Dihydroceramide (BioDeep_00000023381)

   

human metabolite Endogenous


代谢物信息卡片


N-[(2S,3R)-1,3-Dihydroxyoctadecan-2-yl]formamide

化学式: C19H39NO3 (329.29297840000004)
中文名称:
谱图信息: 最多检出来源 Viridiplantae(plant) 0.11%

分子结构信息

SMILES: CCCCCCCCCCCCCCCC(C(CO)NC=O)O
InChI: InChI=1S/C19H39NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19(23)18(16-21)20-17-22/h17-19,21,23H,2-16H2,1H3,(H,20,22)/t18-,19+/m0/s1

描述信息

Dihydroceramide is an intermediate in sphingolipid metabolism. Dihydroceramide is the third to last step in the synthesis of beta-D-Galactosyl-1,4-beta-D glucosylceramide and is converted from sphinganine via the enzyme acyl-CoA-dependent ceramide synthase (EC 2.3.1.24). It is then converted to N-acylsphingosine via the enzyme fatty acid desaturase (EC 1.14.-.-). [HMDB]
Dihydroceramide is an intermediate in sphingolipid metabolism. Dihydroceramide is the third to last step in the synthesis of beta-D-Galactosyl-1,4-beta-D glucosylceramide and is converted from sphinganine via the enzyme acyl-CoA-dependent ceramide synthase (EC 2.3.1.24). It is then converted to N-acylsphingosine via the enzyme fatty acid desaturase (EC 1.14.-.-).

同义名列表

4 个代谢物同义名

N-[(2S,3R)-1,3-Dihydroxyoctadecan-2-yl]formamide; N-(1,3-dihydroxyoctadecan-2-yl)formamide; N-Acylsphinganine; Dihydroceramide



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

36 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(10)

WikiPathways(3)

Plant Reactome(0)

INOH(0)

PlantCyc(1)

COVID-19 Disease Map(0)

PathBank(22)

  • Sphingolipid Metabolism: Glucosylceramide (d18:1/18:0) + Water ⟶ Ceramide (d18:1/18:0) + D-Glucose
  • Gaucher Disease: Glucosylceramide (d18:1/18:0) + Water ⟶ Ceramide (d18:1/18:0) + D-Glucose
  • Globoid Cell Leukodystrophy: Glucosylceramide (d18:1/18:0) + Water ⟶ Ceramide (d18:1/18:0) + D-Glucose
  • Metachromatic Leukodystrophy (MLD): Glucosylceramide (d18:1/18:0) + Water ⟶ Ceramide (d18:1/18:0) + D-Glucose
  • Fabry Disease: Glucosylceramide (d18:1/18:0) + Water ⟶ Ceramide (d18:1/18:0) + D-Glucose
  • Krabbe Disease: Glucosylceramide (d18:1/18:0) + Water ⟶ Ceramide (d18:1/18:0) + D-Glucose
  • Sphingolipid Metabolism: Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate
  • Gaucher Disease: Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate
  • Globoid Cell Leukodystrophy: Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate
  • Metachromatic Leukodystrophy (MLD): Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate
  • Fabry Disease: Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate
  • Krabbe Disease: Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate
  • Sphingolipid Metabolism: Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate
  • Sphingolipid Metabolism: Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate
  • Sphingolipid Metabolism: Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate
  • Sphingolipid Metabolism: Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate
  • Gaucher Disease: Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate
  • Globoid Cell Leukodystrophy: Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate
  • Metachromatic Leukodystrophy (MLD): Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate
  • Fabry Disease: Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate
  • Krabbe Disease: Galactosylceramide (d18:1/16:0) + Phosphoadenosine phosphosulfate ⟶ 3-O-Sulfogalactosylceramide (d18:1/24:0) + Adenosine 3',5'-diphosphate
  • Sphingolipid Metabolism: L-Serine + Palmityl-CoA ⟶ 3-Dehydrosphinganine + Carbon dioxide

