Tocophersolan (BioDeep_00000023475)
human metabolite Endogenous
代谢物信息卡片
1-(2-hydroxyethyl) 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-1-benzopyran-6-yl butanedioate
化学式: C35H58O6 (574.4233168000001)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)CCCC(C)CCCC(C)CCCC1(C)CCC2=C(C)C(OC(=O)CCC(=O)OCCO)=C(C)C(C)=C2O1
InChI: InChI=1S/C35H58O6/c1-24(2)12-9-13-25(3)14-10-15-26(4)16-11-20-35(8)21-19-30-29(7)33(27(5)28(6)34(30)41-35)40-32(38)18-17-31(37)39-23-22-36/h24-26,36H,9-23H2,1-8H3
描述信息
Vitamin E supplement, antioxidant Tocofersolan (INN) or tocophersolan is a synthetic water-soluble version of vitamin E. Natural forms of vitamin E are fat soluble, but not water-soluble. Tocofersolan is polyethylene glycol derivative of -tocopherol that enables water solubility
Vitamin E supplement, antioxidant
同义名列表
24 个代谢物同义名
1-(2-hydroxyethyl) 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-1-benzopyran-6-yl butanedioate; D-alpha-Tocopheryl poly(ethylene glycol) 1000 succinate; (+)-alpha-Tocopheryl polyethylene glycol 1000 succinate; alpha-D-Tocopherol poly(ethylene glycol) 2000 succinate; D-alpha-Tocopheryl poly(ethylene glycol)1000 succinate; alpha-Tocopheryl polyethylene glycol 1000 succinate; Tocopherol poly(ethylene glycol) 2000 succinate; Tocopheryl poly(ethylene glycol) 1000 succinate; alpha-Tocopheryl polyethylene glycol succinate; Tocopheryl polyethylene glycol 1000 succinate; Tocophersolan, (2R-(2R*(4R*,8R*)))-isomer; Tocopherol polyethylene glycol succinate; Vitamine e peg-1000-succinate; Aquasol e TPGS liquid 77iu/ml; Tocophersolan, usan; Tocofersolan, inn; Vitamin e TPGS; Vitamin e-TPGS; Tocofersolanum; Tocophersolan; Tocofersolano; Tocofersolan; TPGS 2K; TPGS
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:176233
- PubChem: 71406
- HMDB: HMDB0034354
- Wikipedia: Tocofersolan
- foodb: FDB012716
- chemspider: 64498
- PMhub: MS000109735
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Van-Trung-Tin Huynh, Suenia de Paiva Lacerda, Fabienne Espitalier, Eric Beyssac, Maria-Inês Ré. Effect of talc and vitamin E TPGS on manufacturability, stability and release properties of trilaurin-based formulations for hot-melt coating.
International journal of pharmaceutics.
2024 Mar; 653(?):123866. doi:
10.1016/j.ijpharm.2024.123866. [PMID: 38286194] - Abdelkader A Metwally, Samayita Ganguly, Nora Biomi, Mingyi Yao, Tamer Elbayoumi. Cationic Vitamin E-TPGS Mixed Micelles of Berberine to Neutralize Doxorubicin-Induced Cardiotoxicity via Amelioration of Mitochondrial Dysfunction and Impeding Apoptosis.
Molecules (Basel, Switzerland).
2024 Mar; 29(5):. doi:
10.3390/molecules29051155. [PMID: 38474668] - Abdelrahman Y Sherif, Gamaleldin I Harisa, Fars K Alanazi. The Chimera of TPGS and Nanoscale Lipid Carriers as Lymphatic Drug Delivery Vehicles to Fight Metastatic Cancers.
Current drug delivery.
2024; 21(4):525-543. doi:
10.2174/1567201820666230512122825. [PMID: 37183467] - Lan Tang, Kaijuan Huang, Wenhui Jiang, Lulu Fu, Ran Zhang, Liting Shen, Zhimin Ou, Ye Huang, Zhenhai Zhang. Exploration of the inhibition action of TPGS on tumor cells and its combined use with chemotherapy drugs.
Drug delivery.
2023 Dec; 30(1):2183830. doi:
10.1080/10717544.2023.2183830. [PMID: 36852689] - Khaled Mahmoud, Mahmoud Teaima, Yasmeen Attia, Mohamed El-Nabarawi, Shady Swidan. Size-optimized simvastatin TPGS modified lipid nanocapsules for targeting epithelial-to-mesenchymal transition in hepatocellular carcinoma: role of PTEN/AKT signaling.
Expert opinion on drug delivery.
2023 May; ?(?):. doi:
10.1080/17425247.2023.2216451. [PMID: 37208857] - Gamaleldin I Harisa, Abdelrahman Y Sherif, Fars K Alanazi, Essam A Ali, Gamal A Omran, Fahd A Nasr, Sabry M Attia, Ali S Alqahtani. TPGS decorated NLC shift gefitinib from portal absorption into lymphatic delivery: Intracellular trafficking, biodistribution and bioavailability studies.
Colloids and surfaces. B, Biointerfaces.
2023 Jan; 223(?):113148. doi:
10.1016/j.colsurfb.2023.113148. [PMID: 36706479] - Han Wang, Yilan Wu, Xiaoyan Lin. Crizotinib loaded polydopamine-polylactide-TPGS nanoparticles in targeted therapy for non-small cell lung cancer.
Medical oncology (Northwood, London, England).
2022 Dec; 40(1):26. doi:
10.1007/s12032-022-01893-8. [PMID: 36459216] - Shaimaa M Badr-Eldin, Hibah M Aldawsari, Usama A Fahmy, Osama A A Ahmed, Nabil A Alhakamy, Mahmoud A Elfaky, Alaa Sirwi, Salman A Hawsawi, Ali H Alzahrani, Abdulrahman Y Yaseen, Mohannad Qassim, Sabna Kotta. Optimized D-α-tocopherol polyethylene glycol succinate/phospholipid self-assembled mixed micelles: A promising lipid-based nanoplatform for augmenting the antifungal activity of fluconazole.
