Aclacinomycin B (BioDeep_00000244902)
代谢物信息卡片
化学式: C42H51NO15 (809.3258536)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC1(CC(C2=C(C3=C(C=C2C1C(=O)OC)C(=O)C4=C(C3=O)C(=CC=C4)O)O)OC5CC(C(C(O5)C)OC6CC7C(C(O6)C)OC8C(O7)CC(=O)C(O8)C)N(C)C)O
InChI: InChI=1S/C42H51NO15/c1-8-42(50)16-28(32-21(34(42)40(49)51-7)12-22-33(37(32)48)36(47)31-20(35(22)46)10-9-11-24(31)44)56-29-13-23(43(5)6)38(18(3)52-29)57-30-15-26-39(19(4)53-30)58-41-27(55-26)14-25(45)17(2)54-41/h9-12,17-19,23,26-30,34,38-39,41,44,48,50H,8,13-16H2,1-7H3/t17-,18-,19-,23-,26-,27-,28-,29-,30-,34-,38+,39+,41-,42+/m0/s1
描述信息
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C259 - Antineoplastic Antibiotic
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor > C1748 - Topoisomerase Inhibitor
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D000970 - Antineoplastic Agents
D007155 - Immunologic Factors
同义名列表
1 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 67280 - Streptomyces bobili: 10.7164/ANTIBIOTICS.34.951
- 33899 - Streptomyces galilaeus: 10.7164/ANTIBIOTICS.34.951
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tomomi Sakai, Takuya Miyazaki, Dong-Mi Shin, Yong-Soo Kim, Chen-Feng Qi, Robert Fariss, Jeeva Munasinghe, Hongsheng Wang, Alexander L Kovalchuk, Parul H Kothari, Charles S Fermaintt, John P Atkinson, Fred W Perrino, Nan Yan, Herbert C Morse. DNase-active TREX1 frame-shift mutants induce serologic autoimmunity in mice.
Journal of autoimmunity.
2017 Jul; 81(?):13-23. doi:
10.1016/j.jaut.2017.03.001. [PMID: 28325644] - Xiao-Rong Ma, Jin Wang, Wang-Gang Zhang, Yin-Xia Chen, Xing-Mei Cao, Ai-Li He, Jie Liu, Jian-Li Wang, Liu-Fang Gu, Bo Lei, Peng-Yu Zhang, Wan-Hong Zhao, Yun Yang, Fang-Xia Wang, Yan Xu. [Cohort Study on GHA and New Combined Priming Chemotherapeutic Regimens in Treatment of Refractory Acute Myeloid Leukemia and Myelodysplastic Syndrome].
Zhongguo shi yan xue ye xue za zhi.
2015 Apr; 23(2):369-74. doi:
10.7534/j.issn.1009-2137.2015.02.014. [PMID: 25948187] - J Tarasiuk, A Garnier-Suillerot. Kinetic parameters for the uptake of anthracycline by drug-resistant and drug-sensitive K562 cells.
European journal of biochemistry.
1992 Mar; 204(2):693-8. doi:
10.1111/j.1432-1033.1992.tb16683.x. [PMID: 1541282] - A S Tsiftsoglou, W Wong, A I Tsamadou, S H Robinson. Cooperative effects of hemin and anthracyclines in promoting terminal erythroid maturation in K562 human erythroleukemia cells.
Experimental hematology.
1991 Oct; 19(9):928-33. doi:
NULL. [PMID: 1893971] - Y Kobayashi, Y Usuda, Y Okutu, F Okumura, H Suzuki, G Yoshida, J Hayakawa, T Shibata. [Ventricular fibrillation after administration of aclacinomycin emulsion into mesenteric lymph nodes in a patient anesthetized with enflurane, nitrous oxide and oxygen].
Masui. The Japanese journal of anesthesiology.
1990 May; 39(5):651-5. doi:
NULL. [PMID: 2384961] - Y Sazuka, K Yoshikawa, H Tanizawa, Y Takino. Effect of aclacinomycin on lipid peroxide levels in tissues of mice.
Chemical & pharmaceutical bulletin.
1989 Dec; 37(12):3412-5. doi:
10.1248/cpb.37.3412. [PMID: 2632090] - Y Sazuka, H Tanizawa, Y Takino. Effect of adriamycin on DNA, RNA and protein biosyntheses in mouse tissues, in connection with its cardiotoxicity.
Japanese journal of cancer research : Gann.
1989 Oct; 80(10):1000-5. doi:
10.1111/j.1349-7006.1989.tb01640.x. [PMID: 2482282] - T Sawada, T Ebihara, K Maruyama, Y Tateyama, Y Yoshimura, S Kawakami, M Fukushima. [Balloon occluded arterial infusion (BOAI) therapy in patients with progressive cervical carcinoma].
Nihon Sanka Fujinka Gakkai zasshi.
1989 Mar; 41(3):293-300. doi:
NULL. [PMID: 2471758] - L Mazzanti, V Scalori, M Mian, M G Alessandrì, L Giovannini. Aclacinomycin tissue distribution in the rat.
Chemioterapia : international journal of the Mediterranean Society of Chemotherapy.
1988 Feb; 7(1):49-52. doi:
NULL. [PMID: 3378277] - T Konno. [Targeting chemotherapy of hepatocellular carcinoma by arterial administration of anticancer agents dissolved in lipiodol].
Gan to kagaku ryoho. Cancer & chemotherapy.
1987 Feb; 14(2):373-80. doi:
NULL. [PMID: 3028275] - T Sakuramoto, T Miura, Y Kubota. [Sensitivity tests of anti-cancer drugs with human tumor stem cell assay. 2. The results in renal cell carcinoma and urothelial carcinoma].
Nihon Hinyokika Gakkai zasshi. The japanese journal of urology.
1985 May; 76(5):645-8. doi:
10.5980/jpnjurol1928.76.5_645. [PMID: 4057715] - P Dodion, M J Egorin, C E Riggs, T A Ferraro, J M Tamburini, N R Bachur. Comparative murine metabolism and disposition of class II anthracycline antibiotics.
Cancer chemotherapy and pharmacology.
1985; 15(2):153-60. doi:
10.1007/bf00257527. [PMID: 3860304] - M Fujii, K Okabe, H Toki, Y Fujita, T Ishimitsu. [Efficacy of intrapleural treatment with aclacinomycin combined with closed tube thoracostomy for malignant pleural effusion].
Gan no rinsho. Japan journal of cancer clinics.
1984 Jul; 30(8):895-8. doi:
NULL. [PMID: 6471394]