Rhinacanthin C (BioDeep_00000239988)
natural product
代谢物信息卡片
化学式: C25H30O5 (410.2093)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C/C=C(\C)CC/C=C(\C)C(=O)OCC(C)(C)CC1=C(O)C(=O)c2ccccc2C1=O
InChI: InChI=1S/C25H30O5/c1-6-16(2)10-9-11-17(3)24(29)30-15-25(4,5)14-20-21(26)18-12-7-8-13-19(18)22(27)23(20)28/h6-8,11-13,26H,9-10,14-15H2,1-5H3/b16-6+,17-11+
描述信息
A naphthoquinone isolated from Rhinacanthus nasutus and has been shown to exhibit antiviral activity.
同义名列表
1 个代谢物同义名
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:66303
- PubChem: 6474554
- PubChem: 464916
- ChEMBL: CHEMBL462962
- KNApSAcK: C00041095
- CAS: 159278-74-7
- PMhub: MS000070713
- MetaboLights: MTBLC66303
- LOTUS: LTS0068380
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
12 个相关的物种来源信息
- 4185 - Acanthaceae: LTS0068380
- 2759 - Eukaryota: LTS0068380
- 3398 - Magnoliopsida: LTS0068380
- 141328 - Rhinacanthus: LTS0068380
- 537489 - Rhinacanthus nasutus: 10.1016/S0031-9422(98)00425-7
- 537489 - Rhinacanthus nasutus: 10.1021/NP9601871
- 537489 - Rhinacanthus nasutus: 10.1248/BPB.29.2070
- 537489 - Rhinacanthus nasutus: 10.1248/BPB.29.2279
- 537489 - Rhinacanthus nasutus: LTS0068380
- 35493 - Streptophyta: LTS0068380
- 58023 - Tracheophyta: LTS0068380
- 33090 - Viridiplantae: LTS0068380
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
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文献列表
- Jirasak Paosupap, Abdul Basit, Warayuth Sajomsang, Sirinporn Nalinbejapun, Sasikarn Sripetthong, Chitchamai Ovatlarnporn. Evaluation of the antifungal properties of nanoliposomes containing rhinacanthin-C isolated from the leaves of Rhinacanthus nasutus.
World journal of microbiology & biotechnology.
2024 Mar; 40(4):129. doi:
10.1007/s11274-024-03916-0
. [PMID: 38459287] - Thongtham Suksawat, Pharkphoom Panichayupakaranant. Variation of rhinacanthin content in Rhinacanthus nasutus and its health products.
Journal of pharmaceutical and biomedical analysis.
2023 Feb; 224(?):115177. doi:
10.1016/j.jpba.2022.115177
. [PMID: 36436487] - Uzma Saleem, Zujajah Gull, Ammara Saleem, Muhammad Ajmal Shah, Muhammad Furqan Akhtar, Fareeha Anwar, Bashir Ahmad, Pharkphoom Panichayupakaranant. Appraisal of anti-Parkinson activity of rhinacanthin-C in haloperidol-induced parkinsonism in mice: A mechanistic approach.
Journal of food biochemistry.
2021 04; 45(4):e13677. doi:
10.1111/jfbc.13677
. [PMID: 33709527] - Wilasinee Dunkoksung, Nontima Vardhanabhuti, Pongpun Siripong, Suree Jianmongkol. Rhinacanthin-C Mediated Herb-Drug Interactions with Drug Transporters and Phase I Drug-Metabolizing Enzymes.
Drug metabolism and disposition: the biological fate of chemicals.
2019 10; 47(10):1040-1049. doi:
10.1124/dmd.118.085647
. [PMID: 31399508] - Muhammad Ajmal Shah, Wantana Reanmongkol, Nisaudah Radenahmad, Ruqaiya Khalil, Zaheer Ul-Haq, Pharkphoom Panichayupakaranant. Anti-hyperglycemic and anti-hyperlipidemic effects of rhinacanthins-rich extract from Rhinacanthus nasutus leaves in nicotinamide-streptozotocin induced diabetic rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 May; 113(?):108702. doi:
10.1016/j.biopha.2019.108702
. [PMID: 30844658] - Ling-Ling Zhao, Emmanuel Ayobami Makinde, Muhammad Ajmal Shah, Opeyemi Joshua Olatunji, Pharkphoom Panichayupakaranant. Rhinacanthins-rich extract and rhinacanthin C ameliorate oxidative stress and inflammation in streptozotocin-nicotinamide-induced diabetic nephropathy.
Journal of food biochemistry.
2019 04; 43(4):e12812. doi:
10.1111/jfbc.12812
. [PMID: 31353582] - Tran Minh Ngoc, Nguyen Thi Thanh Phuong, Nguyen Minh Khoi, SeonJu Park, Hee Jae Kwak, Nguyen Xuan Nhiem, Bui Thi Thu Trang, Bui Huu Tai, Jae-Hyoung Song, Hyun-Jeong Ko, Seung Hyun Kim. A new naphthoquinone analogue and antiviral constituents from the root of Rhinacanthus nasutus.