Acta pharmaceutica (Zagreb, Croatia).
2022 Dec; 72(4):547-560. doi:
10.2478/acph-2022-0028. [PMID: 36651360] - Yavuz Yagiz, Gary P Wang, Liwei Gu. Emulsification by vitamin E TPGS or Quillaja extract enhanced absorption of berberine without affecting its metabolism in humans.
Food & function.
2022 Nov; 13(23):12135-12143. doi:
10.1039/d2fo02288e. [PMID: 36321951] - Sameer S Katiyar, Ravindra Patil, Rohan Ghadi, Kaushik Kuche, Varun Kushwah, Chander Parkash Dora, Sanyog Jain. Lipid- and TPGS-Based Core-Shell-Type Nanocapsules Endowed with High Paclitaxel Loading and Enhanced Anticancer Potential.
AAPS PharmSciTech.
2022 Aug; 23(7):238. doi:
10.1208/s12249-022-02389-4. [PMID: 36002600] - Linghui Zou, Zhongbin Zhang, Jianfang Feng, Wenyou Ding, Yanhua Li, Dan Liang, Tanfang Xie, Fang Li, Yuyang Li, Jinqing Chen, Xu Yang, Ling Tang, Wenya Ding. Paclitaxel-Loaded TPGS2k/Gelatin-Grafted Cyclodextrin/Hyaluronic Acid-Grafted Cyclodextrin Nanoparticles for Oral Bioavailability and Targeting Enhancement.
Journal of pharmaceutical sciences.
2022 06; 111(6):1776-1784. doi:
10.1016/j.xphs.2022.03.013. [PMID: 35341722] - Maomao Tang, Yuzhe Huang, Xiao Liang, Yaotian Tao, Ning He, Zhenbao Li, Jian Guo, Shuangying Gui. Sorafenib-Loaded PLGA-TPGS Nanosystems Enhance Hepatocellular Carcinoma Therapy Through Reversing P-Glycoprotein-Mediated Multidrug Resistance.
AAPS PharmSciTech.
2022 Apr; 23(5):130. doi:
10.1208/s12249-022-02214-y. [PMID: 35487999] - Yujia Liu, Xiaoyu Lu, Zhenhai Zhang, Shulong Jiang, Huixia Lv. mPEG-Cholic acid/TPGS mixed micelles for combined delivery of paclitaxel and bufalin to treat hepatocellular carcinoma.
Pharmaceutical development and technology.
2022 Feb; 27(2):215-227. doi:
10.1080/10837450.2022.2037140. [PMID: 35105263] - Tianyang Ren, Xuehua Zheng, Ruixue Bai, Yuehui Yang, Lingyan Jian. Bioadhesive poly(methyl vinyl ether-co-maleic anhydride)-TPGS copolymer modified PLGA/lipid hybrid nanoparticles for improving intestinal absorption of cabazitaxel.
International journal of pharmaceutics.
2022 Jan; 611(?):121301. doi:
10.1016/j.ijpharm.2021.121301. [PMID: 34793933] - Meng Tong, Xiaoyan Wu, Shuya Zhang, Di Hua, Shukun Li, Xiangyu Yu, Jing Wang, Zhenhai Zhang. Application of TPGS as an efflux inhibitor and a plasticizer in baicalein solid dispersion.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2022 Jan; 168(?):106071. doi:
10.1016/j.ejps.2021.106071. [PMID: 34774716] - Chengying Shen, Baode Shen, Junjun Zhu, Hailong Yuan, Jianxin Hu. Topical delivery of pluronic F127/TPGS mixed micelles-based hydrogel loaded with glycyrrhizic acid for atopic dermatitis treatment.
Drug development and industrial pharmacy.
2021 Dec; 47(12):1975-1985. doi:
10.1080/03639045.2022.2077957. [PMID: 35579672] - Xinhui Du, Na Gao, Xiaoyong Song. Bioadhesive polymer/lipid hybrid nanoparticles as oral delivery system of raloxifene with enhancive intestinal retention and bioavailability.
Drug delivery.
2021 Dec; 28(1):252-260. doi:
10.1080/10717544.2021.1872742. [PMID: 33501870] - Wessam H Abd-Elsalam, Reem R Ibrahim. Span 80/TPGS modified lipid-coated chitosan nanocomplexes of acyclovir as a topical delivery system for viral skin infections.
International journal of pharmaceutics.
2021 Nov; 609(?):121214. doi:
10.1016/j.ijpharm.2021.121214. [PMID: 34678396] - Salma M Mohyeldin, Wael M Samy, Doaa Ragab, Doaa A Abdelmonsif, Rania G Aly, Nazik A Elgindy. Hybrid lipid core chitosan-TPGS shell nanocomposites as a promising integrated nanoplatform for enhanced oral delivery of sulpiride in depressive disorder therapy.
International journal of biological macromolecules.
2021 Oct; 188(?):432-449. doi:
10.1016/j.ijbiomac.2021.08.035. [PMID: 34375663] - Huiru Zhao, Meiling Qi. Amphiphilic tocopheryl polyethylene glycol succinate as gas chromatographic stationary phase for high-resolution separations of challenging isomers and analysis of lavender essential oil.
Journal of separation science.
2021 Oct; 44(19):3600-3607. doi:
10.1002/jssc.202100349. [PMID: 34329529] - Tran Thu Huong, Ha Thi Phuong, Le Thi Vinh, Hoang Thi Khuyen, Do Thi Thao, Le Dac Tuyen, Tran Kim Anh, Le Quoc Minh. Upconversion NaYF4:Yb3+/Er3+@silica-TPGS Bio-Nano Complexes: Synthesis, Characterization, and In Vitro Tests for Labeling Cancer Cells.
