Rohitukine (BioDeep_00000239123)

   


代谢物信息卡片


Rohitukine

化学式: C16H19NO5 (305.1263164)
中文名称: 罗希吐碱
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=CC(=O)C2=C(O1)C(=C(C=C2O)O)C3CCN(CC3O)C
InChI: InChI=1S/C16H19NO5/c1-8-5-10(18)15-12(20)6-11(19)14(16(15)22-8)9-3-4-17(2)7-13(9)21/h5-6,9,13,19-21H,3-4,7H2,1-2H3/t9-,13+/m0/s1

描述信息

A member of the class of chromones that is 4H-chromen-4-one in which the hydrogens at positions 2,5,7 and 8 are replaced by methyl, hydroxy, hydroxy, and (3S,4R)-3-hydroxy-1-methylpiperidin-4-yl groups, respectively. It is an alkaloid initially isolated from Amoora rohituka and is a precursor of the anti-cancer compound flavopiridol.

同义名列表

1 个代谢物同义名

Rohitukine



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Sajad Ahmed, Rekha Chouhan, Alim Junaid, Vijay Lakshmi Jamwal, Jitendra Thakur, Bilal Ahmad Mir, Sumit G Gandhi. Transcriptome analysis and differential expression in Arabidopsis thaliana in response to rohitukine (a chromone alkaloid) treatment. Functional & integrative genomics. 2023 Jan; 23(1):35. doi: 10.1007/s10142-023-00961-0. [PMID: 36629976]
  • V M Balaramnavar, R Srivastava, S Varshney, S Kumar, A K Rawat, H Chandasana, Y S Chhonker, R S Bhatta, A K Srivastava, A N Gaikwad, V Lakshmi, A K Saxena. Synthesis, biological evaluation, and molecular docking study of some new rohitukine analogs as protein tyrosine phosphatase 1B inhibitors. Bioorganic chemistry. 2021 05; 110(?):104829. doi: 10.1016/j.bioorg.2021.104829. [PMID: 33773222]
  • Vikas Kumar, Sonali S Bharate, Deendyal Bhurta, Mehak Gupta, Sumit G Gandhi, Deepika Singh, Sundeep Jaglan, Ajay Kumar, Ram A Vishwakarma, Sandip B Bharate. Evaluation of rohitukine-enriched fraction of Dysoxylum binectariferum Hook.f. (leaves) as anti-arthritic phytopharmaceutical candidate: Chemical standardization, in-vivo validation, formulation development and oral pharmacokinetics. Journal of ethnopharmacology. 2020 May; 254(?):112758. doi: 10.1016/j.jep.2020.112758. [PMID: 32165175]
  • Amarinder Singh, Pankaj Chibber, Praveen Kolimi, Tanveer Ahmad Malik, Nitika Kapoor, Amit Kumar, Narinder Kumar, Sumit G Gandhi, Surjeet Singh, Sheikh Tasduq Abdullah, Ram Vishwakarma, Gurdarshan Singh. Rohitukine inhibits NF-κB activation induced by LPS and other inflammatory agents. International immunopharmacology. 2019 Apr; 69(?):34-49. doi: 10.1016/j.intimp.2019.01.015. [PMID: 30665042]
  • Sunil K Mishra, Shashi Tiwari, Shishir Shrivastava, Ravi Sonkar, Vaibhav Mishra, Sunil K Nigam, Anil K Saxena, Gitika Bhatia, Snober S Mir. Pharmacological evaluation of the efficacy of Dysoxylum binectariferum stem bark and its active constituent rohitukine in regulation of dyslipidemia in rats. Journal of natural medicines. 2018 Sep; 72(4):837-845. doi: 10.1007/s11418-014-0830-3. [PMID: 24677095]
  • Sandip B Bharate, Vikas Kumar, Shreyans K Jain, Mubashir J Mintoo, Santosh K Guru, Vijay K Nuthakki, Mohit Sharma, Sonali S Bharate, Sumit G Gandhi, Dilip M Mondhe, Shashi Bhushan, Ram A Vishwakarma. Discovery and Preclinical Development of IIIM-290, an Orally Active Potent Cyclin-Dependent Kinase Inhibitor. Journal of medicinal chemistry. 2018 02; 61(4):1664-1687. doi: 10.1021/acs.jmedchem.7b01765. [PMID: 29370702]
  • Vikas Kumar, Sonali S Bharate, Ram A Vishwakarma. Modulating lipophilicity of rohitukine via prodrug approach: Preparation, characterization, and in vitro enzymatic hydrolysis in biorelevant media. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2016 Sep; 92(?):203-11. doi: 10.1016/j.ejps.2016.07.010. [PMID: 27422078]
