Ergosta-4,6,8(14),22-tetraen-3-one (BioDeep_00000236565)

   


代谢物信息卡片


(22E)-Ergosta-4,6,8(14),22-tetraen-3-one

化学式: C28H40O (392.307899)
中文名称: 麦角甾-4,6,8(14),22-四烯-3-酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)C(C)C=CC(C)C1CCC2=C3C=CC4=CC(=O)CCC4(C)C3CCC21C
InChI: InChI=1S/C28H40O/c1-18(2)19(3)7-8-20(4)24-11-12-25-23-10-9-21-17-22(29)13-15-27(21,5)26(23)14-16-28(24,25)6/h7-10,17-20,24,26H,11-16H2,1-6H3/b8-7+/t19-,20+,24+,26-,27-,28+/m0/s1

描述信息

An ergostanoid that is (22E)-ergosta-4,6,8(14),22-tetraene substituted by an oxo group at position 3. It has been isolated from the mycelia of Cordyceps sinensis.

同义名列表

2 个代谢物同义名

(22E)-Ergosta-4,6,8(14),22-tetraen-3-one; Ergosta-4,6,8(14),22-tetraen-3-one



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Nadine Kretschmer, Christin Durchschein, Guenther Heubl, Eva-Maria Pferschy-Wenzig, Olaf Kunert, Rudolf Bauer. Discrimination of Zicao Samples Based on DNA Barcoding and HPTLC Fingerprints, and Identification of (22E)-Ergosta-4,6,8(14),22-tetraen-3-one As a Marker Compound. Planta medica. 2023 Jul; 89(8):824-832. doi: 10.1055/a-1855-1778. [PMID: 35868331]
  • Wenge Zhang, Xiuxiang Lu, Luqiong Huo, Sha Zhang, Yan Chen, Zhenxing Zou, Haibo Tan. Sesquiterpenes and Steroids from an Endophytic Eutypella scoparia. Journal of natural products. 2021 06; 84(6):1715-1724. doi: 10.1021/acs.jnatprod.0c01167. [PMID: 34033486]
  • Lin Chen, Dan-Qian Chen, Ming Wang, Dan Liu, Hua Chen, Fang Dou, Nosratola D Vaziri, Ying-Yong Zhao. Role of RAS/Wnt/β-catenin axis activation in the pathogenesis of podocyte injury and tubulo-interstitial nephropathy. Chemico-biological interactions. 2017 Aug; 273(?):56-72. doi: 10.1016/j.cbi.2017.05.025. [PMID: 28578904]
  • Dilusha Fernando, Achyut Adhikari, Chandrika Nanayakkara, E Dilip de Silva, Ravi Wijesundera, Preethi Soysa. Cytotoxic effects of ergone, a compound isolated from Fulviformes fastuosus. BMC complementary and alternative medicine. 2016 Nov; 16(1):484. doi: 10.1186/s12906-016-1471-8. [PMID: 27887609]
  • Thi Hoai Nguyen, Viet Duc Ho, Thi Thao Do, Huu Tai Bui, Van Kiem Phan, Katrin Sak, Ain Raal. A new lignan glycoside from the aerial parts and cytotoxic investigation of Uvaria rufa. Natural product research. 2015 Feb; 29(3):247-52. doi: 10.1080/14786419.2014.971790. [PMID: 25338140]
  • Han Chen, Dan-Qian Chen, Quan-Fu Li, Peng-Fei Li, Hua Chen, Ying-Yong Zhao. [Research progress on pharmacology, pharmacokinetics and determination of ergosta-4,6,8 (14),22-tetraen-3-one]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2014 Oct; 39(20):3905-9. doi: NULL. [PMID: 25751937]
  • Ying-Yong Zhao, Hua Chen, Ting Tian, Dan-Qian Chen, Xu Bai, Feng Wei. A pharmaco-metabonomic study on chronic kidney disease and therapeutic effect of ergone by UPLC-QTOF/HDMS. PloS one. 2014; 9(12):e115467. doi: 10.1371/journal.pone.0115467. [PMID: 25535749]