The journal of physical chemistry. B.
2021 09; 125(34):9768-9775. doi:
10.1021/acs.jpcb.1c05472. [PMID: 34415749] - Kaipei Luo, Feng Xu, Tianyi Yao, Jianping Zhu, Hua Yu, Guangji Wang, Juan Li. TPGS and chondroitin sulfate dual-modified lipid-albumin nanosystem for targeted delivery of chemotherapeutic agent against multidrug-resistant cancer.
International journal of biological macromolecules.
2021 Jul; 183(?):1270-1282. doi:
10.1016/j.ijbiomac.2021.05.070. [PMID: 34004196] - Md Rizwanullah, Ahmad Perwez, Showkat Rasool Mir, Mohd Moshahid Alam Rizvi, Saima Amin. Exemestane encapsulated polymer-lipid hybrid nanoparticles for improved efficacy against breast cancer: optimization,in vitrocharacterization and cell culture studies.
Nanotechnology.
2021 Jul; 32(41):. doi:
10.1088/1361-6528/ac1098. [PMID: 34198267] - Teng Guo, Jianying Lu, Yunlong Fan, Yongtai Zhang, Shuo Yin, Xianyi Sha, Nianping Feng. TPGS assists the percutaneous administration of curcumin and glycyrrhetinic acid coloaded functionalized ethosomes for the synergistic treatment of psoriasis.
International journal of pharmaceutics.
2021 Jul; 604(?):120762. doi:
10.1016/j.ijpharm.2021.120762. [PMID: 34082000] - Yuan Zou, Xiangtao Wang, Dongdong Bi, Jingxin Fu, Jianwei Han, Yifei Guo, Li Feng, Meihua Han. Pterostilbene nanoparticles with small particle size show excellent anti-breast cancer activityin vitroandin vivo.
Nanotechnology.
2021 May; 32(32):. doi:
10.1088/1361-6528/abfdec. [PMID: 33946061] - Danni Li, Shaogang Liu, Jiahao Zhu, Liqun Shen, Qi Ying Zhang, Hua Zhu. Folic acid modified TPGS as a novel nano-micelle for delivery of nitidine chloride to improve apoptosis induction in Huh7 human hepatocellular carcinoma.
BMC pharmacology & toxicology.
2021 01; 22(1):1. doi:
10.1186/s40360-020-00461-y. [PMID: 33407916] - Ashish Kumar, Ajit Singh, S J S Flora, Rahul Shukla. Box-Behnken Design Optimized TPGS Coated Bovine Serum Albumin Nanoparticles Loaded with Anastrozole.
Current drug delivery.
2021; 18(8):1136-1147. doi:
10.2174/1567201818666210202104810. [PMID: 33530907] - Tingting Song, Hong Wang, Yue Liu, Rongshan Cai, Dezhi Yang, Yongai Xiong. TPGS-Modified Long-Circulating Liposomes Loading Ziyuglycoside I for Enhanced Therapy of Myelosuppression.
International journal of nanomedicine.
2021; 16(?):6281-6295. doi:
10.2147/ijn.s326629. [PMID: 34548791] - Xiaoqian He, Jiao Feng, Shenglei Yan, Yonghong Zhang, Cailing Zhong, Yuying Liu, Da Shi, Ruben Abagyan, Tingxiu Xiang, Jingqing Zhang. Biomimetic microbioreactor-supramolecular nanovesicles improve enzyme therapy of hepatic cancer.
Nanomedicine : nanotechnology, biology, and medicine.
2021 01; 31(?):102311. doi:
10.1016/j.nano.2020.102311. [PMID: 33011392] - Charlotte Cuerq, Claire Bordat, Charlotte Halimi, Emilie Blond, Marion Nowicki, Noël Peretti, Emmanuelle Reboul. Comparison of α-Tocopherol, α-Tocopherol Acetate, and α-Tocopheryl Polyethylene Glycol Succinate 1000 Absorption by Caco-2 TC7 Intestinal Cells.
Nutrients.
2020 Dec; 13(1):. doi:
10.3390/nu13010129. [PMID: 33396478] - Xue Feng, Yuting Chen, Luya Li, Yuqian Zhang, Lantong Zhang, Zhiqing Zhang. Preparation, evaluation and metabolites study in rats of novel amentoflavone-loaded TPGS/soluplus mixed nanomicelles.
Drug delivery.
2020 Dec; 27(1):137-150. doi:
10.1080/10717544.2019.1709920. [PMID: 31913733] - Huiyun Zhang, Baoding Chen, Yuan Zhu, Congyong Sun, Michael Adu-Frimpong, Wenwen Deng, Jiangnan Yu, Ximing Xu. Enhanced oral bioavailability of self-assembling curcumin-vitamin E prodrug-nanoparticles by co-nanoprecipitation with vitamin E TPGS.
Drug development and industrial pharmacy.
2020 Nov; 46(11):1800-1808. doi:
10.1080/03639045.2020.1821049. [PMID: 32969718] - Yutong Wang, Yanfang Ding, Youwei Xu, Changyuan Wang, Yingying Ding, Meng Gao, Chengge Ma, Xiaodong Ma, Lei Li. Mixed micelles of TPGS and Soluplus® for co-delivery of paclitaxel and fenretinide: in vitro and in vivo anticancer study.
Pharmaceutical development and technology.
2020 Sep; 25(7):865-873. doi:
10.1080/10837450.2020.1753770. [PMID: 32266855] - Chengying Shen, Junjun Zhu, Jiawen Song, Jing Wang, Baode Shen, Hailong Yuan, Xiaofang Li. Formulation of pluronic F127/TPGS mixed micelles to improve the oral absorption of glycyrrhizic acid.
Drug development and industrial pharmacy.