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Michele Dei Cas, Linda Montavoci, Claudia Pasini, Anna Caretti, Sara Penati, Carla Martinelli, Umberto Gianelli, Sara Casati, Francesca Nardecchia, Annalaura Torella, Nicola Brunetti-Pierri, Marco Trinchera. Loss of function and reduced levels of sphingolipid desaturase DEGS1 variants are both relevant in disease mechanism. Journal of lipid research. 2024 03; 65(3):100517. doi: 10.1016/j.jlr.2024.100517. [PMID: 38342436]
  • M John Chapman, Alexina Orsoni, Natalie A Mellett, Anh Nguyen, Paul Robillard, Jonathan E Shaw, Philippe Giral, Patrice Thérond, Debi Swertfeger, W Sean Davidson, Peter J Meikle. Pitavastatin treatment remodels the HDL subclass lipidome and proteome in hypertriglyceridemia. Journal of lipid research. 2024 02; 65(2):100494. doi: 10.1016/j.jlr.2023.100494. [PMID: 38160756]
  • Patricia Mingo-Casas, Javier Sanchez-Céspedes, Ana-Belén Blázquez, Josefina Casas, María Balsera-Manzanero, Laura Herrero, Ana Vázquez, Jerónimo Pachón, Manuela Aguilar-Guisado, José Miguel Cisneros, Juan-Carlos Saiz, Miguel A Martín-Acebes. Lipid signatures of West Nile virus infection unveil alterations of sphingolipid metabolism providing novel biomarkers. Emerging microbes & infections. 2023 Dec; 12(2):2231556. doi: 10.1080/22221751.2023.2231556. [PMID: 37377355]
  • Brian A Kleiboeker, Cheryl Frankfater, Mary E Davey, Fong-Fu Hsu. Lipidomic analysis of Porphyromonas gingivalis reveals novel glycerol bisphosphoceramide, phosphatidyl-, and phosphoglycerol dipeptide lipid families. Journal of lipid research. 2023 12; 64(12):100470. doi: 10.1016/j.jlr.2023.100470. [PMID: 37924978]
  • Ran Song, Aaron Fond, Xiaohong Li, Miao Tang, Xiaoming Zhan, Ruth Gordillo, Eva Marie Y Moresco, Bruce Beutler, Emre E Turer. The dual lipid desaturase/hydroxylase DEGS2 controls phytoceramide levels necessary to counter intestinal inflammation. Disease models & mechanisms. 2023 Aug; ?(?):. doi: 10.1242/dmm.050043. [PMID: 37589563]
  • Cheryl F Frankfater, Mariana G Sartorio, Ezequiel Valguarnera, Mario F Feldman, Fong-Fu Hsu. Lipidome of the Bacteroides Genus Containing New Peptidolipid and Sphingolipid Families Revealed by Multiple-Stage Mass Spectrometry. Biochemistry. 2023 Mar; ?(?):. doi: 10.1021/acs.biochem.2c00664. [PMID: 36880942]
  • Saskia Wedel, Lisa Hahnefeld, Mohamad Wessam Alnouri, Stefan Offermanns, Felix Hausch, Gerd Geisslinger, Marco Sisignano. The FKBP51 Inhibitor SAFit2 Restores the Pain-Relieving C16 Dihydroceramide after Nerve Injury. International journal of molecular sciences. 2022 Nov; 23(22):. doi: 10.3390/ijms232214274. [PMID: 36430751]
  • Xuantong Zhou, Furong Huang, Gang Ma, Wenqing Wei, Nan Wu, Zhihua Liu. Dysregulated ceramides metabolism by fatty acid 2-hydroxylase exposes a metabolic vulnerability to target cancer metastasis. Signal transduction and targeted therapy. 2022 10; 7(1):370. doi: 10.1038/s41392-022-01199-1. [PMID: 36274060]
  • Lisa Peters, Wolfgang M Kuebler, Szandor Simmons. Sphingolipids in Atherosclerosis: Chimeras in Structure and Function. International journal of molecular sciences. 2022 Oct; 23(19):. doi: 10.3390/ijms231911948. [PMID: 36233252]
