dehydroleucodin (BioDeep_00000238196)

   

PANOMIX_OTCML-2023 PANOMIX_OTCML-2025


代谢物信息卡片


Azuleno(4,5-b)furan-2,7-dione, 3,3a,4,5,9a,9b-hexahydro-6,9-dimethyl-3-methylene-, (3aS-(3aalpha,9aalpha,9bbeta))-

  化学式: C15H16O3 (244.1099)
中文名称: 脱氢乙酰甲基丁香酚
  谱图信息: 最多检出来源 Anoectochilus roxburghii(otcml) 50%

分子结构信息

SMILES: C12=C(CC[C@@H]3[C@@H]([C@H]1C(=CC2=O)C)OC(=O)C3=C)C
InChI: InChI=1S/C15H16O3/c1-7-4-5-10-9(3)15(17)18-14(10)13-8(2)6-11(16)12(7)13/h6,10,13-14H,3-5H2,1-2H3/t10-,13-,14-/m0/s1


描述信息

Dehydroleucodine is a natural product found in Eupatorium capillifolium, Podachaenium eminens, and other organisms with data available.

同义名列表

10 个代谢物同义名

Azuleno(4,5-b)furan-2,7-dione, 3,3a,4,5,9a,9b-hexahydro-6,9-dimethyl-3-methylene-, (3aS-(3aalpha,9aalpha,9bbeta))-; (3aS,9aS,9bS)-6,9-dimethyl-3-methylidene-4,5,9a,9b-tetrahydro-3aH-azuleno[4,5-b]furan-2,7-dione; (1S,6S,2R)-9,13-dimethyl-5-methylene-3- oxatricyclo[8.3.0.0^2,6^]trideca-9,12-diene-4,11-dione; (3aS,9aS,9bS)-6,9-Dimethyl-3-methylene-3,3a,4,5,9a,9b-hexahydro-azuleno[4,5-b]furan-2,7-dione; 6,9-Dimethyl-3-methylene-3,3a,4,5,9a,9b-hexahydro-azuleno[4,5-b]furan-2,7-dione; Dehydroleucodine, >=98\\% (HPLC); Dehydroleucodine; dehydroleucodin; 11,13-Dehydroleucodin; Lidbeckialactone



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome()

BioCyc()

PlantCyc()

代谢反应

个相关的代谢反应过程信息。

Reactome()

BioCyc()

WikiPathways()

Plant Reactome()

INOH()

PlantCyc()

COVID-19 Disease Map()

PathBank()

PharmGKB()