2020 Jul; 46(7):1100-1107. doi:
10.1080/03639045.2020.1775634. [PMID: 32463722] - Mona Elhabak, Rihab Osman, Mona Mohamed, Ola M El-Borady, Gehanne A S Awad, Nahed Mortada. Near IR responsive targeted integrated lipid polymer nanoconstruct for enhanced magnolol cytotoxicity in breast cancer.
Scientific reports.
2020 05; 10(1):8771. doi:
10.1038/s41598-020-65521-z. [PMID: 32472087] - Jiahui Sun, Jing Li, Qi Liu, Min Jiang, Mengjia Yang, Siwen Zhan, Tong Qiu, Kaiyong He, Xueqiong Zhang. Tuning mPEG-PLA/vitamin E-TPGS-based mixed micelles for combined celecoxib/honokiol therapy for breast cancer.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2020 Apr; 146(?):105277. doi:
10.1016/j.ejps.2020.105277. [PMID: 32105783] - Shuo Liu, Rui Li, Jin Qian, Jiabin Sun, Guowen Li, Jianliang Shen, Yan Xie. Combination Therapy of Doxorubicin and Quercetin on Multidrug-Resistant Breast Cancer and Their Sequential Delivery by Reduction-Sensitive Hyaluronic Acid-Based Conjugate/d-α-Tocopheryl Poly(ethylene glycol) 1000 Succinate Mixed Micelles.
Molecular pharmaceutics.
2020 04; 17(4):1415-1427. doi:
10.1021/acs.molpharmaceut.0c00138. [PMID: 32159961] - Sobiya Zafar, Sohail Akhter, Nupur Garg, Angamuthu Selvapandiyan, Gaurav Kumar Jain, Farhan Jalees Ahmad. Co-encapsulation of docetaxel and thymoquinone in mPEG-DSPE-vitamin E TPGS-lipid nanocapsules for breast cancer therapy: Formulation optimization and implications on cellular and in vivo toxicity.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2020 Mar; 148(?):10-26. doi:
10.1016/j.ejpb.2019.12.016. [PMID: 31923585] - Swarupa Ghosh, Ilika Ghosh, Manoswini Chakrabarti, Anita Mukherjee. Genotoxicity and biocompatibility of superparamagnetic iron oxide nanoparticles: Influence of surface modification on biodistribution, retention, DNA damage and oxidative stress.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2020 Feb; 136(?):110989. doi:
10.1016/j.fct.2019.110989. [PMID: 31760074] - Ran Tao, Chengzhang Wang, Yin Lu, Changwei Zhang, Hao Zhou, Hongxia Chen, WenJun Li. Characterization and Cytotoxicity of Polyprenol Lipid and Vitamin E-TPGS Hybrid Nanoparticles for Betulinic Acid and Low-Substituted Hydroxyl Fullerenol in MHCC97H and L02 Cells.
International journal of nanomedicine.
2020; 15(?):2733-2749. doi:
10.2147/ijn.s249773. [PMID: 32368052] - Jiaolin Wen, Zhoufeng Wang, Neng Qiu, Huili Liu, Xiaoming Shu, Zejiang Zhu, Peng Bai, Li Yang, Lijuan Chen. Antitumor Effects of Docetaxel in Truncated Basic Fibroblast Growth Factor- Functionalized Liposomes Delivered by d-α-tocopheryl Polyethylene Glycol 2000 Succinate.
Current pharmaceutical design.
2020; 26(34):4338-4348. doi:
10.2174/1381612826666200423093357. [PMID: 32324508] - Yanfang Ding, Yingying Ding, Yutong Wang, Changyuan Wang, Meng Gao, Youwei Xu, Xiaodong Ma, Jianping Wu, Lei Li. Soluplus®/TPGS mixed micelles for co-delivery of docetaxel and piperine for combination cancer therapy.
Pharmaceutical development and technology.
2020 Jan; 25(1):107-115. doi:
10.1080/10837450.2019.1679834. [PMID: 31603017] - Meng Lei, Guanglan Ma, Sijia Sha, Xueyuan Wang, Haiting Feng, Yongqiang Zhu, Xiao Du. Dual-functionalized liposome by co-delivery of paclitaxel with sorafenib for synergistic antitumor efficacy and reversion of multidrug resistance.
Drug delivery.
2019 Dec; 26(1):262-272. doi:
10.1080/10717544.2019.1580797. [PMID: 30856352] - Mitali Patel, Veenu Mundada, Krutika Sawant. Enhanced intestinal absorption of asenapine maleate by fabricating solid lipid nanoparticles using TPGS: elucidation of transport mechanism, permeability across Caco-2 cell line and in vivo pharmacokinetic studies.
Artificial cells, nanomedicine, and biotechnology.
2019 Dec; 47(1):144-153. doi:
10.1080/21691401.2018.1546186. [PMID: 30669881] - Yutong Wang, Yanfang Ding, Jing Zhao, Changyuan Wang, Meng Gao, Xinming Chi, Baojing Zhang, Xiaodong Ma, Lei Li. Dihydroartemisinin and doxorubicin co-loaded Soluplus®-TPGS mixed micelles: formulation characterization, cellular uptake, and pharmacodynamic studies.
Pharmaceutical development and technology.
2019 Nov; 24(9):1125-1132. doi:
10.1080/10837450.2019.1641726. [PMID: 31305197] - Zhonghui Xie, Zhenhai Zhang, Huixia Lv. Rapamycin loaded TPGS-Lecithins-Zein nanoparticles based on core-shell structure for oral drug administration.
International journal of pharmaceutics.
2019 Sep; 568(?):118529. doi:
10.1016/j.ijpharm.2019.118529. [PMID: 31323368] - Yongshun Sun, Yiping Li, Ying Shen, Jian Wang, Jian Tang, Zhiying Zhao. Enhanced oral delivery and anti-gastroesophageal reflux activity of curcumin by binary mixed micelles.
