Physapubescin (BioDeep_00000024428)

   

human metabolite Endogenous


代谢物信息卡片


6-Hydroxy-15-(1-{2-hydroxy-1,6-dimethyl-3,7-dioxabicyclo[4.1.0]heptan-4-yl}ethyl)-2,16-dimethyl-3-oxo-8-oxapentacyclo[9.7.0.0²,⁷.0⁷,⁹.0¹²,¹⁶]octadec-4-en-13-yl acetic acid

化学式: C30H42O8 (530.2879532000001)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)OC1CC(C(C)C2CC3(C)OC3(C)C(O)O2)C2(C)CCC3C(CC4OC45C(O)C=CC(=O)C35C)C12
InChI: InChI=1S/C30H42O8/c1-14(20-13-27(4)29(6,38-27)25(34)36-20)18-12-19(35-15(2)31)24-16-11-23-30(37-23)22(33)8-7-21(32)28(30,5)17(16)9-10-26(18,24)3/h7-8,14,16-20,22-25,33-34H,9-13H2,1-6H3

描述信息

Physapubescin is found in fruits. Physapubescin is a constituent of Physalis pubescens (ground cherry).

同义名列表

8 个代谢物同义名

6-Hydroxy-15-(1-{2-hydroxy-1,6-dimethyl-3,7-dioxabicyclo[4.1.0]heptan-4-yl}ethyl)-2,16-dimethyl-3-oxo-8-oxapentacyclo[9.7.0.0²,⁷.0⁷,⁹.0¹²,¹⁶]octadec-4-en-13-yl acetic acid; 6-hydroxy-15-(1-{2-hydroxy-1,6-dimethyl-3,7-dioxabicyclo[4.1.0]heptan-4-yl}ethyl)-2,16-dimethyl-3-oxo-8-oxapentacyclo[9.7.0.0²,⁷.0⁷,⁹.0¹²,¹⁶]octadec-4-en-13-yl acetate; 15-Acetoxy-5,6:22,26:24,25-triepoxy-4,26-dihydroxyergost-2-en-1-one, 9ci; Hex-3-ene-1-carboxylic acid; (Z)-Hept-4-enoic acid; (Z)-4-Heptenoic acid; Physapubescin; 4-Heptenoate



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Guihua Wang, Li Xu, Wei Liu, Wen Xu, Yu Mu, Zhanyou Wang, Xueshi Huang, Liya Li. New anti-inflammatory withanolides from Physalis pubescens fruit. Fitoterapia. 2020 Oct; 146(?):104692. doi: 10.1016/j.fitote.2020.104692. [PMID: 32717293]
  • Kai-Yin Yang, Can-Rong Wu, Meng-Zhu Zheng, Ruo-Tian Tang, Xing-Zhou Li, Li-Xia Chen, Hua Li. Physapubescin I from husk tomato suppresses SW1990 cancer cell growth by targeting kidney-type glutaminase. Bioorganic chemistry. 2019 11; 92(?):103186. doi: 10.1016/j.bioorg.2019.103186. [PMID: 31465967]
  • Li Cheng, Can-Rong Wu, Li-Han Zhu, Hua Li, Li-Xia Chen. Physapubescin, a natural withanolide as a kidney-type glutaminase (KGA) inhibitor. Bioorganic & medicinal chemistry letters. 2017 03; 27(5):1243-1246. doi: 10.1016/j.bmcl.2017.01.057. [PMID: 28174105]
  • Lixia Chen, Guiyang Xia, Feng Qiu, Chunli Wu, Andria P Denmon, Xiaolin Zi. Physapubescin selectively induces apoptosis in VHL-null renal cell carcinoma cells through down-regulation of HIF-2α and inhibits tumor growth. Scientific reports. 2016 09; 6(?):32582. doi: 10.1038/srep32582. [PMID: 27581364]
  • Long Ji, Yonglei Yuan, Zhongjun Ma, Zhe Chen, Lishe Gan, Xiaoqiong Ma, Dongsheng Huang. Induction of quinone reductase (QR) by withanolides isolated from Physalis pubescens L. (Solanaceae). Steroids. 2013 Sep; 78(9):860-5. doi: 10.1016/j.steroids.2013.05.008. [PMID: 23685089]