  • Yang Sun, Zhen Ji, Yingyong Zhao, Xuhua Liang, Xiaoyun Hu, Jun Fan. Enhanced distribution and anti-tumor activity of ergosta-4,6,8(14),22-tetraen-3-one by polyethylene glycol liposomalization. Journal of nanoscience and nanotechnology. 2013 Feb; 13(2):1435-9. doi: 10.1166/jnn.2013.6009. [PMID: 23646655]
  • Xuhua Liang, Yang Sun, Lusha Liu, Xuan Ma, Xiaoyun Hu, Jun Fan, Yingyong Zhao. Folate-functionalized nanoparticles for controlled ergosta-4,6,8(14),22-tetraen-3-one delivery. International journal of pharmaceutics. 2013 Jan; 441(1-2):1-8. doi: 10.1016/j.ijpharm.2012.12.018. [PMID: 23262423]
  • Ying-Yong Zhao, Li Zhang, Feng-Ya Long, Xian-Long Cheng, Xu Bai, Feng Wei, Rui-Chao Lin. UPLC-Q-TOF/HSMS/MS(E)-based metabonomics for adenine-induced changes in metabolic profiles of rat faeces and intervention effects of ergosta-4,6,8(14),22-tetraen-3-one. Chemico-biological interactions. 2013 Jan; 201(1-3):31-8. doi: 10.1016/j.cbi.2012.12.002. [PMID: 23246428]
  • Yang Sun, Xuhua Liang, Yingyong Zhao, Jun Fan. A sensitive spectrofluorometric method for determination of ergosta-4,6,8(14),22-tetraen-3-one in rat plasma, feces, and urine for application to pharmacokinetic studies using cerium(III) as a probe. Applied spectroscopy. 2013 Jan; 67(1):106-11. doi: 10.1366/12-06760. [PMID: 23317677]
  • Ying-Yong Zhao, Xian-Long Cheng, Ji-Hong Cui, Xing-Rong Yan, Feng Wei, Xu Bai, Rui-Chao Lin. Effect of ergosta-4,6,8(14),22-tetraen-3-one (ergone) on adenine-induced chronic renal failure rat: a serum metabonomic study based on ultra performance liquid chromatography/high-sensitivity mass spectrometry coupled with MassLynx i-FIT algorithm. Clinica chimica acta; international journal of clinical chemistry. 2012 Oct; 413(19-20):1438-45. doi: 10.1016/j.cca.2012.06.005. [PMID: 22687646]
  • Ying-Yong Zhao, Xian-Long Cheng, Feng Wei, Xu Bai, Rui-Chao Lin. Ultra performance liquid chromatography coupled with electrospray and atmospheric pressure chemical ionization (ESCi)-quadrupole time-of-flight mass spectrometry with novel mass spectrometry(Elevated Energy) (MS(E)) data collection technique: determination and pharmacokinetics, tissue distribution and biliary excretion study of ergone in rat. Journal of separation science. 2012 Jul; 35(13):1619-26. doi: 10.1002/jssc.201200131. [PMID: 22761140]
  • Hong-Lian Ai, Li-Mei Zhang, Yan-Ping Chen, Shu-Hui Zi, Hong Xiang, Da-Ke Zhao, Yong Shen. Two new compounds from an endophytic fungus Alternaria solani. Journal of Asian natural products research. 2012; 14(12):1144-8. doi: 10.1080/10286020.2012.733701. [PMID: 23106531]
  • Ying-Yong Zhao, Li Zhang, Jia-Rong Mao, Xiao-Hong Cheng, Rui-Chao Lin, Yongmin Zhang, Wen-Ji Sun. Ergosta-4,6,8(14),22-tetraen-3-one isolated from Polyporus umbellatus prevents early renal injury in aristolochic acid-induced nephropathy rats. The Journal of pharmacy and pharmacology. 2011 Dec; 63(12):1581-6. doi: 10.1111/j.2042-7158.2011.01361.x. [PMID: 22060289]