Drug development and industrial pharmacy.
2019 Sep; 45(9):1444-1450. doi:
10.1080/03639045.2019.1628041. [PMID: 31170849] - Chunmei Wei, Qilong Wang, Wen Weng, Qiuyu Wei, Yujiao Xie, Michael Adu-Frimpong, Elmurat Toreniyazov, Hao Ji, Ximing Xu, Jiangnan Yu. The characterisation, pharmacokinetic and tissue distribution studies of TPGS modified myricetrin mixed micelles in rats.
Journal of microencapsulation.
2019 May; 36(3):278-290. doi:
10.1080/02652048.2019.1622606. [PMID: 31117852] - Pradnya Bapat, Rohan Ghadi, Dasharath Chaudhari, Sameer S Katiyar, Sanyog Jain. Tocophersolan stabilized lipid nanocapsules with high drug loading to improve the permeability and oral bioavailability of curcumin.
International journal of pharmaceutics.
2019 Apr; 560(?):219-227. doi:
10.1016/j.ijpharm.2019.02.013. [PMID: 30776407] - Su-Fang Gu, Li-Ying Wang, Ying-Jie Tian, Zhu-Xian Zhou, Jian-Bin Tang, Xiang-Rui Liu, Hai-Ping Jiang, You-Qing Shen. Enhanced water solubility, antioxidant activity, and oral absorption of hesperetin by D-α-tocopheryl polyethylene glycol 1000 succinate and phosphatidylcholine.
Journal of Zhejiang University. Science. B.
2019 Mar; 20(3):273-281. doi:
10.1631/jzus.b1800346. [PMID: 30829014] - Parikshit Banerjee, Tianjiao Geng, Arpan Mahanty, Tiantian Li, Li Zong, Bo Wang. Integrating the drug, disulfiram into the vitamin E-TPGS-modified PEGylated nanostructured lipid carriers to synergize its repurposing for anti-cancer therapy of solid tumors.
International journal of pharmaceutics.
2019 Feb; 557(?):374-389. doi:
10.1016/j.ijpharm.2018.12.051. [PMID: 30610896] - Yingkun Liu, Congyong Sun, Wenjing Li, Michael Adu-Frimpong, Qilong Wang, Jiangnan Yu, Ximing Xu. Preparation and Characterization of Syringic Acid-Loaded TPGS Liposome with Enhanced Oral Bioavailability and In Vivo Antioxidant Efficiency.
AAPS PharmSciTech.
2019 Feb; 20(3):98. doi:
10.1208/s12249-019-1290-6. [PMID: 30719694] - Sameer S Katiyar, Varun Kushwah, Chander Parkash Dora, Sanyog Jain. Lipid and TPGS based novel core-shell type nanocapsular sustained release system of methotrexate for intravenous application.
Colloids and surfaces. B, Biointerfaces.
2019 Feb; 174(?):501-510. doi:
10.1016/j.colsurfb.2018.11.053. [PMID: 30497012] - Anna Pham, Paul D Gavin, Roksan Libinaki, Gisela Ramirez, Jamal T Khan, Ben J Boyd. Differential Effects of TPM, A Phosphorylated Tocopherol Mixture, and Other Tocopherol Derivatives as Excipients for Enhancing the Solubilization of Co-Enzyme Q10 as a Lipophilic Drug During Digestion of Lipid- Based Formulations.
Current drug delivery.
2019; 16(7):628-636. doi:
10.2174/1567201816666190806114022. [PMID: 31385769] - Kai Dong, Qiuya Lei, Runhao Guo, Xianglong Wu, Yanni Zhang, Ning Cui, Jian-Yu Shi, Tingli Lu. Regulating intracellular ROS signal by a dual pH/reducing-responsive nanogels system promotes tumor cell apoptosis.
International journal of nanomedicine.
2019; 14(?):5713-5728. doi:
10.2147/ijn.s208089. [PMID: 31413571] - Xiao-Ping Chen, Yi Li, Yu Zhang, Gao-Wei Li. Formulation, Characterization And Evaluation Of Curcumin- Loaded PLGA- TPGS Nanoparticles For Liver Cancer Treatment.
Drug design, development and therapy.
2019; 13(?):3569-3578. doi:
10.2147/dddt.s211748. [PMID: 31802845] - Shujuan Xiong, Zhe Wang, Juan Liu, Xiangping Deng, Runde Xiong, Xuan Cao, Zhizhong Xie, Xiaoyong Lei, Yanming Chen, Guotao Tang. A pH-sensitive prodrug strategy to co-deliver DOX and TOS in TPGS nanomicelles for tumor therapy.
Colloids and surfaces. B, Biointerfaces.
2019 Jan; 173(?):346-355. doi:
10.1016/j.colsurfb.2018.10.012. [PMID: 30316081] - Abhishesh Kumar Mehata, Shreekant Bharti, Priya Singh, Matte Kasi Viswanadh, Lakshmi Kumari, Poornima Agrawal, Sanjay Singh, Biplob Koch, Madaswamy S Muthu. Trastuzumab decorated TPGS-g-chitosan nanoparticles for targeted breast cancer therapy.
Colloids and surfaces. B, Biointerfaces.
2019 Jan; 173(?):366-377. doi:
10.1016/j.colsurfb.2018.10.007. [PMID: 30316083] - Yongjian Yang, Dahai Qiu, Yajun Liu, Lei Chao. Topical anesthetic analgesic therapy using the combination of ropivacaine and dexmedetomidine: hyaluronic acid modified long-acting nanostructured lipid carriers containing a skin penetration enhancer.
Drug design, development and therapy.
2019; 13(?):3307-3319. doi:
10.2147/dddt.s211443. [PMID: 31571832] - Tarek A Ahmed, Khalid M El-Say, Osama Aa Ahmed, Bader M Aljaeid. Superiority of TPGS-loaded micelles in the brain delivery of vinpocetine via administration of thermosensitive intranasal gel.