  • Vikas Kumar, Santosh K Guru, Shreyans K Jain, Prashant Joshi, Sumit G Gandhi, Sandip B Bharate, Shashi Bhushan, Sonali S Bharate, Ram A Vishwakarma. A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties. Bioorganic & medicinal chemistry letters. 2016 08; 26(15):3457-63. doi: 10.1016/j.bmcl.2016.06.046. [PMID: 27363938]
  • Patel Mohana Kumara, Amitava Srimany, Suganya Arunan, Gudasalamani Ravikanth, Ramanan Uma Shaanker, Thalappil Pradeep. Desorption Electrospray Ionization (DESI) Mass Spectrometric Imaging of the Distribution of Rohitukine in the Seedling of Dysoxylum binectariferum Hook. F. PloS one. 2016; 11(6):e0158099. doi: 10.1371/journal.pone.0158099. [PMID: 27362422]
  • P Mohana Kumara, Amitava Srimany, G Ravikanth, R Uma Shaanker, T Pradeep. Ambient ionization mass spectrometry imaging of rohitukine, a chromone anti-cancer alkaloid, during seed development in Dysoxylum binectariferum Hook.f (Meliaceae). Phytochemistry. 2015 Aug; 116(?):104-110. doi: 10.1016/j.phytochem.2015.02.031. [PMID: 25799183]
  • Y S Chhonker, H Chandasana, A Kumar, D Kumar, T S Laxman, S K Mishra, V M Balaramnavar, S Srivastava, A K Saxena, R S Bhatta. Pharmacokinetics, Tissue Distribution and Plasma Protein Binding Studies of Rohitukine: A Potent Anti-hyperlipidemic Agent. Drug research. 2015 Jul; 65(7):380-7. doi: 10.1055/s-0034-1387774. [PMID: 25243649]
  • Vidushi Mahajan, Neha Sharma, Sunil Kumar, Vikram Bhardwaj, Asif Ali, R K Khajuria, Y S Bedi, Ram A Vishwakarma, Sumit G Gandhi. Production of rohitukine in leaves and seeds of Dysoxylum binectariferum: an alternate renewable resource. Pharmaceutical biology. 2015 Mar; 53(3):446-50. doi: 10.3109/13880209.2014.923006. [PMID: 25472605]
  • Safia, Mohd Kamil, Pooja Jadiya, Saba Sheikh, Ejazul Haque, Aamir Nazir, Vijai Lakshmi, Snober S Mir. The Chromone Alkaloid, Rohitukine, Affords Anti-Cancer Activity via Modulating Apoptosis Pathways in A549 Cell Line and Yeast Mitogen Activated Protein Kinase (MAPK) Pathway. PloS one. 2015; 10(9):e0137991. doi: 10.1371/journal.pone.0137991. [PMID: 26405812]
  • Yashpal S Chhonker, Hardik Chandasana, Deepak Kumar, Sunil K Mishra, Shishir Srivastava, Vishal M Balaramnavar, Anil Nilkanth Gaikwad, Sanjeev Kanojiya, Anil K Saxena, Rabi S Bhatta. Pharmacokinetic and metabolism studies of rohitukine in rats by high performance liquid-chromatography with tandem mass spectrometry. Fitoterapia. 2014 Sep; 97(?):34-42. doi: 10.1016/j.fitote.2014.05.004. [PMID: 24840406]
  • Salil Varshney, Kripa Shankar, Muheeb Beg, Vishal M Balaramnavar, Sunil Kumar Mishra, Pankaj Jagdale, Shishir Srivastava, Yashpal S Chhonker, Vijai Lakshmi, Bhushan P Chaudhari, Rabi Shankar Bhatta, Anil Kumar Saxena, Anil Nilkanth Gaikwad. Rohitukine inhibits in vitro adipogenesis arresting mitotic clonal expansion and improves dyslipidemia in vivo. Journal of lipid research. 2014 06; 55(6):1019-32. doi: 10.1194/jlr.m039925. [PMID: 24646949]
  • P Mohana Kumara, K N Soujanya, G Ravikanth, R Vasudeva, K N Ganeshaiah, R Uma Shaanker. Rohitukine, a chromone alkaloid and a precursor of flavopiridol, is produced by endophytic fungi isolated from Dysoxylum binectariferum Hook.f and Amoora rohituka (Roxb).Wight & Arn. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2014 Mar; 21(4):541-6. doi: 10.1016/j.phymed.2013.09.019. [PMID: 24215673]
  • Neetu Singh, Pratibha Singh, Shishir Shrivastva, Sunil Kumar Mishra, Vijai Lakshmi, Rolee Sharma, Gautam Palit. Gastroprotective effect of anti-cancer compound rohitukine: possible role of gastrin antagonism and H(+) K (+)-ATPase inhibition. Naunyn-Schmiedeberg's archives of pharmacology. 2012 Mar; 385(3):277-86. doi: 10.1007/s00210-011-0711-1. [PMID: 22113419]