Horminone (BioDeep_00000235642)

   

PANOMIX_OTCML-2023


代谢物信息卡片


1,4-Phenanthrenedione, 4b,5,6,7,8,8a,9,10-octahydro-3,10-dihydroxy-4b,8,8-trimethyl-2-(1-methylethyl)-, (4bS-(4balpha,8abeta,10beta))-

化学式: C20H28O4 (332.19874880000003)
中文名称: 7α-羟基罗列酮
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 4.35%

Reviewed

Last reviewed on 2024-07-09.

Cite this Page

Horminone. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/horminone (retrieved 2024-09-17) (BioDeep RN: BioDeep_00000235642). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1CC([C@H]2[C@](C1)(C1=C([C@@H](C2)O)C(=O)C(=C(C1=O)O)C(C)C)C)(C)C
InChI: InChI=1S/C20H28O4/c1-10(2)13-16(22)14-11(21)9-12-19(3,4)7-6-8-20(12,5)15(14)18(24)17(13)23/h10-12,21,23H,6-9H2,1-5H3/t11-,12+,20+/m1/s1

描述信息

Horminone is an abietane diterpenoid that is abieta-8,12-diene substituted by hydroxy groups at positions 7 and 12 and oxo groups at positions 11 and 14 (the 7alpha stereoisomer). It has a role as an antibacterial agent, an antineoplastic agent and a metabolite. It is an abietane diterpenoid, a secondary alcohol, a hydroxyquinone and a member of p-quinones.
Horminone is a natural product found in Salvia tomentosa, Salvia virgata, and other organisms with data available.
An abietane diterpenoid that is abieta-8,12-diene substituted by hydroxy groups at positions 7 and 12 and oxo groups at positions 11 and 14 (the 7alpha stereoisomer) .

同义名列表

14 个代谢物同义名

1,4-Phenanthrenedione, 4b,5,6,7,8,8a,9,10-octahydro-3,10-dihydroxy-4b,8,8-trimethyl-2-(1-methylethyl)-, (4bS-(4balpha,8abeta,10beta))-; 1,4-PHENANTHRENEDIONE, 4B,5,6,7,8,8A,9,10-OCTAHYDRO-3,10-DIHYDROXY-4B,8,8-TRIMETHYL-2-(1-METHYLETHYL)-, (4BS,8AS,10R)-; (4bS,8aS,10R)-3,10-dihydroxy-2-isopropyl-4b,8,8-trimethyl- 1,4,4b,5,6,7,8,8a,9,10-decahydrophenanthrene-1,4-dione; (4bS,8aS,10R)-1,10-dihydroxy-4b,8,8-trimethyl-2-propan-2-yl-5,6,7,8a,9,10-hexahydrophenanthrene-3,4-dione; 4b,5,6,7,8,8a,9,10-octahydro-3,10-dihydroxy-4b,8,8-trimethyl-2-(1-methylethyl)-1,4-phenanthrenedione; 1,4-PHENANTHRENEDIONE, 4B,5,6,7,8,8A,9,10-OCTAHYDRO-3,10-DIHYDROXY-4B,8,8-TRIMETHYL-; 7alpha-Hydroxyroyleanone or 7alpha,12-Dihydroxy-8,12-abietadiene,11,14-dione; PODOCARPA-8,12-DIENE-11,14-DIONE, 7.ALPHA.,12-DIHYDROXY-13-ISOPROPYL-; 2-(1-METHYLETHYL)-, (4BS-(4B.ALPHA.,8A.BETA.,10.BETA.))-; (7alpha)-7,12-dihydroxyabieta-8,12-diene-11,14-dione; 7alpha-12-hydroxy-8,12-abietadiene-11,14-dione; 7-Hydroxyroyleanone; NSC 294577; Horminone; 7alpha-Hydroxyroyleanone