International journal of nanomedicine.
2019; 14(?):5555-5567. doi:
10.2147/ijn.s213086. [PMID: 31413562] - Nabil A Alhakamy, Usama A Fahmy, Osama A A Ahmed. Vitamin E TPGS based transferosomes augmented TAT as a promising delivery system for improved transdermal delivery of raloxifene.
PloS one.
2019; 14(12):e0226639. doi:
10.1371/journal.pone.0226639. [PMID: 31881053] - Mingyi Yao, Tamer Elbayoumi. Anionic and Cationic Vitamin E-TPGS Mixed Polymeric Phospholipid Micellar Vehicles.
Methods in molecular biology (Clifton, N.J.).
2019; 2000(?):31-41. doi:
10.1007/978-1-4939-9516-5_3. [PMID: 31148006] - Sumathi Rajamani, Arun Radhakrishnan, Tamizharasi Sengodan, Sivakumar Thangavelu. Augmented anticancer activity of naringenin-loaded TPGS polymeric nanosuspension for drug resistive MCF-7 human breast cancer cells.
Drug development and industrial pharmacy.
2018 Nov; 44(11):1752-1761. doi:
10.1080/03639045.2018.1496445. [PMID: 29968480] - Yude Liu, Lian Rao, Hongguan Zhang, Yanyou Cen, Kaili Cheng. Conjugation of vitamin E-TPGS and guar gum to carry borneol for enhancing blood-brain barrier permeability.
Journal of biomaterials applications.
2018 10; 33(4):590-598. doi:
10.1177/0885328218799551. [PMID: 30208770] - Charlotte Cuerq, Emilie Henin, Lioara Restier, Emilie Blond, Jocelyne Drai, Christophe Marçais, Mathilde Di Filippo, Christian Laveille, Marie-Caroline Michalski, Pierre Poinsot, Cyrielle Caussy, Agnès Sassolas, Philippe Moulin, Emmanuelle Reboul, Sybil Charriere, Emile Levy, Alain Lachaux, Noël Peretti. Efficacy of two vitamin E formulations in patients with abetalipoproteinemia and chylomicron retention disease.
Journal of lipid research.
2018 09; 59(9):1640-1648. doi:
10.1194/jlr.m085043. [PMID: 30021760] - Hongxue Shen, Dandan He, Shuxia Wang, Pinggang Ding, Jianan Wang, Jianming Ju. Preparation, characterization, and pharmacokinetics study of a novel genistein-loaded mixed micelles system.
Drug development and industrial pharmacy.
2018 Sep; 44(9):1536-1542. doi:
10.1080/03639045.2018.1483384. [PMID: 29848136] - Cheng Hu, Kun Liang, Rui An, Xinhong Wang, Lisha You. The characterization, pharmacokinetic, and tissue distribution studies of TPGS-modified artesunate liposome in rats.
Drug development and industrial pharmacy.
2018 Sep; 44(9):1528-1535. doi:
10.1080/03639045.2018.1483383. [PMID: 29862854] - Mengyuan Zhang, Jianhua He, Wenli Zhang, Jianping Liu. Fabrication of TPGS-Stabilized Liposome-PLGA Hybrid Nanoparticle Via a New Modified Nanoprecipitation Approach: In Vitro and In Vivo Evaluation.
Pharmaceutical research.
2018 Aug; 35(11):199. doi:
10.1007/s11095-018-2485-3. [PMID: 30167890] - Akshay Modi, Surendra Kumar Verma, Jayesh Bellare. Extracellular matrix-coated polyethersulfone-TPGS hollow fiber membranes showing improved biocompatibility and uremic toxins removal for bioartificial kidney application.
Colloids and surfaces. B, Biointerfaces.
2018 Jul; 167(?):457-467. doi:
10.1016/j.colsurfb.2018.04.043. [PMID: 29723817] - Hong Li, Yang Liu, Lihua Chen, Qibing Liu, Shanshan Qi, Xinwei Cheng, Young B Lee, Chang-Ho Ahn, Deog Joong Kim, Robert J Lee. Folate receptor-targeted lipid-albumin nanoparticles (F-LAN) for therapeutic delivery of an Akt1 antisense oligonucleotide.
Journal of drug targeting.
2018 Jun; 26(5-6):466-473. doi:
10.1080/1061186x.2018.1433678. [PMID: 29376449] - Yi-Ran Wang, Shi-Yan Yang, Guang-Xia Chen, Ping Wei. Barbaloin loaded polydopamine-polylactide-TPGS (PLA-TPGS) nanoparticles against gastric cancer as a targeted drug delivery system: Studies in vitro and in vivo.
Biochemical and biophysical research communications.
2018 04; 499(1):8-16. doi:
10.1016/j.bbrc.2018.03.069. [PMID: 29534962] - Neill J Liptrott, Marco Giardiello, Tom O McDonald, Steve P Rannard, Andrew Owen. Assessment of interactions of efavirenz solid drug nanoparticles with human immunological and haematological systems.
Journal of nanobiotechnology.
2018 Mar; 16(1):22. doi:
10.1186/s12951-018-0349-y. [PMID: 29544545] - Irene Rossi, Fabio Sonvico, Jason T McConville, Francesca Rossi, Eleonore Fröhlich, Sarah Zellnitz, Alessandra Rossi, Elena Del Favero, Ruggero Bettini, Francesca Buttini. Nebulized coenzyme Q10 nanosuspensions: A versatile approach for pulmonary antioxidant therapy.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2018 Feb; 113(?):159-170. doi:
10.1016/j.ejps.2017.10.024. [PMID: 29066385] - Mayank Kumar Singh, Deep Pooja, Halley Gora Ravuri, Anusha Gunukula, Hitesh Kulhari, Ramakrishna Sistla. Fabrication of surfactant-stabilized nanosuspension of naringenin to surpass its poor physiochemical properties and low oral bioavailability.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2018 Feb; 40(?):48-54. doi:
10.1016/j.phymed.2017.12.021. [PMID: 29496174] - Ahmed Abu-Fayyad, Mohammad M Kamal, Jennifer L Carroll, Ana-Maria Dragoi, Robert Cody, James Cardelli, Sami Nazzal. Development and in-vitro characterization of nanoemulsions loaded with paclitaxel/γ-tocotrienol lipid conjugates.