个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Lara Dürr, Jakob K Reinhardt, Maciej Dobrzyński, Tanja Hell, Martin Smieško, Olivier Pertz, Matthias Hamburger, Eliane Garo. A Dimerosesquiterpene and Sesquiterpene Lactones from Artemisia argyi Inhibiting Oncogenic PI3K/AKT Signaling in Melanoma Cells. Journal of natural products. 2022 11; 85(11):2557-2569. doi: 10.1021/acs.jnatprod.2c00471. [PMID: 36351173]
  • Mariano Ezequiel Vera, María Laura Mariani, Cristina Aguilera, Alicia Beatriz Penissi. Effect of a Cytoprotective Dose of Dehydroleucodine, Xanthatin, and 3-Benzyloxymethyl-5H-furan-2-one on Gastric Mucosal Lesions Induced by Mast Cell Activation. International journal of molecular sciences. 2021 Jun; 22(11):. doi: 10.3390/ijms22115983. [PMID: 34205991]
  • S Abood, M L Veisaga, L A López, M A Barbieri. Dehydroleucodine inhibits mitotic clonal expansion during adipogenesis through cell cycle arrest. Phytotherapy research : PTR. 2018 Aug; 32(8):1583-1592. doi: 10.1002/ptr.6089. [PMID: 29663555]
  • J Zapata-Martínez, G Sánchez-Toranzo, F Chaín, C A N Catalán, M I Bühler. Effect of guaianolides in the meiosis reinitiation of amphibian oocytes. Zygote (Cambridge, England). 2017 Feb; 25(1):10-16. doi: 10.1017/s0967199416000265. [PMID: 27806737]
  • Natalia Bailon-Moscoso, Gabriela González-Arévalo, Gabriela Velásquez-Rojas, Omar Malagon, Giovanni Vidari, Alejandro Zentella-Dehesa, Edward A Ratovitski, Patricia Ostrosky-Wegman. Phytometabolite Dehydroleucodine Induces Cell Cycle Arrest, Apoptosis, and DNA Damage in Human Astrocytoma Cells through p73/p53 Regulation. PloS one. 2015; 10(8):e0136527. doi: 10.1371/journal.pone.0136527. [PMID: 26309132]
  • Valeria V Costantino, Sabrina F Mansilla, Juliana Speroni, Celina Amaya, Darío Cuello-Carrión, Daniel R Ciocca, Horacio A Priestap, Manuel A Barbieri, Vanesa Gottifredi, Luis A Lopez. The sesquiterpene lactone dehydroleucodine triggers senescence and apoptosis in association with accumulation of DNA damage markers. PloS one. 2013; 8(1):e53168. doi: 10.1371/journal.pone.0053168. [PMID: 23341930]
  • Adriana Galvis, Adriana Marcano, Chad Stefancin, Nicole Villaverde, Horacio A Priestap, Carlos E Tonn, Luis A Lopez, Manuel A Barbieri. The effect of dehydroleucodine in adipocyte differentiation. European journal of pharmacology. 2011 Dec; 671(1-3):18-25. doi: 10.1016/j.ejphar.2011.09.033. [PMID: 21963454]
  • L Suhaiman, J Carlos de-Rosas, T Sartor, N Palmada, O S Giordano, L A Lopez. Effect of dehydroleucodine on the reproductive tract of male mice. Andrologia. 2011 Oct; 43(5):297-302. doi: 10.1111/j.1439-0272.2010.01053.x. [PMID: 21714796]
  • A E Vega, G H Wendel, A O M Maria, L Pelzer. Antimicrobial activity of Artemisia douglasiana and dehydroleucodine against Helicobacter pylori. Journal of ethnopharmacology. 2009 Jul; 124(3):653-5. doi: 10.1016/j.jep.2009.04.051. [PMID: 19422904]
  • G H Wendel, A O M María, J A Guzmán, O Giordano, L E Pelzer. Antidiarrheal activity of dehydroleucodine isolated from Artemisia douglasiana. Fitoterapia. 2008 Jan; 79(1):1-5. doi: 10.1016/j.fitote.2007.05.006. [PMID: 17683879]
  • M Cruzado, C Castro, D Fernandez, L Gomez, M Roque, O E Giordano, L A Lopez. Dehydroleucodine inhibits vascular smooth muscle cell proliferation in G2 phase. Cellular and molecular biology (Noisy-le-Grand, France). 2005 Nov; 51(6):525-30. doi: ". [PMID: 16309576]
  • Verónica Jimenez-Ortiz, Silvia D Brengio, Oscar Giordano, Carlos Tonn, Matías Sánchez, Mario H Burgos, Miguel A Sosa. The trypanocidal effect of sesquiterpene lactones helenalin and mexicanin on cultured epimastigotes. The Journal of parasitology. 2005 Feb; 91(1):170-4. doi: 10.1645/ge-3373. [PMID: 15856894]
  • T Guardia, A O Juarez, E Guerreiro, J A Guzmán, L Pelzer. Anti-inflammatory activity and effect on gastric acid secretion of dehydroleucodine isolated from Artemisia douglasiana. Journal of ethnopharmacology. 2003 Oct; 88(2-3):195-8. doi: 10.1016/s0378-8741(03)00211-3. [PMID: 12963142]
  • T Sartor, M Elis Lopez, L Gutierrez, E Guerreiro, O S Giordano, L A López. The sesquiterpene lactone dehydroleucodine reversibly inhibits Allium cepa L. root growth. Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al. 2001 Apr; 25(1):29-34. doi: ". [PMID: 11387874]
  • A O María, M Repetto, S Llesuy, O Giordano, J Guzmán, E Guerreiro. Antioxidant activity of Artemisia douglasiana besser extract and dehydroleucodine. Phytotherapy research : PTR. 2000 Nov; 14(7):558-60. doi: 10.1002/1099-1573(200011)14:7<558::aid-ptr628>3.0.co;2-g. [PMID: 11054852]
  • G Rücker, E P Schenkel, D Manns, R Mayer, B M Hausen, K Heiden. Allergenic sesquiterpene lactones from Eupatorium cannabinum L. and Kaunia rufescens (Lund ex de Candolle). Natural toxins. 1997; 5(6):223-7. doi: 10.1002/(sici)1522-7189(1997)5:6<223::aid-nt1>3.0.co;2-r. [PMID: 9615309]