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Roméo Arago Dougué Kentsop, Valeria Iobbi, Giuliana Donadio, Barbara Ruffoni, Nunziatina De Tommasi, Angela Bisio. Abietane Diterpenoids from the Hairy Roots of Salvia corrugata. Molecules (Basel, Switzerland). 2021 Aug; 26(17):. doi: 10.3390/molecules26175144. [PMID: 34500582]
  • Marcio Fronza, Evelyn Lamy, Stefan Günther, Berta Heinzmann, Stefan Laufer, Irmgard Merfort. Abietane diterpenes induce cytotoxic effects in human pancreatic cancer cell line MIA PaCa-2 through different modes of action. Phytochemistry. 2012 Jun; 78(?):107-19. doi: 10.1016/j.phytochem.2012.02.015. [PMID: 22436445]
  • M Fronza, R Murillo, S Ślusarczyk, M Adams, M Hamburger, B Heinzmann, S Laufer, I Merfort. In vitro cytotoxic activity of abietane diterpenes from Peltodon longipes as well as Salvia miltiorrhiza and Salvia sahendica. Bioorganic & medicinal chemistry. 2011 Aug; 19(16):4876-81. doi: 10.1016/j.bmc.2011.06.067. [PMID: 21775156]
  • Chuang C Chiueh. Methods for studying redox cycling of thioredoxin in mediating preconditioning-induced survival genes and proteins. Methods in enzymology. 2010; 474(?):197-212. doi: 10.1016/s0076-6879(10)74012-x. [PMID: 20609912]
  • Wenhua Han, Harumi Hata, Hiroki Imbe, Qing-Rong Liu, Yukio Takamatsu, Miwako Koizumi, Niall P Murphy, Emiko Senba, George R Uhl, Ichiro Sora, Kazutaka Ikeda. Increased body weight in mice lacking mu-opioid receptors. Neuroreport. 2006 Jun; 17(9):941-4. doi: 10.1097/01.wnr.0000221829.87974.ad. [PMID: 16738492]
  • Darina Slamenová, Irena Masterová, Juraj Lábaj, Eva Horváthová, Pavol Kubala, Jana Jakubíková, Ladislava Wsólová. Cytotoxic and DNA-damaging effects of diterpenoid quinones from the roots of Salvia officinalis L. on colonic and hepatic human cells cultured in vitro. Basic & clinical pharmacology & toxicology. 2004 Jun; 94(6):282-90. doi: 10.1111/j.1742-7843.2004.pto940605.x. [PMID: 15228500]
  • Ayhan Ulubelen, Hüsniye Birman, Sevil Oksüz, Gülaçti Topçu, Ufuk Kolak, Asli Barla, Wolfgang Voelter. Cardioactive diterpenes from the roots of Salvia eriophora. Planta medica. 2002 Sep; 68(9):818-21. doi: 10.1055/s-2002-34408. [PMID: 12357394]
  • A Ulubelen, S Oksüz, G Topcu, A C Gören, W Voelter. Antibacterial diterpenes from the roots of Salvia blepharochlaena. Journal of natural products. 2001 Apr; 64(4):549-51. doi: 10.1021/np0004956. [PMID: 11325249]
  • R Ferreira, F Candeias, F Simões, J Nascimento, J Cruz Morais. Effects of horminone on liver mixed function mono-oxygenases and glutathione enzyme activities of Wistar rat. Journal of ethnopharmacology. 1997 Sep; 58(1):21-30. doi: 10.1016/s0378-8741(97)00073-1. [PMID: 9324001]
  • I Masterová, E Misíková, L Sirotková, S Vaverková, K Ubik. [Royleanones in the roots of Salvia officinalis L. of domestic provenance and their antimicrobial activity]. Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti. 1996 Sep; 45(5):242-5. doi: . [PMID: 9011311]
  • D Rutherford, M Nielsen, N Tokutomi, N Akaike. Effects of plant diterpenes on the neuronal GABAA receptor-operated chloride current. Neuroreport. 1994 Dec; 5(18):2569-72. doi: 10.1097/00001756-199412000-00041. [PMID: 7696606]
  • S G Goijman, J F Turrens, G B Marini-Bettolo, A O Stoppani. [Inhibition of growth and macromolecular biosynthesis in Trypanosoma cruzi by natural products. Effects of miconidine and tingenone]. Medicina. 1984; 44(4):361-70. doi: . [PMID: 6399926]