  • Simona Zarini, Joseph T Brozinick, Karin A Zemski Berry, Amanda Garfield, Leigh Perreault, Anna Kerege, Hai Hoang Bui, Phil Sanders, Parker Siddall, Ming Shang Kuo, Bryan C Bergman. Serum dihydroceramides correlate with insulin sensitivity in humans and decrease insulin sensitivity in vitro. Journal of lipid research. 2022 10; 63(10):100270. doi: 10.1016/j.jlr.2022.100270. [PMID: 36030929]
  • Mario Ruiz, Marcus Henricsson, Jan Borén, Marc Pilon. Palmitic acid causes increased dihydroceramide levels when desaturase expression is directly silenced or indirectly lowered by silencing AdipoR2. Lipids in health and disease. 2021 Nov; 20(1):173. doi: 10.1186/s12944-021-01600-y. [PMID: 34839823]
  • Alberto Canfrán-Duque, Óscar Pastor, David García-Seisdedos, Yessenia L Molina, Bohdan Babiy, Milagros Lerma, Carmen Sánchez-Castellano, Javier Martínez-Botas, Diego Gómez-Coronado, Miguel A Lasunción, Alfonso J Cruz-Jentoft, Rebeca Busto. The Antipsychotic Risperidone Alters Dihydroceramide and Ceramide Composition and Plasma Membrane Function in Leukocytes In Vitro and In Vivo. International journal of molecular sciences. 2021 Apr; 22(8):. doi: 10.3390/ijms22083919. [PMID: 33920193]
  • Fumika Mi-Ichi, Kazutaka Ikeda, Hiroshi Tsugawa, Sharmina Deloer, Hiroki Yoshida, Makoto Arita. Stage-Specific De Novo Synthesis of Very-Long-Chain Dihydroceramides Confers Dormancy to Entamoeba Parasites. mSphere. 2021 03; 6(2):. doi: 10.1128/msphere.00174-21. [PMID: 33731470]
  • Qianyang Huang, Shiying Hao, Xiaoming Yao, Jin You, Xiao Li, Donghai Lai, Chunle Han, James Schilling, Kuo Yuan Hwa, Sheeno Thyparambil, John Whitin, Harvey J Cohen, Henry Chubb, Scott R Ceresnak, Doff B McElhinney, Ronald J Wong, Gary M Shaw, David K Stevenson, Karl G Sylvester, Xuefeng B Ling. High-throughput quantitation of serological ceramides/dihydroceramides by LC/MS/MS: Pregnancy baseline biomarkers and potential metabolic messengers. Journal of pharmaceutical and biomedical analysis. 2021 Jan; 192(?):113639. doi: 10.1016/j.jpba.2020.113639. [PMID: 33017796]
  • Floriane Lachkar, Pascal Ferré, Fabienne Foufelle, Alexandra Papaioannou. Dihydroceramides: their emerging physiological roles and functions in cancer and metabolic diseases. American journal of physiology. Endocrinology and metabolism. 2021 01; 320(1):E122-E130. doi: 10.1152/ajpendo.00330.2020. [PMID: 33135459]
  • Aurélie Carlier, Franck Phan, Anaïs Szpigel, Eric Hajduch, Joe-Elie Salem, Jérémie Gautheron, Wilfried Le Goff, Maryse Guérin, Floriane Lachkar, Vlad Ratziu, Agnès Hartemann, Pascal Ferré, Fabienne Foufelle, Olivier Bourron. Dihydroceramides in Triglyceride-Enriched VLDL Are Associated with Nonalcoholic Fatty Liver Disease Severity in Type 2 Diabetes. Cell reports. Medicine. 2020 12; 1(9):100154. doi: 10.1016/j.xcrm.2020.100154. [PMID: 33377125]
  • Maria Apostolopoulou, Ruth Gordillo, Sofiya Gancheva, Klaus Strassburger, Christian Herder, Irene Esposito, Matthias Schlensak, Philipp E Scherer, Michael Roden. Role of ceramide-to-dihydroceramide ratios for insulin resistance and non-alcoholic fatty liver disease in humans. BMJ open diabetes research & care. 2020 11; 8(2):. doi: 10.1136/bmjdrc-2020-001860. [PMID: 33219119]
