wang, Min-Jung Son, Nguyen Manh Cuong, Sun-Hee Woo. Sensitization of cardiac Ca²⁺ release sites by protein kinase C signaling: evidence from action of murrayafoline A. Pflugers Archiv : European journal of physiology. 2015 Jul; 467(7):1607-1621. doi: 10.1007/s00424-014-1589-9. [PMID: 25095987]
  • Min-Jeong Son, Bojjibabu Chidipi, Joon-Chul Kim, Tran Thu Huong, Bui Huu Tai, Young Ho Kim, Joung Real Ahn, Nguyen Manh Cuong, Sun-Hee Woo. Alterations of contractions and L-type Ca2+ currents by murrayafoline-A in rat ventricular myocytes. European journal of pharmacology. 2014 Oct; 740(?):81-7. doi: 10.1016/j.ejphar.2014.07.001. [PMID: 25016086]
  • Tran Thi Thu Thuy, Nguyen Manh Cuong, Tran Quoc Toan, Ngo Ngoc Thang, Bui Huu Tai, Nguyen Xuan Nhiem, Hye-Jin Hong, Sohyun Kim, Stephanie Legoupy, Young Sang Koh, Young Ho Kim. Synthesis of novel derivatives of murrayafoline A and their inhibitory effect on LPS-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells. Archives of pharmacal research. 2013 Jul; 36(7):832-9. doi: 10.1007/s12272-013-0100-z. [PMID: 23564015]
  • Nguyen Manh Cuong, Tran Quang Hung, Tran Van Sung, Walter Chacles Taylor. A new dimeric carbazole alkaloid from Glycosmis stenocarpa roots. Chemical & pharmaceutical bulletin. 2004 Oct; 52(10):1175-8. doi: 10.1248/cpb.52.1175. [PMID: 15467229]
  • M Itoigawa, Y Kashiwada, C Ito, H Furukawa, Y Tachibana, K F Bastow, K H Lee. Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents. Journal of natural products. 2000 Jul; 63(7):893-7. doi: 10.1021/np000020e. [PMID: 10924160]
  • U Tröhler, J P Bonjour, H Fleisch. Inorganic phosphate homeostasis. Renal adaptation to the dietary intake in intact and thyroparathyroidectomized rats. The Journal of clinical investigation. 1976 Feb; 57(2):264-73. doi: 10.1172/jci108277. [PMID: 3518]
  • A W Mondorf. [Evidence of urinary tubular proteins in inflammatory and toxic kidney damage]. Wiener medizinische Wochenschrift. Supplement. 1975; 27(?):20-3. doi: NULL. [PMID: 5816]