Ikarugamycin (BioDeep_00000244374)
代谢物信息卡片
化学式: C29H38N2O4 (478.2831)
中文名称: 依古霉素
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC1C(C)CC2C1C=CC1C3CC=CC(=O)NCCCC4NC(=O)C(=C4O)C(=O)C=CC3CC12
InChI: InChI=1S/C29H38N2O4/c1-3-18-16(2)14-22-20(18)10-11-21-19-6-4-8-26(33)30-13-5-7-24-28(34)27(29(35)31-24)25(32)12-9-17(19)15-23(21)22/h4,8-12,16-24,34H,3,5-7,13-15H2,1-2H3,(H,30,33)(H,31,35)/b8-4-,12-9+/t16-,17-,18-,19+,20+,21-,22+,23+,24+/m1/s1
描述信息
A polyketide macrolactam containing a tetramic acid (pyrrolidine-2,4-dione) ring system. It is isolated from Streptomyces as an antibiotic with antiprotozoal and cytotoxic activities.
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
同义名列表
1 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:75276
- PubChem: 54680304
- PubChem: 57369669
- ChEMBL: CHEMBL4283254
- KNApSAcK: C00018842
- CAS: 36531-78-9
- PMhub: MS000098183
- MetaboLights: MTBLC75276
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Monica Scali, Alessandra Moscatelli, Luca Bini, Elisabetta Onelli, Rita Vignani, Wei Wang. Protein Analysis of Pollen Tubes after the Treatments of Membrane Trafficking Inhibitors Gains Insights on Molecular Mechanism Underlying Pollen Tube Polar Growth.
The protein journal.
2021 04; 40(2):205-222. doi:
10.1007/s10930-021-09972-x. [PMID: 33751342] - Chensu Wang, Hanspeter Niederstrasser, Peter M Douglas, Rueyling Lin, Juan Jaramillo, Yang Li, Nathaniel W Oswald, Anwu Zhou, Elizabeth A McMillan, Saurabh Mendiratta, Zhaohui Wang, Tian Zhao, Zhiqaing Lin, Min Luo, Gang Huang, Rolf A Brekken, Bruce A Posner, John B MacMillan, Jinming Gao, Michael A White. Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan.
Nature communications.
2017 12; 8(1):2270. doi:
10.1038/s41467-017-02332-3. [PMID: 29273768] - Sarah R Elkin, Nathaniel W Oswald, Dana K Reed, Marcel Mettlen, John B MacMillan, Sandra L Schmid. Ikarugamycin: A Natural Product Inhibitor of Clathrin-Mediated Endocytosis.
Traffic (Copenhagen, Denmark).
2016 10; 17(10):1139-49. doi:
10.1111/tra.12425. [PMID: 27392092] - Chongxi Liu, Xiangjing Wang, Junwei Zhao, Qianfeng Liu, Liang Wang, Xuejiao Guan, Hairong He, Wensheng Xiang. Streptomyces harbinensis sp. nov., an endophytic, ikarugamycin-producing actinomycete isolated from soybean root [Glycine max (L.) Merr].
International journal of systematic and evolutionary microbiology.
2013 Oct; 63(Pt 10):3579-3584. doi:
10.1099/ijs.0.050088-0. [PMID: 23584286] - Vera Bandmann, Ulrike Homann. Clathrin-independent endocytosis contributes to uptake of glucose into BY-2 protoplasts.
The Plant journal : for cell and molecular biology.
2012 May; 70(4):578-84. doi:
10.1111/j.1365-313x.2011.04892.x. [PMID: 22211449] - Elisabetta Onelli, Cristina Prescianotto-Baschong, Marco Caccianiga, Alessandra Moscatelli. Clathrin-dependent and independent endocytic pathways in tobacco protoplasts revealed by labelling with charged nanogold.
Journal of experimental botany.
2008; 59(11):3051-68. doi:
10.1093/jxb/ern154. [PMID: 18603619] - Alessandra Moscatelli, Fabrizio Ciampolini, Simona Rodighiero, Elisabetta Onelli, Mauro Cresti, Nadia Santo, Aurora Idilli. Distinct endocytic pathways identified in tobacco pollen tubes using charged nanogold.
Journal of cell science.
2007 Nov; 120(Pt 21):3804-19. doi:
10.1242/jcs.012138. [PMID: 17940063]