  • Mengzhen Sun, Qiya Wang, Maomao Zhang, Guohua Zhang, Tao Wu, Rui Liu, Wenjie Sui, Jiaojiao Zhang, Jinjin Yin, Min Zhang. Leuconostoc pseudomesenteroides improves microbiota dysbiosis and liver metabolism imbalance and ameliorates the correlation between dihydroceramide and strains of Firmicutes and Proteobacteria in high fat diet obese mice. Food & function. 2020 Aug; 11(8):6855-6865. doi: 10.1039/d0fo01009j. [PMID: 32666978]
  • F Fumeron, A Nicolas, J-P Bastard, S Fellahi, L Wigger, M Ibberson, C Cruciani-Guglielmacci, H Le Stunff, G Velho, C Magnan, M Marre, B Balkau, R Roussel. Dairy consumption is associated with lower plasma dihydroceramides in women from the D.E.S.I.R. cohort. Diabetes & metabolism. 2020 04; 46(2):144-149. doi: 10.1016/j.diabet.2019.06.002. [PMID: 31212089]
  • Katja Jakobi, Sandra Beyer, Alexander Koch, Dominique Thomas, Stephanie Schwalm, Stefan Zeuzem, Josef Pfeilschifter, Georgios Grammatikos. Sorafenib Treatment and Modulation of the Sphingolipid Pathway Affect Proliferation and Viability of Hepatocellular Carcinoma In Vitro. International journal of molecular sciences. 2020 Mar; 21(7):. doi: 10.3390/ijms21072409. [PMID: 32244391]
  • Fang-Fang Li, Ning Liu, Wei Liu, Mei Li, Fan Zhang, Zhen Dong, Jin-Lan Zhang, Hua Sun. Role of dihydroceramides in the progression of acute-on-chronic liver failure in rats. Chinese medical journal. 2020 Jan; 133(2):198-204. doi: 10.1097/cm9.0000000000000601. [PMID: 31880746]
  • Chiaki Yamada, Juliet Akkaoui, Anny Ho, Carolina Duarte, Richard Deth, Toshihisa Kawai, Frank Nichols, Madepalli K Lakshmana, Alexandru Movila. Potential Role of Phosphoglycerol Dihydroceramide Produced by Periodontal Pathogen Porphyromonas gingivalis in the Pathogenesis of Alzheimer's Disease. Frontiers in immunology. 2020; 11(?):591571. doi: 10.3389/fimmu.2020.591571. [PMID: 33329577]
  • Vadim Dolgin, Rachel Straussberg, Ruijuan Xu, Izolda Mileva, Yuval Yogev, Raed Khoury, Osnat Konen, Yael Barhum, Alex Zvulunov, Cungui Mao, Ohad S Birk. DEGS1 variant causes neurological disorder. European journal of human genetics : EJHG. 2019 11; 27(11):1668-1676. doi: 10.1038/s41431-019-0444-z. [PMID: 31186544]
  • A Galih Haribowo, J Thomas Hannich, Agnès H Michel, Márton Megyeri, Maya Schuldiner, Benoît Kornmann, Howard Riezman. Cytotoxicity of 1-deoxysphingolipid unraveled by genome-wide genetic screens and lipidomics in Saccharomyces cerevisiae. Molecular biology of the cell. 2019 10; 30(22):2814-2826. doi: 10.1091/mbc.e19-07-0364. [PMID: 31509475]
  • Emanuele La Corte, Michele Dei Cas, Alberto Raggi, Monica Patanè, Morgan Broggi, Silvia Schiavolin, Chiara Calatozzolo, Bianca Pollo, Carlotta Pipolo, Maria Grazia Bruzzone, Giuseppe Campisi, Rita Paroni, Riccardo Ghidoni, Paolo Ferroli. Long and Very-Long-Chain Ceramides Correlate with A More Aggressive Behavior in Skull Base Chordoma Patients. International journal of molecular sciences. 2019 Sep; 20(18):. doi: 10.3390/ijms20184480. [PMID: 31514293]
