Wilforgin (BioDeep_00000239401)

Main id: BioDeep_00000230671

 

PANOMIX_OTCML-2023


代谢物信息卡片


(8alpha)-8-(Acetyloxy)-O2-deacetyl-8-deoxo-O2-(3-furanylcarbonyl)evonimine

化学式: C41H47NO19 (857.2742)
中文名称: 雷公藤吉碱
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)OCC12C(OC(C)=O)C(OC(C)=O)C3C(OC(C)=O)C14OC3(C)COC(=O)c1cccnc1CCC(C)C(=O)OC(C(OC(=O)c1ccoc1)C2OC(C)=O)C4(C)O
InChI: InChI=1S/C41H47NO19/c1-19-11-12-27-26(10-9-14-42-27)37(50)54-17-38(7)28-29(55-21(3)44)33(57-23(5)46)40(18-53-20(2)43)34(58-24(6)47)30(59-36(49)25-13-15-52-16-25)32(60-35(19)48)39(8,51)41(40,61-38)31(28)56-22(4)45/h9-10,13-16,19,28-34,51H,11-12,17-18H2,1-8H3

描述信息

Wilforgine is a bioactive sesquiterpene alkaloid in Tripterygium wilfordii Hook. F. Wilforgine can induce microstructural and ultrastructural changes in the muscles of Mythimna separata larvae, and the sites of action are proposed to be calcium receptors or channels in the muscular system[1][2].
Wilforgine is a bioactive sesquiterpene alkaloid in Tripterygium wilfordii Hook. F. Wilforgine can induce microstructural and ultrastructural changes in the muscles of Mythimna separata larvae, and the sites of action are proposed to be calcium receptors or channels in the muscular system[1][2].

同义名列表

4 个代谢物同义名

Wilforgine; Wilforgin; (8alpha)-8-(Acetyloxy)-O2-deacetyl-8-deoxo-O2-(3-furanylcarbonyl)evonimine; CID 14108469



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Jieru Chen, Yuanping Xue, Xiaoyu Shuai, Chunxu Ni, Zihui Fang, Ling Ye, Mei Hong. Effect of major components of Tripterygium wilfordii Hook. f on the uptake function of organic anion transporting polypeptide 1B1. Toxicology and applied pharmacology. 2022 01; 435(?):115848. doi: 10.1016/j.taap.2021.115848. [PMID: 34958783]
  • Shujie Ma, Lin Liu, Minxiang Dou, Zhiqing Ma, Xing Zhang. Comparative studies on muscle microstructure and ultrastructure of Mythimna separata Walker treated with wilforgine and chlorantraniliprole. Ecotoxicology and environmental safety. 2018 Jan; 147(?):1023-1034. doi: 10.1016/j.ecoenv.2017.09.067. [PMID: 29976005]
  • Guo-peng Miao, Chuan-shu Zhu, Jun-tao Feng, Li-rong Han, Xing Zhang. Effects of plant stress signal molecules on the production of wilforgine in an endophytic actinomycete isolated from Tripterygium wilfordii Hook.f. Current microbiology. 2015 Apr; 70(4):571-9. doi: 10.1007/s00284-014-0758-6. [PMID: 25523369]
  • Peng-Fei Wen, Jia-Min Lei, Qun Li, Lei Cui, Yan Li, Xing Zhang. [Effects of amino acid on growth and secondary metabolites contents of adventitious roots of Tripterygium wilfordii]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2014 Jun; 39(12):2267-74. doi: ". [PMID: 25244757]
  • Haoyu Ye, Svetlana Ignatova, Houding Luo, Yanfang Li, Aihua Peng, Lijuan Chen, Ian Sutherland. Preparative separation of a terpenoid and alkaloids from Tripterygium wilfordii Hook. f. using high-performance counter-current chromatography. Comparison of various elution and operating strategies. Journal of chromatography. A. 2008 Dec; 1213(2):145-53. doi: 10.1016/j.chroma.2008.09.116. [PMID: 18976997]
  • Sui Lin, Yuan-chao Li, Nobuko Sakurai, Jian-hong Cao, Si-sang Deng, Zhi-lin Xia, Di-lin Xie. [Isolation and structure of wilfordlonging from Tripterygium wilfordii Hook. f]. Yao xue xue bao = Acta pharmaceutica Sinica. 2002 Feb; 37(2):128-30. doi: ". [PMID: 12579958]