International journal of pharmaceutics.
2018 Jan; 536(1):146-157. doi:
10.1016/j.ijpharm.2017.11.062. [PMID: 29195915] - Yanlei Wang, Xiang Zhang, Wenqiang Zhang, Hao Dong, Wenjie Zhang, Jiajia Mao, Yong Dai. Combination of Oxaliplatin and Vit.E-TPGS in Lipid Nanosystem for Enhanced Therapeutic Efficacy in Colon Cancers.
Pharmaceutical research.
2018 Jan; 35(2):27. doi:
10.1007/s11095-017-2297-x. [PMID: 29368145] - Zeting Yuan, Yuxia Yuan, Lin Han, Yanyan Qiu, Xiaqin Huang, Feng Gao, Guohua Fan, Yixi Zhang, Xueyao Tang, Xue He, Ke Xu, Peihao Yin. Bufalin-loaded vitamin E succinate-grafted-chitosan oligosaccharide/RGD conjugated TPGS mixed micelles demonstrated improved antitumor activity against drug-resistant colon cancer.
International journal of nanomedicine.
2018; 13(?):7533-7548. doi:
10.2147/ijn.s170692. [PMID: 30532537] - Cheng Hu, Kun Liang, Rui An, Xin-Hong Wang, Li-Sha You. [Tissue distribution of TPGS modified artesunate liposome and its metabolites in rats].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2018 Jan; 43(2):325-331. doi:
10.19540/j.cnki.cjcmm.20171023.006. [PMID: 29552851] - Xiangju Zhao, Ying Sun, Zhaoguo Li. Topical anesthesia therapy using lidocaine-loaded nanostructured lipid carriers: tocopheryl polyethylene glycol 1000 succinate-modified transdermal delivery system.
Drug design, development and therapy.
2018; 12(?):4231-4240. doi:
10.2147/dddt.s187177. [PMID: 30587919] - Shouwen Zhang, Jingfang Li, Shunpeng Hu, Fangfang Wu, Xianzhao Zhang. Triphenylphosphonium and D-α-tocopheryl polyethylene glycol 1000 succinate-modified, tanshinone IIA-loaded lipid-polymeric nanocarriers for the targeted therapy of myocardial infarction.
International journal of nanomedicine.
2018; 13(?):4045-4057. doi:
10.2147/ijn.s165590. [PMID: 30022826] - Lakshmi Maurya, Sanjay Singh, Vijayakumar M Rajamanickam, Gopeshwar Narayan. Vitamin E TPGS Emulsified Vinorelbine Bitartrate Loaded Solid Lipid Nanoparticles (SLN): Formulation Development, Optimization and In vitro Characterization.
Current drug delivery.
2018; 15(8):1135-1145. doi:
10.2174/1567201815666180409105410. [PMID: 29629662] - Yang Liu, Yueqin Ma, Junnan Xu, Yingchong Chen, Jin Xie, Pengfei Yue, Qin Zheng, Ming Yang. Apolipoproteins adsorption and brain-targeting evaluation of baicalin nanocrystals modified by combination of Tween80 and TPGS.
Colloids and surfaces. B, Biointerfaces.
2017 Dec; 160(?):619-627. doi:
10.1016/j.colsurfb.2017.10.009. [PMID: 29031222] - Helmy Yusuf, Ahlam A Ali, Natalie Orr, Michael M Tunney, Helen O McCarthy, Vicky L Kett. Novel freeze-dried DDA and TPGS liposomes are suitable for nasal delivery of vaccine.
International journal of pharmaceutics.
2017 Nov; 533(1):179-186. doi:
10.1016/j.ijpharm.2017.09.011. [PMID: 28887219] - Akshay Modi, Surendra Kumar Verma, Jayesh Bellare. Graphene oxide nanosheets and d-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS) doping improves biocompatibility and ultrafiltration in polyethersulfone hollow fiber membranes.
Journal of colloid and interface science.
2017 Oct; 504(?):86-100. doi:
10.1016/j.jcis.2017.05.035. [PMID: 28527829] - Basanth Babu Eedara, Suresh Bandari. Lipid-based dispersions of exemestane for improved dissolution rate and intestinal permeability: in vitro and ex vivo characterization.
Artificial cells, nanomedicine, and biotechnology.
2017 Aug; 45(5):917-927. doi:
10.1080/21691401.2016.1193023. [PMID: 27267814] - Jing Zhao, Youwei Xu, Changyuan Wang, Yanfang Ding, Manyu Chen, Yifei Wang, Jinyong Peng, Lei Li, Li Lv. Soluplus/TPGS mixed micelles for dioscin delivery in cancer therapy.
Drug development and industrial pharmacy.
2017 Jul; 43(7):1197-1204. doi:
10.1080/03639045.2017.1304956. [PMID: 28300426] - Yanzuo Chen, Shu Feng, Wenchao Liu, Zeting Yuan, Peihao Yin, Feng Gao. Vitamin E Succinate-Grafted-Chitosan Oligosaccharide/RGD-Conjugated TPGS Mixed Micelles Loaded with Paclitaxel for U87MG Tumor Therapy.
Molecular pharmaceutics.