  • Nicholas B Blackburn, Laura F Michael, Peter J Meikle, Juan M Peralta, Marian Mosior, Scott McAhren, Hai H Bui, Melissa A Bellinger, Corey Giles, Satish Kumar, Ana C Leandro, Marcio Almeida, Jacquelyn M Weir, Michael C Mahaney, Thomas D Dyer, Laura Almasy, John L VandeBerg, Sarah Williams-Blangero, David C Glahn, Ravindranath Duggirala, Mark Kowala, John Blangero, Joanne E Curran. Rare DEGS1 variant significantly alters de novo ceramide synthesis pathway. Journal of lipid research. 2019 09; 60(9):1630-1639. doi: 10.1194/jlr.p094433. [PMID: 31227640]
  • Bhagirath Chaurasia, Trevor S Tippetts, Rafael Mayoral Monibas, Jinqi Liu, Ying Li, Liping Wang, Joseph L Wilkerson, C Rufus Sweeney, Renato Felipe Pereira, Doris Hissako Sumida, J Alan Maschek, James E Cox, Vincent Kaddai, Graeme Iain Lancaster, Monowarul Mobin Siddique, Annelise Poss, Mackenzie Pearson, Santhosh Satapati, Heather Zhou, David G McLaren, Stephen F Previs, Ying Chen, Ying Qian, Aleksandr Petrov, Margaret Wu, Xiaolan Shen, Jun Yao, Christian N Nunes, Andrew D Howard, Liangsu Wang, Mark D Erion, Jared Rutter, William L Holland, David E Kelley, Scott A Summers. Targeting a ceramide double bond improves insulin resistance and hepatic steatosis. Science (New York, N.Y.). 2019 07; 365(6451):386-392. doi: 10.1126/science.aav3722. [PMID: 31273070]
  • Nunya Chotiwan, Barbara G Andre, Irma Sanchez-Vargas, M Nurul Islam, Jeffrey M Grabowski, Amber Hopf-Jannasch, Erik Gough, Ernesto Nakayasu, Carol D Blair, John T Belisle, Catherine A Hill, Richard J Kuhn, Rushika Perera. Dynamic remodeling of lipids coincides with dengue virus replication in the midgut of Aedes aegypti mosquitoes. PLoS pathogens. 2018 02; 14(2):e1006853. doi: 10.1371/journal.ppat.1006853. [PMID: 29447265]
  • Andrej Kováčik, Petra Pullmannová, Jaroslav Maixner, Kateřina Vávrová. Effects of Ceramide and Dihydroceramide Stereochemistry at C-3 on the Phase Behavior and Permeability of Skin Lipid Membranes. Langmuir : the ACS journal of surfaces and colloids. 2018 01; 34(1):521-529. doi: 10.1021/acs.langmuir.7b03448. [PMID: 29228775]
  • Ah Young Lee, Jae Won Lee, Ji-Eun Kim, Hyuck Jun Mock, Sungjin Park, Sanghwa Kim, Seong-Ho Hong, Ji-Young Kim, Eun-Jung Park, Kyung-Sun Kang, Kwang Pyo Kim, Myung-Haing Cho. Dihydroceramide is a key metabolite that regulates autophagy and promotes fibrosis in hepatic steatosis model. Biochemical and biophysical research communications. 2017 12; 494(3-4):460-469. doi: 10.1016/j.bbrc.2017.10.110. [PMID: 29066349]
  • Valeria de Mello-Coelho, Roy G Cutler, Allyson Bunbury, Anita Tammara, Mark P Mattson, Dennis D Taub. Age-associated alterations in the levels of cytotoxic lipid molecular species and oxidative stress in the murine thymus are reduced by growth hormone treatment. Mechanisms of ageing and development. 2017 10; 167(?):46-55. doi: 10.1016/j.mad.2017.08.015. [PMID: 28865931]
  • Wei-Hung Jung, Chung-Chih Liu, Yu-Lian Yu, Yu-Chin Chang, Wen-Yu Lien, Hsi-Chun Chao, Shu-Yi Huang, Ching-Hua Kuo, Han-Chen Ho, Chih-Chiang Chan. Lipophagy prevents activity-dependent neurodegeneration due to dihydroceramide accumulation in vivo. EMBO reports. 2017 07; 18(7):1150-1165. doi: 10.15252/embr.201643480. [PMID: 28507162]