  • Ying-Yong Zhao, Xiang-Yang Qin, Yongmin Zhang, Rui-Chao Lin, Wen-Ji Sun, Xiao-Ye Li. Quantitative HPLC method and pharmacokinetic studies of ergosta-4,6,8(14),22-tetraen-3-one, a natural product with diuretic activity from Polyporus umbellatus. Biomedical chromatography : BMC. 2010 Oct; 24(10):1120-4. doi: 10.1002/bmc.1414. [PMID: 20853466]
  • Ying-Yong Zhao, Xiang-Yang Qin, Xian-Long Cheng, Xue-Ying Liu, Rui-Chao Lin, Yongmin Zhang, Xiao-Ye Li, Xiao-Li Sun, Wen-Ji Sun. Rapid resolution liquid chromatography-mass spectrometry and high-performance liquid chromatography-fluorescence detection for metabolism and pharmacokinetic studies of ergosta-4,6,8(14),22-tetraen-3-one. Analytica chimica acta. 2010 Aug; 675(2):199-206. doi: 10.1016/j.aca.2010.07.029. [PMID: 20800733]
  • Ying-yong Zhao, Xian-Long Cheng, Yongmin Zhang, Xu Chao, Ye Zhao, Rui-chao Lin, Wen-ji Sun. A fast and sensitive HPLC-MS/MS analysis and preliminary pharmacokinetic characterization of ergone in rats. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 Jan; 878(1):29-33. doi: 10.1016/j.jchromb.2009.11.013. [PMID: 19944658]
  • Ying-Yong Zhao, Ren-Ming Xie, Xu Chao, Yongmin Zhang, Rui-Chao Lin, Wen-Ji Sun. Bioactivity-directed isolation, identification of diuretic compounds from Polyporus umbellatus. Journal of ethnopharmacology. 2009 Oct; 126(1):184-7. doi: 10.1016/j.jep.2009.07.033. [PMID: 19665537]
  • Ying-Yong Zhao, Ye Zhao, Yong-Min Zhang, Rui-Chao Lin, Wen-Ji Sun. Qualitative and quantitative analysis of the diuretic component ergone in Polyporus umbellatus by HPLC with fluorescence detection and HPLC-APCI-MS/MS. Die Pharmazie. 2009 Jun; 64(6):366-70. doi: ". [PMID: 19618671]
  • Margareth B C Gallo, Fernanda O Chagas, Marília O Almeida, Cláudia C Macedo, Bruno C Cavalcanti, Francisco W A Barros, Manoel O de Moraes, Letícia V Costa-Lotufo, Cláudia Pessoa, Jairo K Bastos, Mônica T Pupo. Endophytic fungi found in association with Smallanthus sonchifolius (Asteraceae) as resourceful producers of cytotoxic bioactive natural products. Journal of basic microbiology. 2009 Apr; 49(2):142-51. doi: 10.1002/jobm.200800093. [PMID: 18798172]
  • Dan Yuan, Junna Mori, Ken-ich Komatsu, Toshiaki Makino, Yoshihiro Kano. An anti-aldosteronic diuretic component (drain dampness) in Polyporus sclerotium. Biological & pharmaceutical bulletin. 2004 Jun; 27(6):867-70. doi: 10.1248/bpb.27.867. [PMID: 15187435]
  • Dan Yuan, Kei-ichi Yamamoto, Kaishun Bi, Ping Zhang, Fang Liu, Yoshihiro Kano. [Studies on the marker compounds for standardization of traditional Chinese medicine 'polyporus sclerotium ([symbol: see text])']. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2003 Feb; 123(2):53-62. doi: 10.1248/yakushi.123.53. [PMID: 12645138]
  • C W Bacon, J K Porter, J D Robbins, E S Luttrell. Epichloë typhina from toxic tall fescue grasses. Applied and environmental microbiology. 1977 Nov; 34(5):576-81. doi: 10.1128/aem.34.5.576-581.1977. [PMID: 931377]