2017 04; 14(4):1190-1203. doi:
10.1021/acs.molpharmaceut.6b01068. [PMID: 28212490] - Mei Hu, Jinjie Zhang, Rui Ding, Yao Fu, Tao Gong, Zhirong Zhang. Improved oral bioavailability and therapeutic efficacy of dabigatran etexilate via Soluplus-TPGS binary mixed micelles system.
Drug development and industrial pharmacy.
2017 Apr; 43(4):687-697. doi:
10.1080/03639045.2016.1278015. [PMID: 28032534] - Helong Liu, Liangxing Tu, Yongxin Zhou, Zefang Dang, Luting Wang, Junfeng Du, Jianfang Feng, Kaili Hu. Improved Bioavailability and Antitumor Effect of Docetaxel by TPGS Modified Proniosomes: In Vitro and In Vivo Evaluations.
Scientific reports.
2017 03; 7(?):43372. doi:
10.1038/srep43372. [PMID: 28266539] - Hongzhi Qiao, Lihua Chen, Tianqi Rui, Jingxian Wang, Ting Chen, Tingming Fu, Junsong Li, Liuqing Di. Fabrication and in vitro/in vivo evaluation of amorphous andrographolide nanosuspensions stabilized by d-α-tocopheryl polyethylene glycol 1000 succinate/sodium lauryl sulfate.
International journal of nanomedicine.
2017; 12(?):1033-1046. doi:
10.2147/ijn.s120887. [PMID: 28223797] - Anan Yu, Jieqiong Lv, Fang Yuan, Zihua Xia, Kaiyan Fan, Gang Chen, Jialin Ren, Cuicui Lin, Shijie Wei, Fan Yang. mPEG-PLA/TPGS mixed micelles via intranasal administration improved the bioavailability of lamotrigine in the hippocampus.
International journal of nanomedicine.
2017; 12(?):8353-8362. doi:
10.2147/ijn.s145488. [PMID: 29200847] - Jifu Hao, Tiantian Tong, Kai Jin, Qiannan Zhuang, Te Han, Yanping Bi, Jianzhu Wang, Xiaodan Wang. Folic acid-functionalized drug delivery platform of resveratrol based on Pluronic 127/D-α-tocopheryl polyethylene glycol 1000 succinate mixed micelles.
International journal of nanomedicine.
2017; 12(?):2279-2292. doi:
10.2147/ijn.s130094. [PMID: 28392687] - Shreyasi Chakraborty, Nabanita Kar, Leena Kumari, Asit De, Tanmoy Bera. Inhibitory effect of a new orally active cedrol-loaded nanostructured lipid carrier on compound 48/80-induced mast cell degranulation and anaphylactic shock in mice.
International journal of nanomedicine.
2017; 12(?):4849-4868. doi:
10.2147/ijn.s132114. [PMID: 28744120] - Alice Thébaut, Antal Nemeth, Jeannie Le Mouhaër, René Scheenstra, Ulrich Baumann, Bart Koot, Fredéric Gottrand, Roderick Houwen, Laure Monard, Sylvie Lafaye de Micheaux, Dalila Habes, Emmanuel Jacquemin. Oral Tocofersolan Corrects or Prevents Vitamin E Deficiency in Children With Chronic Cholestasis.
Journal of pediatric gastroenterology and nutrition.
2016 12; 63(6):610-615. doi:
10.1097/mpg.0000000000001331. [PMID: 27429423] - Mariana S Oliveira, Bhawani Aryasomayajula, Bhushan Pattni, Samuel V Mussi, Lucas A M Ferreira, Vladmir P Torchilin. Solid lipid nanoparticles co-loaded with doxorubicin and α-tocopherol succinate are effective against drug-resistant cancer cells in monolayer and 3-D spheroid cancer cell models.
International journal of pharmaceutics.
2016 Oct; 512(1):292-300. doi:
10.1016/j.ijpharm.2016.08.049. [PMID: 27568499] - Lei Yang, Jin Xin, Zhenhai Zhang, Hongmei Yan, Jing Wang, E Sun, Jian Hou, Xiaobin Jia, Huixia Lv. TPGS-modified liposomes for the delivery of ginsenoside compound K against non-small cell lung cancer: formulation design and its evaluation in vitro and in vivo.
The Journal of pharmacy and pharmacology.
2016 Sep; 68(9):1109-18. doi:
10.1111/jphp.12590. [PMID: 27368109] - Mahalingam Rajamanickam Vijayakumar, Kiran Yellappa Vajanthri, Chelladurai Karthikeyan Balavigneswaran, Sanjeev Kumar Mahto, Nira Mishra, Madaswamy S Muthu, Sanjay Singh. Pharmacokinetics, biodistribution, in vitro cytotoxicity and biocompatibility of Vitamin E TPGS coated trans resveratrol liposomes.
Colloids and surfaces. B, Biointerfaces.
2016 Sep; 145(?):479-491. doi:
10.1016/j.colsurfb.2016.05.037. [PMID: 27236510] - Yuling Bao, Mingxing Yin, Xiaomeng Hu, Xiangting Zhuang, Yu Sun, Yuanyuan Guo, Songwei Tan, Zhiping Zhang. A safe, simple and efficient doxorubicin prodrug hybrid micelle for overcoming tumor multidrug resistance and targeting delivery.
Journal of controlled release : official journal of the Controlled Release Society.
2016 08; 235(?):182-194. doi:
10.1016/j.jconrel.2016.06.003. [PMID: 27264552] - Bingjun Sun, Cong Luo, Lin Li, Menglin Wang, Yuqian Du, Donghua Di, Dong Zhang, Guolian Ren, Xiaolei Pan, Qiang Fu, Jin Sun, Zhonggui He. Core-matched encapsulation of an oleate prodrug into nanostructured lipid carriers with high drug loading capability to facilitate the oral delivery of docetaxel.
Colloids and surfaces. B, Biointerfaces.
2016 Jul; 143(?):47-55. doi:
10.1016/j.colsurfb.2016.02.065. [PMID: 27011346]