  • Nina Eikelis, Elisabeth A Lambert, Sarah Phillips, Carolina Ika Sari, Piyushkumar A Mundra, Jacquelyn M Weir, Kevin Huynh, Mariee T Grima, Nora E Straznicky, John B Dixon, Markus P Schlaich, Peter J Meikle, Gavin W Lambert. Muscle Sympathetic Nerve Activity Is Associated With Elements of the Plasma Lipidomic Profile in Young Asian Adults. The Journal of clinical endocrinology and metabolism. 2017 06; 102(6):2059-2068. doi: 10.1210/jc.2016-3738. [PMID: 28323975]
  • Hiroyuki Kanzaki, Alexandru Movila, Rayyan Kayal, Marcelo H Napimoga, Kenji Egashira, Floyd Dewhirst, Hajime Sasaki, Mohammed Howait, Ayman Al-Dharrab, Abdulghani Mira, Xiaozhe Han, Martin A Taubman, Frank C Nichols, Toshihisa Kawai. Phosphoglycerol dihydroceramide, a distinctive ceramide produced by Porphyromonas gingivalis, promotes RANKL-induced osteoclastogenesis by acting on non-muscle myosin II-A (Myh9), an osteoclast cell fusion regulatory factor. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2017 May; 1862(5):452-462. doi: 10.1016/j.bbalip.2017.01.008. [PMID: 28153611]
  • Leonore Wigger, Céline Cruciani-Guglielmacci, Anthony Nicolas, Jessica Denom, Neïké Fernandez, Frédéric Fumeron, Pedro Marques-Vidal, Alain Ktorza, Werner Kramer, Anke Schulte, Hervé Le Stunff, Robin Liechti, Ioannis Xenarios, Peter Vollenweider, Gérard Waeber, Ingo Uphues, Ronan Roussel, Christophe Magnan, Mark Ibberson, Bernard Thorens. Plasma Dihydroceramides Are Diabetes Susceptibility Biomarker Candidates in Mice and Humans. Cell reports. 2017 02; 18(9):2269-2279. doi: 10.1016/j.celrep.2017.02.019. [PMID: 28249170]
  • Simon Edvardson, Jae Kyo Yi, Chaim Jalas, Ruijuan Xu, Bryn D Webb, Justin Snider, Anastasia Fedick, Elisheva Kleinman, Nathan R Treff, Cungui Mao, Orly Elpeleg. Deficiency of the alkaline ceramidase ACER3 manifests in early childhood by progressive leukodystrophy. Journal of medical genetics. 2016 06; 53(6):389-96. doi: 10.1136/jmedgenet-2015-103457. [PMID: 26792856]
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  • Melissa E Hansen, Kurtis J Simmons, Trevor S Tippetts, Mikayla O Thatcher, Rex R Saito, Sheryl T Hubbard, Annie M Trumbull, Brian A Parker, Oliver J Taylor, Benjamin T Bikman. Lipopolysaccharide Disrupts Mitochondrial Physiology in Skeletal Muscle via Disparate Effects on Sphingolipid Metabolism. Shock (Augusta, Ga.). 2015 Dec; 44(6):585-92. doi: 10.1097/shk.0000000000000468. [PMID: 26529656]
  • Michelle M Mielke, Veera Venkata Ratnam Bandaru, Dingfen Han, Yang An, Susan M Resnick, Luigi Ferrucci, Norman J Haughey. Demographic and clinical variables affecting mid- to late-life trajectories of plasma ceramide and dihydroceramide species. Aging cell. 2015 Dec; 14(6):1014-23. doi: 10.1111/acel.12369. [PMID: 26193443]
  • B Lee Peterlin, Michelle M Mielke, Alex M Dickens, Subroto Chatterjee, Paul Dash, Guillermo Alexander, Rebeca V A Vieira, Veera Venkata Ratnam Bandaru, Joelle M Dorskind, Gretchen E Tietjen, Norman H Haughey. Interictal, circulating sphingolipids in women with episodic migraine: A case-control study. Neurology. 2015 Oct; 85(14):1214-23. doi: 10.1212/wnl.0000000000002004. [PMID: 26354990]
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