Natural product research.
2019 Feb; 33(3):360-366. doi:
10.1080/14786419.2018.1452004
. [PMID: 29561167] - Parichart Boueroy, Sunitta Saensa‑Ard, Pongpun Siripong, Sakawrat Kanthawong, Chariya Hahnvajanawong. Rhinacanthin-C Extracted from Rhinacanthus nasutus (L.) Inhibits Cholangiocarcinoma Cell Migration and Invasion by Decreasing MMP-2, uPA, FAK and MAPK Pathways.
Asian Pacific journal of cancer prevention : APJCP.
2018 Dec; 19(12):3605-3613. doi:
10.31557/apjcp.2018.19.12.3605
. [PMID: 30583689] - Chih-Zen Chang, Shu-Chuan Wu, Aij-Lie Kwan, Chih-Lung Lin. Rhinacanthin-C, A Fat-Soluble Extract from Rhinacanthus nasutus, Modulates High-Mobility Group Box 1-Related Neuro-Inflammation and Subarachnoid Hemorrhage-Induced Brain Apoptosis in a Rat Model.
World neurosurgery.
2016 Feb; 86(?):349-60. doi:
10.1016/j.wneu.2015.08.071
. [PMID: 26361320] - Siti Hajar Adam, Nelli Giribabu, Pasupuleti Visweswara Rao, Abu Sadat Md Sayem, Aditya Arya, Pharkphoom Panichayupakaranant, Praveen Kumar Korla, Naguib Salleh. Rhinacanthin C ameliorates hyperglycaemia, hyperlipidemia and pancreatic destruction in streptozotocin-nicotinamide induced adult male diabetic rats.
European journal of pharmacology.
2016 Jan; 771(?):173-90. doi:
10.1016/j.ejphar.2015.12.028
. [PMID: 26703866] - Phisit Pouyfung, Aruna Prasopthum, Songklod Sarapusit, Ekaruth Srisook, Pornpimol Rongnoparut. Mechanism-based inactivation of cytochrome P450 2A6 and 2A13 by Rhinacanthus nasutus constituents.
Drug metabolism and pharmacokinetics.
2014; 29(1):75-82. doi:
10.2133/dmpk.dmpk-13-rg-048
. [PMID: 23903410] - Ratjika Wongwanakul, Nontima Vardhanabhuti, Pongpun Siripong, Suree Jianmongkol. Effects of rhinacanthin-C on function and expression of drug efflux transporters in Caco-2 cells.
Fitoterapia.
2013 Sep; 89(?):80-5. doi:
10.1016/j.fitote.2013.05.019
. [PMID: 23742857] - Haruka Horii, Ryuichiro Suzuki, Hiroshi Sakagami, Mineko Tomomura, Akito Tomomura, Yoshiaki Shirataki. New biological activities of Rhinacanthins from the root of Rhinacanthus nasutus.
Anticancer research.
2013 Feb; 33(2):453-9. doi:
"
. [PMID: 23393336] - P Panichayupakaranant, W Meerungrueang. Effect of medium composition and light on root and rhinacanthin formation in Rhinacanthus nasutus cultures.
Pharmaceutical biology.
2010 Nov; 48(11):1192-7. doi:
10.3109/13880200903578747
. [PMID: 20843160] - Supinya Tewtrakul, Pimpimon Tansakul, Pharkphoom Panichayupakaranant. Anti-allergic principles of Rhinacanthus nasutus leaves.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2009 Oct; 16(10):929-34. doi:
10.1016/j.phymed.2009.03.010
. [PMID: 19403288] - P Panichayupakaranant, T Charoonratana, A Sirikatitham. RP-HPLC analysis of rhinacanthins in Rhinacanthus nasutus: validation and application for the preparation of rhinacanthin high-yielding extract.
Journal of chromatographic science.
2009 Sep; 47(8):705-8. doi:
10.1093/chromsci/47.8.705
. [PMID: 19772749] - Pongpun Siripong, Jantana Yahuafai, Kosuke Shimizu, Kanae Ichikawa, Sei Yonezawa, Tomohiro Asai, Kwanjai Kanokmedakul, Somsak Ruchirawat, Naoto Oku. Induction of apoptosis in tumor cells by three naphthoquinone esters isolated from Thai medicinal plant: Rhinacanthus nasutus KURZ.
Biological & pharmaceutical bulletin.
2006 Oct; 29(10):2070-6. doi:
10.1248/bpb.29.2070
. [PMID: 17015953] - A Sendl, J L Chen, S D Jolad, C Stoddart, E Rozhon, M Kernan, W Nanakorn, M Balick. Two new naphthoquinones with antiviral activity from Rhinacanthus nasutus.
Journal of natural products.
1996 Aug; 59(8):808-11. doi:
10.1021/np9601871
. [PMID: 8792629]