Norsalsolinol (BioDeep_00000024181)

   

human metabolite Endogenous


代谢物信息卡片


6,7-Dihydroxy-1,2,3,4-tetrahydroisoquinoline

化学式: C9H11NO2 (165.079)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(endogenous) 12.84%

分子结构信息

SMILES: C1CNCC2=CC(=C(C=C21)O)O
InChI: InChI=1S/C9H11NO2/c11-8-3-6-1-2-10-5-7(6)4-9(8)12/h3-4,10-12H,1-2,5H2

描述信息

Norsalsolinol is a putative metabolic neuromodulators that hs been found to be present in both rat and human brains. It modulates dopaminergic transmission and have been shown to be associated with neurotoxicity within cells and diseases such as alcoholism and Parkinsonism. Norsalsolinol can be synthesized in vivo non-enzymatically by condensation of dopamine with formaldehyde, the oxidized metabolite of methanol.
A human metabolite taken as a putative food compound of mammalian origin [HMDB]

同义名列表

9 个代谢物同义名

6,7-Dihydroxy-1,2,3,4-tetrahydroisoquinoline; 1,2,3,4-tetrahydroisoquinoline-6,7-diol; 1,2,3,4-tetrahydro-6,7-Isoquinolinediol; 6,7-Dihydroxytetrahydroisoquinoline; tetrahydro-6,7-Isoquinolinediol; Norsalsolinol, 3H-labeled CPD; Norsalsolinol hydrochloride; Norsalsolinol hydrobromide; Norsalsolinol



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Veit Roessner, Susanne Walitza, Franz Riederer, Regina Hünnerkopf, Aribert Rothenberger, Manfred Gerlach, Andreas Moser. Tetrahydroisoquinoline derivatives: a new perspective on monoaminergic dysfunction in children with ADHD?. Behavioral and brain functions : BBF. 2007 Dec; 3(?):64. doi: 10.1186/1744-9081-3-64. [PMID: 18070346]
  • J Scholz, I Klingemann, A Moser. Increased systemic levels of norsalsolinol derivatives are induced by levodopa treatment and do not represent biological markers of Parkinson's disease. Journal of neurology, neurosurgery, and psychiatry. 2004 Apr; 75(4):634-6. doi: 10.1136/jnnp.2003.010769. [PMID: 15026514]
  • Y Maruyama, Y Suzuki, A Kazusaka, S Fujita. Uptake of the dopaminergic neurotoxin, norsalsolinol, into PC12 cells via dopamine transporter. Archives of toxicology. 2001 Jun; 75(4):209-13. doi: 10.1007/s002040000202. [PMID: 11482518]
  • Y Maruyama, H Teraoka, H Iwata, A Kazusaka, S Fujita. Inhibitory effects of endogenous dopaminergic neurotoxin, norsalsolinol on dopamine secretion in PC12 rat pheochromocytoma cells. Neurochemistry international. 2001 Jun; 38(7):567-72. doi: 10.1016/s0197-0186(00)00121-2. [PMID: 11290381]
  • Y Maruyama, Y Suzuki, A Kazusaka, S Fujita. Norsalsolinol uptake into secretory vesicles via vesicular monoamine transporter and its secretion by membrane depolarization or purinoceptor stimulation in PC12 cells. The Journal of veterinary medical science. 2001 May; 63(5):493-7. doi: 10.1292/jvms.63.493. [PMID: 11411492]
  • A Shirahata, M Yoshioka, Z Tamura. Fluorometric determination of 1,2,3,4-tetrahydro-6,7-dihydroxyisoquinoline in biological materials by HPLC. Chemical & pharmaceutical bulletin. 1997 Nov; 45(11):1814-9. doi: 10.1248/cpb.45.1814. [PMID: 9396158]
  • F Musshoff, T Daldrup, W Bonte, A Leitner, O M Lesch. Salsolinol and norsalsolinol in human urine samples. Pharmacology, biochemistry, and behavior. 1997 Oct; 58(2):545-50. doi: 10.1016/s0091-3057(97)00251-7. [PMID: 9300617]
  • P Dostert, M Strolin Benedetti, F Della Vedova, C Allievi, R La Croix, G Dordain, D Vernay, F Durif. Dopamine-derived tetrahydroisoquinolines and Parkinson's disease. Advances in neurology. 1993; 60(?):218-23. doi: NULL. [PMID: 8420138]